Abstract:
:The present study was conducted to determine whether methadone maintenance alters the pharmacodynamic effects of single doses of cocaine. Twenty-two current users of IV cocaine who were not seeking treatment for their illicit cocaine use participated while living on a research unit. Eleven were maintained on methadone 50 mg PO daily as treatment for their opioid abuse; 11 were opioid abusers who were not physically dependent on opioids and who provided opioid-free urines throughout the study. Each subject received acute cocaine challenge doses of 0, 12.5, 25, and 50 mg intravenously in random order under double-blind conditions in separate test sessions. Physiologic and subject-rated responses were measured before injection and for 2 h after. In the methadone maintenance group, cocaine challenge sessions occurred 15.5 h after the daily methadone dose. There were significant differences between the methadone-dependent and nondependent groups: 1) baseline differences related to chronic methadone administration and not associated with cocaine administration (lower respiration rates and pupil diameter; higher skin temperature) and 2) differences in response to cocaine administration; cocaine-induced increases in subject ratings of Drug Effect, Rush, Good Effects, Liking, and Desire for Cocaine and in heart rate were greater in the methadone maintenance patients compared to the non-dependent group. These results indicate that the positive subjective effects and some physiological effects of cocaine are enhanced in methadone-maintained individuals, suggesting a pharmacological basis for the high rates of cocaine abuse among methadone maintenance patients.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Preston KL,Sullivan JT,Strain EC,Bigelow GEdoi
10.1007/BF02246276subject
Has Abstractpub_date
1996-01-01 00:00:00pages
15-25issue
1eissn
0033-3158issn
1432-2072journal_volume
123pub_type
临床试验,杂志文章,随机对照试验abstract::A placebo-controlled study with six normal volunteers was carried out using 1 mg haloperidol IM. In some EEG frequency bands, the power density due to haloperidol appeared to increase or decrease depending on the subject. Nevertheless, if the results of the six subjects are taken together, the effects of haloperidol a...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00431753
更新日期:1981-01-01 00:00:00
abstract::Keypecking in one group of pigeons was maintained under schedules in which food was presented only when a specified number of responses was followed by a 30-s pause without a response. d-Amphetamine and pentobarbital increased low rates of responding (and, thus, decreased food presentation) only after initial injectio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426485
更新日期:1977-07-18 00:00:00
abstract::The concurrent influence of dopaminergic, sigma and muscarinic neurotransmitter systems in mediating cocaine-induced lethality is predicted by previous receptor binding results from our laboratories. The present results demonstrate that pharmacological manipulations of these predicted neurotransmitter systems alter th...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050198
更新日期:1997-02-01 00:00:00
abstract::The release of serotonin (5-HT) at serotonergic nerve terminals is regulated by 5-HT(1B) autoreceptors. Several studies have reported that the effects of selective 5-HT reuptake inhibitors (SSRIs) on extracellular 5-HT are augmented by 5-HT(1B) receptor antagonists, whereas administration of these antagonists alone do...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1371-0
更新日期:2003-05-01 00:00:00
abstract::Physostigmine (1.0mg) or placebo were administered intravenously over 1-h period to seven male normal volunteers beginning 35 min after sleep onset. The results indicate that physostigmine induced the onset of REM sleep but did not significantly alter the duration of individual REM sleep periods. Physostigmine signifi...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00426799
更新日期:1978-06-15 00:00:00
abstract::Different benzodiazepines, when administered to fasting cats, increased both the total amount of food eaten and also the rate at which food was ingested. Moreover, when injected to foodsatiated cats, these compounds made them resume eating voraciously. Pentobarbital also stimulated food intake, but was much less poten...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428710
更新日期:1976-05-05 00:00:00
abstract::BALB/cJ, DBA/2J, and C57BL/6J mice were injected with caffeine and tested, in the five choice Yerkes-Thompson Bryant-Bovt Nitti apparatus for patterns discrimination, in two sets of experiments. In the first the patterns were opposite oriented oblique bars, in the second U-shaped figures, one opened toward the right, ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431632
