Abstract:
RATIONALE:Cannabinoid antagonists purportedly have greater effects in reducing the intake of highly palatable food compared to less palatable food. However, this assertion is based on free-feeding studies in which the amount of palatable food eaten under baseline conditions is often confounded with other variables, such as unequal access to both food options and differences in qualitative features of the foods. OBJECTIVE:We attempted to reduce these confounds by using a model of choice that programmed the delivery rates of sucrose and carrot-flavored pellets. METHODS:Lever pressing of ten lean (Fa/Fa or Fa/fa) and ten obese (fa/fa) Zucker rats was placed under three conditions in which programmed ratios for food pellets on two levers were 5:1, 1:1, and 1:5. In phase 1, responses on the two levers produced one type of pellet (sucrose or carrot); in phase 2, responses on one lever produced sucrose pellets and on the other lever produced carrot pellets. After responses stabilized under each food ratio, acute doses of rimonabant (0, 3, and 10 mg/kg) were administered before experimental sessions. The number of reinforcers and responses earned per session under each ratio and from each lever was compared. RESULTS AND CONCLUSIONS:Rimonabant reduced reinforcers in 1:5 and 5:1 food ratios in phase 1, and across all ratios in phase 2. Rimonabant reduced sucrose and carrot-flavored pellet consumption similarly; rimonabant did not affect bias toward sucrose, but increased sensitivity to amount differences in lean rats. This suggests that relative amount of food, not palatability, may be an important behavioral mechanism in the effects of rimonabant.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Buckley JL,Rasmussen EBdoi
10.1007/s00213-013-3366-4subject
Has Abstractpub_date
2014-05-01 00:00:00pages
2159-70issue
10eissn
0033-3158issn
1432-2072journal_volume
231pub_type
杂志文章abstract:RATIONALE:Clinical trials show that chronic cocaine users suffer from sleep disturbances and preclinical research has shown that acute sleep deprivation increases the rate of cocaine self-administration in rats. OBJECTIVE:This study examined the effect of cocaine self-administration on behavioral indices of sleep and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3101-1
更新日期:2013-09-01 00:00:00
abstract::The effects of bilateral nucleus accumbens microinjections of d-ala-met-enkephalinamide (DALA) were assessed in behavioral activation and lateral hypothalamic self-stimulation (LHSS) rate-frequency curve-shift paradigms in normal and accumbens 6-OHDA (4.0 micrograms) treated rats. Microinjections of DALA (2.5 microgra...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244999
更新日期:1994-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02246969
更新日期:1993-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-01-01 00:00:00
abstract::The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50 30 and 40 micrograms/kg IP respectively). Phenoxybenzamine and prazosine did not antagonize the anti-withd...
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pub_type: 杂志文章
doi:10.1007/BF00427276
更新日期:1983-01-01 00:00:00
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更新日期:2006-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:1978-09-15 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00652236
更新日期:1986-01-01 00:00:00
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更新日期:2002-02-01 00:00:00
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journal_title:Psychopharmacology
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doi:10.1007/s002130050138
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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更新日期:2010-07-01 00:00:00
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doi:10.1007/s00213-003-1758-6
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1979-02-28 00:00:00
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更新日期:2000-06-01 00:00:00
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更新日期:2017-08-01 00:00:00
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更新日期:2011-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245832
更新日期:1995-03-01 00:00:00
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更新日期:2006-03-01 00:00:00
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更新日期:2019-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431782
更新日期:1985-01-01 00:00:00
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doi:10.1007/BF00310519
更新日期:1986-01-01 00:00:00