Clocinnamox antagonism of opioid suppression of schedule-controlled responding in rhesus monkeys.

abstract：:The effects of olanzapine [LY 170053; 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2, 3b] [1,5]benzodiazepine), a potential atypical antipsychotic, were determined in pigeons whose keypeck responding was punished. These effects were compared to the anxiolytic agents chlordiazepoxide and pentobarbital, and to other a...

journal_title：Psychopharmacology

authors： Benvenga MJ,Leander JD

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:The exact behavioral nature of drug-induced reinstatement of drug seeking is still debated. As an incentive, the drug can have general facilitatory influences on appetitive behaviors. As an interoceptive stimulus, the drug can acquire discriminative properties and control behavior. OBJECTIVE:This study asses...

journal_title：Psychopharmacology

authors： Keiflin R,Isingrini E,Cador M

更新日期：2008-05-01 00:00:00

abstract：RATIONALE:Serotonergic mechanisms are thought to play an important role in the regulation of mood, motor activity and sleep patterns. Serotonin reuptake is controlled by the serotonin transporter (5-HTT) and by a common functional insertion/deletion polymorphism in the corresponding gene's promoter region (5-HTTLPR). H...

journal_title：Psychopharmacology

authors： Putzhammer A,Schoeler A,Rohrmeier T,Sand P,Hajak G,Eichhammer P

更新日期：2005-03-01 00:00:00

abstract：RATIONALE:It has been demonstrated that major differences between mice of the C57BL/6J and DBA/2J inbred strains for amphetamine-induced place conditioning (preference and avoidance, respectively) are evident in standard housing conditions but abolished by temporary restricted feeding. This gene-experience model may be...

journal_title：Psychopharmacology

authors： Orsini C,Buchini F,Piazza PV,Puglisi-Allegra S,Cabib S

更新日期：2004-03-01 00:00:00

abstract：RATIONALE:Quitting smoking is often very challenging, leading to frequent relapse. Exposure to acute and chronic stress during abstinence increases the likelihood of relapse to smoking. In rodents, stress acutely reinstates nicotine seeking after extinction of nicotine self-administration (SA). However, whether reacqui...

journal_title：Psychopharmacology

authors： Yu G,Chen H,Sharp BM

更新日期：2014-08-01 00:00:00

abstract：RATIONALE:Studies of the discriminative stimulus effects of drug mixtures provide an approach to polydrug abuse and studies on single drugs with multiple effects. OBJECTIVE:This study was designed to investigate whether the use of the AND-OR procedure increases the specificity of drug mixture discriminations. METHODS...

journal_title：Psychopharmacology

authors： Mariathasan EA,Stolerman IP,White JA

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:To evaluate prospectively interferon alpha (IFN-alpha) associated effects on cerebral glucose metabolism and its correlation to neuropsychiatric symptoms during low-dose IFN-alpha-treatment. METHODS:Eleven patients treated with low-dose IFN-alpha for chronic hepatitis C were prospectively evaluated by neurop...

journal_title：Psychopharmacology

authors： Juengling FD,Ebert D,Gut O,Engelbrecht MA,Rasenack J,Nitzsche EU,Bauer J,Lieb K

更新日期：2000-11-01 00:00:00

abstract：RATIONALE:Threatening social stimuli were used in this study as aversive conditions to test anxiety in lactating female mice. The odors of potential infanticidal males or the "stress odor" left by restrained mice represented two aversive conditions that have been suggested to modulate the time spent by the mothers to r...

journal_title：Psychopharmacology

authors： Mandillo S,D'Amato FR

更新日期：1999-10-01 00:00:00

abstract：RATIONALE:Recently, we showed that 2-bromoterguride acted as a dopamine D2 receptor partial agonist, a serotonin 5-HT2A and α2C-adrenergic receptor antagonist, and exhibited antidopaminergic efficacy in amphetamine-induced locomotion (AIL) in rats without inducing catalepsy. OBJECTIVE:To extend our knowledge on the an...

journal_title：Psychopharmacology

authors： Franke RT,Tarland E,Fink H,Pertz HH,Brosda J

更新日期：2016-08-01 00:00:00

abstract：:The augmentation effect of (-)pindolol as used in combination with SSRI to treat major depression has been ascribed to blocking of dorsal raphe nucleus cell body 5-HT autoreceptors. In this study, the radioligand [carbonyl-11C]WAY-100635 and positron emission tomography were used to establish whether pindolol at a cli...

