当前位置： SCI文献检索 > PSYCHOPHARMACOLOGY期刊下所有文献 > Dopamine D2 receptor occupancy by perospirone: a positron emission tomography study in patients with schizophrenia and healthy subjects.

Dopamine D2 receptor occupancy by perospirone: a positron emission tomography study in patients with schizophrenia and healthy subjects.

Abstract：

RATIONALE:Perospirone is a novel second-generation antipsychotic drug with high affinity to dopamine D(2) receptor and short half-life of plasma concentration. There has been no investigation of dopamine D(2) receptor occupancy in patients with schizophrenia and the time course of occupancy by antipsychotics with perospirone-like properties. OBJECTIVE:We investigated dopamine D(2) receptor occupancy by perospirone in patients with schizophrenia and the time course of occupancy in healthy subjects. MATERIALS AND METHODS:Six patients with schizophrenia taking 16-48 mg/day of perospirone participated. Positron emission tomography (PET) scans using [(11)C]FLB457 were performed on each subject, and dopamine D(2) receptor occupancies were calculated. Moreover, baseline and three serial PET using [(11)C]raclopride were performed at 1.5, 8, and 25.5 h after administration of a single dose of 16 mg of perospirone on four healthy male subjects, and occupancy was calculated for each scan. RESULTS:Dopamine D(2) receptor occupancy in the temporal cortex of patients ranged from 39.6% to 83.8%. Especially, occupancy in two patients who took 16 mg of perospirone 2.5 h before PET was over 70%. Mean occupancy in the striatum of healthy subjects was 74.8% at 1.5 h, 60.1% at 8 h, and 31.9% at 25.5 h after administration. CONCLUSION:Sixteen milligrams of perospirone caused over 70% dopamine D(2) receptor occupancy near its peak level, and then occupancy dropped to about half after 22 h. The time courses of receptor occupancy and plasma concentration were quite different. This single dosage may be sufficient for the treatment of schizophrenia and might be useful as a new dosing schedule choice.

journal_name

Psychopharmacology (Berl)

journal_title

Psychopharmacology

authors

Arakawa R,Ito H,Takano A,Okumura M,Takahashi H,Takano H,Okubo Y,Suhara T

doi

10.1007/s00213-010-1783-1

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

285-90

issue

4

eissn

0033-3158

issn

1432-2072

journal_volume

209

pub_type

杂志文章

相关文献

PSYCHOPHARMACOLOGY文献大全
  • Continuous low-level apomorphine administration induces motor abnormalities and hallucinogen-like behaviors.

    abstract：:Continuous low-level (0.825 mg/kg/h for 20 h) administration of AP through SC in-dwelling silicone reservoirs in the rat induced behavioral and biochemical changes that were similar to those induced by low levels (0.1 mg/kg) of acutely administered AP (decreased behavioral activity and decreased dopamine metabolism in...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00427314

    authors： Davis RE,Sant WW,Ellison G

    更新日期：1985-01-01 00:00:00

  • Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity.

    abstract：RATIONALE:Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear. OBJECTIVES:To investigate the effects of an acute manipulation of serotonin and genotype at a functional polymorphism in a gen...

    journal_title：Psychopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00213-005-0104-6

    authors： Clark L,Roiser JP,Cools R,Rubinsztein DC,Sahakian BJ,Robbins TW

    更新日期：2005-11-01 00:00:00

  • Perinatal fluoxetine exposure disrupts the circadian response to a phase-shifting challenge in female rats.

    abstract：RATIONALE:Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-020-05556-2

    authors： Houwing DJ,de Waard J,Ramsteijn AS,Woelders T,de Boer SF,Wams EJ,Olivier JDA

    更新日期：2020-08-01 00:00:00

  • Extrasynaptic GABAA receptor activation reverses recognition memory deficits in an animal model of schizophrenia.

    abstract：RATIONALE:Schizophrenia is a complex psychiatric disorder comprised of three main classes of symptoms: positive, negative and cognitive symptoms. Currently, no approved treatment exists for the cognitive symptoms. There is thus a great need for research aiming at identifying novel targets for treatment of this indicati...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-010-2039-9

    authors： Damgaard T,Plath N,Neill JC,Hansen SL

    更新日期：2011-03-01 00:00:00

  • Adrenoceptor-stimulated inflammatory response in stress-induced serum amyloid A synthesis.

    abstract：RATIONALE:Stressful life events are suggested to contribute to the development of various pathologies, such as cardiovascular disorders, whose etiopathogenesis is highly associated with elevated levels of serum amyloid A (SAA) proteins. SAA synthesis in the liver is regulated by a complex network of cytokines acting in...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-018-5149-4

    authors： Konstandi M,Sotiropoulos I,Matsubara T,Malliou F,Katsogridaki A,Andriopoulou CE,Gonzalez FJ

