Fear-dependent variations in continuous avoidance behavior of pigs. I. Lack of effect of diazepam on performance of discriminative fear conditioning.

abstract：:The novel dopamine autoreceptor antagonists (-)-DS 121 and (+)-UH 232 were tested for their ability to alter cocaine self-administration behavior in rats reinforced on a progressive ratio (PR) schedule. (-)-DS 121 (15 mg/kg) and (+)-UH 232 (30 mg/kg) produced significant decreases in breaking point. (-)-DS 121 produce...

journal_title：Psychopharmacology

authors： Smith A,Piercey M,Roberts DC

更新日期：1995-07-01 00:00:00

abstract：RATIONALE:Neuromedin-U (NmU) is an agonist at NMU1R and NMU2R. The brain distribution of NmU and its receptors, in particular NMU2R, suggests widespread central roles for NmU. In agreement, centrally administered NmU affects feeding behaviour, energy expenditure and pituitary output. Further central nervous system (CNS...

journal_title：Psychopharmacology

authors： Gartlon J,Szekeres P,Pullen M,Sarau HM,Aiyar N,Shabon U,Michalovich D,Steplewski K,Ellis C,Elshourbagy N,Duxon M,Ashmeade TE,Harrison DC,Murdock P,Wilson S,Ennaceur A,Atkins A,Heidbreder C,Hagan JJ,Hunter AJ,Jones

更新日期：2004-12-01 00:00:00

abstract：RATIONALE:Schizophrenia is a disorder with cognitive deficits that could stem from cholinergic dysfunction. OBJECTIVES:Our aim was to examine if donepezil administered to stable, medicated outpatients with schizophrenia improves cognition and psychopathology. METHODS:We conducted a double-blind placebo-controlled tri...

journal_title：Psychopharmacology

authors： Freudenreich O,Herz L,Deckersbach T,Evins AE,Henderson DC,Cather C,Goff DC

更新日期：2005-09-01 00:00:00

abstract：:The effects of clozapine (CLOZ) upon acquired schedule-induced polydipsia in rats were compared to the effects of the dopamine (DA) D1 antagonist SCH 23390 (SCH) and the DA D2 antagonist raclopride (RAC). All three compounds suppressed water consumption, but only SCH and RAC decreased drinking efficiency. SCH was the ...

journal_title：Psychopharmacology

authors： Didriksen M,Olsen GM,Christensen AV

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Ketamine, a well-known general dissociative anesthetic agent that is a non-competitive antagonist of the N-methyl-D-aspartate receptor, perturbs the perception of elapsed time and the expectation of upcoming events. OBJECTIVE:The objective of this study was to determine the influence of ketamine on temporal ...

journal_title：Psychopharmacology

authors： Brulé S,Herlin B,Pouget P,Missal M

更新日期：2021-02-01 00:00:00

abstract：:Intracerebroventricular injections of gamma-aminobutyric acid (GABA) and of the GABA-transaminase inhibitor, ethanolamine-O-sulphate (EOS), decreased the food intake of freely-fed (GABA and EOS) and food-deprived rats (EOS). The effect, still evident 24 h after treatment, was not decreased by the GABA receptor-blocker...

journal_title：Psychopharmacology

authors： Olgiati VR,Netti C,Guidobono F,Pecile A

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Typical neuroleptic medications are still administered to as many as 40% of patients receiving antipsychotic treatment in the US. Intermittent administration or interruption of long-term neuroleptic medication for schizophrenia may increase the incidence of human tardive dyskinesias, and similarly may produce...

journal_title：Psychopharmacology

authors： Linn GS,Lifshitz K,O'Keeffe RT,Lee K,Camp-Lifshitz J

更新日期：2001-01-01 00:00:00

abstract：:Intact male and ovariectomized female rats were trained to lever press under a random ratio (RR) schedule of food reinforcement. Effects of different doses of pentobarbital (1-16 mg/kg) and progesterone (10-80 mg/kg) on response output were studied. Low doses of pentobarbital increased responding, high doses decreased...

journal_title：Psychopharmacology

authors： Heinsbroek RP,van Haaren F,Zantvoord F,van de Poll NE

更新日期：1987-01-01 00:00:00

abstract：:This study examined the possibility that amphetamine-induced stereotypy and facilitation of memory consolidation are both mediated by amphetamine's stimulation of dopaminergic activity in the caudate nucleus. In the first experiment, rats were given pairings of a tone and a shock followed by SC amphetamine (2 mg/kg). ...

