Abstract：
:Two putative predictors of placebo response were studied in three samples of psychiatric outpatients. Two groups, 73 university medical center patients and 56 college health service patients, underwent 1 week of placebo treatment. A quasi-control group of 112 patients receiving no medication waited about 1 week before beginning psychotherapy. One attribute, acquiescence or traditionalism, predicted placebo response, thereby replicating prior findings. Acquiescence was unrelated to change in controls indicating that it may represent a correlate of true placebo effect under some conditions. Additional findings suggested qualifications as to the generality of the relationship. The second attribute, autonomic awareness, was associated with change in all three samples. It appeared to predict nonspecific improvement unrelated to placebo probably due to its relationship to intensity of somatization.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
McNair DM,Gardos G,Haskell DS,Fisher Sdoi
10.1007/BF00433557subject
Has Abstractpub_date
1979-06-21 00:00:00pages
245-50issue
3eissn
0033-3158issn
1432-2072journal_volume
63pub_type
临床试验,杂志文章,随机对照试验abstract：RATIONALE:Prepulse inhibition (PPI) of the startle reflex is a model of pre-attentional inhibitory function. The dopamine baseline in the nucleus accumbens plays a key role in PPI regulation as well as in the rewarding effects of cocaine. OBJECTIVES:The aim of this study was to evaluate the predictive ability of PPI t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-4959-8
更新日期：2018-09-01 00:00:00
abstract：RATIONALE:Evidence that alcohol leads to increased aggressive behaviour is equivocal and confounded by evidence that such effects may operate indirectly via expectancy. One mechanism by which alcohol consumption may increase aggressive behaviour is via alterations in the processing of emotional facial cues. OBJECTIVES...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-009-1463-1
更新日期：2009-06-01 00:00:00
abstract：:Amphetamine (AMP) administered in high doses suppresses feeding. However, in low doses AMP has been shown to both suppress and facilitate feeding. Further, there is some indication of individual differences in the feeding response to low doses of AMP. Evidence indicates that AMP's effects on feeding are dopamine-media...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244426
更新日期：1991-01-01 00:00:00
abstract：:N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON 954) causes a reproducible rest tremor in mice, of rapid onset and short duration with no associated rigidity or akinesia and in the absence of any marked changes in body temperature or accompanying peripheral parasympathomimetic effects. This tremor ca...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00439104
更新日期：1977-04-29 00:00:00
abstract：RATIONALE:Recent studies have shown that pharmacological inhibition of the 12-lipoxygenase pathway selectively blocks opioid inhibition of GABAergic synaptic currents. A similar mechanism has been shown for the regulation of glutamate release in the ventral tegmental area (VTA) during acute withdrawal from morphine, al...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1526-7
更新日期：2003-11-01 00:00:00
abstract：RATIONALE:Several antipsychotic drugs are metabolised by the polymorphic cytochrome P(450) CYP2D6. The impact of the polymorphism on the plasma levels and the occurrence of side effects have not been clearly established. OBJECTIVE:To investigate the impact of the CYP2D6 polymorphism on the steady-state plasma concentr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1059-5
更新日期：2002-06-01 00:00:00
abstract：RATIONALE:Toluene is a misused inhalant with hallucinogenic properties and complex effects. Toluene blocks N-methyl-D-aspartate (NMDA) receptors, releases dopamine (DA), and modifies several neurotransmitter levels; nonetheless, the mechanism by which it produces hallucinations is not well characterized. OBJECTIVES:Th...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4041-8
更新日期：2015-10-01 00:00:00
abstract：:Two experiments examined the effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid intake in water-deprived rats. In the first experiment, pretreatment with 3.0 or 10.0 mg/kg zolpidem IP was found to increase consumption of a novel glucose drink (3% d-glucose and 0.15 sodium saccharine w/v in wat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245521
更新日期：1993-01-01 00:00:00
abstract：:Medial thalamic (MT), and hippocampal (HPC) EEG, and single unit activity, and frontal cortical (CTX) EEG were recorded following IV infusions of 0.625 mg morphine/kg in drug-naive, and following 0.0125 mg naloxone/kg in morphine-dependent paralyzed rats. Particular effort was made to assess the latency of the respons...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433246
更新日期：1980-01-01 00:00:00
abstract：RATIONALE:Anticipatory nausea (AN) experienced by chemotherapy patients is resistant to current anti-nausea treatments. In this study, the effect of manipulation of the endocannabinoid (EC) system on a rat model of nausea (conditioned gaping) was determined. OBJECTIVE:The potential of cannabidiol (CBD) and the fatty a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0970-1
更新日期：2008-02-01 00:00:00
abstract：RATIONALE:The intake of psychostimulant drugs may induce cognitive dysfunction and negative affective-like states, and is associated with increased activity of stress-responsive systems. The corticotropin-releasing factor (CRF) system mediates neuroendocrine, behavioural and autonomic responses to stressors, and might ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3534-1
更新日期：2014-10-01 00:00:00
abstract：:On the heels of clozapine, we now have a number of newer agents (risperidone, olanzapine, quetiapine, sertindole, and ziprasidone). Are they all the same? What are the differences? How do we best understand them? In this article we review current clinical evidence to compare these issues on four measures of atypicalit...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s002130050017
更新日期：2000-01-01 00:00:00
abstract：RATIONALE:Dependence on both alcohol and cocaine is a widespread example of polydrug abuse/dependence. It has been hypothesized that ethanol reward is mediated via increased dopaminergic neurotransmission in mesolimbic striatum, as is the case for cocaine. However, little is known about the neurobiology of ethanol in p...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1233-9
更新日期：2002-12-01 00:00:00
