The central GABAergic system and control of food intake under different experimental conditions.

abstract：RATIONALE:Rats, like humans, are susceptible to the reinforcing effects of reward-related stimuli presented within a compound stimulus array, putatively analogous to the so-called near-miss effect. We have previously demonstrated using a rodent slot machine task (rSMT) that the reward expectancy these stimuli elicit is...

journal_title：Psychopharmacology

authors： Cocker PJ,Lin MY,Barrus MM,Le Foll B,Winstanley CA

更新日期：2016-09-01 00:00:00

abstract：RATIONALE:Converging evidence suggests that dopaminergic and serotonergic mechanisms affect distinct aspects of cognitive performance. Experiments using the rodent five-choice reaction time task have established a critical role for dopaminergic mechanisms in the rat medial prefrontal cortex (mPFC), but have yielded onl...

journal_title：Psychopharmacology

authors： Passetti F,Dalley JW,Robbins TW

更新日期：2003-01-01 00:00:00

abstract：RATIONALE:Inattentional blindness (IB) is the inability to detect a salient yet unexpected task irrelevant stimulus in one's visual field when attention is engaged in an ongoing primary task. The present study is the first to examine the impact of both task difficulty and alcohol consumption on IB and primary task perf...

journal_title：Psychopharmacology

authors： Harvey AJ,Bayless SJ,Hyams G

更新日期：2018-01-01 00:00:00

abstract：:Dose-dependent effects of intravenously administered lorazepam on haemodynamic fluctuations were studied by means of spectral analysis, in order to elucidate sympathetic and parasympathetic components in cardiovascular control during situations of rest and mental stress after benzodiazepine administration. In a double...

journal_title：Psychopharmacology

authors： Tulen JH,Mulder G,Pepplinkhuizen L,Man in 't Veld AJ,van Steenis HG,Moleman P

更新日期：1994-02-01 00:00:00

abstract：RATIONALE:Anxiety and aggression are associated with ethanol self-administration, but these behaviors can serve as either risk factors for or consequences of heavy drinking in rodents and humans. Baseline levels of aggressive-like and anxious-like behavior in non-human primates have not yet been characterized in relati...

journal_title：Psychopharmacology

authors： McClintick MN,Grant KA

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:Understanding an individual's vulnerability to drug addiction has important implications for the development of effective personal treatment plans. Although theories acknowledge impulsive behaviour as a key component of drug addiction, little is known about the influence of trait impulsivity on an individu...

journal_title：Psychopharmacology

authors： Kolokotroni KZ,Rodgers RJ,Harrison AA

更新日期：2014-02-01 00:00:00

abstract：RATIONALE:Intermittent footshock stress effectively reinstates extinguished heroin-, cocaine- and alcohol-taking behaviors, but not behaviors previously maintained by food reinforcers. Here we tested further the generality of the phenomenon of stress-induced reinstatement by determining the effect of footshock on reins...

journal_title：Psychopharmacology

authors： Buczek Y,Lê AD,Wang A,Stewart J,Shaham Y

更新日期：1999-05-01 00:00:00

abstract：RATIONALE:Both methylphenidate (MPH), a catecholamine reuptake blocker, and guanfacine, an alpha2A agonist, are used to treat attention-deficit hyperactivity disorder (ADHD). Childhood impulsivity, including delay discounting, is associated with increased substance use during adolescence. These effects can be mitigated...

journal_title：Psychopharmacology

authors： Freund N,Jordan CJ,Lukkes JL,Norman KJ,Andersen SL

更新日期：2019-02-01 00:00:00

abstract：RATIONALE:A positive relationship exists between chronic ethanol intoxication experiences and the severity of neural hyperactivity and withdrawal seizures. An important possibility is that withdrawal reactions also influence the motivation to obtain and consume ethanol. OBJECTIVES:To test this hypothesis, the effects ...

journal_title：Psychopharmacology

authors： Ciccocioppo R,Lin D,Martin-Fardon R,Weiss F

更新日期：2003-07-01 00:00:00

abstract：RATIONALE:Prior research suggests that high levels of acetylcholine (ACh) in the nucleus accumbens (NAc) are associated with aversive states such as morphine withdrawal, but this has not been tested for nicotine withdrawal. OBJECTIVES:The goal was to test the hypothesis that acute nicotine decreases extracellular ACh ...

