当前位置： SCI文献检索 > PSYCHOPHARMACOLOGY期刊下所有文献 > The sigma1 (sigma1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming.

The sigma1 (sigma1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming.

Abstract：

RATIONALE:Cocaine-seeking behavior can be investigated in rodents using the conditioned place preference (CPP) paradigm, in which the drug-paired environment serves as a conditioned stimulus. Such approach allowed to previously demonstrate the importance of the neuromodulatory sigma1 (sigma1) receptor in acquisition of cocaine-induced CPP. CPP can be extinguished and then reactivated, notably using a cocaine challenge (i.e., priming). OBJECTIVES AND METHODS:In order to examine the role of the sigma1 receptor in reinstatement of Cocaine-seeking, Swiss mice acquired CPP with cocaine (30 mg/kg, i.p.) and then CPP was extinguished. RESULTS:A challenge cocaine priming (15 mg/kg) reactivated CPP up to 140% of the post-conditioning response. Pre-administration of the sigma1 receptor antagonist BD1047 (330 mg/kg, i.p.) or repeated treatment with an antisense probe targeting the sigma1 receptor prevented CPP reactivation. The sigma1 agonist igmesine (1-10 mg/kg, i.p.) or the steroid dehydroepiandrosterone (DHEA, 10-40 mg/kg, s.c.) reactivated CPP, in a BD1047-sensitive manner. Moreover, the in vivo [3H](+)-SKF-10,047 binding levels to the sigma1 receptor were increased after cocaine conditioning in numerous brain structures and these increases subsisted after extinction. Finally, cross-reactivation of cocaine-induced CPP was observed after phencyclidine (PCP), morphine, nicotine and ethanol administration. However, BD1047 blocked reactivation of CPP induced by PCP, morphine and nicotine but not ethanol. CONCLUSIONS:Since activation of the sigma1 receptor is not sufficient to sustain CPP in naive animals [Neuropsychopharmacology 26 (2002) 444], it is concluded that sigma1 receptor activation is a key event for relapse to drug seeking. Activation may occur via sensitization due to enhanced in vivo available of receptors.

journal_name

Psychopharmacology (Berl)

journal_title

Psychopharmacology

authors

Romieu P,Meunier J,Garcia D,Zozime N,Martin-Fardon R,Bowen WD,Maurice T

doi

10.1007/s00213-004-1814-x

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

154-62

issue

eissn

0033-3158

issn

1432-2072

journal_volume

175

pub_type

杂志文章

在线工具

The sigma1 (sigma1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming.