Family history of alcoholism interacts with alcohol to affect brain regions involved in behavioral inhibition.

abstract：RATIONALE:Prepulse inhibition (PPI) and locomotor activity have been used to investigate the effects of antipsychotic and stimulant drugs and their underlying dopaminergic mechanisms. Whereas D2-like agonists consistently decreased PPI and increased locomotion in rats in previous studies, we recently reported that thes...

journal_title：Psychopharmacology

authors： Ralph RJ,Caine SB

更新日期：2007-04-01 00:00:00

abstract：:Functional antagonists at the N-methyl-D-aspartate (NMDA) receptor complex produce anti-depressant-like actions in preclinical models. Thus, an injection of a glycine partial agonist (1-aminocyclopropanecarboxylic acid; ACPC), a competitive NMDA antagonist (2-amino-7-phosphonoheptanoic acid; AP-7) or a use-dependent c...

journal_title：Psychopharmacology

authors： Skolnick P,Miller R,Young A,Boje K,Trullas R

更新日期：1992-01-01 00:00:00

abstract：:The concentration of kynurenine in plasma from depressed patients and control subjects has been measured using a sensitive and specific method. The levels of kynurenine in the plasma of depressed patients and controls are not significantly different and are not influenced by age or sex. The severity of affective distu...

journal_title：Psychopharmacology

authors： Wood K,Harwood J,Coppen A

更新日期：1978-12-08 00:00:00

abstract：:Preclinical studies have exploded our knowledge about the behavioral and biological underpinnings of alcoholism. These studies suggest that certain neurotransmitters, particularly those interacting with the opioid, N-methyl-D-aspartate, and monoamine systems, may play a critical role in the expression of alcohol-drink...

journal_title：Psychopharmacology

authors： Johnson BA,Ait-Daoud N

更新日期：2000-05-01 00:00:00

abstract：:The effects of fixed-ratio (FR) size, scopolamine, and the interactions between FR size and scopolamine were investigated in male F344 rats on working memory as assessed by spatial alternation behavior maintained under FR schedules of food presentation where the interval between trials was varied among values of 2, 4,...

journal_title：Psychopharmacology

authors： Shannon HE,Bemis KG,Hart JC

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Drug-associated environmental stimuli may serve as conditioned reinforcers to enhance drug self-administration behaviors in humans and laboratory animals. However, it can be difficult to distinguish experimentally the conditioned reinforcing effects of a stimulus from other behavioral processes that can chang...

journal_title：Psychopharmacology

authors： Bertz JW,Woods JH

更新日期：2013-09-01 00:00:00

abstract：:Chronic exposure to very mild unpredictable stress has previously been found to depress the consumption of, and preference for, highly palatable sweet solutions. The present study used the place conditioning procedure to investigate whether these effects result from a decreased sensitivity to reward. Rats were subject...

journal_title：Psychopharmacology

authors： Papp M,Willner P,Muscat R

更新日期：1991-01-01 00:00:00

abstract：:The present experiment examined effects of nicotine on body weight of male and female rats when Oreo cookies, potato chips, laboratory chow, and water were available. Body weight and eating behavior were measured for 17-day periods before, during, and after nicotine or saline administration. There was an inverse relat...

journal_title：Psychopharmacology

authors： Grunberg NE,Popp KA,Winders SE

更新日期：1988-01-01 00:00:00

abstract：:The neurochemical specificity of physiological, biochemical, and psychological responses to dextroamphetamine was tested by pretreating volunteers with haloperidol (0.014 mg/kg IM), propranolol (0.1 mg/kg IV), thymoxamine (0.1 mg/kg IV), or placebo prior to 0.3 mg/kg IV amphetamine. Healthy volunteers (N = 12) partici...

journal_title：Psychopharmacology

authors： Nurnberger JI Jr,Simmons-Alling S,Kessler L,Jimerson S,Schreiber J,Hollander E,Tamminga CA,Nadi NS,Goldstein DS,Gershon ES

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Disrupted social behavior, including occasional aggressive outbursts, is characteristic of withdrawal from long-term alcohol (EtOH) use. Heavy EtOH use and exaggerated responses during withdrawal may be treated using glutamatergic N-methyl-D-aspartate receptor (NMDAR) antagonists. OBJECTIVES:The current expe...

journal_title：Psychopharmacology

authors： Hwa LS,Nathanson AJ,Shimamoto A,Tayeh JK,Wilens AR,Holly EN,Newman EL,DeBold JF,Miczek KA

