Pindolol decreases prolactin and growth hormone responses to intravenous L-tryptophan.

abstract：RATIONALE:Dysfunction of glutamatergic neurotransmission has been implicated in the pathophysiology of obsessive-compulsive disorder (OCD) and recent clinical reports suggest that some glutamate modulating agents are efficacious in the treatment of this disorder. N-acetylcysteine (NAC) is a readily available amino acid...

journal_title：Psychopharmacology

authors： Lafleur DL,Pittenger C,Kelmendi B,Gardner T,Wasylink S,Malison RT,Sanacora G,Krystal JH,Coric V

更新日期：2006-01-01 00:00:00

abstract：RATIONALE:Studies of ethanol's effects on TSH carried out during the daytime, when its secretion is at its nadir, do not reflect the true action of alcohol on TSH secretion since TSH peak occurs at night. OBJECTIVE:The present study investigated the effects of alcohol on the serum concentrations of TSH in healthy volu...

journal_title：Psychopharmacology

authors： Danel T,Touitou Y

更新日期：2003-11-01 00:00:00

abstract：RATIONALE:The effects of adolescent marijuana use on the developing brain remain unclear, despite its prevalence. Arterial spin labeling (ASL) is a noninvasive imaging technique that characterizes neurovascular status and cerebral blood flow (CBF), potentially revealing contributors to neuropathological alterations. No...

journal_title：Psychopharmacology

authors： Jacobus J,Goldenberg D,Wierenga CE,Tolentino NJ,Liu TT,Tapert SF

更新日期：2012-08-01 00:00:00

abstract：RATIONALE:Both methylphenidate (MPH), a catecholamine reuptake blocker, and guanfacine, an alpha2A agonist, are used to treat attention-deficit hyperactivity disorder (ADHD). Childhood impulsivity, including delay discounting, is associated with increased substance use during adolescence. These effects can be mitigated...

journal_title：Psychopharmacology

authors： Freund N,Jordan CJ,Lukkes JL,Norman KJ,Andersen SL

更新日期：2019-02-01 00:00:00

abstract：RATIONALE:Converging evidence suggests that dopaminergic and serotonergic mechanisms affect distinct aspects of cognitive performance. Experiments using the rodent five-choice reaction time task have established a critical role for dopaminergic mechanisms in the rat medial prefrontal cortex (mPFC), but have yielded onl...

journal_title：Psychopharmacology

authors： Passetti F,Dalley JW,Robbins TW

更新日期：2003-01-01 00:00:00

abstract：:Behavioral performances of normotensive and hypertensive adult male baboons were tested before, during, and following chronic oral dosing with nifedipine. Performances during a five-color simultaneous match-to-sample task were measured during three dosing schedules (0.20, 0.68, and 1.14 mg/kg/day) and vehicle. Each do...

journal_title：Psychopharmacology

authors： Turkkan JS,Hienz RD

更新日期：1990-01-01 00:00:00

abstract：:A variety of behaviors were studied in an open-field setting after i.v. amphetamine (0.5, 2.0, 8.0 mg/kg), phenmetrazine (1.0, 4.0, 16.0 mg/kg), or fenfluramine (1.0, 4.0, 16.0 mg/kg). Amphetamine and phenmetrazine increased ambulation initially and rearing during the whole experiment, and decreased grooming. At 30 an...

journal_title：Psychopharmacology

authors： Lindquist MP,Götestam KG

更新日期：1977-12-19 00:00:00

abstract：RATIONALE:The extent to which non-α4β2 versus α4β2* nAChRs contribute to the behavioral effects of varenicline and other nAChR agonists is unclear. OBJECTIVES:The purpose of this study was to characterize the discriminative stimulus effects of varenicline and nicotine using various nAChR agonists and antagonists to el...

journal_title：Psychopharmacology

authors： de Moura FB,McMahon LR

更新日期：2017-03-01 00:00:00

abstract：:Muscimol, a structural analog of GABA, significantly potentiated pilocarpine-induced analgesia in rats, but failed to alter pilocarpine-induced catalepsy. It also failed to affect pilocarpine-elicited increase in homovanillic acid levels in the striatum. These findings suggest that the potentiation of pilocarpine-indu...

