Chronic low-dose haloperidol effects on self-stimulation rate-intensity functions.


:Animals responding for biphasic square wave stimulation to the VTA were treated for 26 days with a low dose (0.07 mg/kg) of the neuroleptic haloperidol and tested at 1 h post-injection. Initially the drug induced a pronounced lateral displacement of the baseline rate-intensity function, concomitant with a depression in slope. Over the course of chronic treatment, partial tolerance was observed to the drug-induced increases in threshold concomitant with the onset of a significant suppression in peak response rate. Biochemical tolerance to stimulated dopamine metabolism (as per cent non-drug control) was significant only for mesolimbic (versus neostriatal) regions, in animals receiving haloperidol according to pre- and post-test administration schedules. The observation of sensitization to peak rate reductions parallels previous reports for spontaneous locomotor activity measures and is compatible with depolarization inactivation mechanisms proposed to account for delayed-onset clinical effects. Further, selective biochemical tolerance in mesolimbic regions supports suggestions that mesolimbic dopamine is important as a substrate for subtle low dose neuroleptic effects which may be relevant for studying pharmacotherapeutic treatment issues.




Lynch MR,Carey RJ




Has Abstract


1990-01-01 00:00:00












  • Effects of physostigmine, scopolamine, and mecamylamine on the sleeping time induced by ketamine in the rat.

    abstract::Male Sprague-Dawley rats weighing 116--241 g were injected i.p. with ketamine hydrochloride, 80 mg per kilo of body weight. Immediately after loss of righting reflex, scopolamine, physostigmine, and mecamylamine were administered i.p. to different groups of rats. Control animals received sterile saline by the same rou...


    pub_type: 杂志文章


    authors: Figallo EM,Wingard LB Jr

    更新日期:1979-03-14 00:00:00

  • Presynaptic regulation of extracellular dopamine levels in the medial prefrontal cortex and striatum during tyrosine depletion.

    abstract:RATIONALE:Available neurochemical probes that lower brain dopamine (DA) levels in man are limited by their tolerability and efficacy. For instance, the acute lowering of brain tyrosine is well tolerated, but only modestly lowers brain DA levels. Modification of tyrosine depletion to robustly lower DA levels would provi...


    pub_type: 杂志文章


    authors: Brodnik Z,Double M,Jaskiw GE

    更新日期:2013-05-01 00:00:00

  • Physostigmine alters onset but not duration of REM sleep in man.

    abstract::Physostigmine (1.0mg) or placebo were administered intravenously over 1-h period to seven male normal volunteers beginning 35 min after sleep onset. The results indicate that physostigmine induced the onset of REM sleep but did not significantly alter the duration of individual REM sleep periods. Physostigmine signifi...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gillin JC,Sitaram N,Mendelson WB,Wyatt RJ

    更新日期:1978-06-15 00:00:00

  • Cocaine and salicylate: documentation of hydroxyl radical formation in hearts and brains of 18-day-old chick embryos and unexpected interactive toxicity.

    abstract:RATIONALE:Multiple low doses of cocaine (COC) may cause intermittent vasoconstriction and reperfusion, leading to elevations in damaging reactive oxygen species, such as hydroxyl free radicals (*OH). Salicylate may offer protection because it reacts with *OH and/or because of its anti-inflammatory actions. OBJECTIVE:T...


    pub_type: 杂志文章


    authors: Castelli MC,Venturini L,Sparber SB

    更新日期:2001-06-01 00:00:00

  • Apomorphine, d-amphetamine, strychnine and yohimbine do not alter prepulse inhibition of the acoustic startle reflex.

    abstract::Rats were presented with noise bursts alone or noise bursts 60 ms after presentation of either a 60 dB or an 80 dB prepulse after injection of the dopamine agonists apomorphine (3 mg/kg) or d-amphetamine (4 mg/kg), the glycine antagonist strychnine (1.5 mg/kg) or the alpha 2 antagonist yohimbine (5 mg/kg). Presentatio...


    pub_type: 杂志文章


    authors: Davis M

    更新日期:1988-01-01 00:00:00

  • Melatonin in the afternoons of a gradually advancing sleep schedule enhances the circadian rhythm phase advance.

    abstract:RATIONALE:We test methods to advance (shift earlier) circadian rhythms without producing misalignment between rhythms and sleep. We previously tested (1) a gradually advancing sleep/dark schedule plus morning bright light and afternoon/evening melatonin and (2) the same sleep schedule with only morning bright light. No...


