Olanzapine, an atypical antipsychotic, increases rates of punished responding in pigeons.

abstract：RATIONALE:Chronic stress and corticosterone have been shown to affect serotonin (5-HT) neurotransmission; however, the influence of stress on the activity of the dorsal raphe nucleus (DRN), the main source of 5-HT in the forebrain, is not well understood. In particular, it is unknown if and how stress modifies DRN 5-HT...

journal_title：Psychopharmacology

authors： Sowa J,Kusek M,Siwiec M,Sowa JE,Bobula B,Tokarski K,Hess G

更新日期：2018-12-01 00:00:00

abstract：RATIONALE:The present series of experiments was conducted in order to assess the nature of dopaminergic modulation of the acoustic startle response using agonists and antagonists specific for dopamine D1 and D2 receptors. OBJECTIVES:The objective of the present study was to demonstrate an enhancement of the acoustic s...

journal_title：Psychopharmacology

authors： Meloni EG,Davis M

更新日期：1999-06-01 00:00:00

abstract：:When tested in adulthood, male rats that had been treated daily with 50 mg/kg hydroxyzine HCl SC at 10--29 or 23--29 days of age were significantly facilitated in performance of delayed spontaneous alternation relative to saline-injected rats. Treatment at 10--16 days of age did not produce significant facilitation in...

journal_title：Psychopharmacology

authors： Isseroff A

更新日期：1980-01-01 00:00:00

abstract：:Five elderly depressed patients were treated with amitriptyline (AT) and nortriptyline (NT) in turn, in a cross-over design. Steady-state plasma drug levels were compared with those calculated for eight healthy subjects of previous single-dose studies. Plasma clearances were on average about 2.5 times lower in the pat...

journal_title：Psychopharmacology

authors： Burch JE

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Human behavioral pharmacology studies can examine how medications that target different neurotransmitter systems influence different aspects of smoking. Naltrexone and bupropion have been shown to alter ad lib smoking behavior; however, medication effects on nicotine reward in a cigarette choice paradigm have...

journal_title：Psychopharmacology

authors： Rukstalis M,Jepson C,Strasser A,Lynch KG,Perkins K,Patterson F,Lerman C

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:Gabolysat PC60 is a fish protein hydrolysate with anxiolytic properties commonly used as a nutritional supplement. OBJECTIVE:The diazepam-like effects of PC60 on stress responsiveness of the rat pituitary-adrenal system and on sympathoadrenal activity were studied. METHODS:The activity of the pituitary-adre...

journal_title：Psychopharmacology

authors： Bernet F,Montel V,Noël B,Dupouy JP

更新日期：2000-03-01 00:00:00

abstract：RATIONALE:Thousands of adolescents start smoking daily but information on the effects of tobacco exposure on this age group is scarce. Moreover, the available animal models rely on the effects of nicotine, neglecting other neuroactive components of tobacco. OBJECTIVES:We investigated the effects of exposure of adolesc...

journal_title：Psychopharmacology

authors： Abreu-Villaça Y,Filgueiras CC,Correa-Santos M,Cavina CC,Naiff VF,Krahe TE,Manhães AC,Ribeiro-Carvalho A

更新日期：2015-05-01 00:00:00

abstract：:Self-injection of phencyclidine HCI (PCP) and four of its analogues was examined in baboons. IV injections of drug were dependent upon completion of 160 lever presses (a 160-response fixed-ratio schedule). A 3-h time-out period followed each injection, permitting a maximum of eight injections per day. Self-injection p...

journal_title：Psychopharmacology

authors： Lukas SE,Griffiths RR,Brady JV,Wurster RM

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:The use and misuse of prescription opiates in adolescent populations, and in particular, adolescent female populations, has increased dramatically in the past two decades. Given the significant role that opioids play in neuroendocrine function, exposure to opiates during this critical developmental period cou...

journal_title：Psychopharmacology

authors： Byrnes JJ,Johnson NL,Carini LM,Byrnes EM

更新日期：2013-05-01 00:00:00

abstract：:Low doses of 8-OH-DPAT (62.5-250 micrograms/kg) were reinforcing in the place preference conditioning procedure, while a higher dose (1 mg/kg) supported a conditioned place aversion. The 5-HT synthesis inhibitor PCPA, and the DA antagonists pimozide and sulpiride, had no effect when administered alone, but abolished t...

