Abstract:
:The behavioral effects following intrastriatal MPP+, the neurotoxic metabolite of MPTP, were evaluated in mice. Bilateral injections of 10 micrograms MPP+ to mice previously trained in the shuttle box paradigm produced a 66% decrease in striatal dopamine and significant deficits in all measures of conditioned avoidance responding. In addition, although these mice showed no deficits in baseline rotorod performance, challenge with the cholinergic agonist oxotremorine revealed that MPP+-treated mice exhibited an increased sensitivity to the disruptive effects of the drug at each dose and time point. Finally, MPP+-treated mice also exhibited an increase in tremor induced by 0.1 and 0.15 mg/kg oxotremorine. These observations are discussed in reference to idiopathic parkinsonism.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Wagner GC,Walsh SLdoi
10.1007/BF00176480subject
Has Abstractpub_date
1987-01-01 00:00:00pages
470-2issue
4eissn
0033-3158issn
1432-2072journal_volume
92pub_type
杂志文章abstract::Amitriptyline and zimelidine significantly reduce the uptake of 5-HT into the blood platelets of depressive patients. The degree of inhibition is significantly correlated with the plasma drug level of amitriptyline. No significant relationship could be detected between the degree of inhibition of uptake and therapeuti...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00429689
更新日期:1979-05-25 00:00:00
abstract::The intracerebroventricular administration of carbachol chloride induced a characteristic wet dog shake response in rats. Neither 5,6-dihydroxytryptamine, a serotonergic depletor, nor DL-p-chlorophenylalanine, an inhibitor of 5-HT synthesis, affected wet dog shakes induced by carbachol. Putative antiserotonergic drugs...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426469
更新日期:1981-01-01 00:00:00
abstract::Various doses of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, MK-801 (0.1-0.5 mg/kg) and ketamine (2.5-10 mg/kg), produced a dose-dependent increase in stereotypic behaviour in naive mice. MK-801 (0.1 mg/kg) and ketamine (2.5 mg/kg) potentiated the stereotypic response of apomorphine (0.1-0.5 ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245171
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Prepulse inhibition (PPI) refers to the reduction of the startle response magnitude when a startling stimulus is closely preceded by a weak stimulus. PPI is commonly used to measure sensorimotor gating. In rats, the PPI reduction induced by the dopamine agonist apomorphine can be reversed by systemic administ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3940-z
更新日期:2015-08-01 00:00:00
abstract::The present study was undertaken to evaluate the effects of single and repeated doses of triazolam (1 mg/kg IP) and desipramine (DMI) (10 mg/kg IP) alone and in combination on certain pharmacologic responses and brain catecholamine levels in rats. The significant findings were: (1) triazolam and DMI given alone and in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427882
更新日期:1980-01-01 00:00:00
abstract::It has been shown that pretreatment with dopamine (DA) receptor blockers disrupts the effect of intravenously (IV) and intracerebrally (ICV), but not intraperitoneally (IP) administered cocaine on place preference conditioning (PPC). The present study was undertaken to further evaluate possible differences between IV ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00735892
更新日期:1988-01-01 00:00:00
abstract::Animals responding for biphasic square wave stimulation to the VTA were treated for 26 days with a low dose (0.07 mg/kg) of the neuroleptic haloperidol and tested at 1 h post-injection. Initially the drug induced a pronounced lateral displacement of the baseline rate-intensity function, concomitant with a depression i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245756
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:H(3)-receptor inverse agonists raise a great interest as innovative therapeutics in several central disorders. Whereas their procognitive properties are well established, their antipsychotic-like properties are still debated. OBJECTIVES:We further explored the effect of maximal doses (3-10 mg/kg) of ciproxif...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1863-2
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:There is evidence that mGlu2/3 receptors regulate 5-HT2A signaling, interactions that have been theorized to play a role in the antipsychotic-like effects of mGlu2/3 agonists as well as the hallucinogenic effects of 5-HT2A agonists. One approach to unraveling this interaction is through the chronic administr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5118-y
更新日期:2019-02-01 00:00:00
abstract::In two experiments, phenobarbitone sodium (30 mg/kg) reliably enhanced water consumption and extended the duration of drinking in 24h water-deprived male rats. The opiate receptor antagonists naloxone (0.1-10 mg/kg) and naltrexone (0.1-10 mg/kg) both decreased water intake and reduced the duration of drinking. When th...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433011
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:Central cannabinoid systems have been implicated in appetite regulation through the hyperphagic effects of exogenous and endogenous cannabinoids. These effects may involve activation of reward systems and be mediated in part by opioidergic processes. OBJECTIVE:Cannabinoid-opioid interactions in feeding were ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000596
更新日期:2001-01-01 00:00:00
abstract:RATIONALE:Increasing concomitant abuse of cocaine and morphine-like opioids has prompted a number of studies aimed at understanding how these drugs interact. OBJECTIVE:The present study was designed to determine if variations in opioid pretreatment time would affect how mu opioid agonists interact with cocaine. METHO...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100732
更新日期:2001-08-01 00:00:00
abstract:AIM:The purpose of this study was to determine if acute nicotine attenuated ketamine-induced regional cerebral blood flow (rCBF). METHOD:Following 2-4 h of nicotine abstinence, healthy chronic smokers participated in four sets of rCBF studies, H2(15)O positron emission tomography, during a simple sensory motor control...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1758-2
更新日期:2010-03-01 00:00:00
abstract:RATIONALE:Acute tryptophan depletion (ATD) is a widely used method to study the role of serotonin (5-HT) in affect and cognition. ATD results in a strong but transient decrease in plasma tryptophan and central 5-HT synthesis and availability. Although its use is widespread, the evidence that the numerous functional eff...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0908-7
