Abstract:
:The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50 30 and 40 micrograms/kg IP respectively). Phenoxybenzamine and prazosine did not antagonize the anti-withdrawal effect of clonidine, whereas piperoxane and yohimbine were effective with respect to locomotor activity and a total abstinence score. Piperoxane also reversed the suppressive action of clonidine on body shakes. Other alpha 2-agonists (guanfacine, azepexole and BHT 920) also suppressed DPA-induced behaviour, whereas the lipophilic alpha 1-agonist ST-587 had such an effect only at high doses. The relative potencies of the alpha 2-agonists correlated well with their potency to exert other alpha 2-adrenoceptor mediated actions such as blood pressure lowering and sedation.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
van der Laan JW,Weick G,Hillen FCdoi
10.1007/BF00427276subject
Has Abstractpub_date
1983-01-01 00:00:00pages
267-71issue
3eissn
0033-3158issn
1432-2072journal_volume
81pub_type
杂志文章abstract:RATIONALE:There is evidence that events early in post-weaning life influence brain development and subsequent adult behaviour and therefore play an important role in the causation of certain psychiatric disorders in later life. Exposing rodents to stressors during the juvenile period has been suggested as a model of in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1991-8
更新日期:2011-03-01 00:00:00
abstract:RATIONALE:The synthetic progestin medroxyprogesterone acetate (MPA), widely used in hormone therapy (HT) and as the contraceptive Depo Provera, is implicated in detrimental cognitive effects in women. Recent evidence in aged ovariectomized (Ovx) rodents shows that short-term MPA treatment impairs cognition and alters t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2322-4
更新日期:2011-11-01 00:00:00
abstract:RATIONALE:Recent studies suggest that orexin/hypocretin is involved in drug reward and drug-seeking behaviors, including ethanol self-administration. However, orexin's role in ethanol-induced seeking behaviors remains unclear. OBJECTIVE:These studies examined the role of orexin in the acquisition and expression of eth...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2082-6
更新日期:2011-04-01 00:00:00
abstract:RATIONALE:Gabolysat PC60 is a fish protein hydrolysate with anxiolytic properties commonly used as a nutritional supplement. OBJECTIVE:The diazepam-like effects of PC60 on stress responsiveness of the rat pituitary-adrenal system and on sympathoadrenal activity were studied. METHODS:The activity of the pituitary-adre...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002139900338
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Anti-psychotic treatment appears to be associated with striatal volume increase, but how early this change occurs is still unknown. METHODS:A single prospective cohort of 20 anti-psychotic-naïve patients, newly diagnosed with schizophrenia, underwent magnetic resonance imaging brain scan at baseline. This w...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1619-z
更新日期:2009-10-01 00:00:00
abstract::The effects of vitamin B12 are compared to those of aspirin and 0.9% saline in three different experimental pain models in rats and mice; an electric shock test, the hot-plate test, and the phenylbenzoquinone writhing test. Neither cyanocobalamin nor hydroxocobalamin showed any antinociceptive activity in any of the t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427267
更新日期:1983-01-01 00:00:00
abstract::It is commonly believed that repeated exposures diminish the pleasurable effects of drugs and hence that pleasure must have only a minor role in addiction. In six experiments with rats, repeated exposures to amphetamine, morphine, or cocaine were found to enhance the drug-induced rewarding effect as measured by condit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00451687
更新日期:1989-01-01 00:00:00
abstract::In a double-blind, balanced crossover study, eight healthy male volunteers ingested either DL-308 (10 mg), DL-308 (20 mg), oxazepam (30 mg) or placebo. Subjective estimates of coordination and anxiety, objective performance measurements and cardiovascular measurements were taken at 1, 3, 5 and 8 h after ingestion. DL-...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427573
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:Cocaine-seeking behavior can be investigated in rodents using the conditioned place preference (CPP) paradigm, in which the drug-paired environment serves as a conditioned stimulus. Such approach allowed to previously demonstrate the importance of the neuromodulatory sigma1 (sigma1) receptor in acquisition of...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1814-x
更新日期:2004-09-01 00:00:00
abstract::The performance of healthy volunteer subjects on an auditory latent inhibition (LI) paradigm was assessed following administration of a single oral dose of d-amphetamine or placebo. It was predicted that a low (5 mg), but not a high (10 mg), dose of d-amphetamine would disrupt LI. The prediction was supported with lef...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245170
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:The effect of LSD in humans has been described as occurring in two temporal phases. The behavioral effects in rats also occur in two temporal phases: an initial suppression of exploration followed by increased locomotor activity. OBJECTIVES:We decided to investigate this phenomenon from the perspective that ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-2183-9
更新日期:2005-07-01 00:00:00
abstract:RATIONALE:The gut microbiota is increasingly recognized as a potential mediator of psychiatric diseases. Depressed patients have been shown to have a different microbiota composition compared with healthy controls, and several lines of research now aim to restore this dysbiosis. To develop novel treatments, preclinical...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5094-2
更新日期:2019-05-01 00:00:00
abstract:RATIONALE:Repeated social stress experiences engender "behavioral sensitization" and may also increase the potential for abuse of psychomotor stimulants, particularly cocaine use during "binges." OBJECTIVE:Experimental protocols were designed to induce behavioral sensitization through exposures to social-defeat stress...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100858
更新日期:2001-12-01 00:00:00
abstract::The present studies were undertaken to investigate the neuroactive steroidal modulation of feeding behavior and possible involvement of gamma-aminobutyric acid type-A (GABA-A) and mitochondrial diazepam binding inhibitor (DBI) receptors (MDR) in food-deprived male mice. Allopregnanolone (0.5-2 mg/kg), a neurosteroid, ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050635
