Increased motivation to eat in opiate-withdrawn mice.

abstract：RATIONALE:The precise neural circuitry that encodes fear memory and its extinction within the brain are not yet fully understood. Fearful memories can be persistent, resistant to extinction, and associated with psychiatric disorders, especially post-traumatic stress disorder (PTSD). Here, we investigated the microtopog...

journal_title：Psychopharmacology

authors： Jacques A,Chaaya N,Hettiarachchi C,Carmody ML,Beecher K,Belmer A,Chehrehasa F,Bartlett S,Battle AR,Johnson LR

更新日期：2019-01-01 00:00:00

abstract：RATIONALE:The neuronal actions of methamphetamine (MA) include an increase in extracellular levels of monoamines, presumably via reverse transport involving the monoamine transporters. This action is thought to play an important role in the effects of MA. Therefore, in the present experiment, it was hypothesized that a...

journal_title：Psychopharmacology

authors： Ranaldi R,Anderson KG,Carroll FI,Woolverton WL

更新日期：2000-12-01 00:00:00

abstract：RATIONALE:The effects of acute bouts of physical activity (PA) on Strength of Desire (SoD) and Desire to Smoke (DtS) using individual participant data (IPD) from 19 acute randomised controlled studies were quantified. However, there is a need to identify factors influencing this relationship. OBJECTIVES:To understand ...

journal_title：Psychopharmacology

authors： Haasova M,Warren FC,Ussher M,Janse Van Rensburg K,Faulkner G,Cropley M,Byron-Daniel J,Everson-Hock ES,Oh H,Taylor AH

更新日期：2014-04-01 00:00:00

abstract：:The suggestions that dopamine (DA) systems are involved in "motor control" and "reward" represent the classic working hypotheses on the behavioral functions of these systems. The research generated by these hypotheses has yielded results that are far more complicated than the simplest form of either hypothesis would i...

journal_title：Psychopharmacology

authors： Salamone JD

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:A cue-modulated startle test recently confirmed that smoking cues in smokers may not be withdrawal-like and aversive as traditionally believed. OBJECTIVE:Analogous tests were applied to alcohol cues in inpatient alcoholics. METHODS:Twenty-six withdrawn alcoholics (18 men) were examined. Alcohol-related pict...

journal_title：Psychopharmacology

authors： Mucha RF,Geier A,Stuhlinger M,Mundle G

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:Stress experience during adolescence has been linked to the development of psychiatric disorders in adulthood, many of which are associated with impairments in prefrontal cortex function. OBJECTIVE:The current study was designed to determine the immediate and enduring effects of repeated social stress on a p...

journal_title：Psychopharmacology

authors： Snyder KP,Barry M,Valentino RJ

更新日期：2015-01-01 00:00:00

abstract：RATIONALE:Orexins A and B have recently been discovered and shown to be derived from preproorexin, primarily expressed in the rat hypothalamus. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) administration, including hyperphagia, neuroendocrine modulation and, mo...

journal_title：Psychopharmacology

authors： Duxon MS,Stretton J,Starr K,Jones DN,Holland V,Riley G,Jerman J,Brough S,Smart D,Johns A,Chan W,Porter RA,Upton N

更新日期：2001-01-01 00:00:00

abstract：:Food intake of four adult male baboons (Papio c. anubis) was monitored during daily experimental sessions lasting 22 h. Food was available under a two-component operant schedule. Following completion of the first "procurement component" response requirement, access to food, i.e., a meal, became available under the sec...

journal_title：Psychopharmacology

authors： Foltin RW,Fischman MW,Byrne MF

更新日期：1989-01-01 00:00:00

abstract：:Low doses of 8-OH-DPAT (62.5-250 micrograms/kg) were reinforcing in the place preference conditioning procedure, while a higher dose (1 mg/kg) supported a conditioned place aversion. The 5-HT synthesis inhibitor PCPA, and the DA antagonists pimozide and sulpiride, had no effect when administered alone, but abolished t...

journal_title：Psychopharmacology

authors： Papp M,Willner P

更新日期：1991-01-01 00:00:00

abstract：:Clozapine and molindone administered to mice for 21 days did not elevate the density of striatal 3H-spiperone binding sites at doses clinically equivalent to 1.5 mg/kg haloperidol, which elevated binding by 29%. Thioridazine (25 mg/kg) elevated binding by 25%. It appears that clinically equivalent doses of clozapine a...