journal_title：Psychopharmacology

authors： Carr GD,White NM

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Methylphenidate is a psychostimulant given for extended periods of time as a treatment of attention-deficit/hyperactivity disorder (ADHD). The long-term effects of the drug are not yet known, and it is speculated that repeated exposure may produce drug dependence. OBJECTIVE:To investigate the effects of repe...

journal_title：Psychopharmacology

authors： dela Peña I,Yoon SY,Lee JC,dela Peña JB,Sohn AR,Ryu JH,Shin CY,Cheong JH

更新日期：2012-05-01 00:00:00

abstract：:In the present study we have investigated the effects of diazepam (DZP) (10 mg/kg) treatment of rat dams during different periods of gestation or during lactation on the development and behavior of their offspring. The results show that DZP exposure during different phases of early development has differing effects on...

journal_title：Psychopharmacology

authors： Frieder B,Epstein S,Grimm VE

更新日期：1984-01-01 00:00:00

abstract：:Corticotropin releasing factor (CRF), a neuropeptide secreted by hypothalamic and extrahypothalamic neurons, is thought to mediate stress-related behaviors. The tension reduction hypothesis suggests that ethanol drinking reduces stress; that drinking is reinforced by this reduced stress; and that the probability of dr...

journal_title：Psychopharmacology

authors： Bell SM,Reynolds JG,Thiele TE,Gan J,Figlewicz DP,Woods SC

更新日期：1998-09-01 00:00:00

abstract：:Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component tha...

journal_title：Psychopharmacology

authors： Ellinwood EH Jr,Linnoila M,Easler ME,Molter DW

更新日期：1983-01-01 00:00:00

abstract：:Two sets of experiments were carried out to compare the effects of fenfluramine and fluoxetine on consummatory and operant behaviour. In food-deprived rats allowed access to a 35% sucrose solution, an initial period of sucrose consumption was followed by a short period of grooming and exploratory behaviour, later supe...

journal_title：Psychopharmacology

authors： Willner P,McGuirk J,Phillips G,Muscat R

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Medication and illicit drugs can have detrimental side effects which impair driving performance. A drug's impairing potential should be determined by well-validated, reliable, and sensitive tests and ideally be calibrated by benchmark drugs and doses. To date, no consensus has been reached on the issue of whi...

journal_title：Psychopharmacology

authors： Jongen S,Vuurman E,Ramaekers J,Vermeeren A

更新日期：2014-06-01 00:00:00

abstract：:In the forced swimming-induced immobility (despair) test model, adenosine, and 2-chloroadenosine treatment prolonged the immobilization period in mice. Dipyridamole, which is known to inhibit adenosine uptake, potentiated the adenosine effect. The purinoceptor antagonists caffeine and theophylline blocked purine nucle...

journal_title：Psychopharmacology

authors： Kulkarni SK,Mehta AK

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Repeated administration of psychoactive drugs results in a progressive enhancement of the behavioral effects of these compounds, a phenomenon termed sensitization. OBJECTIVE:We tested whether repeated administration of the non-competitive NMDA receptor antagonist dizocilpine (MK-801) induces sensitization of...

journal_title：Psychopharmacology

authors： Schulz B,Fendt M,Pedersen V,Koch M

更新日期：2001-07-01 00:00:00

abstract：RATIONALE:Genetically determined differences in susceptibility to drug-induced sensitization could be related to risk for drug consumption. OBJECTIVES:Studies were performed to determine whether selective breeding could be used to create lines of mice with different magnitudes of locomotor sensitization to methampheta...

journal_title：Psychopharmacology

authors： Scibelli AC,McKinnon CS,Reed C,Burkhart-Kasch S,Li N,Baba H,Wheeler JM,Phillips TJ

更新日期：2011-04-01 00:00:00

abstract：RATIONALE:Toluene exposure during brain growth spurt has been shown to elevate the seizure susceptibility induced by N-methyl-D: -aspartate (NMDA). In the present study, behavioral responses to NMDA antagonists were studied to determine whether neonatal toluene exposure produces residual deficits in the NMDA glutamater...

journal_title：Psychopharmacology

authors： Chien TH,Chan MH,Tang YC,Chen HH

更新日期：2005-11-01 00:00:00

abstract：RATIONALE:Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) are gut derived hormones. GLP-1 and GLP-2 were shown to have pleiotropic effects in intestinal and pancreatic diseases. OBJECTIVE:We aimed to investigate the activities of GLP-1 and GLP-2 on nociception and inflammation in mice, involving th...

