Sedative and electroencephalographic actions of erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA): relationship to inhibition of brain adenosine deaminase.

Abstract:

:Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-dependent manner. Nonetheless, a marked reduction in electroencephalographically defined sleep was observed in rats during a period when both spontaneous motor activity and ADA activity were profoundly inhibited. These data suggest that EHNA produces in rats a state of 'quiescent waking', which may be related to the observed inhibition of brain ADA activity.

journal_title

Psychopharmacology

authors

Mendelson WB,Kuruvilla A,Watlington T,Goehl K,Paul SM,Skolnick P

doi

10.1007/BF00427798

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

126-9

issue

2-3

eissn

0033-3158

issn

1432-2072

journal_volume

79

pub_type

杂志文章
  • Acute effects of a short bout of moderate versus light intensity exercise versus inactivity on tobacco withdrawal symptoms in sedentary smokers.

    abstract:RATIONALE:A previous study found that a 10-min bout of moderate intensity exercise reduced cigarette withdrawal symptoms and desire to smoke in sedentary smokers but the effect may have been due to participants focusing attention on physical activity rather than the activity itself. OBJECTIVES:This study examined the ...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00213-003-1762-x

    authors: Daniel J,Cropley M,Ussher M,West R

    更新日期:2004-07-01 00:00:00

  • A novel acetylcholinesterase inhibitor and calcium channel blocker SCR-1693 improves Aβ25-35-impaired mouse cognitive function.

    abstract:RATIONALE:The mechanism involved in AD is complex, which has prompted to develop compounds that could simultaneously interact with several potential targets. Here, we report a new synthesized compound SCR-1693 which is designed to target both AChE and calcium channels that are potential for AD therapy. OBJECTIVES:We i...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-015-4133-5

    authors: Zhang Z,Chen R,An W,Wang C,Liao G,Dong X,Bi A,Yin Z,Luo L

    更新日期:2016-02-01 00:00:00

  • Imbalance of a serotonergic system in frontotemporal dementia: implication for pharmacotherapy.

    abstract:RATIONALE:Information is sparse on neurotransmitter deficiencies in frontotemporal dementia (FTD), in particular with reference to distinct histological subgroups and Alzheimer's disease (AD). OBJECTIVES:To evaluate in FTD with the major histologies, and compare with AD and controls, neurotransmission indices, as thes...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-007-0992-8

    authors: Bowen DM,Procter AW,Mann DM,Snowden JS,Esiri MM,Neary D,Francis PT

    更新日期:2008-03-01 00:00:00

  • Differences in the effects of d-fenfluramine and morphine on various responses of rats to painful stimuli.

    abstract::The effects of d-fenfluramine and morphine on various nociceptive responses of rats were investigated. Unlike morphine, which inhibited all the responses examined, d-fenfluramine inhibited jumping and paw licking of rats on a hot plate, but did not increase the latency of tail withdrawal from hot water. The effects of...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00435276

    authors: Rochat C,Cervo L,Romandini S,Samanin R

    更新日期:1982-01-01 00:00:00

  • Abnormal response to methylphenidate across multiple fMRI procedures in cocaine use disorder: feasibility study.

    abstract:RATIONALE:The indirect dopamine agonist methylphenidate remediates cognitive deficits in psychopathology, but the individual characteristics that determine its effects on the brain are not known. OBJECTIVES:We aimed to determine whether targeted dopaminergically modulated traits and individual differences could predic...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-016-4307-9

    authors: Moeller SJ,Konova AB,Tomasi D,Parvaz MA,Goldstein RZ

    更新日期:2016-07-01 00:00:00

  • Brain catecholamines modifications. The effects on memory facilitation induced by oxotremorine in mice.

    abstract::the immediate posttrial injection of oxotremorine (0.250 mu Mol/kg, IP) can facilitate the retention of a passive-avoidance response in mice. After the administration of alfa-methyl-p-tyrosine methylester (alpha-MPT) by intracerebroventricular injection at doses that had no effect on retention (100 microgram, 10 micro...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00433098

    authors: Huygens P,Baratti CM,Gardella JL,Filinger E

    更新日期:1980-01-01 00:00:00

  • Guanfacine modulates the influence of emotional cues on prefrontal cortex activation for cognitive control.

    abstract:RATIONALE:Functional interactions between limbic regions that process emotions and frontal networks that guide response functions provide a substrate for emotional cues to influence behavior. Stimulation of postsynaptic α₂ adrenoceptors enhances the function of prefrontal regions in these networks. However, the impact ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-012-2893-8

    authors: Schulz KP,Clerkin SM,Fan J,Halperin JM,Newcorn JH

    更新日期:2013-03-01 00:00:00

  • Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment.

