Up-regulation of beta 1-adrenergic receptors in rat brain after chronic citalopram and fluoxetine treatments.

abstract：RATIONALE:The role of endogenous opiate systems in cigarette smoking remains unclear. In laboratory animals, opiate antagonists block many of the effects of nicotine, but in humans they do not consistently alter smoking behavior. OBJECTIVE:This study explored the effects of naltrexone, alone and in combination with ni...

journal_title：Psychopharmacology

authors： Brauer LH,Behm FM,Westman EC,Patel P,Rose JE

更新日期：1999-04-01 00:00:00

abstract：:Nicotine has been reported to increase or decrease measures of activity in rats, including locomotor activity and rearing. Nicotine dose and repeated exposure to nicotine are known to be important factors in determining the effects on locomotor behavior. Less information has been gathered on rearing and other measures...

journal_title：Psychopharmacology

authors： Ksir C

更新日期：1994-06-01 00:00:00

abstract：RATIONALE:The development and validation of animal models of the cognitive impairments of schizophrenia have remained challenging subjects. OBJECTIVE:We review evidence from a series of experiments concerning an animal model that dissociates between the disruption of attentional capacities during acute illness periods...

journal_title：Psychopharmacology

authors： Sarter M,Martinez V,Kozak R

更新日期：2009-01-01 00:00:00

abstract：RATIONALE:Zidovudine (AZT) and lamivudine (3TC) are nucleoside analogues administered prenatally in clinical practice, separately or in combination, as antiretroviral drugs to prevent HIV mother-to-child transmission by inhibiting viral reverse transcriptase. In animal studies pre- and/or perinatal exposure to AZT and ...

journal_title：Psychopharmacology

authors： Ricceri L,Venerosi A,Valanzano A,Sorace A,Alleva E

更新日期：2001-02-01 00:00:00

abstract：RATIONALE:Dopamine (DA) D2-like antagonists block several effects of cocaine, including its locomotor stimulant and interoceptive discriminative-stimulus effects. Because these compounds generally lack selectivity among the D2-like DA receptors, the specific roles of the subtypes remain unclear. OBJECTIVES:DA D2 recep...

journal_title：Psychopharmacology

authors： Chausmer AL,Elmer GI,Rubinstein M,Low MJ,Grandy DK,Katz JL

更新日期：2002-08-01 00:00:00

abstract：RATIONALE:Perospirone is a novel second-generation antipsychotic drug with high affinity to dopamine D(2) receptor and short half-life of plasma concentration. There has been no investigation of dopamine D(2) receptor occupancy in patients with schizophrenia and the time course of occupancy by antipsychotics with peros...

journal_title：Psychopharmacology

authors： Arakawa R,Ito H,Takano A,Okumura M,Takahashi H,Takano H,Okubo Y,Suhara T

更新日期：2010-05-01 00:00:00

abstract：:This study was conducted in order to investigate the level of amitriptyline (AT) and its metabolites. Three separate experiments were carried out. In two of these experiments, rats were treated over 7 days with IP doses of AT (10 mg/kg in experiment A and 2 X 20 mg/kg in experiment C). The rats were sacrificed either ...

journal_title：Psychopharmacology

authors： Baumann P,Gaillard JM,Jonzier-Perey M,Gerber C,Bouras C

更新日期：1984-01-01 00:00:00

abstract：:To confirm the conclusions from a previous study supporting the usefullness of electropupillogram (E.P.G.) in predicting clinical response, data from three separate studies with hyperkinetic and learning disabled (L.D.) children treated with stimulants were surveyed. Change in extent of pupillary contraction (E.C.) af...

journal_title：Psychopharmacology

authors： Bhatara V,Arnold LE,Knopp W,Smeltzer DJ

更新日期：1978-04-28 00:00:00

abstract：RATIONALE:Pharmacological manipulation of serotonergic neurotransmission in healthy volunteers impacts on cognitive test performance. Specifically, markers of serotonin function are associated with attention and executive functioning, long-term memory, and general cognitive ability. The serotonin transporter (SERT) pro...

journal_title：Psychopharmacology

authors： Madsen K,Erritzoe D,Mortensen EL,Gade A,Madsen J,Baaré W,Knudsen GM,Hasselbalch SG

更新日期：2011-02-01 00:00:00

abstract：:Using a 15-s intershock interval, an increase in shock-induced fighting was observed following intraventricular 96 microgram 5,7-dihydroxytryptamine (5,7-DHT) and 90 microgram 6-hydroxydopa (6-OHdopa). The incidence of predatory mouse killing was enhanced by 5,7-DHT, but was not affected by 6-OHdopa. Pain sensitivity ...