journal_title：Psychopharmacology

authors： Severson JA,Robinson HE,Simpson GM

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:The five-choice serial reaction time task (5-CSRTT) is regularly used to study attention and impulsivity. In the 5-CSRTT, rodents initiate a trial, then after an inter-trial interval (ITI), a light appears in one of five holes. Responding in the lit vs. unlit hole reflects attention (accuracy), while respondi...

journal_title：Psychopharmacology

authors： Cope ZA,Halberstadt AL,van Enkhuizen J,Flynn AD,Breier M,Swerdlow NR,Geyer MA,Young JW

更新日期：2016-10-01 00:00:00

abstract：:A recent study from our laboratory has demonstrated that C57BL/6 male mice that are chronically injected with nicotine develop a profound tolerance to nicotine that is not associated with changes in brain nicotinic receptors. We have proposed that alterations in the secretion of corticosterone (CCS) may regulate toler...

journal_title：Psychopharmacology

authors： Grun EA,Pauly JR,Collins AC

更新日期：1992-01-01 00:00:00

abstract：:This study was designed to compare the therapeutic and adverse effects of tranylcypromine (a monoamine oxidase inhibitor), nortriptyline (a tricyclic antidepressant), and placebo. A total of 122 depressed outpatients randomly assigned to double-blind treatment with one of these agents completed the 4-week protocol. Tr...

journal_title：Psychopharmacology

authors： White K,Razani J,Cadow B,Gelfand R,Palmer R,Simpson G,Sloane RB

更新日期：1984-01-01 00:00:00

abstract：:Three sets of experiments were carried out in a Y water maze in which mice had to swim toward the light or the dark, in two different procedures. The first procedure involved, orientation toward a light source (L procedure), corresponding to natural preference, the latter involved orientation toward the dark (D proced...

journal_title：Psychopharmacology

authors： Castellano C

更新日期：1976-08-17 00:00:00

abstract：RATIONALE:We previously demonstrated that the addition of the selective norepinephrine reuptake inhibitor reboxetine attenuates olanzapine-induced weight gain. Using the same study sample, we also sought to determine whether reboxetine's weight-attenuating effect was accompanied by a beneficial effect on metabolic and ...

journal_title：Psychopharmacology

authors： Amrami-Weizman A,Maayan R,Gil-Ad I,Pashinian A,Fuchs C,Kotler M,Poyurovsky M

更新日期：2013-11-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) of the startle response in mice is increasingly used as a paradigm of sensory gating with potential predictive and construct validity towards schizophrenia. OBJECTIVES:Establishment of a mouse PPI paradigm in which typical and atypical antipsychotic drugs directly improve a low perf...

journal_title：Psychopharmacology

authors： Olivier B,Leahy C,Mullen T,Paylor R,Groppi VE,Sarnyai Z,Brunner D

更新日期：2001-07-01 00:00:00

abstract：:The present study compared cocaine-induced hyperlocomotion and cocaine i.v. self-administration in DBA/2J and C57BL/6J mice. In the locomotor activity experiment, these strains were tested for hyperlocomotion after i.p. cocaine injection (0-60.0 mg/kg), using a Digiscan Animal Activity Monitoring System. In the cocain...

journal_title：Psychopharmacology

authors： Rocha BA,Odom LA,Barron BA,Ator R,Wild SA,Forster MJ

更新日期：1998-07-01 00:00:00

abstract：:The mood-altering properties of amphetamine (AMPH) in humans (euphoria and depression) have been postulated to be related to the increases and decreases respectively which this drug produces in the sensitivity of the reward system of the brain. The present study further evaluated this relationship by testing the effec...

journal_title：Psychopharmacology

authors： Leith NJ,Barrett RJ

更新日期：1980-01-01 00:00:00

abstract：:Behavioral performances of normotensive and hypertensive adult male baboons were tested before, during, and following chronic oral dosing with nifedipine. Performances during a five-color simultaneous match-to-sample task were measured during three dosing schedules (0.20, 0.68, and 1.14 mg/kg/day) and vehicle. Each do...

journal_title：Psychopharmacology

authors： Turkkan JS,Hienz RD

更新日期：1990-01-01 00:00:00

abstract：:A study was performed to examine behavioral response to a challenge of selective dopamine D-1 and D-2 agonists in rats previously sensitized by subchronic administration of methamphetamine or cocaine. Rats in three groups received repeated injections (IP) of saline, methamphetamine (4 mg/kg/day) or cocaine (20 mg/kg/d...

