Effects of nicotine and mecamylamine-induced withdrawal on extracellular dopamine and acetylcholine in the rat nucleus accumbens.

abstract：:The effects of an "aggression"-reducing drug, fluprazine, and an "aggression"-enhancing drug, ethanol, were evaluated in mice using the target biting and resident-intruder paradigms. Under baseline conditions there was a high target biting rate immediately after the delivery of a 2.0 mA tail shock, an intermediate tar...

journal_title：Psychopharmacology

authors： Wagner GC,Carelli RM

更新日期：1987-01-01 00:00:00

abstract：:BIMT 17, the only compound reported to be a full 5-HT1A agonist and a 5-HT2A antagonist at the frontal cortex, was assessed in three animal paradigms sensitive to antidepressants in rats: olfactory bulbectomy (OB), differential-reinforcement-of-low rate 72-s (DRL 72-s) and learned helplessness (LH). In the OB rats, BI...

journal_title：Psychopharmacology

authors： Borsini F,Cesana R,Kelly J,Leonard BE,McNamara M,Richards J,Seiden L

更新日期：1997-12-01 00:00:00

abstract：:In a 4 week study of the response of neurotic outpatients to treatment with amitriptyline, diazepam, amitriptyline and diazepam, or placebo clinical and psychophysiological variables and plasma levels of the drug were assessed. Clinical improvements were substantial in all treatment groups but clear relationships betw...

journal_title：Psychopharmacology

authors： Johnstone EC,Bourne RC,Crow TJ,Frith CD,Gamble S,Lofthouse R,Owen F,Owens DG,Robinson J,Stevens M

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:It is important to study age-related differences that may put adolescents at risk for alcohol-related problems. Adolescents seem less sensitive to the aversive effects of ethanol than adults. Less is known of appetitive effects of ethanol and stress modulation of these effects. OBJECTIVES:This study aims to ...

journal_title：Psychopharmacology

authors： Acevedo MB,Pautassi RM,Spear NE,Spear LP

更新日期：2013-12-01 00:00:00

abstract：RATIONALE:Pharmacokinetics of melatonin in children might differ from that in adults. OBJECTIVES:This study aims to establish a dose-response relationship for melatonin in advancing dim light melatonin onset (DLMO), sleep onset (SO), and reducing sleep onset latency (SOL) in children between 6 and 12 years with chroni...

journal_title：Psychopharmacology

authors： van Geijlswijk IM,van der Heijden KB,Egberts AC,Korzilius HP,Smits MG

更新日期：2010-10-01 00:00:00

abstract：RATIONALE:The widespread deficits in cognitive flexibility observed across psychiatric disorders call for improved rodent tests to understand the biology of cognitive flexibility and development of better psychotherapeutics. Current reversal learning paradigms have a forced-choice setup that challenges the interpretati...

journal_title：Psychopharmacology

authors： Odland AU,Sandahl R,Andreasen JT

更新日期：2021-02-01 00:00:00

abstract：:Physostigmine (1.0mg) or placebo were administered intravenously over 1-h period to seven male normal volunteers beginning 35 min after sleep onset. The results indicate that physostigmine induced the onset of REM sleep but did not significantly alter the duration of individual REM sleep periods. Physostigmine signifi...

journal_title：Psychopharmacology

authors： Gillin JC,Sitaram N,Mendelson WB,Wyatt RJ

更新日期：1978-06-15 00:00:00

abstract：RATIONALE:Previous experiments have shown that d-amphetamine disrupts timing behaviour in rats. It has been proposed that d-amphetamine's effects reflect a reduction in the period of the pacemaker of the hypothetical internal clock. However, some studies have obtained conflicting results. OBJECTIVE:To examine the effe...

journal_title：Psychopharmacology

authors： Chiang TJ,Al-Ruwaitea AS,Mobini S,Ho MY,Bradshaw CM,Szabadi E

更新日期：2000-06-01 00:00:00

abstract：RATIONALE:The antidepressant nortriptyline is a second-line pharmacotherapy for smoking cessation. Given that there is limited preclinical data available on the effects of nortriptyline on responses to nicotine, the present study sought to evaluate its effects on the reinforcing, discriminative stimulus (DS) and aversi...

journal_title：Psychopharmacology

authors： Wing VC,Shoaib M

更新日期：2012-02-01 00:00:00

abstract：RATIONALE:Psychopharmacology needs novel quantitative measures and theoretical approaches based on computational modelling that can be used to help translate behavioural findings from experimental animals to humans, including patients with neuropsychiatric disorders. OBJECTIVES:This brief review exemplifies this appro...