journal_title：Psychopharmacology

authors： Andrée B,Thorberg SO,Halldin C,Farde L

更新日期：1999-06-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) represents a normal sensorimotor gating response that is typically impaired in schizophrenic patients. It is known that cannabinoid CB1 agonists reduce sensorimotor gating in rats, suggesting that the CB1 receptor and the cannabinoid system are involved in sensorimotor gating. OBJEC...

journal_title：Psychopharmacology

authors： Fernandez-Espejo E,Galan-Rodriguez B

更新日期：2004-09-01 00:00:00

abstract：:Plasma fluphenazine levels and plasma total neuroleptic activity (as quantitated by the neuroleptic receptor binding assay) were related to therapeutic response in 15 DSM-III schizophrenic patients who received a predetermined, fixed dose of fluphenazine for 14 days. Mean neuroleptic activity of the plasma was 84% gre...

journal_title：Psychopharmacology

authors： Hitzemann RJ,Garver DL,Mavroidis M,Hirschowitz J,Zemlan FP

更新日期：1986-01-01 00:00:00

abstract：:Carbachol, muscarine, eserine and neostigmine injected into the cerebral ventricles of conscious cats evoked emotional behaviour with aggression, autonomic and motor phenomena as well as clonic-tonic convulsions. The main and the most impressive feature of the gross behavioural effects of intraventricular carbachol, m...

journal_title：Psychopharmacology

authors： Beleslin DB,Samardzić R

更新日期：1979-04-11 00:00:00

abstract：RATIONALE:Central cannabinoid systems have been implicated in appetite regulation through the hyperphagic effects of exogenous and endogenous cannabinoids. These effects may involve activation of reward systems and be mediated in part by opioidergic processes. OBJECTIVE:Cannabinoid-opioid interactions in feeding were ...

journal_title：Psychopharmacology

authors： Kirkham TC,Williams CM

更新日期：2001-01-01 00:00:00

abstract：:After initial exposure to 80 mg/kg, pigeons trained on a two-key drug discrimination procedure rapidly learned to discriminate 120 mg/kg ethosuximide from saline. When 40-160 mg/kg doses of ethosuximide were administered during generalization tests, the percentage of responses directed to the ethosuximide-appropriate ...

journal_title：Psychopharmacology

authors： Clark RD,Schlinger H,Poling A

更新日期：1987-01-01 00:00:00

abstract：:The effect of aluminum on levels of inorganic phosphorus and acetylcholinesterase in blood and brain and on permeability of the blood-brain barrier (BBB) in different regions of the brain to the neuropeptide delta-sleep-inducing peptide (DSIP) was studied in adult rats. Aluminum (100 mg/kg) significantly increased the...

journal_title：Psychopharmacology

authors： Banks WA,Kastin AJ

更新日期：1985-01-01 00:00:00

abstract：:The effect of postethanol treatment with L-Dopa, aminophylline and/or ephedrine was investigated. In one experiment, healthy, male, moderate drinkers ingested ethanol (0.8 g/kg) and then either L-Dopa (1.5 g), or placebo. In a second experiment, subjects ingested ethanol followed by aminophylline (200 mg), ephedrine (...

journal_title：Psychopharmacology

authors： Alkana RL,Parker ES,Cohen HB,Birch H,Noble EP

更新日期：1977-12-28 00:00:00

abstract：RATIONALE AND OBJECTIVES:Functional (pharmacodynamic) ethanol tolerance can be evidenced within a single session of exposure to ethanol (acute or within-session tolerance), or after repeated ethanol exposures (chronic or between-session tolerance). To investigate whether acute and chronic tolerance to ethanol are inter...

journal_title：Psychopharmacology

authors： Wu PH,Tabakoff B,Szabó G,Hoffman PL

更新日期：2001-06-01 00:00:00

abstract：:The effects of intra-amygdala injections of corticotropin-releasing factor (CRF) on memory and exploratory behavior in rats were examined in the present study. Rats with chronically implanted cannulae received intra-amygdala injections of vehicle or CRF at a dose of 0.01, 0.1 or 1.0 micrograms, either immediately afte...

journal_title：Psychopharmacology

authors： Liang KC,Lee EH

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Dopaminergic therapy improves some cognitive functions and worsens others in patients with Parkinson's disease (PD). These paradoxical effects are explained by the dopamine overdose hypothesis, which proposes that effects of dopaminergic therapy on a cognitive function is determined by the baseline dopamine l...

journal_title：Psychopharmacology

authors： Vo A,Seergobin KN,Morrow SA,MacDonald PA

更新日期：2016-07-01 00:00:00

abstract：RATIONALE:Although the behavioral effects of systemic injection of lipopolysaccharide (LPS) have been extensively investigated, the modulation of these effects by natural environmental factors has received little attention. OBJECTIVES:The present study investigated whether or not locomotor activity reductions and the ...

