Abstract:
:The effects of methylglucamine orotate (MGO) were studied on polygraphic sleep recordings in rats for 8 h per day between 8 a.m. and 4 p.m. MGO (225 mg/kg) was injected intraperitoneally immediately prior to the onset of recording. In the acute experiment, the effect of MGO was compared to pre- and post-drug control days. In the chronic experiment, a sequence of 5 control days, 10 days of MGO treatment, and a further 8 control days was tested. Both acute and chronic administration of MGO resulted in increased paradoxical sleep (PS) latency and a small, but significant, decrease in PS during the first 4 h after injection. This effect seems to be specific to PS, as no effects of MGO on waking or total sleep were found. With chronic administration, no PS rebound occurred within the 8-h recording time during the 8-day post-treatment control period. How the RNA precursor can decrease PS and whether this effect may play a role in the memory-improving action of the substance is discussed in terms of an interrelationship between macromolecular synthesis, sleep, and memory, respectively.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Wetzel W,Ott T,Matthies HK,Matthies Hdoi
10.1007/BF00428551subject
Has Abstractpub_date
1984-01-01 00:00:00pages
380-3issue
4eissn
0033-3158issn
1432-2072journal_volume
83pub_type
杂志文章abstract::An experiment was conducted to test whether centrally acting drugs could act as conditioned stimuli (CS) in a classical conditioning paradigm in which electric shock acted as the unconditioned stimulus (US) and suppression of drinking was used as an indicator of a conditioned response (CR). Thirsty rats were allowed t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244921
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:A cue-modulated startle test recently confirmed that smoking cues in smokers may not be withdrawal-like and aversive as traditionally believed. OBJECTIVE:Analogous tests were applied to alcohol cues in inpatient alcoholics. METHODS:Twenty-six withdrawn alcoholics (18 men) were examined. Alcohol-related pict...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000508
更新日期:2000-09-01 00:00:00
abstract:INTRODUCTION:Dysfunction of brain dopamine systems is involved in various neuropsychiatric disorders. Challenge studies with dopamine receptor agonists have been performed to assess dopamine receptor functioning, classically using the release of growth hormone (GH) from the hindbrain as primary outcome measure. The obj...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1686-1
更新日期:2010-01-01 00:00:00
abstract::The binding kinetics of tritiated quinuclidinyl benzilate (QNB) were studied in membrane preparations from human parotid and rabbit submandibular glands. Inhibition of 3H-QNB was then used to compare the anticholinergic activity of lofepramine, desipramine, imipramine and amitriptyline for muscarinic receptor in the s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00172861
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:A number of studies have indicated a relationship between the intake of palatable foods or fluids and drug self-administration. OBJECTIVES:Two experiments were conducted to determine whether the intake of sucrose or fat was related to subsequent cocaine self-administration. METHODS:In separate groups of rat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000375
更新日期:2000-04-01 00:00:00
abstract:RATIONALE:Cocaine-seeking behavior can be investigated in rodents using the conditioned place preference (CPP) paradigm, in which the drug-paired environment serves as a conditioned stimulus. Such approach allowed to previously demonstrate the importance of the neuromodulatory sigma1 (sigma1) receptor in acquisition of...
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更新日期:2004-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:1981-01-01 00:00:00
abstract:RATIONALE:In drug-dependent individuals, the primary excessive motivation is for drugs. Studies also indicate altered interest for "natural" rewarding activities associated with motivational disorders that may be relevant to drug dependence. However, to date, the impact of drug dependence and withdrawal upon motivation...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2612-x
更新日期:2012-06-01 00:00:00
abstract:RATIONALE:Ketamine, a well-known general dissociative anesthetic agent that is a non-competitive antagonist of the N-methyl-D-aspartate receptor, perturbs the perception of elapsed time and the expectation of upcoming events. OBJECTIVE:The objective of this study was to determine the influence of ketamine on temporal ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05706-6
更新日期:2021-02-01 00:00:00
abstract::In order to validate a new animal model predictive of the profile of antiepileptic drugs, we studied the antagonism by standard antiepileptics of the EEG modifications induced by low-speed IV infusion of pentylenetetrazol (PTZ) in rats. The activity of the drugs was measured by their effects on temporal characteristic...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432718
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:The α7 nicotinic acetylcholine receptor (nAChR) has been implicated as a target in modulating nicotine reward. However, the effect of pharmacological agents that have been shown to alter the channel properties of the α7 nAChR is not well understood in nicotine reward. OBJECTIVES:This study aimed to investiga...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05331-y
更新日期:2019-12-01 00:00:00
abstract:RATIONALE:The emergence of the consumption of highly potent synthetic cannabinoid receptor agonists (spice drugs) that produce important neurological symptoms has prompted the research on the consequences of acute and chronic use of these new psychoactive substances. Most studies on cannabinoid dependence have been per...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05704-8
更新日期:2021-02-01 00:00:00
abstract:RATIONALE:Chronic stress and corticosterone have been shown to affect serotonin (5-HT) neurotransmission; however, the influence of stress on the activity of the dorsal raphe nucleus (DRN), the main source of 5-HT in the forebrain, is not well understood. In particular, it is unknown if and how stress modifies DRN 5-HT...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5045-y
