Cross-familiarisation conditioned taste aversion procedure as a method to reveal stimulus resemblance between drugs: studies on the 5-HT1A agonist 8-OHDPAT.

abstract：:Lu 25-109 [5-(2-ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine] , has M agonistic and M2/M3 antagonistic effects at muscarinic receptors in vitro; a pharmacological profile that may be beneficial in treatment of Alzheimer's disease. In the present study, we compare functional in vivo effects of Lu 25-109 ...

journal_title：Psychopharmacology

authors： Sánchez C,Arnt J,Didriksen M,Dragsted N,Moltzen Lenz S,Matz J

更新日期：1998-06-01 00:00:00

abstract：:Haloperidol has recently been found to be metabolized to its pyridinium ion (HP+). This conversion of haloperidol to HP+ appears to be similar to the activation of the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to N-methyl-4-phenyl pyridinium ion (MPP+). MPP+ is responsible for the dam...

journal_title：Psychopharmacology

authors： Fang J,Zuo D,Yu PH

更新日期：1995-10-01 00:00:00

abstract：RATIONALE:Cognitive processes underlying drug use have typically been assessed in laboratory settings. More detailed and ecologically valid data may be possible if assessments were conducted in an ecological momentary assessment (EMA) setting. OBJECTIVES:We evaluated the feasibility and utility of administering a reac...

journal_title：Psychopharmacology

authors： Waters AJ,Li Y

更新日期：2008-03-01 00:00:00

abstract：:The effect of ovarian steroids on the benzodiazepine receptor was assessed in the elevated plus-maze and, after restraint stress, in benzodiazepine receptor binding assays. Vehicle-treated proestrous rats displayed anxiolytic behavior, relative to diestrus or estrous rats. Anxiolytic behavior was observed after 1 or 2...

journal_title：Psychopharmacology

authors： Bitran D,Dowd JA

更新日期：1996-05-01 00:00:00

abstract：RATIONALE:Cue avoidance training (CAT) reduces alcohol consumption in the laboratory. However, the neural mechanisms that underlie the effects of this intervention are poorly understood. OBJECTIVES:The present study investigated the effects of a single session of CAT on event-related and readiness potentials during pr...

journal_title：Psychopharmacology

authors： Di Lemma LCG,Stancak A,Soto V,Fallon N,Field M

更新日期：2020-05-01 00:00:00

abstract：:Dopaminergic involvement in the regulation of operant behavior was examined by monitoring responding after administration of different dopaminergic agonists. A chain schedule of reinforcement was used to classify the effects of these agonists in long-tailed macaques (Macaca fascicularis). The schedule included the fol...

journal_title：Psychopharmacology

authors： Dooley DJ,Bowden DM

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Morphine and buprenorphine have analgesic and anxiolytic-like properties. While their analgesic effects have been well characterized, their anxiolytic-like properties have not. OBJECTIVES:Effects of acute morphine and buprenorphine on the expression of acoustic fear-potentiated startle (FPS) and naloxone pre...

journal_title：Psychopharmacology

authors： Glover EM,Davis M

更新日期：2008-06-01 00:00:00

abstract：RATIONALE:Past research has found that exposure to alcohol cues causes a narrowing of attentional scope and enhances the neural responses associated with approach motivation. OBJECTIVE:The current research sought to determine if a manipulated broadened (global) attentional scope would reduce approach-motivated neural ...

journal_title：Psychopharmacology

authors： Ryerson NC,Neal LB,Gable PA

更新日期：2017-04-01 00:00:00

abstract：:Recent work with humans and animals has suggested that the cholinergic system plays an important role in the active control of attention. This study was designed to investigate the effects of scopolamine upon subjects' ability to utilize knowledge of the spatial probability bias in a display in the detection of briefl...

journal_title：Psychopharmacology

authors： Dunne MP,Hartley LR

更新日期：1986-01-01 00:00:00

abstract：:Intracerebroventricular injections of gamma-aminobutyric acid (GABA) and of the GABA-transaminase inhibitor, ethanolamine-O-sulphate (EOS), decreased the food intake of freely-fed (GABA and EOS) and food-deprived rats (EOS). The effect, still evident 24 h after treatment, was not decreased by the GABA receptor-blocker...

