Abstract:
:After publication of this paper, the authors determined an error in the calculation of the norepinephrine standard concentrations for the HPLC calibration curves.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Shnitko TA,Taylor SC,Stringfield SJ,Zandy SL,Cofresí RU,Doherty JM,Lynch WB,Boettiger CA,Gonzales RA,Robinson DLdoi
10.1007/s00213-018-4996-3subject
Has Abstractpub_date
2018-09-01 00:00:00pages
2777issue
9eissn
0033-3158issn
1432-2072pii
10.1007/s00213-018-4996-3journal_volume
235pub_type
杂志文章,已发布勘误abstract::Risperidone was studied in a 0.16 mg/kg LSD-saline drug discrimination test procedure. At doses varying from 0.0025 to 0.63 mg/kg, no LSD-like agonist effects were observed. Studies on the antagonism of the LSD-cue indicated that risperidone was able to completely block the discriminative stimulus properties of LSD wi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00442251
更新日期:1989-01-01 00:00:00
abstract::Predicting what will happen in the future in terms of potential reward is essential in daily life. The aim of the current study was to investigate the neurotransmitter systems involved in the anticipation of reward value and probability. We hypothesized that dopaminergic and noradrenergic antagonism would affect antic...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05515-x
更新日期:2020-07-01 00:00:00
abstract::CSF GABA levels were not significantly different in a group of drug-free psychotic patients compared to a group of psychotic patients at two points during haloperidol treatment or a neurological comparison group. In the untreated group, CSF GABA was significantly negatively correlated with clinical ratings of anxiety ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427885
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:A sensitized dopamine system may be linked to the genesis of psychotic symptoms in schizophrenia. Following withdrawal from amphetamine exposures, psychotic-like traits have been robustly demonstrated, but the presence of cognitive/mnemonic deficits remains uncertain. METHODS:Adult male Lewis and Fischer rat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1514-7
更新日期:2009-11-01 00:00:00
abstract:RATIONALE:The metabotropic glutamate (mGlu5) receptor subtype 5 antagonist MPEP attenuates self-administration of numerous drugs of abuse. OBJECTIVES:The purpose of the present study was to explore whether MPEP-induced decreases in nicotine and cocaine self-administration reflect attenuation of the reinforcing and inc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-2070-9
更新日期:2005-04-01 00:00:00
abstract:RATIONALE:F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial in patients with schizophrenia (Bitter et al. Neuropsych...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05387-w
更新日期:2020-02-01 00:00:00
abstract::The protective effects of acute and chronic diazepam administration (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) and picrotoxin were investigated. Considering the incidence of tonic-clonic convulsions, tolerance to the protective effects of diazepam was evident by day 5 if the mice were challenged wi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427828
更新日期:1983-01-01 00:00:00
abstract::The antagonist effects of clocinnamox were evaluated against opioid agonists, acting at mu, kappa and delta-receptors, in rhesus monkeys (n = 3-4) responding under a fixed-ratio 30 (FR 30) schedule for food delivery. Clocinnamox (0.032-0.1 mg/kg) dose-dependently antagonized fentanyl (0.001-0.32 mg/kg) after either a ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246641
更新日期:1996-02-01 00:00:00
abstract::Progabide inhibited male rat sexual behavior at a dose of 200 mg/kg. This dose had only modest effects on ambulatory activity and no effect at all on motor coordination as evaluated by a rotarod test. The GABAA antagonist bicuculline, at a dose of 1 mg/kg, blocked the effects of progabide on sex behavior. In contrast,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050158
更新日期:1997-01-01 00:00:00
abstract::Rats were treated once with doses of haloperidol or of droperidol below and above the acute ID50 vs the dopamine agonist apomorphine; they were later challenged with an acute dose of apomorphine (0.3 mg/kg, SC) and rated for stereotyped behavioral responses. The two neuroleptics were similar in acute anti-apomorphine ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431801
更新日期:1985-01-01 00:00:00
abstract::These experiments examined the neurochemical mechanisms involved in the development and expression of place conditioning produced by heroin. Conditioned place preferences (CPP) lasting up to 8 weeks were obtained with doses of 50-1000 micrograms/kg heroin, using a regimen shown not to produce physical dependence. Nalo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00442007
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects. OBJECTIVES:This double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin relative to a comparison compound administer...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0457-5
更新日期:2006-08-01 00:00:00
abstract::In the rat, the antimuscarinics atropine and scopolamine failed to block the reduction in pentobarbital-induced sleep time produced by either thyrotropin-releasing hormone (TRH) or MK-771 (a TRH analog). Previous reports have indicated that the marked analeptic effect produced by TRH is antagonized by such agents. It ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431749
更新日期:1981-01-01 00:00:00
abstract::The four homoeopathic drugs, Gelsemium, Cannabis Indica, Graphites and Agaricus Muscarius, administered orally in 30th and 200th potencies on white rats, enhanced restraint-induced catalepsy in a similar manner to the two standard drugs pilocarpine and haloperidol (IP injection at 5 mg/kg). All the drugs tested differ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174371
更新日期:1986-01-01 00:00:00
abstract::Seven neuroleptic-free schizophrenic patients received bromocriptine and eight schizophrenic patients received CF 25-397, both ergot derivatives with dopamine agonist activity. Psychosis failed to improve in response to either drug at the relatively low doses administered. Unlike the antipsychotic property of apomorph...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00428312
更新日期:1979-01-01 00:00:00
abstract::The effects of phencyclidine (PCP) on locomotor activity were compared to those of the stereoisomers of N-allylnormetazocine (NAN) after acute administration to rats. PCP produced swaying and falling movements, increased sniffing behavior, and enhanced horizontal locomotor activity. d-NAN also induced swaying, falling...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00310633
更新日期:1986-01-01 00:00:00
abstract::Offensive and defensive components of aggressive behavior were determined in resident and intruder mice. Withdrawal aggression was measured after the removal of a subcutaneous morphine pellet or after precipitation by naloxone in naive mice and after removal of a morphine pellet in mice with prior fighting experience....