abstract：:Methadone as the most prevalent opioid substitution medication has been shown to influence the neurophysiological functions among heroin addicts. However, there is no firm conclusion on acute neuroelectrophysiological changes among methadone-treated subjects as well as the effectiveness of methadone in restoring brain...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5035-0
更新日期：2018-11-01 00:00:00
abstract：:Administration of drugs that reduce the influence of dopamine at its receptor site can lead to postsynaptic supersensitivity, whereas treatment with dopamine (DA) agonists can cause postsynaptic subsensitivity. Both unaltered and enhanced postsynaptic responses to DA have been shown after pretreatment with DA agonists...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428198
更新日期：1985-01-01 00:00:00
abstract：:To assess the effects of chlordiazepoxide (CDP) on a stable discrimination performance, eight rats were trained on a simple brightness discrimination and injected with three dosages (0, 5, and 10 mg/kg) once performance was stable. Signal detection analysis of the results was used to differentiate sensory from motor/r...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433568
更新日期：1979-06-21 00:00:00
abstract：:Lithium elicits opposite effects on two behavioural syndromes in rats: enhancement of the 5-HT1A-linked serotonin syndrome and attenuation of the 5-HT2-linked wet dog shakes. The ability of intracerebroventricular (ICV) myo-inositol or forskolin to reverse the enhancement of the serotonin syndrome by lithium was teste...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245842
更新日期：1995-03-01 00:00:00
abstract：INTRODUCTION:The present study was designed to investigate the rewarding effects induced by tramadol and its active metabolite O-desmethyltramadol (M1) under a neuropathic pain-like state. RESULTS:In opioid receptor binding and G protein activation, we confirmed that M1, but not tramadol, showed mu-opioid receptor (MO...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1180-1
更新日期：2008-10-01 00:00:00
abstract：:Peripheral administration of the unsulphated cholecystokinin octapeptide (CCK-8us) led to an anxiogenic-like action in the elevated plus-maze model of anxiety in rats. Devazepide and L-365,260 showed potent anxiolytic-like effects at similar doses. The fact that devazepide is 1000 times more potent as a CCK-A receptor...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244646
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:The main psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), can impair driving performance. Cannabidiol (CBD), a non-intoxicating cannabis component, is thought to mitigate certain adverse effects of THC. It is possible then that cannabis containing equivalent CBD and THC will differenti...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-019-05246-8
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Postmortem and positron emission tomography (PET) studies have reported several alterations in serotonin 1A receptor (5-HT(1A)) binding parameters in patients with schizophrenia. This study examines 5-HT(1A) availability in vivo in individuals with schizophrenia and schizo-affective disorder. MATERIALS AND ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0543-8
更新日期：2006-12-01 00:00:00
abstract：RATIONALE:Endogenous γ-aminobutyric acidA receptor (GABAAR)-active neurosteroids (e.g., allopregnanolone) regulate central nervous system excitability and many physiological functions, so fluctuations are implicated in several neuropsychiatric disorders. Pertinently, evidence supports an inverse relationship between en...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4671-0
更新日期：2017-09-01 00:00:00
abstract：RATIONALE:The progesterone metabolite 5alpha-pregnane-3alpha-ol-20-one (3alpha,5alpha-THP) is an important modulator of the hypothalamic-pituitary-adrenal axis and stress-induced corticosterone response. Typically, 3alpha,5alpha-THP levels are increased in response to acute stress, which may then reduce corticosterone ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0253-7
更新日期：2006-06-01 00:00:00
abstract：:The exploratory behavior of pigs was studied in two successive daily 20-mn sessions in a two-compartment box by counting the number of crossings from one compartment to the other and observing the activity patterns. Injection of 1 mg/kg diazepam before the first session increased the number of crossings without affect...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431643
更新日期：1977-03-16 00:00:00
abstract：RATIONALE:Although the behavioral effects of systemic injection of lipopolysaccharide (LPS) have been extensively investigated, the modulation of these effects by natural environmental factors has received little attention. OBJECTIVES:The present study investigated whether or not locomotor activity reductions and the ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1554-3
更新日期：2003-12-01 00:00:00
abstract：RATIONALE:Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse. OBJECTIVE:To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacqui...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2640-1
更新日期：2012-07-01 00:00:00
abstract：:The ability of delta 9-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-OH THC and 8 alpha, 11-diOH THC to antagonise the abdominal constriction response in the mouse induced by formic acid, phenylquinone, 5-hydroxytryptamine, prostaglandin E1 (PGE1) and bradykinin was tested. THC was an effective a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432273
更新日期：1979-03-28 00:00:00
abstract：RATIONALE:Several lines of evidence have indicated that the central histaminergic system might be involved in learning and memory OBJECTIVES:The aim of the present study was to ascertain the impact on memory processes of putative histaminergic-cholinergic interactions in the nucleus basalis magnocellularis (NBM) of th...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100892
更新日期：2002-01-01 00:00:00
abstract：RATIONALE:Both methylphenidate (MPH), a catecholamine reuptake blocker, and guanfacine, an alpha2A agonist, are used to treat attention-deficit hyperactivity disorder (ADHD). Childhood impulsivity, including delay discounting, is associated with increased substance use during adolescence. These effects can be mitigated...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5096-0
更新日期：2019-02-01 00:00:00
abstract：:Pigeons were trained to peck each of two response keys. Periods during which pecks on one key (the food key) produced access to grain according to a random-ratio 80 schedule alternated irregularly with periods during which food-key responses had no scheduled consequences (extinction). Both keys remained amber unless a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00422418
更新日期：1981-01-01 00:00:00