journal_title：Psychopharmacology

authors： Rada P,Jensen K,Hoebel BG

更新日期：2001-08-01 00:00:00

abstract：:Evidence has been provided for impaired neurotransmitter functioning in the brain of elderly subjects. In order to assess central GABAergic transmission, the activity of the hypothalamic GABA system may be investigated by basal growth hormone (GH) response to the GABAergic drug sodium valproate (SV). For this purpose ...

journal_title：Psychopharmacology

authors： Monteleone P,Iovino M,Orio F,Steardo L

更新日期：1987-01-01 00:00:00

abstract：:After publication of this paper, the authors determined an error in the calculation of the norepinephrine standard concentrations for the HPLC calibration curves. ...

journal_title：Psychopharmacology

authors： Shnitko TA,Taylor SC,Stringfield SJ,Zandy SL,Cofresí RU,Doherty JM,Lynch WB,Boettiger CA,Gonzales RA,Robinson DL

更新日期：2018-09-01 00:00:00

abstract：:Animals responding for biphasic square wave stimulation to the VTA were treated for 26 days with a low dose (0.07 mg/kg) of the neuroleptic haloperidol and tested at 1 h post-injection. Initially the drug induced a pronounced lateral displacement of the baseline rate-intensity function, concomitant with a depression i...

journal_title：Psychopharmacology

authors： Lynch MR,Carey RJ

更新日期：1990-01-01 00:00:00

abstract：:The role of the nucleus accumbens septi (ACB) and corpus striatum (CPU) in self-stimulation were investigated by injecting directly or indirectly acting stimulant drugs or a dopamine-(DA)-receptor blocking agent into each site bilaterally. d-Amphetamine (68 nmol) facilitated hypothalamic self-stimulation when injected...

journal_title：Psychopharmacology

authors： Stephens DN,Herberg LJ

更新日期：1977-08-31 00:00:00

abstract：RATIONALE:Toluene exposure during brain growth spurt has been shown to elevate the seizure susceptibility induced by N-methyl-D: -aspartate (NMDA). In the present study, behavioral responses to NMDA antagonists were studied to determine whether neonatal toluene exposure produces residual deficits in the NMDA glutamater...

journal_title：Psychopharmacology

authors： Chien TH,Chan MH,Tang YC,Chen HH

更新日期：2005-11-01 00:00:00

abstract：RATIONALE:The development and validation of animal models of the cognitive impairments of schizophrenia have remained challenging subjects. OBJECTIVE:We review evidence from a series of experiments concerning an animal model that dissociates between the disruption of attentional capacities during acute illness periods...

journal_title：Psychopharmacology

authors： Sarter M,Martinez V,Kozak R

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Abnormalities of membrane phospholipid metabolism have been described in Alzheimer's disease (AD). We investigated, with the aid of (31)P magnetic resonance spectroscopy, the in vivo intracerebral availability of phosphomonoesters (PME) and phosphodiesters (PDE) in patients with AD. METHODS:Eighteen outpati...

journal_title：Psychopharmacology

authors： Forlenza OV,Wacker P,Nunes PV,Yacubian J,Castro CC,Otaduy MC,Gattaz WF

更新日期：2005-07-01 00:00:00

abstract：RATIONALE:Lysergic acid diethylamide (LSD) differs from other types of hallucinogens in that it possesses direct dopaminergic effects. The exact nature of this component has not been elucidated. OBJECTIVE:The present study sought to characterize the effects of several dopamine D(4) agonists and antagonists on the disc...

journal_title：Psychopharmacology

authors： Marona-Lewicka D,Chemel BR,Nichols DE

更新日期：2009-04-01 00:00:00

abstract：:Chronic administration of the pre-synaptic alpha-adrenoreceptor agonist clonidine decreases the concentration of the extra-neuronal metabolite of noradrenaline normetanephrine in the amygdaloid cortex and increases it in the mid-brain. Conversely, blockade of these pre-synaptic receptors by yohimbine increases the nor...

journal_title：Psychopharmacology

authors： Fludder JM,Leonard BE

更新日期：1979-09-01 00:00:00

abstract：RATIONALE:Treatment of the most widely abused drugs, nicotine and alcohol, is hampered by high rates of relapse. Varenicline tartrate, an α4β2 nicotinic receptor partial agonist, is currently prescribed as a smoking cessation aid. However, there is emerging evidence that it may also modulate alcohol seeking and cogniti...