journal_title：Psychopharmacology

authors： Kantak KM,Hegstrand LR,Eichelman B

更新日期：1981-01-01 00:00:00

abstract：:Neuroimaging has been identified as a potentially powerful probe for the in vivo study of drug effects on the brain with utility across several phases of drug development spanning preclinical and clinical investigations. Specifically, neuroimaging can provide insight into drug penetration and distribution, target enga...

journal_title：Psychopharmacology

authors： Doyle OM,Mehta MA,Brammer MJ

更新日期：2015-11-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) of the startle reflex is a model of pre-attentional inhibitory function. The dopamine baseline in the nucleus accumbens plays a key role in PPI regulation as well as in the rewarding effects of cocaine. OBJECTIVES:The aim of this study was to evaluate the predictive ability of PPI t...

journal_title：Psychopharmacology

authors： Arenas MC,Navarro-Francés CI,Montagud-Romero S,Miñarro J,Manzanedo C

更新日期：2018-09-01 00:00:00

abstract：:Progabide inhibited male rat sexual behavior at a dose of 200 mg/kg. This dose had only modest effects on ambulatory activity and no effect at all on motor coordination as evaluated by a rotarod test. The GABAA antagonist bicuculline, at a dose of 1 mg/kg, blocked the effects of progabide on sex behavior. In contrast,...

journal_title：Psychopharmacology

authors： Agmo A,Paredes RG,Sierra L,Garcés I

更新日期：1997-01-01 00:00:00

abstract：:Intracerebroventricular injections of gamma-aminobutyric acid (GABA) and of the GABA-transaminase inhibitor, ethanolamine-O-sulphate (EOS), decreased the food intake of freely-fed (GABA and EOS) and food-deprived rats (EOS). The effect, still evident 24 h after treatment, was not decreased by the GABA receptor-blocker...

journal_title：Psychopharmacology

authors： Olgiati VR,Netti C,Guidobono F,Pecile A

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Emerging evidence from agonist-antagonist studies suggests a role for the dopamine D(3) receptor subtype in the regulation of PPI in animals, but such evidence is lacking for human subjects. OBJECTIVES:This study examines the effect of the preferential D(3) agonist ropinirole on PPI in humans. METHODS:PPI w...

journal_title：Psychopharmacology

authors： Giakoumaki SG,Roussos P,Frangou S,Bitsios P

更新日期：2007-10-01 00:00:00

abstract：:These experiments were undertaken to determine if local injection of pilocarpine in the neostriatum of the rat produces oral motor activities that are similar to those produced by systemic administration. In the first experiment, IP administration of 2.0-8.0 mg/kg pilocarpine increased chewing movements and tongue pro...

journal_title：Psychopharmacology

authors： Salamone JD,Johnson CJ,McCullough LD,Steinpreis RE

更新日期：1990-01-01 00:00:00

abstract：:Chronic treatment of rats with the antipsychotic drug molindone (2.5 mg/kg) did not elicit behavioral supersensitivity to apomorphine (AP) (0.25 mg/kg) or increased striatal 3H-spiroperidol binding, whereas treatment with haloperidol (0.5-1.0 mg/kg) produced manifestations of dopaminergic supersensitivity in both para...

journal_title：Psychopharmacology

authors： Meller E

更新日期：1982-01-01 00:00:00

abstract：:This experiment examined the effect of destruction of the ascending 5-hydroxytryptaminergic (5HTergic) pathways on performance in a free-operant timing schedule. Rats received either injections of 5,7-dihydroxytryptamine into the dorsal and median raphe nuclei or sham lesions. They were trained to press levers for a s...

journal_title：Psychopharmacology

authors： al-Zahrani SS,Ho MY,Velazquez Martinez DN,Lopez Cabrera M,Bradshaw CM,Szabadi E

更新日期：1996-10-01 00:00:00

abstract：RATIONALE:Chronic administration of nicotine in rats results in upregulation of neuronal nicotinic receptors. Upregulation has been proposed to reflect receptor desensitization, which may underlie functional tolerance to nicotine's effects. However, evidence indicates that tolerance and upregulation do not always paral...

journal_title：Psychopharmacology

authors： McCallum SE,Caggiula AR,Booth S,Breese CR,Lee MJ,Donny EC,Leonard S,Sved AF