    pub_type: 杂志文章


    authors: Crowley SJ,Eastman CI

    更新日期:2013-02-01 00:00:00

  • Evaluation of the levels of free and total amitriptyline and metabolites in the plasma and brain of the rat after long-term administration of doses used in receptor studies.

    abstract::This study was conducted in order to investigate the level of amitriptyline (AT) and its metabolites. Three separate experiments were carried out. In two of these experiments, rats were treated over 7 days with IP doses of AT (10 mg/kg in experiment A and 2 X 20 mg/kg in experiment C). The rats were sacrificed either ...


    pub_type: 杂志文章


    authors: Baumann P,Gaillard JM,Jonzier-Perey M,Gerber C,Bouras C

    更新日期:1984-01-01 00:00:00

  • The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats.

    abstract:RATIONALE:Coping styles are fundamental characteristics of behavior that affect susceptibility to, and resilience during, mental and physical illness. Shifts from passive to active coping are considered therapeutic goals in many stress-related disorders, but the neural control of coping is poorly understood. Based on e...


    pub_type: 杂志文章


    authors: Haller J,Goldberg SR,Pelczer KG,Aliczki M,Panlilio LV

    更新日期:2013-12-01 00:00:00

  • Reinforcing effects of smoked methamphetamine in rhesus monkeys.

    abstract:RATIONALE:The occurrence of methamphetamine (METH) use by the smoking route is increasing. A nonhuman primate model for examining the reinforcing effects of smoked METH would be valuable for testing potential interventions for treating METH abuse disorders. OBJECTIVE:The purpose of the present study was to examine the...


    pub_type: 杂志文章


    authors: Newman JL,Carroll ME

    更新日期:2006-10-01 00:00:00

  • Dose-dependent effect of ethanol on extracellular dopamine in mesolimbic striatum of awake rhesus monkeys: comparison with cocaine across individuals.

    abstract:RATIONALE:Dependence on both alcohol and cocaine is a widespread example of polydrug abuse/dependence. It has been hypothesized that ethanol reward is mediated via increased dopaminergic neurotransmission in mesolimbic striatum, as is the case for cocaine. However, little is known about the neurobiology of ethanol in p...


    pub_type: 杂志文章


    authors: Bradberry CW

    更新日期:2002-12-01 00:00:00

  • Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats.

    abstract:RATIONALE:Manipulations of the endocannabinoid system could potentially produce therapeutic effects with minimal risk of adverse cannabis-like side effects. Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of the cannabinoid-receptor agonist, anandamide, and show promise for treating a wide ra...


    pub_type: 杂志文章


    authors: Panlilio LV,Thorndike EB,Nikas SP,Alapafuja SO,Bandiera T,Cravatt BF,Makriyannis A,Piomelli D,Goldberg SR,Justinova Z

    更新日期:2016-05-01 00:00:00

  • Acute fluoxetine treatment potentiates amphetamine hyperactivity and amphetamine-induced nucleus accumbens dopamine release: possible pharmacokinetic interaction.

    abstract::Amphetamine stimulates locomotor activity, in large part by activating central dopaminergic systems. Serotonin shares on overlapping distribution with dopamine and has been shown to modulate dopaminergic function and dopamine-mediated behaviors. The present study examined whether increasing serotonergic function, via ...


    pub_type: 杂志文章


    authors: Sills TL,Greenshaw AJ,Baker GB,Fletcher PJ

    更新日期:1999-02-01 00:00:00

  • Developmental emergence of an obsessive-compulsive phenotype and binge behavior in rats.

    abstract:RATIONALE:Obsessive-compulsive disorder (OCD) gradually emerges and reaches clinical significance during early adulthood. Whether a predisposition for OCD manifests as binge eating disorder earlier during adolescence is proposed. OBJECTIVES:To further characterize how OCD-like behaviors increase across maturation and ...


    pub_type: 杂志文章


    authors: Freund N,Thompson BS,Norman KJ,Einhorn P,Andersen SL

    更新日期:2015-09-01 00:00:00

  • Modification of the behavioral effects of morphine in rats by serotonin 5-HT₁A and 5-HT₂A receptor agonists: antinociception, drug discrimination, and locomotor activity.

    abstract:RATIONALE:Indirect-acting serotonin (5-HT) receptor agonists can enhance the antinociceptive effects of morphine; however, the specific 5-HT receptor subtype(s) mediating this enhancement is not established. OBJECTIVE:This study examined interactions between morphine and both 5-HT(1A) and 5-HT(2A) receptor agonists in...