journal_title：Psychopharmacology

authors： Aykan DA,Kesim M,Ayan B,Kurt A

更新日期：2019-06-01 00:00:00

abstract：RATIONALE:Hypersignaling of corticotropin releasing factor (CRF) has been implicated in stress disorders; however, many of its downstream mechanisms of action remain unclear. In vitro, CRF1 receptor activation initiates multiple cell signaling cascades, including protein kinase A (PKA), protein kinase C (PKC), and mito...

journal_title：Psychopharmacology

authors： Toth M,Gresack JE,Hauger RL,Halberstadt AL,Risbrough VB

更新日期：2013-10-01 00:00:00

abstract：RATIONALE:Opioid use disorder (OUD) is a major epidemic in the USA. Despite evidence indicating that OUD may be particularly severe for women, preclinical models have yet to establish sex as a major factor in OUD. OBJECTIVES:Here, we examined sex differences in vulnerability to relapse following intermittent access fe...

journal_title：Psychopharmacology

authors： Bakhti-Suroosh A,Towers EB,Lynch WJ

更新日期：2021-01-06 00:00:00

abstract：RATIONALE:Oleoyl glycine (OlGly), a recently discovered fatty acid amide that is structurally similar to N- acylethanolamines, which include the endocannabinoid, anandamide (AEA), as well as endogenous peroxisome proliferator-activated receptor alpha (PPARα) agonists oleoylethanolamide (OEA) and palmitoylethanolamide (...

journal_title：Psychopharmacology

authors： Petrie GN,Wills KL,Piscitelli F,Smoum R,Limebeer CL,Rock EM,Humphrey AE,Sheppard-Perkins M,Lichtman AH,Mechoulam R,Di Marzo V,Parker LA

更新日期：2019-09-01 00:00:00

abstract：RATIONALE:Effort-related motivational symptoms such as anergia and fatigue are common in patients with depression and other disorders. Research implicates pro-inflammatory cytokines in depression, and administration of cytokines can induce effort-related motivational symptoms in humans. OBJECTIVES:The present experime...

journal_title：Psychopharmacology

authors： Nunes EJ,Randall PA,Estrada A,Epling B,Hart EE,Lee CA,Baqi Y,Müller CE,Correa M,Salamone JD

更新日期：2014-02-01 00:00:00

abstract：RATIONALE:Human behavioral pharmacology studies can examine how medications that target different neurotransmitter systems influence different aspects of smoking. Naltrexone and bupropion have been shown to alter ad lib smoking behavior; however, medication effects on nicotine reward in a cigarette choice paradigm have...

journal_title：Psychopharmacology

authors： Rukstalis M,Jepson C,Strasser A,Lynch KG,Perkins K,Patterson F,Lerman C

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:Electronic cigarettes (ECs) are becoming popular alternatives for smokers, but there has been limited study of their abuse liability. OBJECTIVES:The objective of this study was to evaluate the abuse liability of three Vuse Solo ECs, ranging from 14 to 36 mg in nicotine content, relative to high- and low-abus...

journal_title：Psychopharmacology

authors： Stiles MF,Campbell LR,Graff DW,Jones BA,Fant RV,Henningfield JE

更新日期：2017-09-01 00:00:00

abstract：RATIONALE:Over the last decade, many new psychostimulant analogues have appeared on the recreational drug market and most are derivatives of amphetamine or cathinone. Another class of designer drugs is derived from the 2-aminoindan structural template. Several members of this class, including the parent compound 2-amin...

journal_title：Psychopharmacology

authors： Halberstadt AL,Brandt SD,Walther D,Baumann MH

更新日期：2019-03-01 00:00:00

abstract：RATIONALE:N-methyl-D-aspartate (NMDA) receptor antagonists (e.g., PCP, ketamine) have been shown to impair learning/memory. Well documented in animal models, only limited research in humans has been reported. Findings to date are similar to results of animal studies; however, antagonists are typically administered befo...

journal_title：Psychopharmacology

authors： LaPorte DJ,Blaxton TA,Michaelidis T,Robertson DU,Weiler MA,Tamminga CA,Lahti AC

更新日期：2005-07-01 00:00:00

abstract：:The effects of lormetazepam (0.03 mg/kg IV) a benzodiazepine (BZ) derivative in combination with ZK 93 426 (0.04 mg/kg IV) a beta-carboline, benzodiazepine receptor antagonist were evaluated in humans. Independently, the effects of ZK 93 426 on its own were investigated. A psychometric test battery to evaluate sedatio...

journal_title：Psychopharmacology

authors： Duka T,Goerke D,Dorow R,Höller L,Fichte K

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters the effects of alcohol on psychomotor performance. OBJECTIVES:To test wh...

journal_title：Psychopharmacology

authors： Wright A,Terry P

更新日期：2002-03-01 00:00:00