Selective effects of triazolam on memory.


:The effects of benzodiazepine (triazolam 0.25 and 0.50 mg) on different aspects of cognitive function were assessed. Triazolam impaired free recall and recognition of information presented after drug administration. In contrast to these impairments in explicit memory, a memory function that did not require conscious awareness was not altered by triazolam. Similarly, triazolam did not affect subjects' abilities to access semantic memory.




Weingartner HJ,Hommer D,Lister RG,Thompson K,Wolkowitz O




Has Abstract


1992-01-01 00:00:00












  • Neuroleptic properties of cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide (YM-09151-2) with selective antidopaminergic activity.

    abstract::A new benzamide, cis-N-(1-benzyl-2-methylpyrrolidin - 3 - yl) - 5 - chloro - 2 - methoxy - 4 - methylaminobenzamide (YM-09151-2) exhibited more potent and longer-lasting inhibitory effects on apomorphine-induced behaviours (stereotyped behaviour, emesis and hypothermia), and methamphetamine-induced stereotyped behavio...


    pub_type: 杂志文章


    authors: Usuda S,Nishikori K,Noshiro O,Maeno H

    更新日期:1981-01-01 00:00:00

  • Facilitation and inhibition of feeding by a single dose of amphetamine: relationship to baseline intake and accumbens cholecystokinin.

    abstract::Amphetamine (AMP) administered in high doses suppresses feeding. However, in low doses AMP has been shown to both suppress and facilitate feeding. Further, there is some indication of individual differences in the feeding response to low doses of AMP. Evidence indicates that AMP's effects on feeding are dopamine-media...


    pub_type: 杂志文章


    authors: Sills TL,Vaccarino FJ

    更新日期:1991-01-01 00:00:00

  • Reciprocal cross-sensitization of D1 and D3 receptors following pharmacological stimulation in the hemiparkinsonian rat.

    abstract::In the majority of Parkinson's disease (PD) patients, long-term dopamine (DA) replacement therapy leads to dyskinesia characterized by abnormal involuntary movements (AIMs). There are various mechanisms of dyskinesia, such as the sensitization of striatal DA D1 receptors (D1R) and upregulation of DA D3 receptors (D3R)...


    pub_type: 杂志文章


    authors: Lanza K,Chemakin K,Lefkowitz S,Saito C,Chambers N,Bishop C

    更新日期:2020-01-01 00:00:00

  • Glucocorticoid mechanisms may contribute to ECT-induced retrograde amnesia.

    abstract:RATIONALE:Cortisol levels rise sharply immediately after electroconvulsive therapy (ECT); the resultant stimulation of steroid receptors in the hippocampus may be beneficial or harmful to cognition, depending on the magnitude of the stimulation. Steroid mechanisms may therefore modulate ECT-induced amnesia. OBJECTIVES...


    pub_type: 杂志文章


    authors: Nagaraja N,Andrade C,Sudha S,Madan Singh N,Chandra JS,Venkataraman BV

    更新日期:2007-01-01 00:00:00

  • Age-dependent effects of stress on ethanol-induced motor activity in rats.

    abstract:RATIONALE:It is important to study age-related differences that may put adolescents at risk for alcohol-related problems. Adolescents seem less sensitive to the aversive effects of ethanol than adults. Less is known of appetitive effects of ethanol and stress modulation of these effects. OBJECTIVES:This study aims to ...


    pub_type: 杂志文章


    authors: Acevedo MB,Pautassi RM,Spear NE,Spear LP

    更新日期:2013-12-01 00:00:00

  • Pain sensitivity is altered in animals after subchronic ketamine treatment.

    abstract:RATIONALE:Clinical observations have shown that pain sensitivity is altered in some schizophrenic patients. OBJECTIVES:To study alterations in pain sensitivity, the ketamine model in schizophrenia research was employed. MATERIALS AND METHODS:Rats were subchronically injected with the dissociative anaesthetic ketamine...


    pub_type: 杂志文章


    authors: Becker A,Grecksch G,Schröder H

    更新日期:2006-12-01 00:00:00

  • Effects of buprenorphine and methadone in methadone-maintained subjects.

    abstract::Buprenorphine, a partial mu opioid agonist, is an experimental medication under development for the treatment of opioid dependence as an alternative to methadone maintenance. The present study examined the relationship between level of opioid physical dependence and response to buprenorphine administration as part of ...