journal_title：Psychopharmacology

authors： Robbins TW,Cardinal RN

更新日期：2019-08-01 00:00:00

abstract：:It has been proposed that serotonin (5-HT) antagonists counteract neuroleptic-induced extrapyramidal symptoms by disinhibition of dopamine activity. The effects of the 5-HT antagonist mianserin, the anticholinergic drug procyclidine and placebo were evaluated in 16 psychiatric patients with chronic neuroleptic-induced...

journal_title：Psychopharmacology

authors： Korsgaard S,Friis T

更新日期：1986-01-01 00:00:00

abstract：:Biotransformation of phenacetin via O-deethylation to acetaminophen, an index reaction reflecting activity of Cytochrome P450-1A2, was studied in microsomal preparations from a series of human livers. Acetaminophen formation was consistent with a double Michaelis-Menten system, with low-Km (mean Km1 = 68 microM) and h...

journal_title：Psychopharmacology

authors： von Moltke LL,Greenblatt DJ,Duan SX,Schmider J,Kudchadker L,Fogelman SM,Harmatz JS,Shader RI

更新日期：1996-12-01 00:00:00

abstract：:A venous blood sample and an umbilical cord blood sample were obtained from five young women treated with the neuroleptic drug, cis(Z)-flupentixol decanoate in Viscoleo (intramuscularly) or flupentixol (orally) at the time of giving birth. In two cases amniotic fluid was also obtained, and from three of the mothers mi...

journal_title：Psychopharmacology

authors： Kirk L,Jørgensen A

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Information is sparse on neurotransmitter deficiencies in frontotemporal dementia (FTD), in particular with reference to distinct histological subgroups and Alzheimer's disease (AD). OBJECTIVES:To evaluate in FTD with the major histologies, and compare with AD and controls, neurotransmission indices, as thes...

journal_title：Psychopharmacology

authors： Bowen DM,Procter AW,Mann DM,Snowden JS,Esiri MM,Neary D,Francis PT

更新日期：2008-03-01 00:00:00

abstract：RATIONALE:Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, tolerance, and withdrawal. The neurosteroid allopregnanolone is also able to substitute for drugs with abuse potential and possesses reinforcing properties. OBJECTIVES:The effects of acute treatment with, and ...

journal_title：Psychopharmacology

authors： Concas A,Sogliano C,Porcu P,Marra C,Brundu A,Biggio G

更新日期：2006-06-01 00:00:00

abstract：:Nine VA Medical Centers are participating in a 2-year double-blind placebo controlled study of antioxidant treatment for tardive dyskinesia (TD) conducted by the Department of Veteran Affairs Cooperative Studies Program. One of the principal outcome measures of this study is the score derived from the instrumental ass...

journal_title：Psychopharmacology

authors： Caligiuri MP,Lohr JB,Rotrosen J,Adler L,Lavori P,Edson R,Tracy K

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Marijuana intoxication appears to impair response inhibition, but it is unclear if impaired inhibition and associated brain abnormalities persist after prolonged abstinence among adolescent users. We hypothesized that brain activation during a go/no-go task would show persistent abnormalities in adolescent m...

journal_title：Psychopharmacology

authors： Tapert SF,Schweinsburg AD,Drummond SP,Paulus MP,Brown SA,Yang TT,Frank LR

更新日期：2007-10-01 00:00:00

abstract：RATIONALE:The non-selective nicotinic acetylcholine receptor (nAChR) agonist nicotine has been argued to improve attention via enhanced filtering of irrelevant stimuli. Here, we tested this hypothesis in the context of smooth pursuit eye movements (SPEMs), an oculomotor function previously shown to improve with nicotin...

journal_title：Psychopharmacology

authors： Meyhöfer I,Kasparbauer AM,Steffens M,Ettinger U

更新日期：2019-07-01 00:00:00

abstract：:The effects of brofaremine (CGP 11 305A), a short-acting, reversible and selective inhibitor of MAO-A, on sleep, nocturnal penile tumescence (NPT) and hormonal secretion during the night were studied during a long-term trial. Three healthy males underwent sleep-EEG and NPT recordings during consecutive nights (1) unde...

journal_title：Psychopharmacology

authors： Steiger A,Holsboer F,Benkert O

更新日期：1987-01-01 00:00:00

abstract：:Rats were trained to self-administer cocaine in 1-h sessions on a fixed ratio 5 (FR5) schedule of reinforcement. Acquisition was carried out at a unit dose of 0.3 mg/kg and responding was then stabilized at cocaine doses of 0.1, 0.3, and 1.0 mg/kg/infusion. Pretreatments with naltrexone (0.1-10 mg/kg, SC) 20 min prior...