    更新日期：2019-06-01 00:00:00

  • Interactions between social stress and morphine in the periaqueductal gray: effects on affective vocal and reflexive pain responses in rats.

    abstract：RATIONALE:Endogenous opioid systems within the mesencephalic periaqueductal gray matter (PAG) appear to be intricately involved in many affective, defensive, submissive, and reflexive responses, and these systems are activated by aversive stimuli. OBJECTIVES:The present experiments evaluated the influence of opioid re...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s002130051101

    authors： Vivian JA,Miczek KA

    更新日期：1999-09-01 00:00:00

  • Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats.

    abstract：RATIONALE:Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats. OBJECTIVES:As individual differences exist in central serotonin neurotransmission, the impact of A...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-008-1201-0

    authors： Olivier JD,Jans LA,Korte-Bouws GA,Korte SM,Deen PM,Cools AR,Ellenbroek BA,Blokland A

    更新日期：2008-10-01 00:00:00

  • Binding of the D3-preferring antipsychotic candidate F17464 to dopamine D3 and D2 receptors: a PET study in healthy subjects with [11C]-(+)-PHNO.

    abstract：RATIONALE:F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial in patients with schizophrenia (Bitter et al. Neuropsych...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-019-05387-w

    authors： Slifstein M,Abi-Dargham A,Girgis RR,Suckow RF,Cooper TB,Divgi CR,Sokoloff P,Leriche L,Carberry P,Oya S,Joseph SK,Guiraud M,Montagne A,Brunner V,Gaudoux F,Tonner F

    更新日期：2020-02-01 00:00:00

  • Concentrations of Cis(Z)-flupentixol in maternal serum, amniotic fluid, umbilical cord serum, and milk.

    abstract：:A venous blood sample and an umbilical cord blood sample were obtained from five young women treated with the neuroleptic drug, cis(Z)-flupentixol decanoate in Viscoleo (intramuscularly) or flupentixol (orally) at the time of giving birth. In two cases amniotic fluid was also obtained, and from three of the mothers mi...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00433814

    authors： Kirk L,Jørgensen A

    更新日期：1980-01-01 00:00:00

  • Effects of chlordiazepoxide and diazepam on feeding performance in a food-preference test.

    abstract：:Chlordiazepoxide (5 and 10 mg/kg) and diazepam (2.5 mg/kg) reduced the latency to eat and enhanced feeding response to familiar food in a food-preference test. The increased feeding response resulted from an increased frequency of individual eating episodes (bouts) without significant change in the episode duration. E...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00426525

    authors： Cooper SJ

    更新日期：1980-01-01 00:00:00

  • Potential antidepressant properties of pramipexole detected in locomotor and operant behavioral investigations in mice.

    abstract：RATIONALE:Pramipexole is a dopamine agonist which binds selectively to dopamine D(3) and D(2) receptors. There is evidence that, in addition to its beneficial effects in parkinsonism, this compound may also be of value in addressing symptomatology associated with depressive diseases. OBJECTIVES:The present study was a...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-002-1199-7

    authors： Lehr E

    更新日期：2002-10-01 00:00:00

  • Modification of ethanol intoxication by dopamine agonists and antagonists.

    abstract：:The effects of ethanol on locomotor activity and rotarod performance were measured in the rat. Apomorphine (4 mg/kg s.c.) antagonized and pimozide (0.75 - 1.50 mg/kg s.c.) enhanced the effects of a 2 g/kg dose of ethanol on rotarod performance. No such interaction was seen with pentobarbital, 25 mg/kg, a dose sufficie...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00432293

    authors： Bacopoulos NG,Bize I,Levine J,Van Orden LS 3rd

    更新日期：1979-01-31 00:00:00

  • Serotonin 5-HT1B receptor-mediated behavior and binding in mice with the overactive and dysregulated serotonin transporter Ala56 variant.

    abstract：RATIONALE:Elevated whole-blood serotonin (5-HT) is a robust biomarker in ~ 30% of patients with autism spectrum disorders, in which repetitive behavior is a core symptom. Furthermore, elevated whole-blood 5-HT has also been described in patients with pediatric obsessive-compulsive disorder. The 5-HT1B receptor is assoc...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-020-05758-8

    authors： O'Reilly KC,Connor M,Pierson J,Shuffrey LC,Blakely RD,Ahmari SE,Veenstra-VanderWeele J

    更新日期：2021-01-29 00:00:00

  • Direct effects of diazepam on emotional processing in healthy volunteers.

