Abstract:
RATIONALE:Toluene exposure during brain growth spurt has been shown to elevate the seizure susceptibility induced by N-methyl-D: -aspartate (NMDA). In the present study, behavioral responses to NMDA antagonists were studied to determine whether neonatal toluene exposure produces residual deficits in the NMDA glutamatergic system controlling behaviors. We also investigated if the effect of toluene exposure depends strongly on the developmental stage. OBJECTIVES:The long-term effects of neonatal and adolescent toluene exposure on MK-801 and/or ketamine-induced hyperlocomotor activity, motor coordination, hypnotic response, and cognitive deficits in early adulthood were compared. METHODS:Sprague-Dawley male rats were treated with toluene (500 mg/kg i.p.) daily over postnatal day (PN) 4-9 or 25-30. Locomotor activity was analyzed in a computerized open-field system, motor coordination was measured by rotarod, hypnotic response was tested by loss of righting reflex, and long-term memory was assessed with the inhibitory avoidance learning task during PN 56-60. RESULTS:Toluene exposure during brain growth spurt reduced behavioral responses including locomotor activity, motor incoordination, and hypnosis to MK-801 and/or ketamine, while leaving cognitive deficits in inhibitory avoidance learning tasks unaffected. No significant change in behavioral responses to NMDA antagonists was observed following adolescent toluene exposure. CONCLUSION:These results indicate that neonatal but not adolescent toluene exposure produces long-term effects on selective behaviors induced by NMDA antagonists. Theses findings further support the hypothesis that functional changes in NMDA receptors may be related to the neurobehavioral dysfunction associated with fetal solvent syndrome.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Chien TH,Chan MH,Tang YC,Chen HHdoi
10.1007/s00213-005-0137-xsubject
Has Abstractpub_date
2005-11-01 00:00:00pages
468-74issue
4eissn
0033-3158issn
1432-2072journal_volume
182pub_type
杂志文章abstract:BACKGROUND:Opioid neurotransmission mediates hedonic value of sweet tastants; their intake may be exaggerated by the consumption of exogenous opioids (e.g., opioid dependence). Sweet Taste Test (STT) is a validated quantitative instrument assessing taste perception and hedonic features of sugar (sucrose) using a random...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2503-1
更新日期:2012-04-01 00:00:00
abstract::Nine VA Medical Centers are participating in a 2-year double-blind placebo controlled study of antioxidant treatment for tardive dyskinesia (TD) conducted by the Department of Veteran Affairs Cooperative Studies Program. One of the principal outcome measures of this study is the score derived from the instrumental ass...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s002130050320
更新日期:1997-07-01 00:00:00
abstract::Animal experimental studies suggest that the therapeutic effect of selective serotonin re-uptake inhibitors (SSRIs) may involve neuroadaptive changes in pre- and post-synaptic serotonin1A (5-HT1A) receptors. We used the endocrine and hypothermic responses to the 5-HT1A receptor agonist, gepirone (20 mg orally), to ass...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050348
更新日期:1997-08-01 00:00:00
abstract::Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate 5 mg/kg phenytoin from saline injections. When 1.25-20 mg/kg doses of phenytoin were substituted for the training dose, the percentage of responses directed to the phenytoin-appropriate key varied directly with dose. Chlor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433021
更新日期:1983-01-01 00:00:00
abstract::This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), as well as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) the elevated plus-maze test in rats. In add...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245224
更新日期:1994-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427969
更新日期:1983-01-01 00:00:00
abstract::Cortical and hippocampal EEGs in animal models of schizophrenia were compared to those obtained with psychotomimetics or antipsychotic agents by utilizing power spectral analysis. Models of positive schizophrenic symptoms were created with methamphetamine (MAP) and cocaine, and a model of both negative and positive sy...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050306
更新日期:1997-06-01 00:00:00
abstract:RATIONALE:The elevated plus-maze and the light/dark box are two established anxiety tests in rodents, which are useful to screen putative anxiogenic effects of drugs. OBJECTIVE:Caffeine is well known to promote anxious behaviour in humans and animal models, but the precise site of action of the drug is still a matter ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050037
更新日期:2000-02-01 00:00:00
abstract:RATIONALE:The touchscreen continuous trial-unique non-matching-to-location task (cTUNL) has been developed to optimise a battery of tasks under NEWMEDS (Novel Methods leading to New Medication in Depression and Schizophrenia, http://www.newmeds-europe.com ). It offers novel task features of both a practical and a theor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4019-6
更新日期:2015-11-01 00:00:00
abstract:RATIONALE:Diazepam, a benzodiazepine with a relatively rapid onset of clinical effects, has been associated with suicide and other self-aggressive acts. The evidence for this association, however, comes exclusively from retrospective non-experimental studies. Although suggestive, the results of these studies do not sup...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-004-1966-8
更新日期:2005-02-01 00:00:00
abstract:RATIONALE:To date, the literature on the intravenous self-administration of cocaine by laboratory animals lacks a compelling demonstration of an ascending limb to the dose-response function. It has been argued that previous demonstrations of an ascending limb are confounded by the extinction process. OBJECTIVE:The obj...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1336-3
更新日期:2003-02-01 00:00:00
abstract::Key-press responding of mice was maintained under a fixed-ratio (FR) 30-response schedule of food presentation. Successive 3-min periods during which the experimental chamber was illuminated and the schedule was in effect were preceded by 10-min time-out (TO) periods during which all lights were out and responses had ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00177563
更新日期:1988-01-01 00:00:00
abstract::Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-depend...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427798
更新日期:1983-01-01 00:00:00
