Effects of chlorpromazine on food-maintained and observing behavior.

abstract：:In the majority of Parkinson's disease (PD) patients, long-term dopamine (DA) replacement therapy leads to dyskinesia characterized by abnormal involuntary movements (AIMs). There are various mechanisms of dyskinesia, such as the sensitization of striatal DA D1 receptors (D1R) and upregulation of DA D3 receptors (D3R)...

journal_title：Psychopharmacology

authors： Lanza K,Chemakin K,Lefkowitz S,Saito C,Chambers N,Bishop C

更新日期：2020-01-01 00:00:00

abstract：:Serotonin is a neurotransmitter that is widely distributed throughout the central nervous system. The role of serotonin in schizophrenia is still unclear. Postmortem studies of serotonin receptor subtypes in schizophrenia have been inconclusive for the most part. The most promising findings involve a reduction in 5-HT...

journal_title：Psychopharmacology

authors： Ohuoha DC,Hyde TM,Kleinman JE

更新日期：1993-01-01 00:00:00

abstract：:The effects of olanzapine [LY 170053; 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2, 3b] [1,5]benzodiazepine), a potential atypical antipsychotic, were determined in pigeons whose keypeck responding was punished. These effects were compared to the anxiolytic agents chlordiazepoxide and pentobarbital, and to other a...

journal_title：Psychopharmacology

authors： Benvenga MJ,Leander JD

更新日期：1995-05-01 00:00:00

abstract：:Depression is common in patients with senile dementia of the Alzheimer type (SDAT) and may precede the onset of the dementia; the underlying biological and neurotransmitter mechanisms may be common to both diseases, so far as norepinephrine lesions are concerned. The major routes of metabolism of amines in the brain u...

journal_title：Psychopharmacology

authors： Chan-Palay V

更新日期：1992-01-01 00:00:00

abstract：:Two methods were used to assess nicotine-induced antinociception: tail withdrawal from a hot water bath and hind paw withdrawal from a hotplate. Nicotine doses which produced 75-80% maximum response were 0.75 mg/kg (free base) for tail withdrawal and 0.35 mg/kg for paw withdrawal. The peripheral blocker chlorisondamin...

journal_title：Psychopharmacology

authors： Caggiula AR,Epstein LH,Perkins KA,Saylor S

更新日期：1995-12-01 00:00:00

abstract：:Pretreatment of rats with hydantoin (75 mg/kg, PO, an anticonvulsant), trihexyphenidyl (10 mg/kg, SC, a muscarinic cholinergic antagonist), or piperonyl butoxide (500 mg/kg, PO, a metabolic inhibitor) had no effect on the whole blood or brain tissue levels of orally administered DDT (75 mg/kg) or its metabolites DDD a...

journal_title：Psychopharmacology

authors： Herr DW,Hong JS,Chen P,Tilson HA,Harry GJ

更新日期：1986-01-01 00:00:00

abstract：:Male volunteer subjects smoked one marijuana cigarette containing 100, 200, or 250 micrograms/kg delta-9-tetrahydrocannabinol (THC) and were tested on three perceptual-motor performance measures related to driving. Performance was measured and blood samples were collected for 24 h after smoking. The covariation betwee...

journal_title：Psychopharmacology

authors： Barnett G,Licko V,Thompson T

更新日期：1985-01-01 00:00:00

abstract：:This paper examines noradrenergic hyperactivity in response to stress in the development of spontaneous recurrences of methamphetamine (MAP) psychosis, a phenomenon known as flashbacks, in studies of psychedelic drug use. We studied predictors of flashbacks in 36 subjects with flashbacks, along with 80 subjects with a...

journal_title：Psychopharmacology

authors： Yui K,Ishiguro T,Goto K,Ikemoto S

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVES:Previous studies have investigated the occupancy of the serotonin reuptake transporter (SERT) after clinical doses of citalopram and other selective serotonin reuptake inhibitors. In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioli...

journal_title：Psychopharmacology

authors： Klein N,Sacher J,Geiss-Granadia T,Mossaheb N,Attarbaschi T,Lanzenberger R,Spindelegger C,Holik A,Asenbaum S,Dudczak R,Tauscher J,Kasper S

更新日期：2007-04-01 00:00:00

abstract：:Dose-dependent effects of intravenously administered lorazepam on haemodynamic fluctuations were studied by means of spectral analysis, in order to elucidate sympathetic and parasympathetic components in cardiovascular control during situations of rest and mental stress after benzodiazepine administration. In a double...

journal_title：Psychopharmacology

authors： Tulen JH,Mulder G,Pepplinkhuizen L,Man in 't Veld AJ,van Steenis HG,Moleman P