更新日期:2007-12-01 00:00:00
abstract::The purpose of this study was to determine if multiple aspects of drug and food-reinforced behavior could be measured in a single study. Drug or food seeking can be observed under four conditions: 1) internal drug or food cues and external stimulus cues present; self-administration, 2) only internal cues present; prim...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050338
更新日期:1997-08-01 00:00:00
abstract:RATIONALE:The elevated plus-maze and the light/dark box are two established anxiety tests in rodents, which are useful to screen putative anxiogenic effects of drugs. OBJECTIVE:Caffeine is well known to promote anxious behaviour in humans and animal models, but the precise site of action of the drug is still a matter ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050037
更新日期:2000-02-01 00:00:00
abstract::Two groups of schizophrenic outpatients were treated with perphenazine decanoate (N = 20) and cis(z)-flupentixol decanoate (N = 24) respectively. Every 3 months the dose was gradually reduced until symptoms appeared that were suggestive of a prodromal phase of a psychotic episode. A slightly higher dose was then promp...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02316862
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Both methylphenidate (MPH), a catecholamine reuptake blocker, and guanfacine, an alpha2A agonist, are used to treat attention-deficit hyperactivity disorder (ADHD). Childhood impulsivity, including delay discounting, is associated with increased substance use during adolescence. These effects can be mitigated...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5096-0
更新日期:2019-02-01 00:00:00
abstract:RATIONALE:Comorbidity with gambling disorder (GD) and alcohol use disorder (AUD) is well documented. OBJECTIVE:The purpose of our study was to examine the influence of genetic alcohol drinking tendency on reward-guided decision making behavior of rats and the impact of dopamine releaser D-amphetamine on this behavior....
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-4847-2
更新日期:2018-05-01 00:00:00
abstract:RATIONALE:Psychomotor stimulants can induce psychotic states in humans that closely resemble those observed in patients with idiopathic schizophrenia. Attentional and sensorimotor gating impairments are observed in schizophrenic patients using the latent inhibition (LI) and prepulse inhibition (PPI) behavioral assays, ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1254-4
更新日期:2003-09-01 00:00:00
abstract:INTRODUCTION:Dopamine D2 receptor occupancy levels needed for the maintenance treatment of schizophrenia remain to be elucidated. We examined 3-year clinical outcomes of patients with schizophrenia who received long-acting injectable risperidone (LAI risperidone) at baseline and investigated their dopamine D2 receptor ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4428-1
更新日期:2016-12-01 00:00:00
abstract::Chronic treatment of rats with the antipsychotic drug molindone (2.5 mg/kg) did not elicit behavioral supersensitivity to apomorphine (AP) (0.25 mg/kg) or increased striatal 3H-spiroperidol binding, whereas treatment with haloperidol (0.5-1.0 mg/kg) produced manifestations of dopaminergic supersensitivity in both para...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432549
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:Although the behavioral effects of systemic injection of lipopolysaccharide (LPS) have been extensively investigated, the modulation of these effects by natural environmental factors has received little attention. OBJECTIVES:The present study investigated whether or not locomotor activity reductions and the ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1554-3
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:To compare matched paliperidone-ER- and olanzapine-treated schizophrenic patients on measures of glucose and lipid metabolism. METHODS:Eighty hospitalized patients with schizophrenia (DSM-IV) were randomly assigned to treatment with paliperidone ER or olanzapine for a period of 12 weeks. At baseline and ever...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-013-3073-1
更新日期:2013-11-01 00:00:00
abstract::We investigated the striatal dopamine-2 (D2) receptor occupancy caused by different antipsychotic substances in 18 psychotic patients (16 with schizophrenic and two with schizoaffective disorder according to DSM-IV) with single photon emission computed tomography (SPECT) using 123I-iodobenzamide (IBZM) as tracer subst...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130050409
更新日期:1997-10-01 00:00:00
abstract:RATIONALE:Clinical observations have shown that pain sensitivity is altered in some schizophrenic patients. OBJECTIVES:To study alterations in pain sensitivity, the ketamine model in schizophrenia research was employed. MATERIALS AND METHODS:Rats were subchronically injected with the dissociative anaesthetic ketamine...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0557-2
更新日期:2006-12-01 00:00:00
abstract::The effects of benzodiazepine (BZ) antagonists on operant behavior were examined in rats chronically administered a low dose of diazepam (DZ). The low maintenance dose of DZ (5 mg/kg twice daily) was selected as more closely associated with its anxiolytic effects than the higher treatment doses previously used to stud...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244103
更新日期:1990-01-01 00:00:00
abstract::Risperidone, a new antipsychotic agent, was studied for its effects on spontaneous motor activity in rats in comparison with haloperidol. Motor activity was recorded via the optical scanning technique (horizontal and vertical activity) and via a recently developed technique based on the piezo-electric principle which,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00172961
更新日期:1988-01-01 00:00:00
abstract::Chlordiazepoxide (5 and 10 mg/kg) and diazepam (2.5 mg/kg) reduced the latency to eat and enhanced feeding response to familiar food in a food-preference test. The increased feeding response resulted from an increased frequency of individual eating episodes (bouts) without significant change in the episode duration. E...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426525
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:An important goal of addiction research is to discover neurobiological markers that could predict the severity of addiction and help to determine appropriate treatment. Brain-derived neurotrophic factor (BDNF) and thiobarbituric acid reactive substances (TBARS) are being related to cerebral plasticity and imp...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3542-1
更新日期:2014-10-01 00:00:00