    pub_type: 杂志文章


    authors: Li JX,Shah AP,Patel SK,Rice KC,France CP

    更新日期:2013-02-01 00:00:00

  • The dopamine D2 receptor antagonist sulpiride modulates striatal BOLD signal during the manipulation of information in working memory.

    abstract:RATIONALE:Dopamine (DA) plays an important role in working memory. However, the precise functions supported by different DA receptor subtypes in different neural regions remain unclear. OBJECTIVE:The present study used pharmacological, event-related fMRI to test the hypothesis that striatal dopamine is important for t...


    pub_type: 临床试验,杂志文章


    authors: Dodds CM,Clark L,Dove A,Regenthal R,Baumann F,Bullmore E,Robbins TW,Müller U

    更新日期:2009-11-01 00:00:00

  • Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys.

    abstract:RATIONALE:Several halogenated analogs of benztropine (BZT) have previously been characterized as potent DA uptake inhibitors with behavioral profiles that indicate diminished psychomotor stimulant effects relative to cocaine. In a previous study using a fixed-ratio 10 schedule, two chloro-analogs (3'-Cl-BZT and 4'-Cl-B...


    pub_type: 杂志文章


    authors: Woolverton WL,Hecht GS,Agoston GE,Katz JL,Newman AH

    更新日期:2001-04-01 00:00:00

  • Discriminative stimulus properties of a new anxiolytic, DN-2327, in rats.

    abstract::In an operant learning lever-pressing procedure on an FR10 schedule of milk reinforcement, male Wistar rats were trained to discriminate between saline and 3 mg/kg IP DN-2327, a new anxiolytic which acts on benzodiazepine receptors, 3 mg/kg IP diazepam or 15 mg/kg IP pentylenetetrazol (PTZ). More than 80% appropriate ...


    pub_type: 杂志文章


    authors: Wada T,Fukuda N

    更新日期:1993-01-01 00:00:00

  • The effects of exercise on cigarette cravings and brain activation in response to smoking-related images.

    abstract:RATIONALE:Smokers show heightened activation toward smoking-related stimuli and experience increased cravings which can precipitate smoking cessation relapse. Exercise can be effective for modulating cigarette cravings and attenuating reactivity to smoking cues, but the mechanism by which these effects occur remains un...


    pub_type: 杂志文章,随机对照试验


    authors: Janse Van Rensburg K,Taylor A,Benattayallah A,Hodgson T

    更新日期:2012-06-01 00:00:00

  • Role of neuro-immunological factors in the pathophysiology of mood disorders.

    abstract::Mood disorders, despite the widespread availability of monoamine-based antidepressant treatments, are associated with persistently high rates of disability, together with elevated rates of mortality due to suicide, cardiovascular disease, and other causes. The development of more effective treatments has been hindered...


    pub_type: 杂志文章,评审


    authors: Bhattacharya A,Derecki NC,Lovenberg TW,Drevets WC

    更新日期:2016-05-01 00:00:00

  • D-2 but not D-1 dopamine agonists produce augmented behavioral response in rats after subchronic treatment with methamphetamine or cocaine.

    abstract::A study was performed to examine behavioral response to a challenge of selective dopamine D-1 and D-2 agonists in rats previously sensitized by subchronic administration of methamphetamine or cocaine. Rats in three groups received repeated injections (IP) of saline, methamphetamine (4 mg/kg/day) or cocaine (20 mg/kg/d...


    pub_type: 杂志文章


    authors: Ujike H,Akiyama K,Otsuki S

    更新日期:1990-01-01 00:00:00

  • Activation of forebrain dopamine systems by phencyclidine and footshock stress: evidence for distinct mechanisms.

    abstract::Phencyclidine combined with footshock stress produced a greater increase in the homovanillic acid content of prefrontal cortex than either phencyclidine or footshock alone. Phencyclidine decreased both substance P and substance K in the ventral tegmental area. The results suggest that phencyclidine and footshock activ...


    pub_type: 杂志文章


    authors: Bowers MB Jr,Bannon MJ,Hoffman FJ Jr

    更新日期:1987-01-01 00:00:00

  • Effects of LSD and BOL on the catecholamine synthesis and turnover in various brain regions.

