Selective inhibition of MAO-A, not MAO-B, results in antidepressant-like effects on DRL 72-s behavior.

abstract：RATIONALE:Heavy ecstasy use in humans has been associated with cognitive impairments and changes in cognitive brain function supposedly due to damage to the serotonin system. There is concern that even a single dose of 3,4-methylenedioxymethamphetamine may be neurotoxic, but very little is known about the consequences ...

journal_title：Psychopharmacology

authors： Jager G,de Win MM,Vervaeke HK,Schilt T,Kahn RS,van den Brink W,van Ree JM,Ramsey NF

更新日期：2007-08-01 00:00:00

abstract：RATIONALE:Receptor mechanisms underlying the behavioral effects of clinically used nicotinic acetylcholine receptor agonists have not been fully established. OBJECTIVE:Drug discrimination was used to compare receptor mechanisms underlying the effects of smoking cessation aids. METHODS:Separate groups of male C57BL/6J...

journal_title：Psychopharmacology

authors： Cunningham CS,McMahon LR

更新日期：2013-07-01 00:00:00

abstract：RATIONALE:Schizophrenia is a complex neuropsychiatric disorder characterized, in part, by impaired dopamine signaling. TAK-063 is a selective inhibitor of phosphodiesterase 10A, a key regulator of intracellular signaling pathways that is highly expressed in the striatum. OBJECTIVE:Safety, tolerability, and pharmacokin...

journal_title：Psychopharmacology

authors： Tsai M,Chrones L,Xie J,Gevorkyan H,Macek TA

更新日期：2016-10-01 00:00:00

abstract：RATIONALE:Relapse to smoking is often precipitated by stress, yet little is known about the effects of nicotine withdrawal on responses to acute stress, or whether nicotine replacement reverses withdrawal-induced changes in stress response. OBJECTIVES:The aim of the present study is to use an effective social stressor...

journal_title：Psychopharmacology

authors： Wardle MC,Munafò MR,de Wit H

更新日期：2011-11-01 00:00:00

abstract：RATIONALE:Nicotine increases glutamate release in the ventral tegmental area and the nucleus accumbens, and thus enhances dopamine neurotransmission in the mesolimbic system that has been implicated in mediating the rewarding effects of drugs. Metabotropic glutamate receptors 5 (mGluR5) are found in the nucleus accumbe...

journal_title：Psychopharmacology

authors： Paterson NE,Semenova S,Gasparini F,Markou A

更新日期：2003-05-01 00:00:00

abstract：RATIONALE:Schizophrenia is a complex psychiatric disorder comprised of three main classes of symptoms: positive, negative and cognitive symptoms. Currently, no approved treatment exists for the cognitive symptoms. There is thus a great need for research aiming at identifying novel targets for treatment of this indicati...

journal_title：Psychopharmacology

authors： Damgaard T,Plath N,Neill JC,Hansen SL

更新日期：2011-03-01 00:00:00

abstract：:A number of clinically used benzodiazepines were tested for their effectiveness in blocking muscimol-induced myoclonic jerks in mice. Their ED50 values were determined from their dose-response curves. These data gave the following relative potencies with respect to diazepam: diazepam = 1, medazepam = 0.24, oxazepam = ...

journal_title：Psychopharmacology

authors： Menon MK,Vivonia CA,Haddox VG

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in "bath salts" products. While there are currently no pharmacotherapies for MDPV abuse, rodent studies suggest immunotherapy may offer a feasible treatment option. OBJECTIVES:These studies test...

journal_title：Psychopharmacology

authors： McClenahan SJ,Gunnell MG,Owens SM,Fantegrossi WE

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:The primary aim of this project was to examine the role of alcohol use in smoking lapse behavior, as alcohol consumption is a known risk factor for poor smoking cessation outcomes. MATERIALS AND METHODS:We have developed a novel human laboratory model to examine two primary aspects of alcohol-mediated tobacc...

journal_title：Psychopharmacology

authors： McKee SA,Krishnan-Sarin S,Shi J,Mase T,O'Malley SS

更新日期：2006-12-01 00:00:00

abstract：:The effects of lormetazepam (0.03 mg/kg IV) a benzodiazepine (BZ) derivative in combination with ZK 93 426 (0.04 mg/kg IV) a beta-carboline, benzodiazepine receptor antagonist were evaluated in humans. Independently, the effects of ZK 93 426 on its own were investigated. A psychometric test battery to evaluate sedatio...