journal_title：Psychopharmacology

authors： Franklin AE,Engeland CG,Kavaliers M,Ossenkopp KP

更新日期：2003-12-01 00:00:00

abstract：:The effects of eight serotonin (5-HT) receptor antagonists on the anorectic effect of d-fenfluramine (3.0 mg/kg, IP) were examined in a test of sweet mash consumption, using non-deprived male rats. d-Fenfluramine's effect was attenuated by the mixed 5-HT1/5-HT2 receptor antagonists, methiothepin and metergoline; by th...

journal_title：Psychopharmacology

authors： Neill JC,Cooper SJ

更新日期：1989-01-01 00:00:00

abstract：:Rats were trained to bar-press for intravenous infusions of morphine sulfate during 1-h daily test sessions. Rates of morphine self-administration were enhanced by lesions of the frontal cortex and hippocampus and transiently reduced by lesions of the medial forebrain bundle and medial thalamus. Dose-response studies ...

journal_title：Psychopharmacology

authors： Glick SD,Cox RD

更新日期：1978-05-31 00:00:00

abstract：RATIONALE:Considerable evidence suggests that genetic factors combine with environmental influences to impact on the development of aggressive behavior. A genetic variant that has repeatedly been reported to render individuals more sensitive to the presence of adverse experiences, including stress exposure during fetal...

journal_title：Psychopharmacology

authors： Buchmann AF,Zohsel K,Blomeyer D,Hohm E,Hohmann S,Jennen-Steinmetz C,Treutlein J,Becker K,Banaschewski T,Schmidt MH,Esser G,Brandeis D,Poustka L,Zimmermann US,Laucht M

更新日期：2014-08-01 00:00:00

abstract：:Two sets of experiments were carried out to compare the effects of fenfluramine and fluoxetine on consummatory and operant behaviour. In food-deprived rats allowed access to a 35% sucrose solution, an initial period of sucrose consumption was followed by a short period of grooming and exploratory behaviour, later supe...

journal_title：Psychopharmacology

authors： Willner P,McGuirk J,Phillips G,Muscat R

更新日期：1990-01-01 00:00:00

abstract：:A novel form of experimentally-induced conflict behavior based on the conditioned suppression of drinking (CSD) is described and compared with two conventional animal models of human anxiety--a modified Geller-Seifter and an Estes-Skinner (Conditioned Emotional Response) procedure. The CSD procedure offered significan...

journal_title：Psychopharmacology

authors： Kilts CD,Commissaris RL,Rech RH

更新日期：1981-01-01 00:00:00

abstract：:The behavioral consequences of prolonged continuous exposure to cocaine were examined in rhesus monkeys. Operant behavior was sampled for 0.5 h every 6 h, and cocaine was continuously infused through an intravenous catheter. Cocaine (4.0-32 mg/kg/day) initially caused reductions in the rate of responding for food and ...

journal_title：Psychopharmacology

authors： Woolverton WL,Kleven MS

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Effort-related motivational symptoms such as anergia and fatigue are common in patients with depression and other disorders. Research implicates pro-inflammatory cytokines in depression, and administration of cytokines can induce effort-related motivational symptoms in humans. OBJECTIVES:The present experime...

journal_title：Psychopharmacology

authors： Nunes EJ,Randall PA,Estrada A,Epling B,Hart EE,Lee CA,Baqi Y,Müller CE,Correa M,Salamone JD

更新日期：2014-02-01 00:00:00

abstract：RATIONALE:Manipulations of the endocannabinoid system could potentially produce therapeutic effects with minimal risk of adverse cannabis-like side effects. Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of the cannabinoid-receptor agonist, anandamide, and show promise for treating a wide ra...

journal_title：Psychopharmacology

authors： Panlilio LV,Thorndike EB,Nikas SP,Alapafuja SO,Bandiera T,Cravatt BF,Makriyannis A,Piomelli D,Goldberg SR,Justinova Z

更新日期：2016-05-01 00:00:00

abstract：:The conditioned place preference technique was used to assess the affective properties of the direct dopamine D1 agonist, SKF38393, and the direct D2 agonist, LY171555 (quinpirole). A three compartment apparatus was used: the animals' pre-experimental preference for the two choice compartments was equal and, within ea...

journal_title：Psychopharmacology

authors： White NM,Packard MG,Hiroi N

更新日期：1991-01-01 00:00:00