Abstract:
:A group of 14 schizophrenics who remained symptomatic after neuroleptic treatment received either 0.02 mcg/kg CCK-8 or saline placebo intravenously. Thereafter, 13 received the alternative infusion as a crossover treatment. A second group of 16 such patients received 0.04 mcg/kg CCK-8 or saline intravenously and, thereafter, 14 of these received the alternative infusion as a crossover treatment. Psychopathology was rated prior to, 2-3 h post, and on days 3, 5 and 7 after each infusion. Ratings consisted of the BPRS, the Abrams and Taylor Scale for Emotional Blunting, the Hamilton Anxiety Scale and a Schneiderian "Positive" symptom scale abstracted from the President State Examination. Parallel groups and cross over design analyses failed to show efficacy for CCK-8.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Peselow E,Angrist B,Sudilovsky A,Corwin J,Siekierski J,Trent F,Rotrosen Jdoi
10.1007/BF00690931subject
Has Abstractpub_date
1987-01-01 00:00:00pages
80-4issue
1eissn
0033-3158issn
1432-2072journal_volume
91pub_type
临床试验,杂志文章abstract::Neuroimaging has been identified as a potentially powerful probe for the in vivo study of drug effects on the brain with utility across several phases of drug development spanning preclinical and clinical investigations. Specifically, neuroimaging can provide insight into drug penetration and distribution, target enga...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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abstract:RATIONALE:Treatment of the most widely abused drugs, nicotine and alcohol, is hampered by high rates of relapse. Varenicline tartrate, an α4β2 nicotinic receptor partial agonist, is currently prescribed as a smoking cessation aid. However, there is emerging evidence that it may also modulate alcohol seeking and cogniti...
journal_title:Psychopharmacology
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pub_type: 临床试验,杂志文章,随机对照试验
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abstract:RATIONALE:Hypofunction of striatal dopamine neurotransmission, or hypodopaminergia, is a consequence of excessive ethanol use and is hypothesized to be a critical component of alcoholism, driving alcohol intake in an attempt to restore dopamine levels; however, the neurochemical mechanisms involved in these dopaminergi...
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-02-01 00:00:00
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更新日期:2012-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1996-02-01 00:00:00
abstract:RATIONALE:Endogenous and exogenous cannabinoids acting through the CB1 cannabinoid receptors are implicated in the control of a variety of behavioural and neuroendocrine functions, including emotional responses, and learning and memory processes. Recently, knockout mice deficient in the CB1 cannabinoid receptor have be...
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更新日期:2002-02-01 00:00:00
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更新日期:1999-07-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2010-10-01 00:00:00
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