Contribution of the prefrontal cortex and basolateral amygdala to behavioral decision-making under reward/punishment conflict.

abstract：RATIONALE:The notion that the onset of action of antidepressant drugs (ADs) takes weeks is widely accepted; however, the sequence of events necessary for therapeutic effects still remains obscure. OBJECTIVE:We aimed to evaluate a time-course of ADs-induced alterations in the expression of 95 selected genes in 4 region...

journal_title：Psychopharmacology

authors： Gąska M,Kuśmider M,Solich J,Faron-Górecka A,Krawczyk MJ,Kułakowski K,Dziedzicka-Wasylewska M

更新日期：2012-10-01 00:00:00

abstract：RATIONALE:Central CB1 cannabinoid receptors regulate anxiety-like and appetitive consummatory behaviors. Pharmacological antagonism/inverse-agonism of CB1 receptors increases anxiety and decreases appetitive behaviors; however, neither well-defined dose nor context dependence of these effects has been simultaneously as...

journal_title：Psychopharmacology

authors： Gamble-George JC,Conger JR,Hartley ND,Gupta P,Sumislawski JJ,Patel S

更新日期：2013-08-01 00:00:00

abstract：:The mesolimbic dopamine (DA) system has been implicated in conditioned reward (CR), locomotor sensitization, and the reinforcing properties of psychomotor stimulants. Stimuli with formerly motivationally neutral properties that gain incentive properties by their predictive association with primary reinforcers are term...

journal_title：Psychopharmacology

authors： Taylor JR,Horger BA

更新日期：1999-02-01 00:00:00

abstract：:In a 4 week study of the response of neurotic outpatients to treatment with amitriptyline, diazepam, amitriptyline and diazepam, or placebo clinical and psychophysiological variables and plasma levels of the drug were assessed. Clinical improvements were substantial in all treatment groups but clear relationships betw...

journal_title：Psychopharmacology

authors： Johnstone EC,Bourne RC,Crow TJ,Frith CD,Gamble S,Lofthouse R,Owen F,Owens DG,Robinson J,Stevens M

更新日期：1981-01-01 00:00:00

abstract：:In the rat, the antimuscarinics atropine and scopolamine failed to block the reduction in pentobarbital-induced sleep time produced by either thyrotropin-releasing hormone (TRH) or MK-771 (a TRH analog). Previous reports have indicated that the marked analeptic effect produced by TRH is antagonized by such agents. It ...

journal_title：Psychopharmacology

authors： Santori EM,Schmidt DE,Kalivas PW,Horita A

更新日期：1981-01-01 00:00:00

abstract：:Dopamine (DA), injected unilaterally into rat forebrain after pretreatment with a monoamine oxidase inhibitor, equipotently induced locomotor arousal when placed in the nucleus accumbens septi (a limbic site) and contralateral deviation of the head when placed in the corpus striatum (an extrapyramidal target); testing...

journal_title：Psychopharmacology

authors： Campbell A,Yeghiayan S,Baldessarini RJ,Neumeyer JL

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Methamphetamine (METH) is a powerfully addictive stimulant associated with serious health conditions. Accumulating evidence suggests a role of oxidative stress in METH-induced behavioral abnormalities. Sulforaphane (SFN), found in cruciferous vegetables, is a potent antioxidant. It is of interest to determine...

journal_title：Psychopharmacology

authors： Chen H,Wu J,Zhang J,Fujita Y,Ishima T,Iyo M,Hashimoto K

更新日期：2012-07-01 00:00:00

abstract：RATIONALE:Using a rat relapse model, recent studies reported time dependent increases in cocaine seeking induced by re-exposure to cocaine cues, but not cocaine itself, over withdrawal periods of up to 3 months. OBJECTIVES:In the present study, we explored the time course of cocaine seeking induced by priming injectio...

journal_title：Psychopharmacology

authors： Lu L,Dempsey J

更新日期：2004-10-01 00:00:00

abstract：:Doses of eight phenylethylamines were substituted for cocaine on a drug-maintained behavior baseline in baboons. Intravenous infusions of drug were contingent upon completion of 160 lever presses (a 160-response fixed-ratio schedule; FR 160). A 3-h time-out period followed each infusion, permitting a maximum of 8 infu...

journal_title：Psychopharmacology

authors： Griffiths RR,Winger G,Brady JV,Snell JD

更新日期：1976-11-24 00:00:00

abstract：:Metergoline given IP reduced the response to noxious stimulation in the mouse formalin test. Tolerance to this effect developed after a chronic treatment schedule consisting of ten daily injections of 5 mg/kg. Twenty four hours after the last injection a test dose of metergoline (2.5 mg/kg) reduced the licking time in...

