Abstract：
:The effects of benzodiazepine (BZ) antagonists on operant behavior were examined in rats chronically administered a low dose of diazepam (DZ). The low maintenance dose of DZ (5 mg/kg twice daily) was selected as more closely associated with its anxiolytic effects than the higher treatment doses previously used to study BZ dependence. Food-restricted rats were trained to press a lever for food reinforcement under a FR20 schedule of reinforcement prior to the start of DZ administration. Acute administration of DZ caused a dose-dependent reduction of response rates, with 5 mg/kg causing a 50% decrease. Rats treated chronically with DZ became tolerant to its rate-suppressant effects as shown by a 5-fold increase in the dose of DZ required to reduce FR20 response rates by 50%. The BZ antagonist flumazenil (formerly Ro 15-1788; 10-56 mg/kg) suppressed rates of responding in rats treated chronically with DZ. The suppression of operant responding was obtained when flumazenil was given up to 3 h, but not 18 h, after the last treatment with DZ. In contrast, only the highest dose of flumazenil (56 mg/kg) caused reductions of operant responding when given to rats treated with saline. The BZ antagonist CGS 8216 (3.3-33 mg/kg IP), given 10 min prior to the session, was similarly more potent and effective at suppressing operant responding in rats treated chronically with DZ than saline. This procedure may provide a model for the clinical problem of physical dependence to chronically-administered low, anxiolytic doses of BZ tranquilizers.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Lucki I,Kucharik RFdoi
10.1007/BF02244103subject
Has Abstractpub_date
1990-01-01 00:00:00pages
350-6issue
3eissn
0033-3158issn
1432-2072journal_volume
102pub_type
杂志文章abstract：RATIONALE:(1S,3aS)-8-(2,3,3,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198), a non-peptidic agonist for the opioid receptor-like1 (ORL1) receptor, exhibits anxiolytic properties in stressful conditions. OBJECTIVE:The present study was aimed at evaluating whether activation of ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1020-7
更新日期：2002-05-01 00:00:00
abstract：:Repeated amphetamine (AMPH) administration into the nucleus accumbens does not enhance (sensitize) the locomotor activity produced by a subsequent systemic AMPH challenge. We report here, however, that pretreatment with systemic injections of AMPH does produce a significant enhancement in the locomotor stimulant effec...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244569
更新日期：1991-01-01 00:00:00
abstract：RATIONALE:Cannabis (CB) use and dependence are associated with regionally specific alterations to brain circuitry and substantial psychosocial impairment. OBJECTIVES:The objective of this study was to investigate the association between CB use and dependence, and the volumes of brain regions critically involved in goa...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4606-9
更新日期：2017-07-01 00:00:00
abstract：RATIONALE:Pramipexole is a dopamine agonist which binds selectively to dopamine D(3) and D(2) receptors. There is evidence that, in addition to its beneficial effects in parkinsonism, this compound may also be of value in addressing symptomatology associated with depressive diseases. OBJECTIVES:The present study was a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1199-7
更新日期：2002-10-01 00:00:00
abstract：:The existence of cyclical (circadian) variations in lithium toxicity in mice was determined. Mice, standardized to a light-dark cycle, were injected with lithium chloride (940 mg/kg) at one of six times (20:00, 24:00, 4:00, 8:00, 12:00, and 16:00) and subsequently observed for mortality over 28 h. A significant (P les...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00571418
更新日期：1978-01-31 00:00:00
abstract：RATIONALE:Opioid use disorder (OUD) is a major epidemic in the USA. Despite evidence indicating that OUD may be particularly severe for women, preclinical models have yet to establish sex as a major factor in OUD. OBJECTIVES:Here, we examined sex differences in vulnerability to relapse following intermittent access fe...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05750-2
更新日期：2021-01-06 00:00:00
abstract：OBJECTIVES:Ayahuasca is a traditional South American psychoactive beverage and the central sacrament of Brazilian-based religious groups, with followers in Europe and the United States. The tea contains the psychedelic indole N,N-dimethyltryptamine (DMT) and beta-carboline alkaloids with monoamine oxidase-inhibiting pr...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-007-0963-0
更新日期：2008-02-01 00:00:00
