Abstract：
:The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present investigation was set out to characterize these interactions in vitro using rat liver microsomes and in vivo by analysing levels of clomipramine and metabolites in sera of depressed patients treated concomitantly with fluvoxamine and clomipramine. Clomipramine was N-demethylated and hydroxylated in vitro by microsomes to N-desmethyl-clomipramine, 8-hydroxyclomipramine, and 10-hydroxyclomipramine. Kinetic analyses revealed Km values of 6.2 microM for N-demethylation and 1.2 microM for 8-hydroxylation. Fluvoxamine was a non-competitive inhibitor for N-demethylation with mean Ki value of 6 microM. In the sera of patients treated with daily doses of 150 mg clomipramine and varying doses of fluvoxamine, decrease in the formation of N-desmethylclomipramine and 8-hydroxyclomipramine were found in comparison to those in sera of patients receiving clomipramine as monotherapy. Taken together, the data give evidence that fluvoxamine is a potent non-competitive inhibitor of N-demethylation and to a minor extent of 8-hydroxylation of clomipramine. Because of the species differences in the metabolism of xenobiotics between rodents and humans, conclusions from animal studies on the clinical situation must be drawn cautiously. Nevertheless, the in vitro approach was helpful to understand drug interactions between clomipramine and fluvoxamine in psychiatric patients.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Härtter S,Arand M,Oesch F,Hiemke Cdoi
10.1007/BF02245180subject
Has Abstractpub_date
1995-01-01 00:00:00pages
149-53issue
2eissn
0033-3158issn
1432-2072journal_volume
117pub_type
杂志文章abstract：RATIONALE:Serotonin (5-HT) plays a key role in different aspects of value-based decision-making. A recent framework proposed that tonic 5-HT (together with dopamine, DA) codes future average reward expectations, providing a baseline against which possible choice outcomes are compared to guide decision-making. OBJECTIV...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-4913-9
更新日期：2018-07-01 00:00:00
abstract：:When tested in adulthood, male rats that had been treated daily with 50 mg/kg hydroxyzine HCl SC at 10--29 or 23--29 days of age were significantly facilitated in performance of delayed spontaneous alternation relative to saline-injected rats. Treatment at 10--16 days of age did not produce significant facilitation in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427646
更新日期：1980-01-01 00:00:00
abstract：:Administration of the serotonin (5-HT)1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) facilitates the expression of masculine sexual behavior in male and female rats as well as in male rhesus monkeys and inhibits lordosis behavior in female rats. In the present study the effects of 8-OH-DPAT on ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244989
更新日期：1994-05-01 00:00:00
abstract：RATIONALE:The synthetic progestin medroxyprogesterone acetate (MPA), widely used in hormone therapy (HT) and as the contraceptive Depo Provera, is implicated in detrimental cognitive effects in women. Recent evidence in aged ovariectomized (Ovx) rodents shows that short-term MPA treatment impairs cognition and alters t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2322-4
更新日期：2011-11-01 00:00:00
abstract：:The increasing interest in subjective well-being and quality of life of schizophrenic patients represents a conceptual shift in therapeutic outcome criteria. Symptom reduction alone was the most essential outcome parameter for a long time; with the development of atypical antipsychotics more ambitious success criteria...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-002-1052-z
更新日期：2002-06-01 00:00:00
abstract：RATIONALE:Effort-related motivational symptoms such as anergia and fatigue are common in patients with depression and other disorders. Research implicates pro-inflammatory cytokines in depression, and administration of cytokines can induce effort-related motivational symptoms in humans. OBJECTIVES:The present experime...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3285-4
更新日期：2014-02-01 00:00:00
abstract：:Food reward has been associated with activation of noradrenergic mechanisms in the brain. Using rats trained to press a lever for food reward, we have investigated the effects of 6-hydroxydopamine lesions, which severly depleted hypothalamic noradrenaline, on the willingness of the rats to press the lever for food rew...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427343
更新日期：1979-06-28 00:00:00