    pub_type: 临床试验,杂志文章


    authors: Walsh SL,June HL,Schuh KJ,Preston KL,Bigelow GE,Stitzer ML

    更新日期:1995-06-01 00:00:00

  • The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats.

    abstract:RATIONALE:Recent studies have shown that metabotropic glutamate receptor 5 (mGluR5) can modulate N-methyl-D-aspartate (NMDA) receptor function in vivo. For example, the mGluR5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP) can potentiate PCP (phencyclidine)-evoked hyperactivity and PCP-induced disruptions in pr...


    pub_type: 杂志文章


    authors: Campbell UC,Lalwani K,Hernandez L,Kinney GG,Conn PJ,Bristow LJ

    更新日期:2004-09-01 00:00:00

  • Effect of destruction of the 5-hydroxytryptaminergic pathways on behavioural timing and "switching" in a free-operant psychophysical procedure.

    abstract::This experiment examined the effect of destruction of the ascending 5-hydroxytryptaminergic (5HTergic) pathways on performance in a free-operant timing schedule. Rats received either injections of 5,7-dihydroxytryptamine into the dorsal and median raphe nuclei or sham lesions. They were trained to press levers for a s...


    pub_type: 杂志文章


    authors: al-Zahrani SS,Ho MY,Velazquez Martinez DN,Lopez Cabrera M,Bradshaw CM,Szabadi E

    更新日期:1996-10-01 00:00:00

  • Interactions between the reinforcing effects of cocaine and heroin in a drug-vs-food choice procedure in rhesus monkeys: a dose-addition analysis.

    abstract:RATIONALE:Concurrent abuse of cocaine and heroin is a common form of polydrug abuse, but the interactions between the reinforcing effects of cocaine and heroin are poorly understood. Dose-addition analysis is a tool for the quantitative assessment of drug interactions, but this analysis has not been applied to evaluati...


    pub_type: 杂志文章


    authors: Negus SS

    更新日期:2005-06-01 00:00:00

  • Memory deficits and neurochemical changes induced by C-reactive protein in rats: implication in Alzheimer's disease.

    abstract:RATIONALE:C-reactive protein (CRP), an acute phase protein that is released in response to inflammatory stimuli, is implicated in Alzheimer's disease (AD). However, the role of CRP in memory deficits associated with AD remains unclear. OBJECTIVE:Experiments were carried out to determine whether CRP impaired memory and...


    pub_type: 杂志文章


    authors: Lin HB,Yang XM,Li TJ,Cheng YF,Zhang HT,Xu JP

    更新日期:2009-07-01 00:00:00

  • Effects of thymoleptics on behavior associated with changes in brain dopamine. II. Modification and potentiation of apomorphine-induced stimulation of mice.

    abstract::The thymoleptics potentiate and modify the behavioral effects of apomorphine (probably the most specific dopaminergic agonist) as well as those of Dopa. The effect of the thymoleptics is not abolished by emptying of amine stores, and this together with other evidence suggests that these drugs facilitate the access of ...


    pub_type: 杂志文章


    authors: Molander L,Randrup A

    更新日期:1976-09-17 00:00:00

  • On the possible involvement of glutamate receptors in conditioning of behavioural effects of apomorphine.

    abstract::It was shown previously that behavioural effects of apomorphine (locomotor activation and stereotyped behaviour) can be conditioned when they are associated with well-defined environmental stimuli. In the present study, the hypothesis was tested that glutamatergic mechanisms play an important role either in formation ...


    pub_type: 杂志文章


    authors: Welsch-Kunze S,Kuschinsky K

    更新日期:1990-01-01 00:00:00

  • Behavioral effects of benzylideneoxymorphone (BOM), a low efficacy µ opioid receptor agonist and a δ opioid receptor antagonist.

    abstract:RATIONALE:Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects often limit use. Drugs acting concomitantly as agonists at μ opioid receptors and antagonists at δ opioid receptors produce antinociceptive effects with a reduced profile of adverse effects; one such drug, benzyl...


    pub_type: 杂志文章


    authors: Mada S,Gerak LR,Soyer A,Maguire DR,Hu Z,Minervini V,Cunningham CW,France CP

    更新日期:2020-12-01 00:00:00

  • Impacts of inter-trial interval duration on a computational model of sign-tracking vs. goal-tracking behaviour.

