Abstract:
:Rats were trained to self-administer cocaine in 1-h sessions on a fixed ratio 5 (FR5) schedule of reinforcement. Acquisition was carried out at a unit dose of 0.3 mg/kg and responding was then stabilized at cocaine doses of 0.1, 0.3, and 1.0 mg/kg/infusion. Pretreatments with naltrexone (0.1-10 mg/kg, SC) 20 min prior to the start of self-administration sessions resulted in decreases in cocaine self-administration at doses of 0.1 and 0.3 mg/kg/infusion, but not at 1.0 mg/kg/infusion. Decreases depended on the dose of naltrexone used, with greater decreases in self-administration occurring at higher antagonist doses. In addition, treatment with the opiate antagonist naloxone also reduced cocaine self-administration at a unit dose of 0.3 mg/kg. A group of rats trained to self-administer nicotine at a dose of 0.03 mg/kg/infusion on the same schedule of reinforcement was unaffected by naltrexone treatment. These results may indicate that an endogenous opiate system plays a role in cocaine reinforcement.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Corrigall WA,Coen KMdoi
10.1007/BF02244173subject
Has Abstractpub_date
1991-01-01 00:00:00pages
167-70issue
2eissn
0033-3158issn
1432-2072journal_volume
104pub_type
杂志文章abstract::Methadone as the most prevalent opioid substitution medication has been shown to influence the neurophysiological functions among heroin addicts. However, there is no firm conclusion on acute neuroelectrophysiological changes among methadone-treated subjects as well as the effectiveness of methadone in restoring brain...
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更新日期:2001-12-01 00:00:00
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更新日期:2014-04-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-05-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00