更新日期:1977-03-16 00:00:00
abstract::Withdrawal was precipitated by naloxone at different intervals, up to 22.5 h, following a last maintenance injection in morphine-dependent rats. Different symptoms of withdrawal were found to be preeminent following different morphine-naloxone intervals. Locomotor activity, jumping, and writhing were precipitated most...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426773
更新日期:1977-10-20 00:00:00
abstract::We examined the effects on sucrose consumption of a dopamine (DA) D2/D3 antagonist (raclopride, 0-0.3 mg/kg), a serotonin 5-HT2/2c antagonist (ritanserin, 0-0.4 mg/kg), and raclopride (0.15 mg/kg) combined with ritanserin (0-0.4 mg/kg). Three different concentrations of sucrose solution (0.7%, 7.0% and 34%) were teste...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246286
更新日期:1996-01-01 00:00:00
abstract:RATIONALE:The use and misuse of prescription opiates in adolescent populations, and in particular, adolescent female populations, has increased dramatically in the past two decades. Given the significant role that opioids play in neuroendocrine function, exposure to opiates during this critical developmental period cou...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2960-1
更新日期:2013-05-01 00:00:00
abstract:RATIONALE:The involvement of glutamate in fear extinction is perhaps the most promising in terms of facilitating clinical interventions for posttraumatic stress disorder (PTSD). This study was aimed at elucidating the possible role of zif268 on the D-cycloserine (DCS) facilitation effect on extinction. OBJECTIVE:We in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4042-7
更新日期:2015-10-01 00:00:00
abstract:RATIONALE:The elevated plus-maze and the light/dark box are two established anxiety tests in rodents, which are useful to screen putative anxiogenic effects of drugs. OBJECTIVE:Caffeine is well known to promote anxious behaviour in humans and animal models, but the precise site of action of the drug is still a matter ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050037
更新日期:2000-02-01 00:00:00
abstract::Two putative predictors of placebo response were studied in three samples of psychiatric outpatients. Two groups, 73 university medical center patients and 56 college health service patients, underwent 1 week of placebo treatment. A quasi-control group of 112 patients receiving no medication waited about 1 week before...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00433557
更新日期:1979-06-21 00:00:00
abstract::Brain 5-hydroxytryptamine (5-HT) was depleted in rats by intraventricular injection with 5,7-dihyroxytryptamine (5,7-DHT) prior to feeding rats a liquid diet containing ethanol. After withdrawal of ethanol, withdrawal reactions were significantly less severe in 5-HT-depleted rats than control rats. Sleeping times afte...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427597
更新日期:1980-01-01 00:00:00
abstract::A continuous intravenous infusion of the opiate receptor antagonist naloxone, at doses ranging from 0.7 to 1.0 micrograms/kg/min (total dose 8.8-13.2 mg), was performed in eight normal subjects during the first 240 min of night sleep. A significant reduction in stage REM and in stage 4 percent duration was observed. P...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00429731
更新日期:1984-01-01 00:00:00
abstract::We investigated the striatal dopamine-2 (D2) receptor occupancy caused by different antipsychotic substances in 18 psychotic patients (16 with schizophrenic and two with schizoaffective disorder according to DSM-IV) with single photon emission computed tomography (SPECT) using 123I-iodobenzamide (IBZM) as tracer subst...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130050409
更新日期:1997-10-01 00:00:00
abstract::The aim of the present study was to evaluate the effects of nicotinic acetylcholine receptor (nACh-R) agonists such as (-)-nicotine and related compounds on brain monoamine turnover. A single administration of (-)-nicotine (0.04, 0.2, 1.0, and 5.0 mg/kg SC) increased both noradrenaline (NA) and dopamine (DA) turnover ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050184
更新日期:1997-02-01 00:00:00
abstract:RATIONALE:Individuals with schizophrenia have high smoking-related morbidity and mortality rates and need powerful and innovative smoking cessation interventions. OBJECTIVES:This proof-of-concept study investigated the feasibility and initial efficacy of combining a contingency management intervention with bupropion t...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2282-8
更新日期:2011-09-01 00:00:00
abstract::The effects of meperidine on operant behavioral thermoregulation were investigated using a convective thermal controller and mice trained to alternate at will the thermal-drive condition, changing it from an air flow of 15 degrees C to one of 45 degrees C, and vice versa. Administration of 15 mg/kg meperidine resulted...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00491979