更新日期：2015-08-01 00:00:00

abstract：RATIONALE:Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters the effects of alcohol on psychomotor performance. OBJECTIVES:To test wh...

journal_title：Psychopharmacology

authors： Wright A,Terry P

更新日期：2002-03-01 00:00:00

abstract：:The effects of methaqualone on isonicotinic acid hydrazide, 6-mercapto propionic acid, picrotoxin, and strychnine-induced convulsion were studied in mice and the results compared with diazepam. Methaqualone, like diazepam, was found to be a selective antagonist of isoniazid-induced convulsion and a much less effective...

journal_title：Psychopharmacology

authors： Naik SR,Naid PR,Sheth UK

更新日期：1978-04-14 00:00:00

abstract：:Methamphetamine (MAP: 1 and 2 mg/kg SC) and caffeine (CAF: 1, 3, 10 and 30 mg/kg SC) dose-dependently increased ambulation in mice. Repeated administration (5 times at 3 to 4-day intervals) of MAP, but not CAF, induced sensitization to its effect. Furthermore, the mice repeatedly receiving CAF showed no significant ch...

journal_title：Psychopharmacology

authors： Kuribara H

更新日期：1994-10-01 00:00:00

abstract：INTRODUCTION:Understanding an individual's vulnerability to drug addiction has important implications for the development of effective personal treatment plans. Although theories acknowledge impulsive behaviour as a key component of drug addiction, little is known about the influence of trait impulsivity on an individu...

journal_title：Psychopharmacology

authors： Kolokotroni KZ,Rodgers RJ,Harrison AA

更新日期：2014-02-01 00:00:00

abstract：:The novel dopamine autoreceptor antagonists (-)-DS 121 and (+)-UH 232 were tested for their ability to alter cocaine self-administration behavior in rats reinforced on a progressive ratio (PR) schedule. (-)-DS 121 (15 mg/kg) and (+)-UH 232 (30 mg/kg) produced significant decreases in breaking point. (-)-DS 121 produce...

journal_title：Psychopharmacology

authors： Smith A,Piercey M,Roberts DC

更新日期：1995-07-01 00:00:00

abstract：:Aggressive rats could be differentiated from non-aggressive rats on a lower rate of rearing reactions in the open-field activity, as well as on a weaker aptitude for learning, increasing with the complication of the test. The two groups of rats had comparable activity, and a comparable response to pain. Apomorphine de...

journal_title：Psychopharmacology

authors： Senault B

更新日期：1976-07-09 00:00:00

abstract：RATIONALE:We recently reported that simultaneous exposure to amphetamine and various stressors resulted in reduced hypothalamic-pituitary-adrenal (HPA) and glycemic responses to the stressors. Since this is a new and relevant phenomenon, we wanted to further explore this interaction. OBJECTIVES:This study aims (i) to ...

journal_title：Psychopharmacology

authors： Gagliano H,Ortega-Sanchez JA,Nadal R,Armario A

更新日期：2017-10-01 00:00:00

abstract：:The problem of the advantage of using nortriptyline (NT) plasma level during treatment for endogenous depression has been approached. In an ordinary psychiatric department, 34 patients had their NT level checked the second week of treatment and their dosage subsequently adjusted, if it was outside the recommended ther...

journal_title：Psychopharmacology

authors： Sørensen B,Kragh-Sørensen P,Larsen NE,Hvidberg EF

更新日期：1978-09-15 00:00:00

abstract：RATIONALE:Group I metabotropic glutamate receptor antagonists, which block both the mGlu1 and mGlu5 receptors, have been shown to have anxiolytic effects in the lick suppression test in rats. OBJECTIVE:The anxiolytic potential of the selective mGlu1 antagonist 3,4-dihydro-2H-pyrano[2,3]beta-quinolin-7-yl)(cis-4-methox...

journal_title：Psychopharmacology

authors： Steckler T,Lavreysen H,Oliveira AM,Aerts N,Van Craenendonck H,Prickaerts J,Megens A,Lesage AS

更新日期：2005-04-01 00:00:00

abstract：:The effects of caffeine (1-100 mg/kg, IP), (-)N-((R)-1-methyl-2-phenylethyl)-adenosine (PIA) (0.01-1 mg/kg, IP), and of the two drugs in combination were studied in mice responding under a mult FR30 FI600 s schedule of food presentation. The lowest dose of caffeine, 1 mg/kg, had no effect on responding under either co...

