Abstract:
:Amphetamine (AMP) administered in high doses suppresses feeding. However, in low doses AMP has been shown to both suppress and facilitate feeding. Further, there is some indication of individual differences in the feeding response to low doses of AMP. Evidence indicates that AMP's effects on feeding are dopamine-mediated and that the nucleus accumbens (Acb) may be an important site of action. Of interest here is the fact that CCK terminals exist within the Acb and CCK modulates DA activity. Experiment 1 investigated the effects of intra-Acb CCK administration as a function of individual differences in the feeding response to a low dose of systemic AMP. Results indicate that response to AMP was baseline dependent. AMP stimulated feeding in low baseline feeders and suppressed feeding in high baseline feeders. Intra-Acb CCK blocked the AMP-induced increase in feeding but not the AMP-induced anorexia. In experiment 2, the effects of intra-Acb CCK administration on baseline feeding were assessed. Intra-Acb CCK suppressed baseline feeding, but only when there was a high level of intake. It is speculated that Acb-DAergic activity may play a role in the observed feeding effects of both AMP and CCK.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Sills TL,Vaccarino FJdoi
10.1007/BF02244426subject
Has Abstractpub_date
1991-01-01 00:00:00pages
329-34issue
3eissn
0033-3158issn
1432-2072journal_volume
105pub_type
杂志文章abstract::Much of the research implicating learning in the development of tolerance to ethanol-induced impairment has used an experimental design in which different groups receive drug either before or after an opportunity to perform an instrumental or operant task. The stronger tolerance observed in subjects who perform while ...
journal_title:Psychopharmacology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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更新日期:1979-02-28 00:00:00
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更新日期:2009-07-01 00:00:00
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更新日期:1988-01-01 00:00:00
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更新日期:1999-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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更新日期:2015-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-06-01 00:00:00
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更新日期:2003-09-01 00:00:00
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更新日期:2010-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-03-01 00:00:00
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更新日期:2008-03-01 00:00:00
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