更新日期：1994-02-01 00:00:00

abstract：RATIONALE:Neuroanatomical evidence suggests that GABAergic deficits and progressive cortical atrophy occur with schizophrenia. OBJECTIVE:To evaluate the hypothesis that neurodevelopmental deficits affect neurodegeneration occurring with schizophrenia, this study examined a novel animal model for schizophrenia-related ...

journal_title：Psychopharmacology

authors： Abekawa T,Ito K,Nakato Y,Koyama T

更新日期：2011-06-01 00:00:00

abstract：RATIONALE:Clozapine is a unique antipsychotic with very low propensity to cause motor side effects. In contrast to most other antipsychotics that block more than 70% of dopamine D(2) receptors at therapeutic doses, clozapine occupies less than 70%. Furthermore, even at maximum occupancy, 70% is not exceeded. Several me...

journal_title：Psychopharmacology

authors： Suhara T,Okauchi T,Sudo Y,Takano A,Kawabe K,Maeda J,Kapur S

更新日期：2002-02-01 00:00:00

abstract：RATIONALE:Epidemiological studies of smokers suggest that there is a link between nicotine and depression. Nonetheless, few studies have examined the potential use of nicotinic ligands in the treatment of depression. OBJECTIVES:The goal of this study was to evaluate the effects of SIB-1508Y, a novel subtype-selective ...

journal_title：Psychopharmacology

authors： Ferguson SM,Brodkin JD,Lloyd GK,Menzaghi F

更新日期：2000-10-01 00:00:00

abstract：RATIONALE:Children and adolescents will readily abuse household products that contain solvents such as toluene. It is likely that reinforcing exposures to toluene alter brain glucose metabolism. OBJECTIVE:Using an animal model of drug reinforcement, we sought to identify a metabolic signature of toluene abuse in the a...

journal_title：Psychopharmacology

authors： Schiffer WK,Lee DE,Alexoff DL,Ferrieri R,Brodie JD,Dewey SL

更新日期：2006-06-01 00:00:00

abstract：:Rats were trained to bar-press for intravenous infusions of morphine sulfate during 1-h daily test sessions. Rates of morphine self-administration were enhanced by lesions of the frontal cortex and hippocampus and transiently reduced by lesions of the medial forebrain bundle and medial thalamus. Dose-response studies ...

journal_title：Psychopharmacology

authors： Glick SD,Cox RD

更新日期：1978-05-31 00:00:00

abstract：:Phencyclidine (PCP; 2.5 or 5.0 mg/kg) potentiated the effects of rewarding hypothalamic brain stimulation, causing parallel leftward shifts of the functions that relate rate of responding to stimulation frequency. Thus, like a number of other drugs of abuse, PCP lowered the "dose" of stimulation required to maintain r...

journal_title：Psychopharmacology

authors： Carlezon WA Jr,Wise RA

更新日期：1993-01-01 00:00:00

abstract：:This study was conducted in order to investigate the level of amitriptyline (AT) and its metabolites. Three separate experiments were carried out. In two of these experiments, rats were treated over 7 days with IP doses of AT (10 mg/kg in experiment A and 2 X 20 mg/kg in experiment C). The rats were sacrificed either ...

journal_title：Psychopharmacology

authors： Baumann P,Gaillard JM,Jonzier-Perey M,Gerber C,Bouras C

更新日期：1984-01-01 00:00:00

abstract：:The intensity of the head-twitch response and the 5-hydroxytryptamine (5-HT) syndrome (tremor, fore-paw treading, head-weaving and hind-limb abduction) was measured in male CFLP mice following IP injection of 5 mg/kg 5-methoxy-N,N-dimethyltryptamine (5-MeODMT). The results of separate experiments carried out at 1.5-h ...

journal_title：Psychopharmacology

authors： Moser PC,Redfern PH

更新日期：1985-01-01 00:00:00

abstract：:To investigate the role of D1 dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 mg/kg, IM) from saline. Administration of various doses of cocaine resulted in a dose-related in...

journal_title：Psychopharmacology

authors： Kleven MS,Anthony EW,Goldberg LI,Woolverton WL

更新日期：1988-01-01 00:00:00

abstract：:Three sets of experiments were carried out in a Y water maze in which mice had to swim toward the light or the dark, in two different procedures. The first procedure involved, orientation toward a light source (L procedure), corresponding to natural preference, the latter involved orientation toward the dark (D proced...