    abstract:RATIONALE:A rigorously investigated model of stress and antidepressant administration during pregnancy is needed to evaluate possible effects on the mother. OBJECTIVE:The objective of this study was to develop a model of clinically relevant prenatal exposure to an antidepressant and stress during pregnancy to evaluate...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-013-3030-z

    authors: Bourke CH,Capello CF,Rogers SM,Yu ML,Boss-Williams KA,Weiss JM,Stowe ZN,Owens MJ

    更新日期:2013-07-01 00:00:00

  • Characterisation of olanzapine-induced weight gain and effect of aripiprazole vs olanzapine on body weight and prolactin secretion in female rats.

    abstract:RATIONALE:Atypical antipsychotic drug (APD)-induced weight gain causes non-compliance, increasing the risk of relapse and medical complications. OBJECTIVES:In an animal model, we assessed body weights, food intake, body fat/lean body mass contents and blood serum levels of glucose and lipids in female rats treated wit...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-005-0081-9

    authors: Kalinichev M,Rourke C,Daniels AJ,Grizzle MK,Britt CS,Ignar DM,Jones DN

    更新日期:2005-10-01 00:00:00

  • Effects of buprenorphine versus buprenorphine/naloxone tablets in non-dependent opioid abusers.

    abstract:RATIONALE:Buprenorphine is an opioid agonist-antagonist under development in the United States as a sublingual medication for treatment of opioid dependence. Buprenorphine may be abused; therefore, tablets combining buprenorphine with naloxone have been developed with the intent of reducing the abuse risk in people phy...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s002130050066

    authors: Strain EC,Stoller K,Walsh SL,Bigelow GE

    更新日期:2000-03-01 00:00:00

  • A randomized controlled trial of ganaxolone in posttraumatic stress disorder.

    abstract::Preclinical and clinical research supports a role for neuroactive steroids in the pathophysiology of posttraumatic stress disorder (PTSD). We investigated ganaxolone (a synthetic 3β-methylated derivative of allopregnanolone, a GABAergic neuroactive steroid) for treatment of PTSD in a proof-of-concept, multisite, doubl...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00213-017-4649-y

    authors: Rasmusson AM,Marx CE,Jain S,Farfel GM,Tsai J,Sun X,Geracioti TD,Hamner MB,Lohr J,Rosse R,Summerall L,Naylor JC,Cusin C,Lang AJ,Raman R,Stein MB

    更新日期:2017-08-01 00:00:00

  • Risk-seeking for losses is associated with 5-HTTLPR, but not with transient changes in 5-HT levels.

    abstract:RATIONALE:Serotonin (5-HT) plays a key role in different aspects of value-based decision-making. A recent framework proposed that tonic 5-HT (together with dopamine, DA) codes future average reward expectations, providing a baseline against which possible choice outcomes are compared to guide decision-making. OBJECTIV...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-018-4913-9

    authors: Neukam PT,Kroemer NB,Deza Araujo YI,Hellrung L,Pooseh S,Rietschel M,Witt SH,Schwarzenbolz U,Henle T,Smolka MN

    更新日期:2018-07-01 00:00:00

  • Co-modulation of an allosteric modulator of nicotinic receptor-cholinesterase inhibitor (galantamine) and a 5-HT4 receptor agonist (RS-67333): effect on scopolamine-induced memory deficit in the mouse.

    abstract:AIM:It is widely assumed that the upcoming therapeutics for Alzheimer's disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase inhibitor galantamine can act synergistically with the type 4 serotonin re...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-017-4664-z

    authors: Freret T,Lelong-Boulouard V,Lecouflet P,Hamidouche K,Dauphin F,Boulouard M

    更新日期:2017-08-01 00:00:00

  • Efficacy and safety of quetiapine extended release monotherapy in bipolar depression: a multi-center, randomized, double-blind, placebo-controlled trial.

    abstract:RATIONALE:Quetiapine extended release (XR) has been used to treat various psychiatric disorders, including depressive episodes associated with bipolar I and II disorders. Quetiapine XR is the first approved drug in China for the treatment of bipolar disorder. OBJECTIVES:The study evaluated the efficacy and safety of s...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00213-016-4215-z

    authors: Li H,Gu N,Zhang H,Wang G,Tan Q,Yang F,Ning Y,Zhang H,Lu Z,Xu X,Shi J,Gao C,Li L,Zhang K,Tian H,Wang X,Li K,Li H,Xu Y,Xie S,Yu X