journal_title：Psychopharmacology

authors： Olgiati VR,Netti C,Guidobono F,Pecile A

更新日期：1980-01-01 00:00:00

abstract：:The ability of delta 9-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-OH THC and 8 alpha, 11-diOH THC to antagonise the abdominal constriction response in the mouse induced by formic acid, phenylquinone, 5-hydroxytryptamine, prostaglandin E1 (PGE1) and bradykinin was tested. THC was an effective a...

journal_title：Psychopharmacology

authors： Sanders J,Jackson DM,Starmer GA

更新日期：1979-03-28 00:00:00

abstract：:Dose-dependent effects of intravenously administered lorazepam on haemodynamic fluctuations were studied by means of spectral analysis, in order to elucidate sympathetic and parasympathetic components in cardiovascular control during situations of rest and mental stress after benzodiazepine administration. In a double...

journal_title：Psychopharmacology

authors： Tulen JH,Mulder G,Pepplinkhuizen L,Man in 't Veld AJ,van Steenis HG,Moleman P

更新日期：1994-02-01 00:00:00

abstract：:This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), as well as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) the elevated plus-maze test in rats. In add...

journal_title：Psychopharmacology

authors： Griebel G,Moreau JL,Jenck F,Misslin R,Martin JR

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:The party drug ecstasy is frequently used in combination with other drugs like marihuana and alcohol. In addition, a substantial proportion of the MDMA users has claimed to drive a car when under the influence of MDMA and/or other drugs. OBJECTIVE:To assess the effects of MDMA and alcohol, combined and alone...

journal_title：Psychopharmacology

authors： Kuypers KP,Samyn N,Ramaekers JG

更新日期：2006-09-01 00:00:00

abstract：RATIONALE:Adolescence marks a period of increased vulnerability to the development of substance use disorders. High sweet preference is a genetically mediated behavioral trait that also predicts vulnerability to substances of abuse. Previous research has shown that while adolescent rats selectively bred for high (HiS) ...

journal_title：Psychopharmacology

authors： Holtz NA,Carroll ME

更新日期：2013-05-01 00:00:00

abstract：:Aniamls were administered increasing doses of morphine for 16 days. During withdrawal they were challenged with an apomorphine ester or lergotrile. These dopamine agonists produced quantitatively different effects on behaviour. The results suggest that chronic morphine administration leads to dopamine supersensitivity...

journal_title：Psychopharmacology

authors： Tye NC,Horsman L,Wright FC,Pullar IA

更新日期：1979-05-15 00:00:00

abstract：:BALB/cJ, DBA/2J, and C57BL/6J mice were injected with caffeine and tested, in the five choice Yerkes-Thompson Bryant-Bovt Nitti apparatus for patterns discrimination, in two sets of experiments. In the first the patterns were opposite oriented oblique bars, in the second U-shaped figures, one opened toward the right, ...

journal_title：Psychopharmacology

authors： Castellano C

更新日期：1977-03-16 00:00:00

abstract：BACKGROUND AND RATIONALE:Pain is a complex sensory experience, involving cognitive factors, environment (setting, society, and culture), experience, and gender and is modulated significantly by the central nervous system (CNS). The mechanisms by which opioid analgesics work are understood, but this class of drugs is no...

journal_title：Psychopharmacology

authors： Kivell B,Prisinzano TE

更新日期：2010-06-01 00:00:00

abstract：RATIONALE:Deficits in response inhibition associated with heroin use could last several months after abstinence in heroin users, and their response inhibition can also be interfered with task-irrelevant drug-related cues. However, it is unclear whether exposure to drug-related cues affects subsequent response inhibitio...

journal_title：Psychopharmacology

authors： Su B,Li S,Yang L,Zheng M

更新日期：2020-04-01 00:00:00

abstract：:Naloxone, an opioid receptor antagonist, attenuates a wide range of behavioral effects of d-amphetamine, such as the stimulation of motor activity. To investigate the pharmacological selectivity of the naloxone/amphetamine interaction, we assessed the effects of naloxone (5.0 mg/kg SC) upon motor activity induced in r...

journal_title：Psychopharmacology

authors： Jones DN,Holtzman SG

更新日期：1994-03-01 00:00:00

abstract：RATIONALE:Hypofunction of striatal dopamine neurotransmission, or hypodopaminergia, is a consequence of excessive ethanol use and is hypothesized to be a critical component of alcoholism, driving alcohol intake in an attempt to restore dopamine levels; however, the neurochemical mechanisms involved in these dopaminergi...