abstract：:Three-hour sessions of differential reinforcement of low-rate behavior (DRL 45-s) in rats were used to investigate alprazolam, caffeine, and their interactions at the onset, peak and disappearance of serum alprazolam, while caffeine level remained constant. The dose-response curve (DRC) method of Pöch permitted an ext...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246346
更新日期：1996-07-01 00:00:00
abstract：RATIONALE:Studies about whether or not the cognitive performance of women is influenced by changes in levels of sex steroid hormones across the menstrual cycle have produced ambiguous results. OBJECTIVES:This study tested whether flight simulator performance differs significantly between the menstrual and the luteal p...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100700
更新日期：2001-05-01 00:00:00
abstract：:The low rate of success for identifying effective treatments for cognitive dysfunction has prompted recent efforts to improve pharmaceutical discovery and development. In particular, investigators have emphasized improving translation from pre-clinical to clinical research. A specific area of focus has been touchscree...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4012-0
更新日期：2015-11-01 00:00:00
abstract：RATIONALE:The touchscreen continuous trial-unique non-matching-to-location task (cTUNL) has been developed to optimise a battery of tasks under NEWMEDS (Novel Methods leading to New Medication in Depression and Schizophrenia, http://www.newmeds-europe.com ). It offers novel task features of both a practical and a theor...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4019-6
更新日期：2015-11-01 00:00:00
abstract：:Postsynaptic dopamine-cholecystokinin (CCK) interactions in the nucleus accumbens were studied in two behavioral preparations of DA receptor supersensitivity: chronic-neuroleptic treated and 6-hydroxydopamine (6-OHDA) denervated rats. Subcutaneous (SC) injections of apomorphine (APO; 0.15 mg/kg) in experiment 1 produc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00445568
更新日期：1989-01-01 00:00:00
abstract：:Two experiments were conducted to study the effects of anxiogenic drugs on dopamine release and metabolism in nucleus accumbens. Microdialysis probes were implanted into the nucleus accumbens, and rats were tested the day after implantation. In the first experiment, groups of rats received injections of saline, 1.25 o...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245888
更新日期：1992-01-01 00:00:00
abstract：:The present studies were undertaken to investigate the neuroactive steroidal modulation of feeding behavior and possible involvement of gamma-aminobutyric acid type-A (GABA-A) and mitochondrial diazepam binding inhibitor (DBI) receptors (MDR) in food-deprived male mice. Allopregnanolone (0.5-2 mg/kg), a neurosteroid, ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050635
更新日期：1998-06-01 00:00:00
abstract：RATIONALE:The integrity of cortical cholinergic transmission is vital to attentional processing. A growing literature suggests that alterations in attentional processing accompany addictive drug use. This study examined the effects of acute and repeated administration of nicotine on cortical acetylcholine release. OBJ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1260-6
更新日期：2003-02-01 00:00:00
abstract：RATIONALE:Initial sensitivity to drugs of abuse often predicts subsequent use and abuse, but this relationship is not always observed in human studies. Moreover, studies examining the relationship between initial locomotor sensitivity and the rewarding and reinforcing effects of drugs in animal models have also been eq...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-4834-7
更新日期：2018-04-01 00:00:00
abstract：RATIONALE:Although environmental enrichment renders rats more sensitive to the neurobehavioral effects of acute amphetamine, a previous study found that enriched rats self-administer less amphetamine than isolated rats at a low unit dose (0.03 mg/kg per infusion). In that study, however, acquisition of self-administrat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1134-y
更新日期：2002-08-01 00:00:00
abstract：RATIONALE:Control of reward-seeking behavior under conditions of punishment is an important function for survival. OBJECTIVES AND METHODS:We designed a task in which rats could choose to either press a lever and obtain a food pellet accompanied by a footshock or refrain from pressing the lever to avoid footshock, in r...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05398-7
更新日期：2020-03-01 00:00:00