journal_title：Psychopharmacology

authors： Wouda JA,Riga D,De Vries W,Stegeman M,van Mourik Y,Schetters D,Schoffelmeer AN,Pattij T,De Vries TJ

更新日期：2011-07-01 00:00:00

abstract：:The serotonin 5-HT(3) receptor is thought to play a role in the reward pathway and drug abuse by modulating dopamine release within the mesolimbic pathway. Dopamine release stimulated by cocaine and methamphetamine is blocked by administration of 5-HT(3) receptor antagonists. Animal studies demonstrate that 5-HT(3) re...

journal_title：Psychopharmacology

authors： Allan AM,Galindo R,Chynoweth J,Engel SR,Savage DD

更新日期：2001-10-01 00:00:00

abstract：RATIONALE:Dopamine (DA) D2-like antagonists block several effects of cocaine, including its locomotor stimulant and interoceptive discriminative-stimulus effects. Because these compounds generally lack selectivity among the D2-like DA receptors, the specific roles of the subtypes remain unclear. OBJECTIVES:DA D2 recep...

journal_title：Psychopharmacology

authors： Chausmer AL,Elmer GI,Rubinstein M,Low MJ,Grandy DK,Katz JL

更新日期：2002-08-01 00:00:00

abstract：RATIONALE:Studies have shown that social drinkers are poor estimators of alcohol-induced impairment. Underestimates of blood alcohol concentration and other indices of intoxication are associated with decisions to perform risky behaviors, such as operating a motor vehicle. It is possible that self-evaluations of impair...

journal_title：Psychopharmacology

authors： Harrison EL,Fillmore MT

更新日期：2005-02-01 00:00:00

abstract：:The effect of long-term treatment with clozapine in schizophrenia and schizoaffective disorder was evaluated in a retrospective study comprising 96 patients treated with the drug during the period 1974-1986 at the Psychiatric Research Center in Uppsala. All patients had previously been treated with different kinds of ...

journal_title：Psychopharmacology

authors： Lindström LH

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Cocaine dependence is a major health concern and there are no effective pharmacotherapies currently available. Although cocaine is an indirect DA agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (DAT) than norepinephrine (NET) and serot...

journal_title：Psychopharmacology

authors： Cook CD,Carroll IF,Beardsley PM

更新日期：2001-12-01 00:00:00

abstract：RATIONALE:Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convu...

journal_title：Psychopharmacology

authors： Jutkiewicz EM,Rice KC,Traynor JR,Woods JH

更新日期：2005-11-01 00:00:00

abstract：:The problem of the advantage of using nortriptyline (NT) plasma level during treatment for endogenous depression has been approached. In an ordinary psychiatric department, 34 patients had their NT level checked the second week of treatment and their dosage subsequently adjusted, if it was outside the recommended ther...

journal_title：Psychopharmacology

authors： Sørensen B,Kragh-Sørensen P,Larsen NE,Hvidberg EF

更新日期：1978-09-15 00:00:00

abstract：:The effects of intra-amygdala injections of corticotropin-releasing factor (CRF) on memory and exploratory behavior in rats were examined in the present study. Rats with chronically implanted cannulae received intra-amygdala injections of vehicle or CRF at a dose of 0.01, 0.1 or 1.0 micrograms, either immediately afte...

journal_title：Psychopharmacology

authors： Liang KC,Lee EH

更新日期：1988-01-01 00:00:00

abstract：:Ethanol-induced locomotor stimulation has been proposed to be positively correlated with the rewarding effects of ethanol (Wise and Bozarth 1987). The present experiments provided a test of this hypothesis using a genetic model. Three behavioral indices of the motivational effects of ethanol (drinking, taste condition...

journal_title：Psychopharmacology

authors： Risinger FO,Malott DH,Prather LK,Niehus DR,Cunningham CL

更新日期：1994-10-01 00:00:00

abstract：:Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administratio...

journal_title：Psychopharmacology

authors： Pomara N,Stanley B,Block R,Guido J,Russ D,Berchou R,Stanley M,Greenblatt DJ,Newton RE,Gershon S

更新日期：1984-01-01 00:00:00