journal_title：Psychopharmacology

authors： Fasmer OB,Berge OG,Hole K

更新日期：1987-01-01 00:00:00

abstract：INTRODUCTION:Non-medical use of prescription opioids such as the mu opioid receptor (MOP-r) agonist oxycodone is a growing problem in the USA and elsewhere. There is limited information about oxycodone's impact on diverse gene systems in the brain. OBJECTIVES:The current study was designed to examine how chronic oxyco...

journal_title：Psychopharmacology

authors： Zhang Y,Liang Y,Levran O,Randesi M,Yuferov V,Zhao C,Kreek MJ

更新日期：2017-08-01 00:00:00

abstract：RATIONALE AND OBJECTIVE:Because of the important role of dopamine in neurotransmission, it would be useful to be able to image brain dopamine receptor-mediated signal transduction in animals and humans. Administering the D1-D2 receptor agonist apomorphine may allow us to do this, as the D2-like receptor is reported to ...

journal_title：Psychopharmacology

authors： Bhattacharjee AK,Chang L,White L,Bazinet RP,Rapoport SI

更新日期：2008-05-01 00:00:00

abstract：:The effects of monoamine oxidase inhibitors (MAOIs) that selectively inhibit the MAO-A or MAO-B forms of MAO were studied in rats performing under a differential-reinforcement-of-low-rate 72-s (DRL 72-s) schedule of reinforcement. Clorgyline and CGP11'305A, irreversible and reversible MAO-A inhibitors, respectively, i...

journal_title：Psychopharmacology

authors： Marek GJ,Seiden LS

更新日期：1988-01-01 00:00:00

abstract：:Two studies were conducted to replicate and extend previous demonstrations of smoking-induced, dose-related reports of euphoria, and to confirm this relationship using measures of plasma nicotine. In experiment 1, overnight-deprived subjects, in three different sessions, smoked ultralow-, high-nicotine, and usual-bran...

journal_title：Psychopharmacology

authors： Pomerleau CS,Pomerleau OF

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Demonstrations of associative tolerance to the analgesic effects of morphine, not confounded by practice or novelty effects, have been restricted to the tail-flick and flinch-jump tests. OBJECTIVES:Experiment 1 investigated whether associative tolerance would be found on two other nociceptive assessment meth...

journal_title：Psychopharmacology

authors： Cepeda-Benito A,Tiffany ST,Cox LS

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:There is evidence that mGlu2/3 receptors regulate 5-HT2A signaling, interactions that have been theorized to play a role in the antipsychotic-like effects of mGlu2/3 agonists as well as the hallucinogenic effects of 5-HT2A agonists. One approach to unraveling this interaction is through the chronic administr...

journal_title：Psychopharmacology

authors： Halberstadt AL,van der Zee JVF,Chatha M,Geyer MA,Powell SB

更新日期：2019-02-01 00:00:00

abstract：:The benzodiazepines are typified by a profile of side effects which includes drowsiness, ataxia and incoordination. Ro 15-1788, an imidazodiazepine derivative, exhibits marked antagonism of the behavioural and biochemical effects of the benzodiazepines in animals and man. It is devoid of any behavioural activity in an...

journal_title：Psychopharmacology

authors： Darragh A,Lambe R,O'Boyle C,Kenny M,Brick I

更新日期：1983-01-01 00:00:00

abstract：:Four macaques with lesions of dorsolateral frontal cortex and 4 normal monkeys were injected with 1 mg/kg d-amphetamine. Observations of social behaviors and motor activity were conducted over a 1-month period. The results of this experiment show a partial dissociation of effects of amphetamines on behavior of normal ...

journal_title：Psychopharmacology

authors： Miller MH

更新日期：1976-05-05 00:00:00

abstract：RATIONALE:Repeated treatment with morphine has been shown to sensitize rats to its stimulant effects on motor activity and mesolimbic dopamine (DA) transmission. OBJECTIVES:The aim of this study is to investigate if morphine sensitization is associated to changes in the behavioral reactions to appetitive and aversive ...

journal_title：Psychopharmacology

authors： De Luca MA,Bimpisidis Z,Bassareo V,Di Chiara G

更新日期：2011-08-01 00:00:00

abstract：:The concurrent influence of dopaminergic, sigma and muscarinic neurotransmitter systems in mediating cocaine-induced lethality is predicted by previous receptor binding results from our laboratories. The present results demonstrate that pharmacological manipulations of these predicted neurotransmitter systems alter th...