journal_title：Psychopharmacology

authors： Papp M,Willner P

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Adolescence marks a period of increased vulnerability to the development of substance use disorders. High sweet preference is a genetically mediated behavioral trait that also predicts vulnerability to substances of abuse. Previous research has shown that while adolescent rats selectively bred for high (HiS) ...

journal_title：Psychopharmacology

authors： Holtz NA,Carroll ME

更新日期：2013-05-01 00:00:00

abstract：RATIONALE:Acid sensing ion channels (ASICs) are proton-gated ion channels located in the central and peripheral nervous systems. Of particular interest is ASIC1a, which is located in areas associated with fear and anxiety behaviors. Recent reports suggest a role for ASIC1a in preclinical models of fear conditioning and...

journal_title：Psychopharmacology

authors： Dwyer JM,Rizzo SJ,Neal SJ,Lin Q,Jow F,Arias RL,Rosenzweig-Lipson S,Dunlop J,Beyer CE

更新日期：2009-03-01 00:00:00

abstract：RATIONALE:A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers. OBJECTIVE:To determine whether previously reported male>female acoustic PPI reflect sex differences in smoking effects on PPI...

journal_title：Psychopharmacology

authors： Swerdlow NR,Geyer MA,Hartman PL,Sprock J,Auerbach PP,Cadenhead K,Perry W,Braff DL

更新日期：1999-09-01 00:00:00

abstract：RATIONALE:3-(4-Fluorophenylselenyl)-2,5-diphenylselenophene (F-DPS) is a promising organoselenium compound that shows antidepressant-like properties related to interaction with the serotonergic system. OBJECTIVES:In this study, a mouse model of anxiety/depressant-like behavior induced by long-term corticosterone treat...

journal_title：Psychopharmacology

authors： Gai BM,Bortolatto CF,Heck SO,Stein AL,Duarte MM,Zeni G,Nogueira CW

更新日期：2014-05-01 00:00:00

abstract：:A continuous intravenous infusion of the opiate receptor antagonist naloxone, at doses ranging from 0.7 to 1.0 micrograms/kg/min (total dose 8.8-13.2 mg), was performed in eight normal subjects during the first 240 min of night sleep. A significant reduction in stage REM and in stage 4 percent duration was observed. P...

journal_title：Psychopharmacology

authors： Cianchetti C,Masala C,Olivari P,Giordano G

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Available neurochemical probes that lower brain dopamine (DA) levels in man are limited by their tolerability and efficacy. For instance, the acute lowering of brain tyrosine is well tolerated, but only modestly lowers brain DA levels. Modification of tyrosine depletion to robustly lower DA levels would provi...

journal_title：Psychopharmacology

authors： Brodnik Z,Double M,Jaskiw GE

更新日期：2013-05-01 00:00:00

abstract：:EEG measures have been shown to differ in human subjects who are at genetically increased risk for the development of alcoholism. In the present study, EEG was recorded in rats that were selectively bred for alcohol-preferring (P) and nonpreferring (NP) behaviors during an ethanol self-administration paradigm. In this...

journal_title：Psychopharmacology

authors： Robledo P,Lumeng L,Li TK,Ehlers CL

更新日期：1993-01-01 00:00:00

abstract：:A simple new method, the "tape test" has been developed for studying the enhancement of learning by drugs in "learning-dull" rats. A piece of adhesive tape is pressed on the left front pad of the rats. The time of tape removal by the animal, i.e., the problem-solving time is measured. In our experiments the selected l...

journal_title：Psychopharmacology

authors： Ezer E,Szporny L

更新日期：1976-07-09 00:00:00

abstract：RATIONALE:The C57BL/6 is one of the most widely used mouse strains in behavioral, pharmacological, and genetic research but little is known about their response on tests for antidepressant drugs. OBJECTIVES:The behavior of C57BL/6 mice, and mice from other strains, was examined in the tail suspension test (TST), a com...

journal_title：Psychopharmacology

authors： Mayorga AJ,Lucki I

更新日期：2001-04-01 00:00:00

abstract：RATIONALE:Patients with obsessive compulsive disorder (OCD) demonstrate impaired cognition in some selected domains. Although serotoninergic dysfunction has been implicated in OCD, recent evidence suggests that dopamine may play a role as well. OBJECTIVE:The aim of the study was to evaluate learning and working memory...