更新日期：2000-05-01 00:00:00

abstract：RATIONALE:Disrupted social behavior, including occasional aggressive outbursts, is characteristic of withdrawal from long-term alcohol (EtOH) use. Heavy EtOH use and exaggerated responses during withdrawal may be treated using glutamatergic N-methyl-D-aspartate receptor (NMDAR) antagonists. OBJECTIVES:The current expe...

journal_title：Psychopharmacology

authors： Hwa LS,Nathanson AJ,Shimamoto A,Tayeh JK,Wilens AR,Holly EN,Newman EL,DeBold JF,Miczek KA

更新日期：2015-08-01 00:00:00

abstract：RATIONALE:The beneficial effects of nicotinic acetylcholine receptor (nAChR) agonists on cognitive performance have been widely shown. Paradoxically, recent preclinical studies employing extremely low doses of nAChR antagonists have also found cognitive enhancement, perhaps pointing to a novel treatment mechanism for c...

journal_title：Psychopharmacology

authors： Yuille MB,Olmstead CK,Wells AK,Hahn B

更新日期：2017-01-01 00:00:00

abstract：RATIONALE:Cessation of daily caffeine consumption produces a withdrawal syndrome comprised of subjective symptoms and functional impairment. Few controlled studies have examined the physiological effects of caffeine withdrawal. OBJECTIVE:The present study examined the effect of caffeine withdrawal on cerebral blood fl...

journal_title：Psychopharmacology

authors： Jones HE,Herning RI,Cadet JL,Griffiths RR

更新日期：2000-01-01 00:00:00

abstract：:N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON 954) causes a reproducible rest tremor in mice, of rapid onset and short duration with no associated rigidity or akinesia and in the absence of any marked changes in body temperature or accompanying peripheral parasympathomimetic effects. This tremor ca...

journal_title：Psychopharmacology

authors： Coward DM,Doggett NS

更新日期：1977-04-29 00:00:00

abstract：:The place-preference paradigm was evaluated as a measure of morphine's positive reinforcing properties. Previous place-preference studies obtained a morphine place preference of 26%-63%. In order to examine whether differences in procedure may account for this scatter, the present experiment investigated whether there...

journal_title：Psychopharmacology

authors： Blander A,Hunt T,Blair R,Amit Z

更新日期：1984-01-01 00:00:00

abstract：:The rabbit classical eyeblink conditioning paradigm was used to assess the effects of haloperidol on hippocampal function. Haloperidol disrupted hippocampal activity and conditioned responses (CRs) at low but not high conditioned stimulus (CS) intensities. The observed relationship of hippocampal activity and the CR s...

journal_title：Psychopharmacology

authors： Sears LL,Steinmetz JE

更新日期：1997-04-01 00:00:00

abstract：:Lymphocyte beta adrenergic receptor binding using [125I]CNP was determined in patients with panic disorder (N = 4) or agoraphobia with panic attacks (N = 17) and age- and sex-matched healthy subjects (N = 22). The patients showed a significantly lower number of beta-adrenergic receptor binding sites and a significantl...

journal_title：Psychopharmacology

authors： Brown SL,Charney DS,Woods SW,Heninger GR,Tallman J

更新日期：1988-01-01 00:00:00

abstract：:The ability of delta 9-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-OH THC and 8 alpha, 11-diOH THC to antagonise the abdominal constriction response in the mouse induced by formic acid, phenylquinone, 5-hydroxytryptamine, prostaglandin E1 (PGE1) and bradykinin was tested. THC was an effective a...

journal_title：Psychopharmacology

authors： Sanders J,Jackson DM,Starmer GA

更新日期：1979-03-28 00:00:00

abstract：RATIONALE:The cholinergic system is linked extensively to memory, but its exact role remains controversial. In particular, scopolamine-induced impairment in rodents is not task specific, which may be due to difficulty in developing rodent protocols to assess deficits in recent memory, in which the remembered event is b...

journal_title：Psychopharmacology

authors： Araujo JA,Chan AD,Winka LL,Seymour PA,Milgram NW

更新日期：2004-08-01 00:00:00

abstract：:Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component tha...

journal_title：Psychopharmacology

authors： Ellinwood EH Jr,Linnoila M,Easler ME,Molter DW

更新日期：1983-01-01 00:00:00

abstract：:Two experiments were conducted to test the hypothesis that tolerance to the hypothermic effect of ethanol fails to develop if rats are denied the unconditional stimulus represented by hypothermia. In both experiments, rats were injected with either ethanol (1.9 or 2.5 g/kg) or saline and given microwave hyperthermia (...

journal_title：Psychopharmacology

authors： Hjeresen DL,Reed DR,Woods SC

更新日期：1986-01-01 00:00:00