journal_title：Psychopharmacology

authors： Ritz MC,George FR

更新日期：1997-02-01 00:00:00

abstract：RATIONALE:Antidepressants (ADs) are slow to produce their therapeutic effect. This long latency promotes the development of new strategies to short their onset of action. Previous reports indicated that 17beta-estradiol (E(2)) promotes the antidepressant-like activity of fluoxetine (FLX) and desipramine (DMI) in the fo...

journal_title：Psychopharmacology

authors： Estrada-Camarena E,Rivera NM,Berlanga C,Fernández-Guasti A

更新日期：2008-12-01 00:00:00

abstract：RATIONALE:Human behavioral pharmacology studies can examine how medications that target different neurotransmitter systems influence different aspects of smoking. Naltrexone and bupropion have been shown to alter ad lib smoking behavior; however, medication effects on nicotine reward in a cigarette choice paradigm have...

journal_title：Psychopharmacology

authors： Rukstalis M,Jepson C,Strasser A,Lynch KG,Perkins K,Patterson F,Lerman C

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:(+/-)-3,4-methylenedioxymethamphet-amine (MDMA; 'ecstasy'), a commonly used recreational drug, has typically been found to be related to poor cognitive function in humans. However, cannabis consumption may not have been adequately controlled for in these studies. OBJECTIVE:The present study was designed to f...

journal_title：Psychopharmacology

authors： Croft RJ,Mackay AJ,Mills AT,Gruzelier JG

更新日期：2001-01-01 00:00:00

abstract：:The effects of the benzomorphan antagonist Mr 2266 and the selective delta-antagonist ICI 154,129 on the body weight gain of 6-day-old suckling rat pups was observed. Mr 2266 significantly reduced body weight gain in these animals, though ICI 154,129 had no affect on this variable. These findings suggest that mu- and ...

journal_title：Psychopharmacology

authors： Jackson HC,Sewell RD

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Alcohol intoxication produces effects that can impair judgment and increase engagement in risky behaviors, including alcohol-impaired driving (AID). Real-world AID decisions are informed by contextual circumstances and judgments of associated risk. How individuals vary in their AID decision-making across cont...

journal_title：Psychopharmacology

authors： Motschman CA,Warner OM,Wycoff AM,Davis-Stober CP,McCarthy DM

更新日期：2020-12-01 00:00:00

abstract：RATIONALE:Repeated exposure to psychostimulant drugs causes a long-lasting increase in the psychomotor and reinforcing effects of these drugs and an array of neuroadaptations. One such alteration is a hypersensitivity of striatal activity such that a low dose of amphetamine in sensitized animals produces dorsal striata...

journal_title：Psychopharmacology

authors： Nordquist RE,Vanderschuren LJ,Jonker AJ,Bergsma M,de Vries TJ,Pennartz CM,Voorn P

更新日期：2008-05-01 00:00:00

abstract：:Pigs trained to avoid shocks by crossing a barrier in a shuttle-box according to a continuous avoidance procedure were submitted to a Pavlovian discriminative fear-conditioning procedure in which a tone was always followed by unavoidable shock (CS+) and another tone never followed by shock (CS-). The presentation of t...

journal_title：Psychopharmacology

authors： Dantzer R,Mormede P

更新日期：1976-08-26 00:00:00

abstract：:Patients who develop persistent parkinsonism while on chronic neuroleptic therapy may be predisposed towards the development of tardive dyskinesia (TD). We investigated this issue in an animal model of TD by examining the association between catalepsy and the syndrome of neuroleptic-induced vacuous chewing movements (...

journal_title：Psychopharmacology

authors： Hyde TM,Egan MF,Wing LL,Wyatt RJ,Weinberger DR,Kleinman JE

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Obsessive-compulsive disorder (OCD) gradually emerges and reaches clinical significance during early adulthood. Whether a predisposition for OCD manifests as binge eating disorder earlier during adolescence is proposed. OBJECTIVES:To further characterize how OCD-like behaviors increase across maturation and ...

journal_title：Psychopharmacology

authors： Freund N,Thompson BS,Norman KJ,Einhorn P,Andersen SL

更新日期：2015-09-01 00:00:00

abstract：:Systemic administration of RB 101, a complete inhibitor of the enkephalin degrading enzymes, has been reported to induce naltrindole-reversed antidepressant-like effects in the conditioned suppression of motility (CSM) test in mice. The selective CCKB antagonist L-365,260 also elicits the same naltrindole-blocked resp...

journal_title：Psychopharmacology

authors： Smadja C,Maldonado R,Turcaud S,Fournie-Zaluski MC,Roques BP

更新日期：1995-08-01 00:00:00