    更新日期:2016-04-01 00:00:00

  • Ovarian steroids modify the behavioral and neurochemical responses of the central benzodiazepine receptor.

    abstract::The effect of ovarian steroids on the benzodiazepine receptor was assessed in the elevated plus-maze and, after restraint stress, in benzodiazepine receptor binding assays. Vehicle-treated proestrous rats displayed anxiolytic behavior, relative to diestrus or estrous rats. Anxiolytic behavior was observed after 1 or 2...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02247394

    authors: Bitran D,Dowd JA

    更新日期:1996-05-01 00:00:00

  • Sex difference in the association of body mass index and BDNF levels in Chinese patients with chronic schizophrenia.

    abstract:RATIONALE AND OBJECTIVE:Schizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex difference...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-018-5107-1

    authors: Yang F,Wang K,Du X,Deng H,Wu HE,Yin G,Ning Y,Huang X,Teixeira AL,de Quevedo J,Soares JC,Li X,Lang X,Zhang XY

    更新日期:2019-02-01 00:00:00

  • Caffeine withdrawal, acute effects, tolerance, and absence of net beneficial effects of chronic administration: cerebral blood flow velocity, quantitative EEG, and subjective effects.

    abstract:RATIONALE:Although the subjective effects of caffeine abstinence, acute and chronic administration, and tolerance are well described, the corresponding neurophysiological effects are not. OBJECTIVES:Caffeine withdrawal, acute caffeine effects, caffeine tolerance, and net beneficial effects of chronic caffeine administ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-009-1489-4

    authors: Sigmon SC,Herning RI,Better W,Cadet JL,Griffiths RR

    更新日期:2009-07-01 00:00:00

  • Responsiveness to cocaine challenge in adult rats following prenatal exposure to cocaine.

    abstract::Adult rats that were gestationally exposed to cocaine and control offspring were examined for their sensitivity to challenge doses of cocaine. Offspring were derived from Sprague-Dawley dams that had received subcutaneous injections of 40 mg/kg per 3 cc cocaine hydrochloride daily on gestational days 8-20, pair-fed da...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02244870

    authors: Heyser CJ,Rajachandran L,Spear NE,Spear LP

    更新日期:1994-09-01 00:00:00

  • Cannabidiol modulation of antinociceptive tolerance to Δ9-tetrahydrocannabinol.

    abstract:RATIONALE:Humans typically self-administer cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) together repeatedly (as in cannabis, cannabis extract, or Sativex®) to relieve pain. It has been suggested that one benefit of the drug combination may be decreased tolerance development. OBJECTIVE:The present study com...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-018-5036-z

    authors: Greene NZ,Wiley JL,Yu Z,Clowers BH,Craft RM

    更新日期:2018-11-01 00:00:00

  • Mepiprazole, a new psychotropic drug: effects on uptake and retention of monoamines in rat brain synaptosomes.

    abstract::The influence of mepiprazole (EMD 16,923), a new pyrazol-ylalkyl-piperazine derivative, on the uptake of 3H-norepinephrine (NE), 3H-dopamine (DA), and 3H-serotonin (5-HT) into rat brain synaptosomes from cerebral cortex, corpus striatum, and hypothalamus was investigated in comparison with several psychotropic drugs, ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00496865

    authors: Placheta P,Singer E,Kriwanek W,Hertting G

    更新日期:1976-08-17 00:00:00

  • Effects of diazepam on operant behavior in man.

    abstract::The effects of diazepam (10 mg orally) on the responding of normal human volunteers was studied in a procedure that involved the maintenance of operant behavior by monetary reinforcement and its suppression by monetary loss (punishment). Diazepam produced an antipunishment effect as shown by an increase in behavior su...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00426457

    authors: Carlton PL,Siegel JL,Murphree HB,Cook L

    更新日期:1981-01-01 00:00:00

  • Reinstatement of punishment-suppressed opioid self-administration in rats: an alternative model of relapse to drug abuse.

    abstract:RATIONALE:Animal models of relapse to drug abuse typically assess the ability of various manipulations to reinstate responding that has ceased due to non-reinforcement (extinction). However, there is a lack of information concerning the reinstatement of responding that has ceased for reasons other than extinction. OBJ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-002-1193-0

    authors: Panlilio LV,Thorndike EB,Schindler CW

    更新日期:2003-07-01 00:00:00

  • A test of the cognitive-enhancing potential of low-dose mecamylamine in healthy non-smokers.