abstract：:Progabide inhibited male rat sexual behavior at a dose of 200 mg/kg. This dose had only modest effects on ambulatory activity and no effect at all on motor coordination as evaluated by a rotarod test. The GABAA antagonist bicuculline, at a dose of 1 mg/kg, blocked the effects of progabide on sex behavior. In contrast,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050158
更新日期：1997-01-01 00:00:00
abstract：RATIONALE:Nicotine replacement is commonly used to treat tobacco use in heavy-drinking smokers. However, few studies have examined the effect of nicotine replacement on subjective and physiological responses to alcohol and alcohol drinking behavior. OBJECTIVE:The primary aim of this within-subject, double-blind study ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-007-0952-3
更新日期：2008-02-01 00:00:00
abstract：RATIONALE:Depression is a frequent non-motor symptom in Parkinson's disease (PD) with increasing rates with the progression of the disease. Molecular imaging studies have shown a reduction of dopamine transporter (DAT) density in depressed PD patients (dPD); however, DAT role in the pathophysiology of PD depression is ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1867-y
更新日期：2010-07-01 00:00:00
abstract：:Nine human subjects were exposed to a multiple fixed-ratio (FR) differential-reinforcement-of-low-rate (DRL) schedule of monetary reinforcement. Presses on a manipulandum requiring relatively high force were occasionally followed by an increased money total displayed on a computer screen. Subjects were exposed to the ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00177913
更新日期：1987-01-01 00:00:00
abstract：:Rats were chronically administered either haloperidol (HAL) or fluphenazine (FLU) via depot injections for 8 months, given these same drugs in their drinking water for the next 2 months, and then withdrawn from the drugs. Throughout the experiment the animals were tested repeatedly in an enclosed tube using a computer...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174701
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:Repetitive cocaine exposure has been shown to induce GABAergic thalamic alterations. Given the key role of T-type (Ca(V)3) calcium channels in thalamocortical physiology, the direct involvement of these calcium channels in cocaine-mediated effects needs to be further explored. OBJECTIVE:The objective of this...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1947-z
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVES:To investigate the relationship between benzodiazepine and risk of developing pneumonia in patients with schizophrenia, whose benzodiazepine dosage and usage frequency was higher than that of the general population. METHODS:We conducted a nested case-control study to assess the association between benzodiaz...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5039-9
更新日期：2018-11-01 00:00:00
abstract：:Naloxone HCl (10 micrograms/0.5 ml) was injected in the locus coeruleus (LC) of morphine-dependent rats and the behavioural manifestations of morphine withdrawal and the cortical levels of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) were measured 30 min later. Naloxone precipitated a withdrawal syndrome...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00187263
更新日期：1987-01-01 00:00:00
abstract：:Changes in saccadic eye movements before and after up to 10 mg oral diazepam were measured electrooculographically in diazepam-naive humans. Diazepam produced dose-dependent increases in saccade duration and decreases in maximum saccade velocity over a 2--36 degrees range of saccade amplitudes. The magnitude of drug-i...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00427100
更新日期：1981-01-01 00:00:00
abstract：:The fatty acid specificity of the depressant actions associated with prostaglandin (PG) administration was studied in mice. Administration of PG-E2 (0.4 and 1.0 mg/kg) or PG-D2 (0.4 and 4 mg/kg) significantly potentiated pentobarbital sleeping time. Arachidonic acid (3.3 mg/kg) administration also significantly potent...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00555225
更新日期：1984-01-01 00:00:00
abstract：:The effects of naloxone, metenkephalin, and morphine were tested on phencyclidine(PCP)-induced stereotyped behaviors, ataxia, and hyperactivity in the rat. Naloxone (8 mg/kg) significantly decreased stereotypy, ataxia, and hyperactivity across all PCP doses tested (2.0, 4.0, and 6.0 mg/kg). Metenkephalin (40 microgram...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00470593
更新日期：1982-01-01 00:00:00