    abstract::In the context of Pavlovian conditioning, two types of behaviour may emerge within the population (Flagel et al. Nature, 469(7328): 53-57, 2011). Animals may choose to engage either with the conditioned stimulus (CS), a behaviour known as sign-tracking (ST) which is sensitive to dopamine inhibition for its acquisition...


    pub_type: 杂志文章


    authors: Cinotti F,Marchand AR,Roesch MR,Girard B,Khamassi M

    更新日期:2019-08-01 00:00:00

  • Anxiolytic-like action of the 3-PPP enantiomers in the Vogel conflict paradigm.

    abstract::The effect of the (+)- and (-)-enantiomers of 3-PPP [conventional and atypical dopamine (DA)-receptor active agent, respectively] were investigated in a commonly used animal model of anxiety: the Vogel licking-conflict test. Low doses (less than or equal to 0.5 mg/kg SC) of both 3-PPP enantiomers resulted in anti-conf...


    pub_type: 杂志文章


    authors: Hjorth S,Carlsson A,Engel JA

    更新日期:1987-01-01 00:00:00

  • Interaction of apomorphine and haloperidol: effects on locomotion and other behaviour in the marmoset.

    abstract::The behavioural effects of increasing doses of apomorphine and haloperidol were observed in a group of six marmosets. Behaviour was classified quantitatively into categories: Locomotion, inactivity, checking (small head movements), social interaction and purposeful activities. Statistical analysis revealed that apomor...


    pub_type: 杂志文章


    authors: Scraggs PR,Baker HF,Ridley RM

    更新日期:1979-01-01 00:00:00

  • The stimulus properties of gamma-hydroxybutyrate.

    abstract::Fourteen rats were trained to discriminate the effects of gamma-hydroxybutyrate (GHB) (sodium salt, 200 mg/kg) and saline in a two-lever choice task using a fixed ratio 10 schedule of water reinforcement. Intermediate responding, i.e., responding not fully appropriate for either training condition was observed in test...


    pub_type: 杂志文章


    authors: Winter JC

    更新日期:1981-01-01 00:00:00

  • Response to alcohol in females with a paternal history of alcoholism.

    abstract:RATIONALE:Several studies have demonstrated that males with a family history of alcoholism (FHP) show less of a response to alcohol (e.g. lower ratings of intoxication) than males without a family history of alcoholism (FHN). The purpose of this pilot study was to determine if FHP females also showed a reduced sensitiv...


    pub_type: 临床试验,杂志文章


    authors: Evans SM,Levin FR

    更新日期:2003-08-01 00:00:00

  • Residual effects of hypnotics: triazolam, flurazepam, and nitrazepam.

    abstract::The residual effects of three hypnotics were investigated by the method of 24-h polygraphy (EEG, EMG, and EOG). The drugs were triazolam 0.25 mg and 0.5 mg, flurazepam 15 mg and 30 mg, nitrazepam 5 mg and 10 mg, and placebo. The subjects were healthy volunteers, eight men and eight women with an average age of 34.3 ye...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ogura C,Nakazawa K,Majima K,Nakamura K,Ueda H,Umezawa Y,Wardell WM

    更新日期:1980-01-01 00:00:00

  • Early postnatal stimulation alters pregnane neurosteroids in the hippocampus.

    abstract:RATIONALE:The progesterone metabolite 5alpha-pregnane-3alpha-ol-20-one (3alpha,5alpha-THP) is an important modulator of the hypothalamic-pituitary-adrenal axis and stress-induced corticosterone response. Typically, 3alpha,5alpha-THP levels are increased in response to acute stress, which may then reduce corticosterone ...


    pub_type: 杂志文章


    authors: Frye CA,Rhodes ME,Raol YH,Brooks-Kayal AR

    更新日期:2006-06-01 00:00:00

  • Effect of cocaine sensitization prior to pregnancy on maternal care and aggression in the rat.

    abstract:RATIONALE:Although many studies have investigated the effects of gestational and lactational cocaine use on maternal behavior, few studies have examined the effects of prior adult cocaine use on maternal behavior. METHODS:In the current study, intraperitoneal cocaine or saline was administered to adult female rats for...


    pub_type: 杂志文章


    authors: Nephew BC,Febo M

    更新日期:2010-03-01 00:00:00

  • 2,4-Dithiobiuret in rats: cognitive facilitation after acute injection precedes motor impairment after repeated daily injections.