更新日期:2018-12-01 00:00:00
abstract::In a placebo-controlled study, we investigated the influence of nicotine on late-day aviation performance in 15 non-smoking subjects. In a within-subjects design, subjects were tested on 2 days, each lasting 8 h and consisting of three 75-min simulator flights (late-afternoon practice, evening test, night test). Prior...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130050736
更新日期:1998-11-01 00:00:00
abstract:RATIONALE:Consistent sex differences are observed in human drug addiction, with females often exceeding males on drug intake. However, there is still a need for animal models for some aspects of addiction such as acquisition of drug self-administration and the subsequent development of drug-seeking. OBJECTIVES:The pre...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4183-8
更新日期:2016-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174371
更新日期:1986-01-01 00:00:00
abstract::The behavioral responses to separate and combined administration of the D1 agonist SKF-38393 and the D2 agonist quinpirole following acute dopamine (DA) depletion via alpha-methyl-p-tyrosine (AMPT) or AMPT/reserpine were examined in infant (10-day-old) and weanling (21-day-old) rat pups. At both ages, AMPT pretreatmen...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244963
更新日期:1992-01-01 00:00:00
abstract::The administration of large doses of probenecid has been used to study the central nervous system metabolism of catecholamines and indoleamines in patients with affective disease. It has been reported that alterations of the binding of L-tryptophan to plasma albumin binding sites occur during probenecid administration...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00492369
更新日期:1977-08-16 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100720
更新日期:2001-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
abstract:RATIONALE:Relapse to drug-seeking in abstinent heroin addicts and reinstatement in experimental animals are observed when exposed to drug-associated stimuli or cues, the drug itself, and stressful events. It has been shown that footshock-induced stress increases the rewarding effects of opiates, delays extinction, and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0345-z
更新日期:2006-05-01 00:00:00
abstract:RATIONALE:Recent research highlights the need to extend our understanding of how exercise may aid smoking cessation, through exploration of different modes, intensity and duration of exercise. OBJECTIVES:The purpose of the study was to examine the effects of a 1-mile self-paced walk on different measures of urges to s...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-2216-4
更新日期:2005-08-01 00:00:00
abstract:RATIONALE:Higher rates of delay discounting, or impulsive choice, may be related to relapse during abstinence reinforcement interventions for cigarette smoking, and a transdermal nicotine patch may attenuate delay discounting. OBJECTIVE:The objectives of this study are to assess the relation between delay discounting ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0627-5
更新日期:2007-03-01 00:00:00
abstract::The purpose of this study was to assess the effects of acute nicotine administration, following a 12-h cigarette deprivation period, using a computerized performance assessment battery (PAB). The PAB was comprised of five tasks which were selected to reflect a variety of complex acquired behaviors, sometimes referred ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00443406
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Several previous neuroendocrine studies have demonstrated reduced 5-HT1A receptor function in major depressive disorder (MDD). However, hypercortisolaemia or previous drug treatment may have been significant confounds. OBJECTIVES:To replicate previous studies in subjects with MDD who had been drug free for a...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-003-1475-1
更新日期:2003-08-01 00:00:00
abstract:RATIONALE:Dysfunction of executive neuropsychological performance, mediated by the prefrontal cortex, has been the central focus of recent attention deficit/ hyperkinetic disorder (AD-HKD) research. The role of other potential neuropsychological "risk factors", such as recognition memory, remains understudied. Further,...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-004-1833-7
更新日期:2004-09-01 00:00:00
abstract:RATIONALE:Studies about whether or not the cognitive performance of women is influenced by changes in levels of sex steroid hormones across the menstrual cycle have produced ambiguous results. OBJECTIVES:This study tested whether flight simulator performance differs significantly between the menstrual and the luteal p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100700
更新日期:2001-05-01 00:00:00
abstract::Using a 15-s intershock interval, an increase in shock-induced fighting was observed following intraventricular 96 microgram 5,7-dihydroxytryptamine (5,7-DHT) and 90 microgram 6-hydroxydopa (6-OHdopa). The incidence of predatory mouse killing was enhanced by 5,7-DHT, but was not affected by 6-OHdopa. Pain sensitivity ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432684
更新日期:1981-01-01 00:00:00
abstract::Cigarette smokers have a wide variety of "tar" and nicotine yields to choose from in the current market, ranging from 0.5 mg "tar" and less than 0.05 mg nicotine to 27 mg "tar" and 1.8 mg nicotine by the Federal Trade Commission (FTC) method. To understand better the relationship between FTC nicotine yields and actual...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02246082
更新日期:1995-11-01 00:00:00
abstract::The central effects of acetylsalicylic acid (ASA) are discussed controversially. In animal models, it has been shown that ASA can interact with the central serotonergic and catecholaminergic neuronal system. However, the relevance of this interaction for humans is still unknown. We performed a study on the influence o...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050683
更新日期:1998-08-01 00:00:00