    abstract：RATIONALE:Pharmacological agents used in the treatment of anxiety have been reported to decrease threat relevant processing in patients and healthy controls, suggesting a potentially relevant mechanism of action. However, the effects of the anxiolytic diazepam have typically been examined at sedative doses, which do no...

    journal_title：Psychopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00213-008-1082-2

    authors： Murphy SE,Downham C,Cowen PJ,Harmer CJ

    更新日期：2008-09-01 00:00:00

  • Antidepressant-like effects of the subtype-selective nicotinic acetylcholine receptor agonist, SIB-1508Y, in the learned helplessness rat model of depression.

    abstract：RATIONALE:Epidemiological studies of smokers suggest that there is a link between nicotine and depression. Nonetheless, few studies have examined the potential use of nicotinic ligands in the treatment of depression. OBJECTIVES:The goal of this study was to evaluate the effects of SIB-1508Y, a novel subtype-selective ...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s002130000531

    authors： Ferguson SM,Brodkin JD,Lloyd GK,Menzaghi F

    更新日期：2000-10-01 00:00:00

  • The effect of d-amphetamine on performance on two operant timing schedules.

    abstract：RATIONALE:Previous experiments have shown that d-amphetamine disrupts timing behaviour in rats. It has been proposed that d-amphetamine's effects reflect a reduction in the period of the pacemaker of the hypothetical internal clock. However, some studies have obtained conflicting results. OBJECTIVE:To examine the effe...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s002130000422

    authors： Chiang TJ,Al-Ruwaitea AS,Mobini S,Ho MY,Bradshaw CM,Szabadi E

    更新日期：2000-06-01 00:00:00

  • Depression and senile dementia of the Alzheimer type: a role for moclobemide.

    abstract：:Depression is common in patients with senile dementia of the Alzheimer type (SDAT) and may precede the onset of the dementia; the underlying biological and neurotransmitter mechanisms may be common to both diseases, so far as norepinephrine lesions are concerned. The major routes of metabolism of amines in the brain u...

    journal_title：Psychopharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/BF02246259

    authors： Chan-Palay V

    更新日期：1992-01-01 00:00:00

  • Binding of antiparkinsonian ergot derivatives to the dopamine receptor.

    abstract：:The effects of bromocriptine, lisuride and apomorphine on specific binding of 3H-spiroperidol to homogenates of rat caudate nucleus were studied. (+)-Butaclamol was used to define specific binding. Bromocriptine and lisuride inhibited binding markedly, in vitro and also 30 min after in vivo injection. Bromocriptine co...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00432172

    authors： Weir RL,Hruska RE,Silbergeld EK

    更新日期：1981-01-01 00:00:00

  • Increased motivation to eat in opiate-withdrawn mice.

    abstract：RATIONALE:In drug-dependent individuals, the primary excessive motivation is for drugs. Studies also indicate altered interest for "natural" rewarding activities associated with motivational disorders that may be relevant to drug dependence. However, to date, the impact of drug dependence and withdrawal upon motivation...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-011-2612-x

    authors： Rouibi K,Contarino A

    更新日期：2012-06-01 00:00:00

  • Higher anhedonia during withdrawal from initial opioid exposure is protective against subsequent opioid self-administration in rats.

    abstract：RATIONALE:Understanding factors contributing to individual differences in vulnerability to opioid addiction is essential for developing more effective preventions and treatments, yet few reliable behavioral predictors of subsequent opioid self-administration have been identified in rodents. Sensitivity to the acute eff...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-020-05532-w

    authors： Swain Y,Muelken P,Skansberg A,Lanzdorf D,Haave Z,LeSage MG,Gewirtz JC,Harris AC

    更新日期：2020-08-01 00:00:00

  • Alcohol-associated conditioned reinforcement.

    abstract：:Research was conducted to examine the ability of alcohol to impart conditioned reinforcement. Rats were allowed to self-administer solutions of either saline or alcohol (25, 50, and 100 mg/kg/infusion) by the intragastric route. Superimposed on the infusion interval was a buzzer (conditioned reinforcing stimulus). Tes...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00492355

    authors： Smith SG,Werner TE,Davis WM

    更新日期：1977-08-16 00:00:00

  • Selective effects of triazolam on memory.

    abstract：:The effects of benzodiazepine (triazolam 0.25 and 0.50 mg) on different aspects of cognitive function were assessed. Triazolam impaired free recall and recognition of information presented after drug administration. In contrast to these impairments in explicit memory, a memory function that did not require conscious a...

