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Effects of ibogaine on responding maintained by food, cocaine and heroin reinforcement in rats.

Abstract：

:The effects of ibogaine (40 and 80 mg/kg, i.p.), an indole alkaloid proposed for the treatment of drug abuse, were determined in three different groups of rats responding under an FR10 schedule of food, cocaine or heroin reinforcement. Ibogaine (80 mg/kg, i.p.) given 60 min before the start of the session resulted in a 97% decrease in the number of ratios completed under the food reinforcement schedule and resulted in a decrease in responding the following day. Neither 40 mg/kg ibogaine given 60 min prior to the session nor 80 mg/kg given 24 h before the session suppressed responding maintained by cocaine infusions (0.33 mg/infusion). Pretreatment with 80 mg/kg ibogaine either 60 or 90 min prior to the session suppressed cocaine self-administration on the day it was administered and the longer pretreatment continued to suppress responding for 48 h. Responding maintained by heroin (18 micrograms/infusion) was the most sensitive to the effects of ibogaine. Both 40 and 80 mg/kg ibogaine resulted in an almost complete suppression of responding following a 60-min pretreatment period. Responding maintained by heroin returned to control levels the day following the administration of ibogaine.

journal_name

Psychopharmacology (Berl)

journal_title

Psychopharmacology

authors

Dworkin SI,Gleeson S,Meloni D,Koves TR,Martin TJ

doi

10.1007/BF02246099

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

257-61

issue

3

eissn

0033-3158

issn

1432-2072

journal_volume

117

pub_type

杂志文章

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