Cocaine seeking over extended withdrawal periods in rats: time dependent increases of responding induced by heroin priming over the first 3 months.

Abstract:

RATIONALE:Using a rat relapse model, recent studies reported time dependent increases in cocaine seeking induced by re-exposure to cocaine cues, but not cocaine itself, over withdrawal periods of up to 3 months. OBJECTIVES:In the present study, we explored the time course of cocaine seeking induced by priming injections of heroin over the first 3 months of withdrawal from cocaine. METHODS:Rats were trained to self-administer intravenous cocaine for 6 h/day over a period of 10 days. Cocaine seeking induced by heroin priming was then assessed in different groups of rats after 1 day, and 1 and 3 months of withdrawal from cocaine. During the test day, rats were first given six 1-h extinction sessions. Subsequently, reinstatement of cocaine seeking induced by non-contingent saline and heroin injections (0.125 and 0.25 mg/kg, s.c.) was assessed during three 1-h sessions. RESULTS:As in previous studies, extinction responding was substantially greater after 1 and 3 months of withdrawal than after 1 day. More importantly, we also found that the effect of heroin priming on reinstatement of cocaine seeking is time dependent, with higher responding occurring after 1 and 3 months than after 1 day. CONCLUSION:The present results replicate previous findings on the time dependent increases in resistance to extinction after withdrawal from cocaine, and further indicate that the duration of the drug withdrawal period is a critical modulator of the effect of heroin priming on cocaine seeking. These data may have implications for the treatment of cocaine relapse induced by other drugs.

journal_title

Psychopharmacology

authors

Lu L,Dempsey J

doi

10.1007/s00213-004-1861-3

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

109-14

issue

1

eissn

0033-3158

issn

1432-2072

journal_volume

176

pub_type

杂志文章
  • Efficacy of olanzapine monotherapy for treatment of bipolar I depression: a randomized, double-blind, placebo controlled study.

    abstract:RATIONALE AND OBJECTIVE:Depression symptoms are now recognized to be the predominant cause of disability for bipolar disorder (BD) patients. The treatment strategies for the depressed phase of BD remain more anecdotal than data-based. Olanzapine has been investigated as an alternative to antidepressants and a mood stab...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-014-3453-1

    authors: Wang M,Tong JH,Huang DS,Zhu G,Liang GM,Du H

    更新日期:2014-07-01 00:00:00

  • The effects of chronic buprenorphine on intake of heroin and cocaine in rats and its effects on nucleus accumbens dopamine levels during self-administration.

    abstract:RATIONALE:Buprenorphine reduces both heroin and cocaine intake in opioid addicts, but the mechanisms remain unclear. OBJECTIVES:To determine the effects of chronic buprenorphine treatment on intake of heroin and/or cocaine and measure nucleus accumbens (NAc) dopamine (DA) levels during self-administration. METHODS:In...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-006-0485-1

    authors: Sorge RE,Stewart J

    更新日期:2006-09-01 00:00:00

  • A naturalistic investigation of the effects of day-long consumption of tea, coffee and water on alertness, sleep onset and sleep quality.

    abstract:RATIONALE:The effects of caffeine, especially caffeinated coffee, on human performance have been extensively studied. However, few studies have been naturalistic representations of how tea/coffee is normally consumed in terms of dose and time of consumption. OBJECTIVES:This study investigated the effects of day-long c...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s002130000383

    authors: Hindmarch I,Rigney U,Stanley N,Quinlan P,Rycroft J,Lane J

    更新日期:2000-04-01 00:00:00

  • Effects of chlorpromazine on food-maintained and observing behavior.

    abstract::Pigeons were trained to peck each of two response keys. Periods during which pecks on one key (the food key) produced access to grain according to a random-ratio 80 schedule alternated irregularly with periods during which food-key responses had no scheduled consequences (extinction). Both keys remained amber unless a...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00422418

    authors: Dearing ME,Branch MN

    更新日期:1981-01-01 00:00:00

  • The role of NMDA receptors in the signal attenuation rat model of obsessive-compulsive disorder.

    abstract:RATIONALE:In recent years, an increasing body of evidence points to the involvement of the glutamatergic system and specifically the glutamatergic ionotropic N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of obsessive-compulsive disorder (OCD). OBJECTIVES:To test the role of NMDA receptors in compulsive b...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-010-1808-9

    authors: Albelda N,Bar-On N,Joel D

    更新日期:2010-05-01 00:00:00

  • Increased incidence of dyskinesias and other behavioral effects of re-exposure to neuroleptic treatment in social colonies of Cebus apella monkeys.