journal_title：Psychopharmacology

authors： Duka T,Goerke D,Dorow R,Höller L,Fichte K

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Dysfunction of executive neuropsychological performance, mediated by the prefrontal cortex, has been the central focus of recent attention deficit/ hyperkinetic disorder (AD-HKD) research. The role of other potential neuropsychological "risk factors", such as recognition memory, remains understudied. Further,...

journal_title：Psychopharmacology

authors： Rhodes SM,Coghill DR,Matthews K

更新日期：2004-09-01 00:00:00

abstract：RATIONALE:The contribution of dopamine receptor subtypes in mediating the discriminative stimulus effects of cocaine is not fully established. Many drug discrimination studies use food to maintain responding, necessitating food restriction, which can alter drug effects. OBJECTIVE:This study established stimulus contro...

journal_title：Psychopharmacology

authors： Baladi MG,Newman AH,France CP

更新日期：2014-02-01 00:00:00

abstract：:Marked changes in biophysical properties, including structural order, have been observed in the hydrophobic core of cell membranes exposed to phenothiazines in vitro. In this study, similar changes are reported in vivo in cell membranes from the brains of rats treated with phenothiazines at doses thought to yield tiss...

journal_title：Psychopharmacology

authors： Cohen BM,Zubenko GS

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Preclinical evidence suggests that non-cannabinoid neurotransmitter systems are involved in the behavioral and physiological effects of cannabinoids, but relatively little research has been conducted in humans. OBJECTIVES:The aims of this study were to assess whether oral Delta(9)-tetrahydrocannabinol (Delta...

journal_title：Psychopharmacology

authors： Lile JA,Kelly TH,Pinsky DJ,Hays LR

更新日期：2009-04-01 00:00:00

abstract：:The effects of methylglucamine orotate (MGO) were studied on polygraphic sleep recordings in rats for 8 h per day between 8 a.m. and 4 p.m. MGO (225 mg/kg) was injected intraperitoneally immediately prior to the onset of recording. In the acute experiment, the effect of MGO was compared to pre- and post-drug control d...

journal_title：Psychopharmacology

authors： Wetzel W,Ott T,Matthies HK,Matthies H

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:2-Bromoterguride, a dopamine D2 receptor partial agonist with antagonist properties at serotonin 5-HT2A receptors and α2C-adrenoceptors, meets the prerequisites of a putative atypical antipsychotic drug (APD). We recently showed that 2-bromoterguride is effective in tests of positive symptoms of schizophrenia...

journal_title：Psychopharmacology

authors： Tarland E,Franke RT,Fink H,Pertz HH,Brosda J

更新日期：2018-01-01 00:00:00

abstract：RATIONALE:It has been demonstrated that major differences between mice of the C57BL/6J and DBA/2J inbred strains for amphetamine-induced place conditioning (preference and avoidance, respectively) are evident in standard housing conditions but abolished by temporary restricted feeding. This gene-experience model may be...

journal_title：Psychopharmacology

authors： Orsini C,Buchini F,Piazza PV,Puglisi-Allegra S,Cabib S

更新日期：2004-03-01 00:00:00

abstract：:The residual effects of three hypnotics were investigated by the method of 24-h polygraphy (EEG, EMG, and EOG). The drugs were triazolam 0.25 mg and 0.5 mg, flurazepam 15 mg and 30 mg, nitrazepam 5 mg and 10 mg, and placebo. The subjects were healthy volunteers, eight men and eight women with an average age of 34.3 ye...

journal_title：Psychopharmacology

authors： Ogura C,Nakazawa K,Majima K,Nakamura K,Ueda H,Umezawa Y,Wardell WM

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Repeated administrations of ethanol induce a progressive and enduring increase in its locomotor stimulant effects, a phenomenon termed behavioral sensitization that has not been systematically characterized. OBJECTIVE:The aim of the present studies was to characterize the development and expression of ethano...

journal_title：Psychopharmacology

authors： Didone V,Quoilin C,Tirelli E,Quertemont E

更新日期：2008-12-01 00:00:00

abstract：RATIONALE:Evidence suggesting that the endogenous cannabinoid (eCB) system can be manipulated to facilitate or impair extinction of learned behaviours has important consequences for opiate withdrawal and abstinence. We demonstrated that the fatty acid amide hydrolase (FAAH) inhibitor URB597, which increases eCB levels,...