    abstract::2,4-Dithiobiuret (DTB) is a sulfonated derivative of urea that is used as a reducing agent in chemical manufacture. Its low acute toxicity to rodents belies a peripherally mediated, delayed-onset muscle weakness which develops during repeated daily exposure. In experiment 1, a standard dose regimen of DTB (0.5 mg/kg p...


    pub_type: 杂志文章


    authors: Bushnell PJ,Oshiro WM

    更新日期:1996-02-01 00:00:00

  • Cocaine-induced place conditioning: importance of route of administration and other procedural variables.

    abstract::It has been shown that pretreatment with dopamine (DA) receptor blockers disrupts the effect of intravenously (IV) and intracerebrally (ICV), but not intraperitoneally (IP) administered cocaine on place preference conditioning (PPC). The present study was undertaken to further evaluate possible differences between IV ...


    pub_type: 杂志文章


    authors: Nomikos GG,Spyraki C

    更新日期:1988-01-01 00:00:00

  • Central serotonin transporter levels are associated with stress hormone response and anxiety.

    abstract:RATIONALE:Negative mood states are characterized by both stress hormone dysregulation and serotonergic dysfunction, reflected by altered thalamic serotonin transporter (5-HTT) levels. However, so far, no study examined the individual association between cortisol response and cerebral in vivo 5-HTT levels in patients su...


    pub_type: 杂志文章


    authors: Reimold M,Knobel A,Rapp MA,Batra A,Wiedemann K,Ströhle A,Zimmer A,Schönknecht P,Smolka MN,Weinberger DR,Goldman D,Machulla HJ,Bares R,Heinz A

    更新日期:2011-02-01 00:00:00

  • Evidence of central cholinergic mechanisms in the appearance of affective aggressive behaviour: dissociation of aggression from autonomic and motor phenomena.

    abstract::Carbachol, muscarine, eserine and neostigmine injected into the cerebral ventricles of conscious cats evoked emotional behaviour with aggression, autonomic and motor phenomena as well as clonic-tonic convulsions. The main and the most impressive feature of the gross behavioural effects of intraventricular carbachol, m...


    pub_type: 杂志文章


    authors: Beleslin DB,Samardzić R

    更新日期:1979-04-11 00:00:00

  • Effect of (-)-DS 121 and (+)-UH 232 on cocaine self-administration in rats.

    abstract::The novel dopamine autoreceptor antagonists (-)-DS 121 and (+)-UH 232 were tested for their ability to alter cocaine self-administration behavior in rats reinforced on a progressive ratio (PR) schedule. (-)-DS 121 (15 mg/kg) and (+)-UH 232 (30 mg/kg) produced significant decreases in breaking point. (-)-DS 121 produce...


    pub_type: 杂志文章


    authors: Smith A,Piercey M,Roberts DC

    更新日期:1995-07-01 00:00:00

  • Trazodone and triazolam: acute subject-rated and performance-impairing effects in healthy volunteers.

    abstract::The present study compared the acute subject-rated and performance-impairing effects of trazodone and triazolam in seven healthy humans. Trazodone (50, 100 and 200 mg), triazolam (0.125, 0.25, 0.50 mg) and placebo were administered orally in a double-blind, crossover design. Drug effects were measured approximately 30...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rush CR,Madakasira S,Hayes CA,Johnson CA,Goldman NH,Pazzaglia PJ

    更新日期:1997-05-01 00:00:00

  • Citalopram, a selective serotonin reuptake inhibitor: clinical antidepressive and long-term effect--a phase II study.

    abstract::In a phase II study the antidepressive effect of citalopram, a selective and potent serotonin reuptake inhibitor, was examined in 20 endogenously and three non-endogenously depressed hospitalized patients. Four endogenously depressed patients dropped out due to deterioration early in the treatment period. The remainin...


    pub_type: 杂志文章


    authors: Pedersen OL,Kragh-Sørensen P,Bjerre M,Overø KF,Gram LF

    更新日期:1982-01-01 00:00:00

  • Effects of lorazepam on cardiac vagal tone during rest and mental stress: assessment by means of spectral analysis.

    abstract::Dose-dependent effects of intravenously administered lorazepam on haemodynamic fluctuations were studied by means of spectral analysis, in order to elucidate sympathetic and parasympathetic components in cardiovascular control during situations of rest and mental stress after benzodiazepine administration. In a double...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tulen JH,Mulder G,Pepplinkhuizen L,Man in 't Veld AJ,van Steenis HG,Moleman P

    更新日期:1994-02-01 00:00:00