    abstract:RATIONALE:Typical neuroleptic medications are still administered to as many as 40% of patients receiving antipsychotic treatment in the US. Intermittent administration or interruption of long-term neuroleptic medication for schizophrenia may increase the incidence of human tardive dyskinesias, and similarly may produce...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130000572

    authors: Linn GS,Lifshitz K,O'Keeffe RT,Lee K,Camp-Lifshitz J

    更新日期:2001-01-01 00:00:00

  • Effect of ICV taurine on the impairment of learning, convulsions and death caused by hypoxia.

    abstract::The effect of the intracerebroventricular (ICV) administration of taurine on amnesia, convulsions and death caused by hypoxia was investigated in mice. Taurine in doses of 80-100 micrograms/mouse impaired acquisition of a single trial in passive avoidance performance, but protected mice from the learning impairment in...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00451681

    authors: Malcangio M,Bartolini A,Ghelardini C,Bennardini F,Malmberg-Aiello P,Franconi F,Giotti A

    更新日期:1989-01-01 00:00:00

  • Modulation of MK-801-induced behaviour by noradrenergic agents in mice.

    abstract:RATIONALE:Inhibition of glutamatergic N-methyl-D-aspartate (NMDA) receptors following the administration of NMDA receptor antagonists results in psychotic-like behaviour. Whereas it is known that pharmacological manipulation of dopaminergic and serotonergic pathways affect this drug-induced psychosis, a role for noradr...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130000630

    authors: Harkin A,Morris K,Kelly JP,O'Donnell JM,Leonard BE

    更新日期:2001-03-01 00:00:00

  • Involvement of the orexin/hypocretin system in ethanol conditioned place preference.

    abstract:RATIONALE:Recent studies suggest that orexin/hypocretin is involved in drug reward and drug-seeking behaviors, including ethanol self-administration. However, orexin's role in ethanol-induced seeking behaviors remains unclear. OBJECTIVE:These studies examined the role of orexin in the acquisition and expression of eth...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-010-2082-6

    authors: Voorhees CM,Cunningham CL

    更新日期:2011-04-01 00:00:00

  • Accumbens neurochemical adaptations produced by binge-like alcohol consumption.

    abstract:RATIONALE:The Scheduled High Alcohol Consumption (SHAC) binge drinking model is a simple, partial murine model with which to investigate some of the neurobiological underpinnings of alcoholism. OBJECTIVES:The SHAC model was used to characterize monoamine and amino acid adaptations produced in the nucleus accumbens (NA...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-006-0641-7

    authors: Szumlinski KK,Diab ME,Friedman R,Henze LM,Lominac KD,Bowers MS

    更新日期:2007-03-01 00:00:00

  • Insights into functional pharmacology of α₁ GABA(A) receptors: how much does partial activation at the benzodiazepine site matter?

    abstract:RATIONALE:Synthesis of ligands inactive or with low activity at α₁ GABA(A) receptors has become the key concept for development of novel, more tolerable benzodiazepine (BZ)-like drugs. WYS8, a remarkably (105 times) α₁-subtype selective partial positive modulator, may serve as a pharmacological tool for refining the ro...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-013-3143-4

    authors: Joksimović S,Varagic Z,Kovačević J,Van Linn M,Milić M,Rallapalli S,Timić T,Sieghart W,Cook JM,Savić MM

    更新日期:2013-11-01 00:00:00

  • Purine nucleoside--mediated immobility in mice: reversal by antidepressants.

    abstract::In the forced swimming-induced immobility (despair) test model, adenosine, and 2-chloroadenosine treatment prolonged the immobilization period in mice. Dipyridamole, which is known to inhibit adenosine uptake, potentiated the adenosine effect. The purinoceptor antagonists caffeine and theophylline blocked purine nucle...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00429665

    authors: Kulkarni SK,Mehta AK

    更新日期:1985-01-01 00:00:00

  • Rapid evidence review of the comparative effectiveness, harms, and cost-effectiveness of pharmacogenomics-guided antidepressant treatment versus usual care for major depressive disorder.

    abstract:OBJECTIVE:This study aims to conduct an evidence review of the effectiveness, harms, and cost-effectiveness of pharmacogenomics-guided antidepressant treatment for major depressive disorder. METHODS:We searched MEDLINE®, the Cochrane Central Registry of Controlled Trials, and PsycINFO through February 2017. We used pr...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1007/s00213-017-4622-9

    authors: Peterson K,Dieperink E,Anderson J,Boundy E,Ferguson L,Helfand M

    更新日期:2017-06-01 00:00:00

  • The relationship between level of cigarette consumption and latency to the onset of retrospectively reported withdrawal symptoms.