更新日期:1979-09-01 00:00:00
abstract::The effects of eight serotonin (5-HT) receptor antagonists on the anorectic effect of d-fenfluramine (3.0 mg/kg, IP) were examined in a test of sweet mash consumption, using non-deprived male rats. d-Fenfluramine's effect was attenuated by the mixed 5-HT1/5-HT2 receptor antagonists, methiothepin and metergoline; by th...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00442252
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Indirect-acting serotonin (5-HT) receptor agonists can enhance the antinociceptive effects of morphine; however, the specific 5-HT receptor subtype(s) mediating this enhancement is not established. OBJECTIVE:This study examined interactions between morphine and both 5-HT(1A) and 5-HT(2A) receptor agonists in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2870-2
更新日期:2013-02-01 00:00:00
abstract:RATIONALE:Previous experiments have shown that d-amphetamine disrupts timing behaviour in rats. It has been proposed that d-amphetamine's effects reflect a reduction in the period of the pacemaker of the hypothetical internal clock. However, some studies have obtained conflicting results. OBJECTIVE:To examine the effe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000422
更新日期:2000-06-01 00:00:00
abstract::The purpose of this study was to examine the relationship between the development of tolerance to ethanol and the hypothalamic-pituitary-adrenal cortex (H-P-AC) system by modifying the H-P-AC system through the use of a synthetic glucocorticoid, dexamethasone. Also this study determined whether repeated drug administr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426602
更新日期:1977-03-23 00:00:00
abstract:RATIONALE:The circumstances of drug taking are thought to play a role in drug abuse but the evidence of it is anecdotal. Previous studies have shown that the intravenous self-administration of cocaine is facilitated in rats non-residing in the test chambers relative to rats that live in the test chambers at all times. ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1154-3
更新日期:2008-06-01 00:00:00
abstract:RATIONALE:Several halogenated analogs of benztropine (BZT) have previously been characterized as potent DA uptake inhibitors with behavioral profiles that indicate diminished psychomotor stimulant effects relative to cocaine. In a previous study using a fixed-ratio 10 schedule, two chloro-analogs (3'-Cl-BZT and 4'-Cl-B...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000616
更新日期:2001-04-01 00:00:00
abstract::This was a 4-week, three-center, double-blind, randomized, parallel, placebo-controlled evaluation of the efficacy and safety of bupropion in hospitalized depressed patients. Results from 27 placebo and 48 bupropion-treated patients were analyzed for efficacy and safety. Assessments of efficacy and safety were made at...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00433415
更新日期:1983-01-01 00:00:00
abstract::The effects of dopamine agonists on self-stimulation are a matter of considerable dispute. Apomorphine has variously been reported to inhibit, have no effect on, or to facilitate lever-press self-stimulation. To investigate the possibility that these discrepancies may reflect peculiarities of the lever-press test situ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433261
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:Nicotine can enhance attentional performance in humans, a property that may be of therapeutic utility. OBJECTIVES:To identify brain sites mediating nicotine-induced attentional enhancement. METHODS:Nicotine (0, 1, 2, 4 and 8 microg) was injected bilaterally into the dorsal hippocampus and the prelimbic area...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1438-6
更新日期:2003-07-01 00:00:00
abstract::7-Hydroxychlorpromazine (7-OHCPZ) has been identified and quantified in CSF from chlorpromazine (CPZ)-treated schizophrenic patients. The level of the metabolite in CSF was similar to that of CPZ. In serum the amount of 7-OHCPZ was about 30% of CPZ. The concentration of 7-OHCPZ in csf was positively and significantly ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432774
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:Buprenorphine is a low-efficacy mu opioid agonist that can reduce drug taking in opioid abusers; however, the mechanism by which buprenorphine modifies the actions of other drug taking and the consequences of repeated treatment with buprenorphine are not fully understood. OBJECTIVE:The purposes of this study...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-001-0943-8
更新日期:2002-03-01 00:00:00