更新日期:1998-06-01 00:00:00
abstract::The effects of benzodiazepine (triazolam 0.25 and 0.50 mg) on different aspects of cognitive function were assessed. Triazolam impaired free recall and recognition of information presented after drug administration. In contrast to these impairments in explicit memory, a memory function that did not require conscious a...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245415
更新日期:1992-01-01 00:00:00
abstract::On the heels of clozapine, we now have a number of newer agents (risperidone, olanzapine, quetiapine, sertindole, and ziprasidone). Are they all the same? What are the differences? How do we best understand them? In this article we review current clinical evidence to compare these issues on four measures of atypicalit...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130050017
更新日期:2000-01-01 00:00:00
abstract:RATIONALE:Repeated administrations of ethanol induce a progressive and enduring increase in its locomotor stimulant effects, a phenomenon termed behavioral sensitization that has not been systematically characterized. OBJECTIVE:The aim of the present studies was to characterize the development and expression of ethano...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1266-9
更新日期:2008-12-01 00:00:00
abstract::N-Methyl-D-aspartate (NMDA) antagonists induce psychotomimetic effects in humans that closely resemble negative and cognitive symptoms of schizophrenia. NMDA agonists, in contrast, may significantly ameliorate such symptoms. In rodents, phencyclidine (PCP) and other NMDA antagonists induce a hyperlocomotory syndrome t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050168
更新日期:1997-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The mechanisms underlying relapse to cocaine seeking induced by exposure to priming cocaine injections, cues associated with cocaine self-administration and environmental stressors have been studied in rats. Here we describe a reinstatement method for studying relapse to cocaine seeking in mice...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1047-9
更新日期:2002-06-01 00:00:00
abstract::The peripheral BDZ receptor ligand Ro 5-4864 was administered to rabbits in doses ranging from 0.2 to 7 mg/kg IV. Changes in electrocortical activity appeared within 1 min after administration, characterized by trains of slow waves in the posterior sensorimotor and optic cortices (0.6-2 mg/kg) and by grand mal seizure...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00180835
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Paired-associate learning (PAL), as part of the Cambridge Neuropsychological Test Automated Battery, is able to predict who from an at-risk population will develop Alzheimer's disease. Schizophrenic patients are also impaired on this same task. An automated rodent model of PAL would be extremely beneficial in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1526-3
更新日期:2009-07-01 00:00:00
abstract:RATIONALE:Serotonin 5-HT2A and 5-HT2C receptors are thought to be the primary pharmacological mechanisms for serotonin-mediated hallucinogenic drugs, but recently there has been interest in metabotropic glutamate (mGluR2) receptors as contributors to the mechanism of hallucinogens. OBJECTIVE:The present study assesses...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3658-3
更新日期:2015-01-01 00:00:00
abstract::Male rats of the Long-Evans strain were divided into two equal groups of nine each and given either 7.0 mg/kg trimethyltin (TMT) or 0.9% saline by intragastric gavage. The pattern of self-selection of alcohol in concentrations of 3%--30% was examined in both groups at 21 and 150 days following the gavage. The TMT-trea...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00470580
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:We recently reported that simultaneous exposure to amphetamine and various stressors resulted in reduced hypothalamic-pituitary-adrenal (HPA) and glycemic responses to the stressors. Since this is a new and relevant phenomenon, we wanted to further explore this interaction. OBJECTIVES:This study aims (i) to ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4675-9
更新日期:2017-10-01 00:00:00
abstract:RATIONALE:Premature discontinuation of antidepressant drugs is a frequent clinical problem. Adverse effects are common, occur early on in treatment and are reported to be one of the main reasons for discontinuation of antidepressant treatment. OBJECTIVES:To investigate the association between adverse effects occurring...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-014-3467-8
更新日期:2014-08-01 00:00:00
abstract:RATIONALE:Nicotine infusions that are self-administered (contingent) or response-independent (noncontingent) increase lever pressing for a reinforcing nonpharmacological stimulus in rats, suggesting that in addition to primary reinforcement, nicotine self-administration may result from nicotine enhancing the reinforcem...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0454-8
更新日期:2007-02-01 00:00:00
abstract:RATIONALE:Calcineurin is a protein regulating cytokine expression in T lymphocytes and calcineurin inhibitors such as cyclosporine A (CsA) are widely used for immunosuppressive therapy. It also plays a functional role in distinct neuronal processes in the central nervous system. Disturbed information processing as seen...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05751-1
更新日期:2020-12-21 00:00:00
abstract::A simple new method, the "tape test" has been developed for studying the enhancement of learning by drugs in "learning-dull" rats. A piece of adhesive tape is pressed on the left front pad of the rats. The time of tape removal by the animal, i.e., the problem-solving time is measured. In our experiments the selected l...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00423313
更新日期:1976-07-09 00:00:00
abstract::Fluctuations in extracellular dopamine and DOPAC levels in nucleus accumbens septi (NAS) were monitored in 1-min microdialysis samples taken from rats engaged in intravenous cocaine self-administration. For four rats the dose per injection was fixed at 2.0 mg/kg; for four others the dose per injection was varied irreg...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246140
更新日期:1995-07-01 00:00:00
abstract:RATIONALE:Considerable evidence suggests that genetic factors combine with environmental influences to impact on the development of aggressive behavior. A genetic variant that has repeatedly been reported to render individuals more sensitive to the presence of adverse experiences, including stress exposure during fetal...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3484-7
更新日期:2014-08-01 00:00:00