    abstract::In the rat, lysergic acid diethylamide (LSD) 0.5 mg/kg and 2-bromo lysergic acid diethylamide (BOL) 0.5 mg/kg increased the rate of the striatal in vivo tyrosine hydroxylation as measured by the DOPA accumulation after decarboxylase inhibition. Neither LSD nor BOL significantly changed the DOPA accumulation in the olf...


    pub_type: 杂志文章


    authors: Persson SA

    更新日期:1978-10-31 00:00:00

  • Effects of pentobarbital and progesterone on random ratio responding in male and female rats.

    abstract::Intact male and ovariectomized female rats were trained to lever press under a random ratio (RR) schedule of food reinforcement. Effects of different doses of pentobarbital (1-16 mg/kg) and progesterone (10-80 mg/kg) on response output were studied. Low doses of pentobarbital increased responding, high doses decreased...


    pub_type: 杂志文章


    authors: Heinsbroek RP,van Haaren F,Zantvoord F,van de Poll NE

    更新日期:1987-01-01 00:00:00

  • Inhibition of activity in rats by rubidium chloride.

    abstract::Effects of two dosages of rubidium chloride on exploration, locomotion, rearing and immobility were assessed for male and female rats in an exploration box and an open field. In contrast to previous findings, rubidium was found to decrease locomotion and rearing in the exploratory box, and also to decrease locomotion ...


    pub_type: 杂志文章


    authors: Syme GJ,Syme LA

    更新日期:1979-03-22 00:00:00

  • Marijuana, alcohol, and combined drug effects on the time course of glare recovery.

    abstract::The time course of light adaptation after intense light exposure is significantly delayed by alcohol, marijuana, and a combined dose of alcohol and marijuana. These effects were found in a double blind experiment, using 10 subjects. The experimental treatments were placebo, 0.75 ml/kg of 95% ethanol, 8 and 15 mg of de...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Adams AJ,Brown B,Haegerstrom-Portnoy G,Flom MC,Jones RT

    更新日期:1978-01-31 00:00:00

  • Differential vulnerability to relapse into heroin versus cocaine-seeking as a function of setting.

    abstract:RATIONALE:Previous studies have shown that the effect of setting on drug-taking is substance specific in both humans and rats. In particular, we have shown that when the setting of drug self-administration (SA) coincides with the home environment of the rats (resident rats), the rats tend to prefer heroin to cocaine. T...


    pub_type: 杂志文章


    authors: Montanari C,Stendardo E,De Luca MT,Meringolo M,Contu L,Badiani A

    更新日期:2015-07-01 00:00:00

  • The effect of chronic nicotine treatment on nicotine-induced seizures.

    abstract::Tolerance to nicotine occurs in mice after its chronic administration. This tolerance is accompanied by an up-regulation of nicotinic receptors as assessed by the binding of (3H)-nicotine and alpha-(125I)-bungarotoxin (BTX). Past studies (Marks et al. 1983, 1986) have shown that the increase in BTX binding sites is mo...


    pub_type: 杂志文章


    authors: Miner LL,Collins AC

    更新日期:1988-01-01 00:00:00

  • Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment.

    abstract:RATIONALE:A rigorously investigated model of stress and antidepressant administration during pregnancy is needed to evaluate possible effects on the mother. OBJECTIVE:The objective of this study was to develop a model of clinically relevant prenatal exposure to an antidepressant and stress during pregnancy to evaluate...


    pub_type: 杂志文章


    authors: Bourke CH,Capello CF,Rogers SM,Yu ML,Boss-Williams KA,Weiss JM,Stowe ZN,Owens MJ

    更新日期:2013-07-01 00:00:00

  • Facilitation by dexamethasone of tolerance to ethanol in the rat.

    abstract::The purpose of this study was to examine the relationship between the development of tolerance to ethanol and the hypothalamic-pituitary-adrenal cortex (H-P-AC) system by modifying the H-P-AC system through the use of a synthetic glucocorticoid, dexamethasone. Also this study determined whether repeated drug administr...


    pub_type: 杂志文章


    authors: Wood WG

    更新日期:1977-03-23 00:00:00

  • Responses of neurons in dorsal striatum during amphetamine-induced focused stereotypy.

    abstract::The phase of highly focused, repetitive behavior (stereotypy) induced by amphetamine in rats emerges after an initial period of locomotor activation. To assess the neuronal correlates of this behavioral transition, single-unit activity was recorded from the dorsal striatum of awake, unrestrained rats. Units were first...


    pub_type: 杂志文章


    authors: Rebec GV,White IM,Puotz JK

    更新日期:1997-04-01 00:00:00