journal_title：Psychopharmacology

authors： Siciliano CA,Calipari ES,Yorgason JT,Lovinger DM,Mateo Y,Jimenez VA,Helms CM,Grant KA,Jones SR

更新日期：2016-04-01 00:00:00

abstract：RATIONALE:The zebrafish dopaminergic system is thought to be evolutionarily conserved and may be amenable to pharmacological manipulation using drugs developed for mammalian receptors. However, only few studies have examined the role of specific receptor subtypes in behaviour of adult zebrafish. OBJECTIVES:The objecti...

journal_title：Psychopharmacology

authors： Tran S,Nowicki M,Muraleetharan A,Gerlai R

更新日期：2015-02-01 00:00:00

abstract：:Nine human subjects were exposed to a multiple fixed-ratio (FR) differential-reinforcement-of-low-rate (DRL) schedule of monetary reinforcement. Presses on a manipulandum requiring relatively high force were occasionally followed by an increased money total displayed on a computer screen. Subjects were exposed to the ...

journal_title：Psychopharmacology

authors： Rumbold GR,White JM

更新日期：1987-01-01 00:00:00

abstract：:A venous blood sample and an umbilical cord blood sample were obtained from five young women treated with the neuroleptic drug, cis(Z)-flupentixol decanoate in Viscoleo (intramuscularly) or flupentixol (orally) at the time of giving birth. In two cases amniotic fluid was also obtained, and from three of the mothers mi...

journal_title：Psychopharmacology

authors： Kirk L,Jørgensen A

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:An increased risk of drug intake produced by drug cues may reflect the fact that the cues are withdrawal-like or aversive, reflecting a conditioned adaptation to the drug's acute effects. More recent work suggests that they may also be appetitive, signalling the goal characteristics of drug taking. OBJECTIVE...

journal_title：Psychopharmacology

authors： Mucha RF,Geier A,Pauli P

更新日期：1999-12-01 00:00:00

abstract：:Benztropine mesylate (Cogentin) and physostigmine salicylate (Antilirium), were tested for changes in tongue protrusions, retrusions, and swallowing acts in rats anesthetized with a 100 mg/kg IM injection of ketamine hydrochloride. These ketamine-induced linguopharyngeal events were monitored by means of a force displ...

journal_title：Psychopharmacology

authors： Marco LA,Joshi RS,Brown C,Aldes LD,Chronister RB

更新日期：1988-01-01 00:00:00

abstract：:Clozapine and molindone administered to mice for 21 days did not elevate the density of striatal 3H-spiperone binding sites at doses clinically equivalent to 1.5 mg/kg haloperidol, which elevated binding by 29%. Thioridazine (25 mg/kg) elevated binding by 25%. It appears that clinically equivalent doses of clozapine a...

journal_title：Psychopharmacology

authors： Severson JA,Robinson HE,Simpson GM

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Endogenous and exogenous cannabinoids acting through the CB1 cannabinoid receptors are implicated in the control of a variety of behavioural and neuroendocrine functions, including emotional responses, and learning and memory processes. Recently, knockout mice deficient in the CB1 cannabinoid receptor have be...

journal_title：Psychopharmacology

authors： Martin M,Ledent C,Parmentier M,Maldonado R,Valverde O

更新日期：2002-02-01 00:00:00

abstract：:Intravenous self-administration of d-amphetamine (0.25 mg/kg/injection) decreased in a dose-related fashion after injections of the dopaminergic agonists apomorphine and piribedil. The dopaminergic agonists appear to suppress amphetamine intake in the same way as do 'free' amphetamine injections, by extending drug sat...

journal_title：Psychopharmacology

authors： Yokel RA,Wise RA

更新日期：1978-07-19 00:00:00

abstract：:Amphetamine stimulates locomotor activity, in large part by activating central dopaminergic systems. Serotonin shares on overlapping distribution with dopamine and has been shown to modulate dopaminergic function and dopamine-mediated behaviors. The present study examined whether increasing serotonergic function, via ...

journal_title：Psychopharmacology

authors： Sills TL,Greenshaw AJ,Baker GB,Fletcher PJ

更新日期：1999-02-01 00:00:00