    abstract:RATIONALE:Subthreshold smokers (who smoke < or =5 cigarettes/day) experience withdrawal symptoms, yet they smoke less than is required to maintain serum nicotine levels. OBJECTIVES:For study 1, our aim was to determine (1) if adult subthreshold smokers report withdrawal symptoms; (2) how they rate symptom severity; (3...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-006-0497-x

    authors: Fernando WW,Wellman RJ,Difranza JR

    更新日期:2006-10-01 00:00:00

  • Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference.

    abstract:INTRODUCTION:Recently we demonstrated that genetic or pharmacological suppression of the central ghrelin signaling system, involving the growth hormone secretagogue receptor 1A (GHS-R1A), lead to a reduced reward profile from alcohol. As the target circuits for ghrelin in the brain include a mesolimbic reward pathway t...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-010-1907-7

    authors: Jerlhag E,Egecioglu E,Dickson SL,Engel JA

    更新日期:2010-09-01 00:00:00

  • Development of tolerance to the antinociceptive effect of metergoline.

    abstract::Metergoline given IP reduced the response to noxious stimulation in the mouse formalin test. Tolerance to this effect developed after a chronic treatment schedule consisting of ten daily injections of 5 mg/kg. Twenty four hours after the last injection a test dose of metergoline (2.5 mg/kg) reduced the licking time in...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02439580

    authors: Fasmer OB,Berge OG,Hole K

    更新日期:1987-01-01 00:00:00

  • Reinstatement of punishment-suppressed opioid self-administration in rats: an alternative model of relapse to drug abuse.

    abstract:RATIONALE:Animal models of relapse to drug abuse typically assess the ability of various manipulations to reinstate responding that has ceased due to non-reinforcement (extinction). However, there is a lack of information concerning the reinstatement of responding that has ceased for reasons other than extinction. OBJ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-002-1193-0

    authors: Panlilio LV,Thorndike EB,Schindler CW

    更新日期:2003-07-01 00:00:00

  • Stimulation of serotonin1B receptors induces conditioned place aversion and facilitates cocaine place conditioning in rats.

    abstract:RATIONALE:Changes in serotonin(1B) (5-HT(1B)) receptor function appear to modify the reinforcing properties of cocaine, but the direction of this effect is not completely clear. Pharmacological stimulation of 5-HT(1B) enhanced the rewarding properties of self-administered cocaine while attenuating the threshold-reducin...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-002-1145-8

    authors: Cervo L,Rozio M,Ekalle-Soppo CB,Carnovali F,Santangelo E,Samanin R

    更新日期:2002-09-01 00:00:00

  • The aluminum-induced increase in blood-brain barrier permeability to delta-sleep-inducing peptide occurs throughout the brain and is independent of phosphorus and acetylcholinesterase levels.

    abstract::The effect of aluminum on levels of inorganic phosphorus and acetylcholinesterase in blood and brain and on permeability of the blood-brain barrier (BBB) in different regions of the brain to the neuropeptide delta-sleep-inducing peptide (DSIP) was studied in adult rats. Aluminum (100 mg/kg) significantly increased the...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00431689

    authors: Banks WA,Kastin AJ

    更新日期:1985-01-01 00:00:00

  • Prior stress attenuates the analgesic response but sensitizes the corticosterone and cortical dopamine responses to stress 10 days later.

    abstract::This study demonstrates that pre-exposure to stress influences subsequent effects of stress on pain sensitivity (stress-induced analgesia) and on plasma corticosterone and brain catecholamine activity. Animals exposed to a 30 min shock session (S1 = 8, 5.0 s shocks) 10 days earlier showed a significant attenuation of ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00442814

    authors: Caggiula AR,Antelman SM,Aul E,Knopf S,Edwards DJ

    更新日期:1989-01-01 00:00:00

  • Reversal of alcohol dependence-induced deficits in cue-guided behavior via mGluR2/3 signaling in mice.

    abstract:RATIONALE:Alcohol use disorders are associated with deficits in adaptive behavior. While some behavioral impairments that are associated with alcohol use disorders may predate exposure to drugs of abuse, others may result directly from exposure to drugs of abuse, including alcohol. Identifying a causal role for how alc...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-015-4101-0

    authors: Barker JM,Lench DH,Chandler LJ

    更新日期:2016-01-01 00:00:00

  • Acute intranasal oxytocin improves positive self-perceptions of personality.