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174059
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Catecholamine transmission modulates numerous cognitive and reward-related processes that can subserve more complex functions such as cost/benefit decision making. Dopamine has been shown to play an integral role in decisions involving reward uncertainty, yet there is a paucity of research investigating the c...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3904-3
更新日期:2015-08-01 00:00:00
abstract:RATIONALE:Recent research highlights the need to extend our understanding of how exercise may aid smoking cessation, through exploration of different modes, intensity and duration of exercise. OBJECTIVES:The purpose of the study was to examine the effects of a 1-mile self-paced walk on different measures of urges to s...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-2216-4
更新日期:2005-08-01 00:00:00
abstract::Dopaminergic involvement in the regulation of operant behavior was examined by monitoring responding after administration of different dopaminergic agonists. A chain schedule of reinforcement was used to classify the effects of these agonists in long-tailed macaques (Macaca fascicularis). The schedule included the fol...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429014
更新日期:1983-01-01 00:00:00
abstract::The effects of chronic lithium treatment on methylphenidate-, D1 dopamine receptor agonist (A-77636)-, and tactile stimulation-induced increases in frontal cortical acetylcholine release were studied in the rat using in vivo brain microdialysis. Cortical acetylcholine release in control rats was maximally stimulated b...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02249415
更新日期:1996-05-01 00:00:00
abstract:RATIONALE:Caffeine and the adenosine A(1) and A(2A) receptor antagonist CGS15943 produce many behavioral effects that are similar to those produced by classic stimulant drugs (e.g. cocaine and amphetamines). OBJECTIVES:The current study evaluated whether CGS15943 would maintain self-administration and reinstate exting...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1410-5
更新日期:2003-07-01 00:00:00
abstract:RATIONALE:Electronic cigarettes (ECs) are becoming popular alternatives for smokers, but there has been limited study of their abuse liability. OBJECTIVES:The objective of this study was to evaluate the abuse liability of three Vuse Solo ECs, ranging from 14 to 36 mg in nicotine content, relative to high- and low-abus...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-017-4665-y
更新日期:2017-09-01 00:00:00
abstract::The effects of an "aggression"-reducing drug, fluprazine, and an "aggression"-enhancing drug, ethanol, were evaluated in mice using the target biting and resident-intruder paradigms. Under baseline conditions there was a high target biting rate immediately after the delivery of a 2.0 mA tail shock, an intermediate tar...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00217061
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:The use and misuse of prescription opiates in adolescent populations, and in particular, adolescent female populations, has increased dramatically in the past two decades. Given the significant role that opioids play in neuroendocrine function, exposure to opiates during this critical developmental period cou...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2960-1
更新日期:2013-05-01 00:00:00
abstract::The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present investigation was set out to characterize these interactions in vitro using rat liver microsomes and in vivo by analysing levels of clomipramine and metabolites in sera of depressed patients ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245180
更新日期:1995-01-01 00:00:00
abstract:RATIONALE:N-methyl-D-aspartate (NMDA) receptors play crucial roles in learning and memory, but the role of each NMDA receptor subtype in a specific cognitive process is unclear. Non-selective blockers of NMDA receptor are used to model the cognitive impairment in schizophrenia and Alzheimer's disease. Counter-intuitive...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4008-9
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Caffeine has a well-established effect on reaction times (RTs) but the neurocognitive mechanisms underlying this are unclear. METHODS:In the present study, 15 female participants performed an oddball task after ingesting caffeine or a placebo, and electroencephalographic data were obtained. Single-trial P3b...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4790-7
更新日期:2018-03-01 00:00:00
abstract::Amphetamine (AMP) administered in high doses suppresses feeding. However, in low doses AMP has been shown to both suppress and facilitate feeding. Further, there is some indication of individual differences in the feeding response to low doses of AMP. Evidence indicates that AMP's effects on feeding are dopamine-media...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244426
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Both central serotonergic and nicotinic systems play important roles in a variety of neurobehavioral functions; however, the interactions of these two systems have not been fully characterized. The current study served to determine the impact of a relatively selective 5-HT2A receptor antagonist, ketanserin, o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-2060-y
更新日期:2005-05-01 00:00:00