journal_title：Psychopharmacology

authors： Manwell LA,Mallet PE

更新日期：2015-05-01 00:00:00

abstract：:Nine depressed patients were treated with alaproclate, a selective 5-HT uptake inhibitor, for 3 weeks in a dose of 400 mg daily. The pupillary responses to tyramine, phenylephrine, and pilocarpine eye drops were measured on consecutive days before, after 1 week and after 3 weeks of treatment. The tyramine-induced mydr...

journal_title：Psychopharmacology

authors： Thompson C,Checkley SA

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine. METHODS:Using an isolation-r...

journal_title：Psychopharmacology

authors： Liu YP,Wilkinson LS,Robbins TW

更新日期：2017-05-01 00:00:00

abstract：:The effects of an "aggression"-reducing drug, fluprazine, and an "aggression"-enhancing drug, ethanol, were evaluated in mice using the target biting and resident-intruder paradigms. Under baseline conditions there was a high target biting rate immediately after the delivery of a 2.0 mA tail shock, an intermediate tar...

journal_title：Psychopharmacology

authors： Wagner GC,Carelli RM

更新日期：1987-01-01 00:00:00

abstract：:The present study compared the acute subject-rated and performance-impairing effects of trazodone and triazolam in seven healthy humans. Trazodone (50, 100 and 200 mg), triazolam (0.125, 0.25, 0.50 mg) and placebo were administered orally in a double-blind, crossover design. Drug effects were measured approximately 30...

journal_title：Psychopharmacology

authors： Rush CR,Madakasira S,Hayes CA,Johnson CA,Goldman NH,Pazzaglia PJ

更新日期：1997-05-01 00:00:00

abstract：:A neutral stimulus can acquire conditioned rewarding properties through association with an intrinsically rewarding stimulus. The acquisition of responding for conditioned rewards requires that environmental stimuli and reward processes interact in a highly specific manner; analyses of this phenomenon may provide valu...

journal_title：Psychopharmacology

authors： Sutton MA,Beninger RJ

更新日期：1999-05-01 00:00:00

abstract：:The effects of flurazepam (0.0, 0.5, and 3.0 mg/kg) on methylphenidate-induced increases in stereotypy, gnawing, sniffing, and locomotion were evaluated in Swiss-Webster mice in daytime and nighttime experiments. Methylphenidate (50 mg/kg) increased overall stereotypy and stereotyped gnawing behavior; two doses of met...

journal_title：Psychopharmacology

authors： Risch C,Kripke D,Janowsky D

更新日期：1980-01-01 00:00:00

abstract：:Two experiments examined the effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid intake in water-deprived rats. In the first experiment, pretreatment with 3.0 or 10.0 mg/kg zolpidem IP was found to increase consumption of a novel glucose drink (3% d-glucose and 0.15 sodium saccharine w/v in wat...

journal_title：Psychopharmacology

authors： Stanhope KJ,Roe S,Dawson G,Draper F,Jackson A

更新日期：1993-01-01 00:00:00

abstract：:CSF GABA levels were not significantly different in a group of drug-free psychotic patients compared to a group of psychotic patients at two points during haloperidol treatment or a neurological comparison group. In the untreated group, CSF GABA was significantly negatively correlated with clinical ratings of anxiety ...

journal_title：Psychopharmacology

authors： Bowers MB Jr,Gold BI,Roth RH

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Endogenous opioid systems within the mesencephalic periaqueductal gray matter (PAG) appear to be intricately involved in many affective, defensive, submissive, and reflexive responses, and these systems are activated by aversive stimuli. OBJECTIVES:The present experiments evaluated the influence of opioid re...

journal_title：Psychopharmacology

authors： Vivian JA,Miczek KA

更新日期：1999-09-01 00:00:00

abstract：RATIONALE:Despite animal evidence that methylenedioxymethamphetamine (ecstasy) causes lasting damage in brain regions related to long-term memory, results regarding human memory performance have been variable. This variability may reflect the cognitive complexity of the memory tasks. However, previous studies have test...

journal_title：Psychopharmacology

authors： Brown J,McKone E,Ward J

更新日期：2010-03-01 00:00:00