Abstract:
RATIONALE:Schizophrenia is a disorder with cognitive deficits that could stem from cholinergic dysfunction. OBJECTIVES:Our aim was to examine if donepezil administered to stable, medicated outpatients with schizophrenia improves cognition and psychopathology. METHODS:We conducted a double-blind placebo-controlled trial of donepezil up to 10 mg/day added for 8 weeks to ongoing antipsychotic treatment in 36 typical community-treated schizophrenia patients not selected for cognitive impairment. RESULTS:Donepezil did not improve measures of cognition or psychopathology. It was well tolerated. CONCLUSION:Consistent with other studies, addition of donepezil to stable patients with schizophrenia did not improve cognition or measures of psychopathology. This result does not support the hypothesis that residual symptoms and cognitive problems result from a cholinergic deficit that can be remedied by an acetylcholinesterase inhibitor. A donepezil add-on strategy might make sense in selected schizophrenia cases where a pathological process is known to affect cholinergic neurons (e.g., history of head injury or comorbid dementia).
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Freudenreich O,Herz L,Deckersbach T,Evins AE,Henderson DC,Cather C,Goff DCdoi
10.1007/s00213-005-2235-1subject
Has Abstractpub_date
2005-09-01 00:00:00pages
358-63issue
2eissn
0033-3158issn
1432-2072journal_volume
181pub_type
杂志文章,随机对照试验abstract::The place-preference paradigm was evaluated as a measure of morphine's positive reinforcing properties. Previous place-preference studies obtained a morphine place preference of 26%-63%. In order to examine whether differences in procedure may account for this scatter, the present experiment investigated whether there...
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychopharmacology
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