abstract::Forskolin, a diterpene isolated from the plant Coleus forskolii, activates the catalytic subunit of adenylate cyclase, resulting in a hormone receptor-independent increase in the intracellular production of cyclic AMP. This study was undertaken to assess the effect of chronic in vivo infusion of forskolin on noradrene...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432514
更新日期:1985-01-01 00:00:00
abstract::N-Methyl-D-aspartate (NMDA) antagonists induce psychotomimetic effects in humans that closely resemble negative and cognitive symptoms of schizophrenia. NMDA agonists, in contrast, may significantly ameliorate such symptoms. In rodents, phencyclidine (PCP) and other NMDA antagonists induce a hyperlocomotory syndrome t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050168
更新日期:1997-01-01 00:00:00
abstract::The behavioural effects of selective mu-, kappa- and delta-opioid agonists in 5-, 10- and 20-day-old rats were investigated by observational analysis. The predominant response to mu-agonists was behavioural depression. High doses (10 mg/kg IP) of morphine and DAGO (D-Ala2, NMe-Phe4, Glyol5-enkephalin) produced overt s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439459
更新日期:1989-01-01 00:00:00
abstract::A group of 14 schizophrenics who remained symptomatic after neuroleptic treatment received either 0.02 mcg/kg CCK-8 or saline placebo intravenously. Thereafter, 13 received the alternative infusion as a crossover treatment. A second group of 16 such patients received 0.04 mcg/kg CCK-8 or saline intravenously and, ther...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00690931
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:Compared to men, the smoking behavior of women may be less responsive to nicotine and more responsive to nonpharmacological factors, perhaps including verbal information (e.g., dose instructions). OBJECTIVE:This study compared the influence of the presence vs absence of dose instructions on the subjective an...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0103-7
更新日期:2006-03-01 00:00:00
abstract:RATIONALE:Attention-deficit/hyperactivity disorder (ADHD) is thought to involve hypofunctional catecholamine systems in the striatum, nucleus accumbens, and prefrontal cortex (PFC); however, recent clinical evidence has implicated glutamate dysfunction in the pathophysiology of ADHD. Recent studies show that increased ...
journal_title:Psychopharmacology
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更新日期:2014-08-01 00:00:00
abstract:RATIONALE:Little is known about patterns of opiate use by heroin addicts. OBJECTIVES:To describe opiate use over time among heroin addicts who had access to legally prescribed intravenous heroin and oral opiates. METHODS:Analysis of daily drug administration records of 37 patients enrolled in the Geneva heroin mainte...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02431537
更新日期:1988-01-01 00:00:00
abstract::The development of a differential tolerance to morphine was investigated with respect to the mean effective dose, the threshold dose of tolerance, the degree of tolerance after a fixed dose, and the speed of tolerance loss. The mean effective doses, the threshold doses of tolerance, and the degree of tolerance differe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428157
更新日期:1982-01-01 00:00:00
abstract::In order to study the role of dopamine (DA) in the regulation of seizure mechanisms in man, a non-emetic dose of apomorphine, a direct stimulant of DA receptors, was administered to eight patients effected by different types of epilepsy. The EEG changes induced by apomorphine administration in comparison to those elic...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427814
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:Environmental context has been shown to influence responding under multiple schedules of food reinforcement and to modify the behavioral effects of drugs. However, no systematic study has been conducted under conditions of cocaine self-administration. The hypothesis was that changes in the magnitude of food r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1202-3
更新日期:2002-10-01 00:00:00
abstract:RATIONALE:Psychomotor stimulants can induce psychotic states in humans that closely resemble those observed in patients with idiopathic schizophrenia. Attentional and sensorimotor gating impairments are observed in schizophrenic patients using the latent inhibition (LI) and prepulse inhibition (PPI) behavioral assays, ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1254-4
更新日期:2003-09-01 00:00:00
abstract::Patients taking lithium often report difficulties in concentration, memory, learning, and attention and many of these complaints are verified on psychometric testing. Laboratory tests of cognitive functions in healthy volunteers on chronic lithium demonstrate that disruptions in memory-learning processes are apparent ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427911
更新日期:1985-01-01 00:00:00
abstract::Rats chronically treated with increasing daily doses of delta 9-tetrahydrocannabinol (delta 9-THC) for up to 5 or 10 days exhibit a withdrawal-like behavioural response when challenged with clomipramine, a potent inhibitor of serotonin (5-hydroxytryptamine) reuptake, at the time when the next injection of delta 9-THC ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431112
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the relationship between zolpidem use and the risk of acute pancreatitis in Taiwan. METHODS:In this population-based case-control study using the database from the Taiwan National Health Insurance Program from 2000 to 2011, we selected 4535 subjects aged 20-84 years ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3833-6
更新日期:2015-06-01 00:00:00
abstract::Psychopharmacological studies using caffeinated beverages or caffeine have rarely considered temporal effects on psychological and physiological function or the specific contribution of caffeine, hot water, or beverage type to the observed effects. The effect of 400 ml hot tea, coffee, and water consumption on systoli...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130050438
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:The serotonin (5-HT) deficiency hypothesis of aggression is being seriously challenged by pharmacological data showing robust anti-aggressive effects of 5-HT1A receptor agonists in dose ranges that concomitantly inhibit 5-HT neurotransmission. Hence, an adequate interpretation of the role of 5-HT activity in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4173-x
更新日期:2016-03-01 00:00:00