journal_title：Psychopharmacology

authors： Castellano C

更新日期：1976-08-17 00:00:00

abstract：RATIONALE:The hallucinatory effect and potential abuse of salvinorin A, the major ingredient of Salvia divinorum, has not been documented in animals. OBJECTIVE:The effects of salvinorin A on the zebrafish (Danio rerio) model, through its swimming behavior and conditioned place preference (CPP) task, was studied. MATE...

journal_title：Psychopharmacology

authors： Braida D,Limonta V,Pegorini S,Zani A,Guerini-Rocco C,Gori E,Sala M

更新日期：2007-03-01 00:00:00

abstract：RATIONALE AND OBJECTIVE:Because of the important role of dopamine in neurotransmission, it would be useful to be able to image brain dopamine receptor-mediated signal transduction in animals and humans. Administering the D1-D2 receptor agonist apomorphine may allow us to do this, as the D2-like receptor is reported to ...

journal_title：Psychopharmacology

authors： Bhattacharjee AK,Chang L,White L,Bazinet RP,Rapoport SI

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND RATIONALE:More than two decades ago, Wise proposed his "anhedonia hypothesis" to explain the role of dopamine in motivated behaviors. The hypothesis posits that dopamine mediates the pleasure experienced by reward obtainment. However, some experimental findings have contested this hypothesis and several ...

journal_title：Psychopharmacology

authors： Barbano MF,Cador M

更新日期：2007-04-01 00:00:00

abstract：RATIONALE:Repetitive cocaine exposure has been shown to induce GABAergic thalamic alterations. Given the key role of T-type (Ca(V)3) calcium channels in thalamocortical physiology, the direct involvement of these calcium channels in cocaine-mediated effects needs to be further explored. OBJECTIVE:The objective of this...

journal_title：Psychopharmacology

authors： Bisagno V,Raineri M,Peskin V,Wikinski SI,Uchitel OD,Llinás RR,Urbano FJ

更新日期：2010-10-01 00:00:00

abstract：:Neonatal treatment with monoamine reuptake inhibitors results in a constellation of neurobehavioral alterations in adult rats that may model human depression. Since alterations in circadian rhythmicity have been reported in both depressed patients and in animal depression models, the present study examined the effects...

journal_title：Psychopharmacology

authors： Rosenwasser AM,Hayes MJ

更新日期：1994-06-01 00:00:00

abstract：RATIONALE:Marijuana and alcohol, when used separately and in combination, contribute to automobile accidents and failed sobriety tests of standing balance. However, the extent to which the drugs have additive effects on both of these measures is unknown. OBJECTIVES:This study was designed to compare directly the separ...

journal_title：Psychopharmacology

authors： Liguori A,Gatto CP,Jarrett DB

更新日期：2002-10-01 00:00:00

abstract：RATIONALE:Pharmacological manipulation of serotonergic neurotransmission in healthy volunteers impacts on cognitive test performance. Specifically, markers of serotonin function are associated with attention and executive functioning, long-term memory, and general cognitive ability. The serotonin transporter (SERT) pro...

journal_title：Psychopharmacology

authors： Madsen K,Erritzoe D,Mortensen EL,Gade A,Madsen J,Baaré W,Knudsen GM,Hasselbalch SG

更新日期：2011-02-01 00:00:00

abstract：RATIONALE:Impulsive behavior is associated with both alcohol use disorders and a family history of alcoholism (FHA). One operational definition of impulsive behavior is the stop-signal task (SST) which measures the time needed to stop a ballistic hand movement. OBJECTIVE:Employ functional magnetic resonance imaging (f...

journal_title：Psychopharmacology

authors： Kareken DA,Dzemidzic M,Wetherill L,Eiler W 2nd,Oberlin BG,Harezlak J,Wang Y,O'Connor SJ

更新日期：2013-07-01 00:00:00

abstract：RATIONALE:Repeated social stress experiences engender "behavioral sensitization" and may also increase the potential for abuse of psychomotor stimulants, particularly cocaine use during "binges." OBJECTIVE:Experimental protocols were designed to induce behavioral sensitization through exposures to social-defeat stress...

journal_title：Psychopharmacology

authors： Covington HE 3rd,Miczek KA

更新日期：2001-12-01 00:00:00

abstract：:Quantitative receptor autoradiography was used to study the effects of the selective serotonin reuptake inhibitors citalopram and fluoxetine and the tricyclic antidepressant imipramine on the regulation of beta 1-adrenergic receptors in the rat brain. Rats were treated with saline, citalopram (10 mg kg-1), fluoxetine ...

journal_title：Psychopharmacology

authors： Pälvimäki EP,Laakso A,Kuoppamäki M,Syvälahti E,Hietala J

更新日期：1994-08-01 00:00:00