journal_title：Psychopharmacology

authors： Morein-Zamir S,Craig KJ,Ersche KD,Abbott S,Muller U,Fineberg NA,Bullmore ET,Sahakian BJ,Robbins TW

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the correlation of BDNF...

journal_title：Psychopharmacology

authors： Zhen YF,Zhang J,Liu XY,Fang H,Tian LB,Zhou DH,Kosten TR,Zhang XY

更新日期：2013-05-01 00:00:00

abstract：RATIONALE:Compared to men, the smoking behavior of women may be less responsive to nicotine and more responsive to nonpharmacological factors, perhaps including verbal information (e.g., dose instructions). OBJECTIVE:This study compared the influence of the presence vs absence of dose instructions on the subjective an...

journal_title：Psychopharmacology

authors： Perkins KA,Doyle T,Ciccocioppo M,Conklin C,Sayette M,Caggiula A

更新日期：2006-03-01 00:00:00

abstract：:A theory of acute tolerance to alcohol is proposed that includes two assumptions: 1) acute tolerance is a linear process with time, and 2) the slope of the line is a measure of the magnitude of the acute tolerance effect. Evidence that supports the validity of the theory is presented both from studies in which blood a...

journal_title：Psychopharmacology

authors： Radlow R

更新日期：1994-02-01 00:00:00

abstract：RATIONALE:Sex differences in the dopaminergic response to psychostimulants could have implications for drug abuse risk and other psychopathology involving the dopamine system, but human data are limited and mixed. OBJECTIVES:Here, we sought to investigate sex differences in dopamine release after oral D-amphetamine ad...

journal_title：Psychopharmacology

authors： Smith CT,Dang LC,Burgess LL,Perkins SF,San Juan MD,Smith DK,Cowan RL,Le NT,Kessler RM,Samanez-Larkin GR,Zald DH

更新日期：2019-02-01 00:00:00

abstract：RATIONALE:Cannabinoid CB1 receptors are expressed in the prefrontal cortex, but their role in mediating executive functions such as behavioral flexibility is unclear. OBJECTIVE:The present study examined the effect of pharmacological activation or blockade of the cannabinoid CB1 receptors on behavioral flexibility usi...

journal_title：Psychopharmacology

authors： Hill MN,Froese LM,Morrish AC,Sun JC,Floresco SB

更新日期：2006-08-01 00:00:00

abstract：RATIONALE:Psychopharmacology needs novel quantitative measures and theoretical approaches based on computational modelling that can be used to help translate behavioural findings from experimental animals to humans, including patients with neuropsychiatric disorders. OBJECTIVES:This brief review exemplifies this appro...

journal_title：Psychopharmacology

authors： Robbins TW,Cardinal RN

更新日期：2019-08-01 00:00:00

abstract：:Three sets of experiments were carried out in a Y water maze in which mice had to swim toward the light or the dark, in two different procedures. The first procedure involved, orientation toward a light source (L procedure), corresponding to natural preference, the latter involved orientation toward the dark (D proced...

journal_title：Psychopharmacology

authors： Castellano C

更新日期：1976-08-17 00:00:00

abstract：:Patients who develop persistent parkinsonism while on chronic neuroleptic therapy may be predisposed towards the development of tardive dyskinesia (TD). We investigated this issue in an animal model of TD by examining the association between catalepsy and the syndrome of neuroleptic-induced vacuous chewing movements (...

journal_title：Psychopharmacology

authors： Hyde TM,Egan MF,Wing LL,Wyatt RJ,Weinberger DR,Kleinman JE

更新日期：1995-03-01 00:00:00

abstract：:Red blood cell (RBC) glycine levels were examined in 27 bipolar patients, treated with lithium carbonate for a minimum of 8 months, who were either hypomanic, depressed, or euthymic in their mood. We found no difference in the RBC glycine or in the RBC: plasma glycine ratio between the hypomanic, depressed, or euthymi...

journal_title：Psychopharmacology

authors： Peselow ED,Deutsch SI,Stanley M,Banay-Schwartz M,Virgilio J,Fieve RR

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Initial sensitivity to drugs of abuse often predicts subsequent use and abuse, but this relationship is not always observed in human studies. Moreover, studies examining the relationship between initial locomotor sensitivity and the rewarding and reinforcing effects of drugs in animal models have also been eq...

journal_title：Psychopharmacology

authors： Roberts AJ,Casal L,Huitron-Resendiz S,Thompson T,Tarantino LM

更新日期：2018-04-01 00:00:00