journal_title：Psychopharmacology

authors： Ujike H,Akiyama K,Otsuki S

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Several theories propose alternative explanations for drug addiction. OBJECTIVES:We propose a general theory of transition to addiction that synthesizes knowledge generated in the field of addiction into a unitary explanatory frame. MAJOR PRINCIPLES OF THE THEORY:Transition to addiction results from a sequ...

journal_title：Psychopharmacology

authors： Piazza PV,Deroche-Gamonet V

更新日期：2013-10-01 00:00:00

abstract：:Red blood cell (RBC) glycine levels were examined in 27 bipolar patients, treated with lithium carbonate for a minimum of 8 months, who were either hypomanic, depressed, or euthymic in their mood. We found no difference in the RBC glycine or in the RBC: plasma glycine ratio between the hypomanic, depressed, or euthymi...

journal_title：Psychopharmacology

authors： Peselow ED,Deutsch SI,Stanley M,Banay-Schwartz M,Virgilio J,Fieve RR

更新日期：1982-01-01 00:00:00

abstract：:The study compares the behavioral profiles induced in rats (N = 118) by the D2-dopaminergic receptor agonist quinpirole (0.03 and 0.5 mg/kg), and the D1-agonist SKF38393 (1.25-40 mg/kg), and both agonists administered together. Locomotion and snout contact frequency were reduced by the low but increased by the high do...

journal_title：Psychopharmacology

authors： Eilam D,Talangbayan H,Canaran G,Szechtman H

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA) produces a long-term depletion of serotonin (5-HT) in the rat brain; this depletion may have some functional consequences. OBJECTIVE:The aim of the present study was to evaluate the acute effects of MDMA on the extracellular concentrations of dopamine and 5-HT, body t...

journal_title：Psychopharmacology

authors： Shankaran M,Gudelsky GA

更新日期：1999-11-01 00:00:00

abstract：:The anxiolytic activity of diazepam (DZP) (0.25-1 mg/kg) was investigated in streptozotocin (STZ)-induced diabetic adult Charles Foster albino rats of either sex. Diabetes was induced by injecting STZ IP (50 mg/kg; in citrate buffer, pH 4.5). Experiments were performed 72 h later. The rats were subjected to various an...

journal_title：Psychopharmacology

authors： Ramanathan M,Jaiswal AK,Bhattacharya SK

更新日期：1998-02-01 00:00:00

abstract：:The behavioral effects following intrastriatal MPP+, the neurotoxic metabolite of MPTP, were evaluated in mice. Bilateral injections of 10 micrograms MPP+ to mice previously trained in the shuttle box paradigm produced a 66% decrease in striatal dopamine and significant deficits in all measures of conditioned avoidanc...

journal_title：Psychopharmacology

authors： Wagner GC,Walsh SL

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:During the last few decades, alcohol use disorders (AUD) have reached an epidemic prevalence, yet social influences on alcoholism have not been fully addressed. Several factors can modulate alcohol intake. On one hand, stress can reinforce ethanol-induced behaviors and be an important component in AUD and alc...

journal_title：Psychopharmacology

authors： Bahi A,Dreyer JL

更新日期：2020-03-01 00:00:00

abstract：RATIONALE:Nicotine displays rewarding and aversive effects, and while dopamine has been linked with nicotine's reward, the neurotransmitter(s) involved with aversion remains speculative. The kappa-dynorphinergic system has been associated with negative motivational and affective states, and whether dynorphin (Dyn) cont...

journal_title：Psychopharmacology

authors： Isola R,Zhang H,Tejwani GA,Neff NH,Hadjiconstantinou M

更新日期：2009-01-01 00:00:00

abstract：RATIONALE:Dronabinol (Δ(9)tetrahydrocannabinol) is approved for HIV-related anorexia, yet, little is known about its effects in HIV-positive marijuana smokers. HIV-negative marijuana smokers require higher than recommended dronabinol doses to experience expected effects. OBJECTIVES:Employing a within-subjects, double-...

journal_title：Psychopharmacology

authors： Bedi G,Foltin RW,Gunderson EW,Rabkin J,Hart CL,Comer SD,Vosburg SK,Haney M

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Ketamine, a non-competitive N-methyl-D: -aspartic acid antagonist, has been widely used for anaesthetic purposes. At sub-anaesthetic dosage, it induces a dissociative state similar to schizophrenia. The discovery of this effect on dissociative state has led to its use as a pharmacological model of schizophre...

journal_title：Psychopharmacology

authors： Pouget P,Wattiez N,Rivaud-Péchoux S,Gaymard B

更新日期：2010-05-01 00:00:00