journal_title：Psychopharmacology

authors： Corrigall WA,Coen KM

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Synthetic psychostimulant abuse, including cathinone-derived 3,4-methylenedioxypyrovalerone (MDPV), continues to increase in many countries. Similar to cocaine but with greater potency, MDPV elicits a transient sympathomimetic response by blocking cellular uptake of dopamine (DA) and norepinephrine (NE)-admin...

journal_title：Psychopharmacology

authors： Simmons SJ,Martorana R,Philogene-Khalid H,Tran FH,Gentile TA,Xu X,Su S,Rawls SM,Muschamp JW

更新日期：2017-11-01 00:00:00

abstract：RATIONALE:Anticipatory nausea (AN) experienced by chemotherapy patients is resistant to current anti-nausea treatments. In this study, the effect of manipulation of the endocannabinoid (EC) system on a rat model of nausea (conditioned gaping) was determined. OBJECTIVE:The potential of cannabidiol (CBD) and the fatty a...

journal_title：Psychopharmacology

authors： Rock EM,Limebeer CL,Mechoulam R,Piomelli D,Parker LA

更新日期：2008-02-01 00:00:00

abstract：:Twenty-nine subjects performed a reaction time task with four levels of choice-task complexity under non-smoking, sham smoking, and low, medium and high nicotine cigarette conditions. Nicotine reduced decision time, while sham smoking increased decision time. This effect was independent of subjects' habitual levels of...

journal_title：Psychopharmacology

authors： Bates T,Pellett O,Stough C,Mangan G

更新日期：1994-03-01 00:00:00

abstract：RATIONALE:Nicotine replacement is commonly used to treat tobacco use in heavy-drinking smokers. However, few studies have examined the effect of nicotine replacement on subjective and physiological responses to alcohol and alcohol drinking behavior. OBJECTIVE:The primary aim of this within-subject, double-blind study ...

journal_title：Psychopharmacology

authors： McKee SA,O'Malley SS,Shi J,Mase T,Krishnan-Sarin S

更新日期：2008-02-01 00:00:00

abstract：RATIONALE:Glucose administration may decrease desire to smoke in abstinent smokers. Moreover, glucose administration has been associated with improved performance on measures of attention in healthy humans but evidence remains modest. OBJECTIVE:The present study aimed to determine whether reported craving and nicotine...

journal_title：Psychopharmacology

authors： Harakas P,Foulds J

更新日期：2002-05-01 00:00:00

abstract：RATIONALE:Modafinil is a well-tolerated psychostimulant drug with low addictive potential that is used to treat patients with narcolepsy or attention deficit disorders and to enhance vigilance in sleep-deprived military personal. So far, understanding of the cognitive enhancing effects of modafinil and the relevant neu...

journal_title：Psychopharmacology

authors： Müller U,Steffenhagen N,Regenthal R,Bublak P

更新日期：2004-12-01 00:00:00

abstract：:Peripheral administration of the unsulphated cholecystokinin octapeptide (CCK-8us) led to an anxiogenic-like action in the elevated plus-maze model of anxiety in rats. Devazepide and L-365,260 showed potent anxiolytic-like effects at similar doses. The fact that devazepide is 1000 times more potent as a CCK-A receptor...

journal_title：Psychopharmacology

authors： Chopin P,Briley M

更新日期：1993-01-01 00:00:00

abstract：:Progabide inhibited male rat sexual behavior at a dose of 200 mg/kg. This dose had only modest effects on ambulatory activity and no effect at all on motor coordination as evaluated by a rotarod test. The GABAA antagonist bicuculline, at a dose of 1 mg/kg, blocked the effects of progabide on sex behavior. In contrast,...

journal_title：Psychopharmacology

authors： Agmo A,Paredes RG,Sierra L,Garcés I

更新日期：1997-01-01 00:00:00

abstract：:Fluctuations in extracellular dopamine and DOPAC levels in nucleus accumbens septi (NAS) were monitored in 1-min microdialysis samples taken from rats engaged in intravenous cocaine self-administration. For four rats the dose per injection was fixed at 2.0 mg/kg; for four others the dose per injection was varied irreg...

journal_title：Psychopharmacology

authors： Wise RA,Newton P,Leeb K,Burnette B,Pocock D,Justice JB Jr

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Postmortem and positron emission tomography (PET) studies have reported several alterations in serotonin 1A receptor (5-HT(1A)) binding parameters in patients with schizophrenia. This study examines 5-HT(1A) availability in vivo in individuals with schizophrenia and schizo-affective disorder. MATERIALS AND ...

journal_title：Psychopharmacology

authors： Frankle WG,Lombardo I,Kegeles LS,Slifstein M,Martin JH,Huang Y,Hwang DR,Reich E,Cangiano C,Gil R,Laruelle M,Abi-Dargham A

更新日期：2006-12-01 00:00:00