abstract：:Acute and chronic effects of ethosuximide (40, 80, and 120 mg/kg), phenytoin (2.5, 5, and 7.5 mg/kg), clonazepam (0.25, 0.5, and 0.75 mg/kg), and valproic acid (40, 80, and 120 mg/kg) were examined in pigeons performing under a delayed-matching-to-sample procedure. Acute administration of clonazepam or valproic acid p...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00180828
更新日期：1986-01-01 00:00:00
abstract：RATIONALE:Reductions in cue-induced craving and subjective response to drugs of abuse are commonly used as initial outcome measures when testing novel medications for the treatment of addiction. Yet neither the relationship between these two measures at the individual level nor the moderating effects of pharmacotherapi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4607-8
更新日期：2017-07-01 00:00:00
abstract：RATIONALE:There is a requirement to ensure that UK armed forces are provided with the best possible medical countermeasures to prevent or mitigate the effects of exposure to nerve agents. When pretreatments are under consideration, it is of particular importance to ensure that they do not in themselves give rise to adv...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1324-7
更新日期：2003-03-01 00:00:00
abstract：:Rats were trained to discriminate fenfluramine (1.0 mg/kg) from saline in a two-lever drug discrimination task. The dose-response curve for this discrimination was orderly with an ED50 of about one-half of the training dose (0.52 mg/kg). In substitution tests, indirect (p-chloroamphetamine) and direct (quipazine, MK-2...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00429199
更新日期：1981-01-01 00:00:00
abstract：:The [14C]-2-deoxyglucose method was used to map the in vivo metabolic response of glucose to savoxepine, a novel tetracyclic cyano-dibenzoxepino-azepine. Savoxepine is reported to have higher affinity for dopamine (DA) receptors in the hippocampus than in the striatum and hence should have dose-dependent, anatomically...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244849
更新日期：1994-03-01 00:00:00
abstract：INTRODUCTION:Dopamine D2 receptor occupancy levels needed for the maintenance treatment of schizophrenia remain to be elucidated. We examined 3-year clinical outcomes of patients with schizophrenia who received long-acting injectable risperidone (LAI risperidone) at baseline and investigated their dopamine D2 receptor ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4428-1
更新日期：2016-12-01 00:00:00
abstract：:The effects of acute marijuana intoxication on remote memory and new learning were assessed. To test for the effects of marijuana on remote memory, titles of one-season television shows, aired up to 14 years previously, were used in three tests measuring recognition, temporal judgement and detailed recall of facts fro...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00432561
更新日期：1982-01-01 00:00:00
abstract：:In order to assess the contribution of cerebellar effects of ethanol to the production of ataxia, "nervous" (nr/nr) and control (nr/+ or +/+) C3H mice were tested for locomotor ability 2 min after being given intraperitoneal ethanol injections. The nr/nr mice suffer from loss of most of their cerebellar Purkinje cells...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00423259
更新日期：1976-07-28 00:00:00
abstract：RATIONALE:Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains unclear whether intravenous (i.v.) administration would facilitate the rapi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05623-8
更新日期：2020-11-01 00:00:00
abstract：RATIONALE:It has been proposed that brain aldehyde dehydrogenase (ALDH) plays a role in the modulation of some psychopharmacological effects of ethanol. Diethyldithiocarbamate (DDTC), an ALDH inhibitor, elevates blood acetaldehyde levels in the presence of ethanol. Concurrent administration with 4-methylpyrazole (4-MP)...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-001-0991-0
更新日期：2002-04-01 00:00:00
abstract：:There have been a number of claims that high-dose administration of cocaine to rats leads to neurotoxic effects on dopamine neurons. In this study possible neurotoxic effects on monoamine neurons were examined by measuring the effects of cocaine (35 mg/kg daily for 10 days) on the binding of radioligands to uptake sit...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244815
更新日期：1992-01-01 00:00:00
abstract：:Murine neuroblastoma cells (clone N1E-115) possess both high- and low-affinity muscarinic receptors. The low-affinity muscarinic receptor, when stimulated, initiates the formation of cyclic GMP by activating the enzyme guanylate cyclase; whereas stimulation of the high-affinity receptor inhibits prostaglanding E1-medi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427901
更新日期：1985-01-01 00:00:00