    journal_title：Psychopharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF02245415

    authors： Weingartner HJ,Hommer D,Lister RG,Thompson K,Wolkowitz O

    更新日期：1992-01-01 00:00:00

  • Differential effects of the dopamine D2/D3 receptor antagonist sulpiride on self-administration of morphine into the ventral tegmental area or the nucleus accumbens.

    abstract：RATIONALE:The involvement of dopamine neurotransmission in opiate reward remains controversial. OBJECTIVE:To investigate the dopaminergic basis of opiate reward by comparing the effect of systemic injection of the D2/D3 antagonist sulpiride on morphine self-administration (ICSA) into the ventral tegmental area (VTA) o...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-001-0981-2

    authors： David V,Durkin TP,Cazala P

    更新日期：2002-03-01 00:00:00

  • Reinstatement of drug-seeking behavior produced by heroin-predictive environmental stimuli.

    abstract：:The current study examined whether stimuli predictive of heroin availability were capable of inducing a relapse of drug-seeking behavior in an operant runway task. Olfactory stimuli (orange and almond food extract) served as discriminative cues about the availability (S+) or unavailability (S-) of heroin reinforcement...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s002130050269

    authors： McFarland K,Ettenberg A

    更新日期：1997-05-01 00:00:00

  • Appetitve effects of drug cues modelled by pictures of the intake ritual: generality of cue-modulated startle examined with inpatient alcoholics.

    abstract：RATIONALE:A cue-modulated startle test recently confirmed that smoking cues in smokers may not be withdrawal-like and aversive as traditionally believed. OBJECTIVE:Analogous tests were applied to alcohol cues in inpatient alcoholics. METHODS:Twenty-six withdrawn alcoholics (18 men) were examined. Alcohol-related pict...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s002130000508

    authors： Mucha RF,Geier A,Stuhlinger M,Mundle G

    更新日期：2000-09-01 00:00:00

  • Deficits of long-term memory in ecstasy users are related to cognitive complexity of the task.

    abstract：RATIONALE:Despite animal evidence that methylenedioxymethamphetamine (ecstasy) causes lasting damage in brain regions related to long-term memory, results regarding human memory performance have been variable. This variability may reflect the cognitive complexity of the memory tasks. However, previous studies have test...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-009-1766-2

    authors： Brown J,McKone E,Ward J

    更新日期：2010-03-01 00:00:00

  • NMDA receptor antagonism: escalation of aggressive behavior in alcohol-drinking mice.

    abstract：RATIONALE:Memantine is a potential treatment for alcoholic patients, yet few studies investigate the effect of concurrent treatment with memantine and ethanol on aggression. We evaluated aggressive behavior following ethanol consumption and treatment with glutamatergic drugs to characterize interactions between these c...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-012-2734-9

    authors： Newman EL,Chu A,Bahamón B,Takahashi A,Debold JF,Miczek KA

    更新日期：2012-11-01 00:00:00

  • Cognitive and subjective dose-response effects of acute oral Delta 9-tetrahydrocannabinol (THC) in infrequent cannabis users.

    abstract：RATIONALE:Although some aspects of memory functions are known to be acutely impaired by delta(9)-tetrahydrocannabinol (delta(9)-THC; the main active constituent of marijuana), effects on other aspects of memory are not known and the time course of functional impairments is unclear. OBJECTIVE:The present study aimed to...

    journal_title：Psychopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00213-002-1169-0

    authors： Curran HV,Brignell C,Fletcher S,Middleton P,Henry J

    更新日期：2002-10-01 00:00:00

  • Intravenous cocaine self-administration in a panel of inbred mouse strains differing in acute locomotor sensitivity to cocaine.

    abstract：RATIONALE:Initial sensitivity to drugs of abuse often predicts subsequent use and abuse, but this relationship is not always observed in human studies. Moreover, studies examining the relationship between initial locomotor sensitivity and the rewarding and reinforcing effects of drugs in animal models have also been eq...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-018-4834-7

    authors： Roberts AJ,Casal L,Huitron-Resendiz S,Thompson T,Tarantino LM

    更新日期：2018-04-01 00:00:00

  • The aluminum-induced increase in blood-brain barrier permeability to delta-sleep-inducing peptide occurs throughout the brain and is independent of phosphorus and acetylcholinesterase levels.

    abstract：:The effect of aluminum on levels of inorganic phosphorus and acetylcholinesterase in blood and brain and on permeability of the blood-brain barrier (BBB) in different regions of the brain to the neuropeptide delta-sleep-inducing peptide (DSIP) was studied in adult rats. Aluminum (100 mg/kg) significantly increased the...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00431689

    authors： Banks WA,Kastin AJ

    更新日期：1985-01-01 00:00:00