    abstract:RATIONALE:The beneficial effects of nicotinic acetylcholine receptor (nAChR) agonists on cognitive performance have been widely shown. Paradoxically, recent preclinical studies employing extremely low doses of nAChR antagonists have also found cognitive enhancement, perhaps pointing to a novel treatment mechanism for c...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-016-4443-2

    authors: Yuille MB,Olmstead CK,Wells AK,Hahn B

    更新日期:2017-01-01 00:00:00

  • Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: a positron emission tomography imaging study with [11C]WAY 100635.

    abstract:BACKGROUND:Postmortem and positron emission tomography (PET) studies have reported several alterations in serotonin 1A receptor (5-HT(1A)) binding parameters in patients with schizophrenia. This study examines 5-HT(1A) availability in vivo in individuals with schizophrenia and schizo-affective disorder. MATERIALS AND ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-006-0543-8

    authors: Frankle WG,Lombardo I,Kegeles LS,Slifstein M,Martin JH,Huang Y,Hwang DR,Reich E,Cangiano C,Gil R,Laruelle M,Abi-Dargham A

    更新日期:2006-12-01 00:00:00

  • Acute fluoxetine treatment potentiates amphetamine hyperactivity and amphetamine-induced nucleus accumbens dopamine release: possible pharmacokinetic interaction.

    abstract::Amphetamine stimulates locomotor activity, in large part by activating central dopaminergic systems. Serotonin shares on overlapping distribution with dopamine and has been shown to modulate dopaminergic function and dopamine-mediated behaviors. The present study examined whether increasing serotonergic function, via ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130050852

    authors: Sills TL,Greenshaw AJ,Baker GB,Fletcher PJ

    更新日期:1999-02-01 00:00:00

  • Effects of nicotine on body weight in rats with access to "junk" foods.

    abstract::The present experiment examined effects of nicotine on body weight of male and female rats when Oreo cookies, potato chips, laboratory chow, and water were available. Body weight and eating behavior were measured for 17-day periods before, during, and after nicotine or saline administration. There was an inverse relat...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00212851

    authors: Grunberg NE,Popp KA,Winders SE

    更新日期:1988-01-01 00:00:00

  • Thalamic inputs to dorsomedial striatum are involved in inhibitory control: evidence from the five-choice serial reaction time task in rats.

    abstract:RATIONALE:Corticostriatal circuits are widely implicated in the top-down control of attention including inhibitory control and behavioural flexibility. However, recent neurophysiological evidence also suggests a role for thalamic inputs to striatum in behaviours related to salient, reward-paired cues. OBJECTIVES:Here,...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-017-4627-4

    authors: Saund J,Dautan D,Rostron C,Urcelay GP,Gerdjikov TV

    更新日期:2017-08-01 00:00:00

  • Evidence of a role for the 5-HTTLPR genotype in the modulation of motor response to antidepressant treatment.

    abstract:RATIONALE:Serotonergic mechanisms are thought to play an important role in the regulation of mood, motor activity and sleep patterns. Serotonin reuptake is controlled by the serotonin transporter (5-HTT) and by a common functional insertion/deletion polymorphism in the corresponding gene's promoter region (5-HTTLPR). H...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-004-1995-3

    authors: Putzhammer A,Schoeler A,Rohrmeier T,Sand P,Hajak G,Eichhammer P

    更新日期:2005-03-01 00:00:00

  • Effects of third intracerebroventricular injections of corticotropin-releasing factor (CRF) on ethanol drinking and food intake.

    abstract::Corticotropin releasing factor (CRF), a neuropeptide secreted by hypothalamic and extrahypothalamic neurons, is thought to mediate stress-related behaviors. The tension reduction hypothesis suggests that ethanol drinking reduces stress; that drinking is reinforced by this reduced stress; and that the probability of dr...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130050697

    authors: Bell SM,Reynolds JG,Thiele TE,Gan J,Figlewicz DP,Woods SC

    更新日期:1998-09-01 00:00:00

  • SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist, alleviates disturbances of novelty discrimination in a social context in rats, a putative model of selective attention deficit.

    abstract:RATIONALE:Selective attention deficit, characterised by the inability to differentiate relevant from irrelevant information, is considered to underlie many cognitive deficits of schizophrenia, and appears to be only marginally responsive to treatment with current antipsychotics. OBJECTIVES:We compared the activity of ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-005-2268-5

    authors: Terranova JP,Chabot C,Barnouin MC,Perrault G,Depoortere R,Griebel G,Scatton B

    更新日期:2005-08-01 00:00:00