abstract：:The cholinergic hypothesis of Alzheimer's disease (AD) has strongly influenced research on learning and memory over the last decade. However, there has been limited success treating AD dementia with cholinomimetics. Furthermore, there are indications that other neurotransmitter systems affected by this disease may be ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02247440
更新日期：1996-04-01 00:00:00
abstract：:This experiment examined the effect of destruction of the ascending 5-hydroxytryptaminergic (5HTergic) pathways on performance in a free-operant timing schedule. Rats received either injections of 5,7-dihydroxytryptamine into the dorsal and median raphe nuclei or sham lesions. They were trained to press levers for a s...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050096
更新日期：1996-10-01 00:00:00
abstract：:Twelve healthy male volunteers took part in a double-blind randomised cross-over study composed of three treatment sessions: remoxipride 100 mg; remoxipride 100 mg plus biperiden 4 mg; and biperiden 4 mg. Plasma and urine concentrations of remoxipride and biperiden, plasma prolactin levels, salivary flow and adverse e...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02257403
更新日期：1993-01-01 00:00:00
abstract：:The effects of the antiepilepsy drugs methsuximide and mephenytoin were examined in pigeons responding under a fixed-consecutive-number (FCN) schedule with and without an added external discriminative stimulus. On this schedule, food was delivered whenever subjects responded between 8 and 12 times on one response key ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174512
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:Enhancement of dopamine (DA) release by corticosteroids may be of aetiological importance in substance misuse. OBJECTIVES:To examine the effect of sub-chronic administration of hydrocortisone on the response to amphetamine in healthy male volunteers. METHODS:Following baseline assessment, 20 volunteers were...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00213-003-1609-5
更新日期：2004-02-01 00:00:00
abstract：RATIONALE:Dysfunction of executive neuropsychological performance, mediated by the prefrontal cortex, has been the central focus of recent attention deficit/ hyperkinetic disorder (AD-HKD) research. The role of other potential neuropsychological "risk factors", such as recognition memory, remains understudied. Further,...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00213-004-1833-7
更新日期：2004-09-01 00:00:00
abstract：:A paradigm for assessing benzodiazepine receptor sensitivity was developed using intravenous midazolam in normal volunteers. After administration of incremental doses of midazolam, alterations in saccadic eye movement parameters and psychological self ratings were assessed. Significant changes included dose-dependent ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244431
更新日期：1991-01-01 00:00:00
abstract：:Triadimefon is a triazole fungicide that produces hyperactivity in both mice and rats similar to that seen following administration of compounds with catecholaminergic activity (e.g., d-amphetamine). To determine whether the triadimefon-induced hyperactivity is due to an action on CNS catecholaminergic systems, we eva...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00439445
更新日期：1989-01-01 00:00:00
abstract：:The forced swimming test is reviewed. This test appears to be suitable for detecting antidepressant activity in rats but not in mice. Difference in experimental procedure may account for the different sensitivity to drugs of the two animal species. ...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF00176837
更新日期：1988-01-01 00:00:00
abstract：:In experiment 1, rats (n = 12) were trained to discriminate the benzodiazepine (BDZ) compound chlordiazepoxide (CDP, 20 mg/kg, IP) from saline in a two-lever food-reinforced procedure, and subsequently were tested for stimulus control with different doses of CDP, Ro 15-1788 (a proposed BDZ receptor antagonist) and Ro ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00652236
更新日期：1986-01-01 00:00:00
abstract：:After publication of this paper, the authors determined an error in the calculation of the norepinephrine standard concentrations for the HPLC calibration curves. ...
journal_title：Psychopharmacology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00213-018-4996-3
更新日期：2018-09-01 00:00:00
abstract：:The present study assessed the discriminative stimulus effects of the delta-opioid agonist [D-Pen2-D-Pen5]enkephalin (DPDPE) in pigeons. Food-restricted pigeons were trained to discriminate between i.c.v injections of 100 micrograms [D-Pen2-D-Pen5]enkephalin (DPDPE) and saline in a two-key operant procedure; acquisiti...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
