Abstract:
RATIONALE AND OBJECTIVES:Functional (pharmacodynamic) ethanol tolerance can be evidenced within a single session of exposure to ethanol (acute or within-session tolerance), or after repeated ethanol exposures (chronic or between-session tolerance). To investigate whether acute and chronic tolerance to ethanol are inter-related phenomena, the effect of chronic ethanol exposure was evaluated in mice selectively bred for high (HAFT) or low (LAFT) acute functional tolerance to an ataxic effect of ethanol, i.e., loss of balance on a stationary dowel. METHODS:Mice were tested for sensitivity (threshold ethanol concentration for loss of balance on the stationary dowel) and acute functional tolerance to ethanol before and after a regimen of chronic ethanol exposure (twice-daily ethanol injections for 6 days). RESULTS:Chronic ethanol treatment did not alter the threshold for ethanol's ataxic effect (i.e., produced no change in sensitivity). However, this treatment, in a dose-dependent manner, resulted in an increase in the magnitude and rate of development of acute functional tolerance. CONCLUSIONS:This finding supports previous postulates that chronic ethanol tolerance can be characterized by a more rapid acquisition or a greater magnitude of acute (within-session) tolerance. However, the increase in acute tolerance that occurred after chronic ethanol exposure was similar in both selected lines of mice, indicating little or no genetic correlation between acute tolerance and chronic tolerance.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Wu PH,Tabakoff B,Szabó G,Hoffman PLdoi
10.1007/s002130100722subject
Has Abstractpub_date
2001-06-01 00:00:00pages
405-12issue
4eissn
0033-3158issn
1432-2072journal_volume
155pub_type
杂志文章abstract:RATIONALE:Pramipexole is a dopamine agonist which binds selectively to dopamine D(3) and D(2) receptors. There is evidence that, in addition to its beneficial effects in parkinsonism, this compound may also be of value in addressing symptomatology associated with depressive diseases. OBJECTIVES:The present study was a...
journal_title:Psychopharmacology
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
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pub_type: 杂志文章
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更新日期:2000-03-01 00:00:00
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更新日期:2015-10-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:1976-08-26 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2005-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-01-01 00:00:00