    abstract:RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be on...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-011-2527-6

    authors: Cardoso C,Ellenbogen MA,Linnen AM

    更新日期:2012-04-01 00:00:00

  • Discriminative stimulus properties of a new anxiolytic, DN-2327, in rats.

    abstract::In an operant learning lever-pressing procedure on an FR10 schedule of milk reinforcement, male Wistar rats were trained to discriminate between saline and 3 mg/kg IP DN-2327, a new anxiolytic which acts on benzodiazepine receptors, 3 mg/kg IP diazepam or 15 mg/kg IP pentylenetetrazol (PTZ). More than 80% appropriate ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02251282

    authors: Wada T,Fukuda N

    更新日期:1993-01-01 00:00:00

  • Added donepezil for stable schizophrenia: a double-blind, placebo-controlled trial.

    abstract:RATIONALE:Schizophrenia is a disorder with cognitive deficits that could stem from cholinergic dysfunction. OBJECTIVES:Our aim was to examine if donepezil administered to stable, medicated outpatients with schizophrenia improves cognition and psychopathology. METHODS:We conducted a double-blind placebo-controlled tri...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-005-2235-1

    authors: Freudenreich O,Herz L,Deckersbach T,Evins AE,Henderson DC,Cather C,Goff DC

    更新日期:2005-09-01 00:00:00

  • Evidence for behavioral sensitization to cocaine in preweanling rat pups.

    abstract::While chronic intermittent administration of stimulants often induces behavioral sensitization in adulthood, stimulant sensitization has rarely been reported prior to weaning [around postnatal day (P) 21]. Consistent pairing of drug administration with the test context often facilitates sensitization in adults, yet yo...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130050653

    authors: Wood RD,Tirelli E,Snyder KJ,Heyser CJ,LaRocca TM,Spear LP

    更新日期:1998-07-01 00:00:00

  • Modulation of the effects of alcohol on driving-related psychomotor skills by chronic exposure to cannabis.

    abstract:RATIONALE:Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters the effects of alcohol on psychomotor performance. OBJECTIVES:To test wh...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00213-001-0955-4

    authors: Wright A,Terry P

    更新日期:2002-03-01 00:00:00

  • Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity.

    abstract:OBJECTIVES:The present study investigates the effects of injections of a specific N-methyl-D-aspartic acid (NMDA) antagonist 3-[(R)-2-carboxypiperazin-4-yl]-propyl-1-phophonic acid (CPP) into the prefrontal cortex (PFC) on the extracellular concentrations of dopamine and acetylcholine in the nucleus accumbens (NAc) and...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-008-1288-3

    authors: Del Arco A,Segovia G,Mora F

    更新日期:2008-12-01 00:00:00

  • The sigma1 (sigma1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming.

    abstract:RATIONALE:Cocaine-seeking behavior can be investigated in rodents using the conditioned place preference (CPP) paradigm, in which the drug-paired environment serves as a conditioned stimulus. Such approach allowed to previously demonstrate the importance of the neuromodulatory sigma1 (sigma1) receptor in acquisition of...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-004-1814-x

    authors: Romieu P,Meunier J,Garcia D,Zozime N,Martin-Fardon R,Bowen WD,Maurice T

    更新日期:2004-09-01 00:00:00

  • The psychopharmacology of impulsive behaviour in rats VIII: effects of amphetamine, methylphenidate, and other drugs on responding maintained by a fixed consecutive number avoidance schedule.

    abstract:RATIONALE:Impulsive behaviour is a component of psychiatric disorders such as bipolar disorder, attention deficit hyperactivity disorder (ADHD), or personality disorders. Most experimental studies on impulsive behaviour punish impulsive choices by loss or delay of reward. In the present study, impulsive behaviour was p...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-005-2163-0

    authors: Evenden J,Ko T

    更新日期:2005-07-01 00:00:00

  • Methamphetamine addiction: involvement of CREB and neuroinflammatory signaling pathways.

    abstract:RATIONALE AND OBJECTIVES:Addiction to psychostimulant methamphetamine (METH) remains a major public health problem in the world. Animal models that use METH self-administration incorporate many features of human drug-taking behavior and are very helpful in elucidating mechanisms underlying METH addiction. These models ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1007/s00213-016-4235-8

    authors: Krasnova IN,Justinova Z,Cadet JL

    更新日期:2016-05-01 00:00:00