journal_title：Psychopharmacology

authors： Glowa JR,Sobel E,Malaspina S,Dews PB

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:The endocannabinoid system has been implicated in the pathogenesis of major depression (MD) as well as in the mediation of antidepressant drug effects. OBJECTIVES:To analyze CNR1 gene variants in MD and clinical response to citalopram (selective serotonin re-uptake inhibitors [SSRI]). METHODS:The role of CN...

journal_title：Psychopharmacology

authors： Mitjans M,Serretti A,Fabbri C,Gastó C,Catalán R,Fañanás L,Arias B

更新日期：2013-06-01 00:00:00

abstract：:Administration of various doses of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) to rats produced dose-related decreases in 1-h food intake in the food-deprived paradigm. Pretreatment with spiperone (5-HT1A/5-HT2/D2 antagonist), propranolol or CGP361A (beta-adrenoceptor antagonists that also have binding affinit...

journal_title：Psychopharmacology

authors： Aulakh CS,Hill JL,Yoney HT,Murphy DL

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial in patients with schizophrenia (Bitter et al. Neuropsych...

journal_title：Psychopharmacology

authors： Slifstein M,Abi-Dargham A,Girgis RR,Suckow RF,Cooper TB,Divgi CR,Sokoloff P,Leriche L,Carberry P,Oya S,Joseph SK,Guiraud M,Montagne A,Brunner V,Gaudoux F,Tonner F

更新日期：2020-02-01 00:00:00

abstract：:Much of the research implicating learning in the development of tolerance to ethanol-induced impairment has used an experimental design in which different groups receive drug either before or after an opportunity to perform an instrumental or operant task. The stronger tolerance observed in subjects who perform while ...

journal_title：Psychopharmacology

authors： Cunningham CL,Losli SM,Risinger FO

更新日期：1992-01-01 00:00:00

abstract：:The aim of the present study was to investigate the locomotor stimulant effects of the atypical antipsychotic agent, olanzapine, in mice depleted of their dopamine by reserpine and alpha-methyl-DL-p-tyrosine pretreatment. Olanzapine (0.5, 1 and 2 mg/kg) dose-dependently increased locomotor activity, which was complete...

journal_title：Psychopharmacology

authors： Ninan I,Kulkarni SK

更新日期：1999-02-01 00:00:00

abstract：:Rats injected with doses of d-amphetamine 0--5.0 mg/kg were observed continuously in either an enclosed Y-maze or on an elevated Y-shaped platform. Patterns of increased walking and stereotypy were unaffected by the type of apparatus, but rearing remained totally suppressed at all dose levels on the elevated platform....

journal_title：Psychopharmacology

authors： Mumford L,Teixeira AR,Kumar R

更新日期：1979-04-25 00:00:00

abstract：:The release of serotonin (5-HT) at serotonergic nerve terminals is regulated by 5-HT(1B) autoreceptors. Several studies have reported that the effects of selective 5-HT reuptake inhibitors (SSRIs) on extracellular 5-HT are augmented by 5-HT(1B) receptor antagonists, whereas administration of these antagonists alone do...

journal_title：Psychopharmacology

authors： de Groote L,Klompmakers AA,Olivier B,Westenberg HG

更新日期：2003-05-01 00:00:00

abstract：RATIONALE:There is an emerging body of evidence that implicates a crucial role of γ-aminobutyric acid subtype A (GABAA) receptors in modulating the rewarding effects of a number of abused drugs. Modulation of GABAA receptors may therefore represent a novel drug-class independent mechanism for the development of abuse t...

journal_title：Psychopharmacology

authors： Tracy ME,Banks ML,Shelton KL

更新日期：2016-02-01 00:00:00

abstract：RATIONALE:Rats selectively bred for high saccharin (HiS) intake consume more alcohol and acquire intravenous (i.v.) cocaine self-administration more rapidly than their low saccharin (LoS)-consuming counterparts. The present experiment was designed to determine whether HiS and LoS rats differed in other aspects of drug ...

journal_title：Psychopharmacology

authors： Carroll ME,Anderson MM,Morgan AD

更新日期：2007-02-01 00:00:00

abstract：RATIONALE:Caffeine is commonly believed to offset the acute effects of alcohol, but some evidence suggests that cognitive processes remain impaired when caffeine and alcohol are coadministered. OBJECTIVES:No previous study has investigated the separate and joint effects of alcohol and caffeine on conflict monitoring a...

journal_title：Psychopharmacology

authors： Bailey K,Amlung MT,Morris DH,Price MH,Von Gunten C,McCarthy DM,Bartholow BD

更新日期：2016-04-01 00:00:00