journal_title：Psychopharmacology

authors： Naik SR,Kelkar MR,Amladi SR,Sheth UK

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:The search for novel antipsychotic drugs to treat schizophrenia is driven by the poor treatment efficacy, serious side effects, and poor patient compliance of current medications. Recently, a class of compounds known as tetrahydroprotoberberines, which includes the compound d,l-govadine, have shown promise in...

journal_title：Psychopharmacology

authors： Lins BR,Marks WN,Phillips AG,Howland JG

更新日期：2017-04-01 00:00:00

abstract：:Rats were trained in a Y-maze on a two-choice simultaneous black-white discrimination with either black or white as S+. Animals were then transferred to one of three discrimination tasks. In task 1 (New S-), a new stimulus, either vertical or horizontal stripes, was substituted for the original S-. In task 2 (New S+),...

journal_title：Psychopharmacology

authors： Weiner I,Feldon J,Ben-Horin E

更新日期：1987-01-01 00:00:00

abstract：:In a shuttle-box self-stimulation paradigm, analgesic doses of morphine increase the amount of time a rat leaves rewarding brain stimulation on, without altering average OFF times. This paradigm may serve as a model for the euphoria induced by narcotic drugs and as a useful tool for evaluating the reinforcing effects ...

journal_title：Psychopharmacology

authors： Levitt RA,Baltzer JH,Evers TM,Stilwell DJ,Furby JE

更新日期：1977-11-15 00:00:00

abstract：:Passive avoidance learning was significantly impaired by atropine (5 mg/kg, IP) or scopolamine (0.5 mg/kg), but not by methyl-atropine (5 mg/kg) or methyl-scopolamine (0.5 mg/kg), from postnatal day 15 on. In contrast, an improvement was observed, not significant at 11 days and significant at 13 days, probably due to ...

journal_title：Psychopharmacology

authors： Blozovski D,Hennocq N

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Serotonin (5-HT) and norepinephrine (NE) re-uptake inhibitors (SNRIs) have been proposed to have a higher efficacy and/or faster onset of action than previously available antidepressants. OBJECTIVES:We examined in biochemical, electrophysiological and behavioural assays the antidepressant properties of (S)-(...

journal_title：Psychopharmacology

authors： Artaiz I,Zazpe A,Innerárity A,Del Olmo E,Díaz A,Ruiz-Ortega JA,Castro E,Pena R,Labeaga L,Pazos A,Orjales A

更新日期：2005-11-01 00:00:00

abstract：:It has been suggested that the GAbAergic striatonigral projection may form part of the efferent pathway responsible for the expression of dopamine-related oral behaviour. Consistent with this suggestion are reports that bilateral injection of the GABA agonist muscimol can produce stereotyped gnawing and biting. We rep...

journal_title：Psychopharmacology

authors： Taha EB,Dean P,Redgrave P

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:There is evidence that events early in post-weaning life influence brain development and subsequent adult behaviour and therefore play an important role in the causation of certain psychiatric disorders in later life. Exposing rodents to stressors during the juvenile period has been suggested as a model of in...

journal_title：Psychopharmacology

authors： Peleg-Raibstein D,Feldon J

更新日期：2011-03-01 00:00:00

abstract：:Evaluation of the efficacy of antidepressant agents needs to take into account factors which increase the "effect size", such as dosage, treatment duration, the use of two-phase trials, and pattern analysis of responders. Although many patients are thought to receive inadequate doses of antidepressants, relatively few...

journal_title：Psychopharmacology

authors： Quitkin FM

更新日期：1992-01-01 00:00:00

abstract：:The ability of mu and kappa opioids to alter the discriminative-stimulus and rate-decreasing effects of the 5-HT1A receptor agonist 8-OH-DPAT was examined in rats trained to discriminate either a low (0.1 mg/kg) or a high (0.3 mg/kg) dose of 8-OH-DPAT from water using a two-lever food-reinforced drug discrimination pr...

journal_title：Psychopharmacology

authors： Morgan D,Picker MJ

更新日期：1995-12-01 00:00:00

abstract：:7-Hydroxychlorpromazine (7-OHCPZ) has been identified and quantified in CSF from chlorpromazine (CPZ)-treated schizophrenic patients. The level of the metabolite in CSF was similar to that of CPZ. In serum the amount of 7-OHCPZ was about 30% of CPZ. The concentration of 7-OHCPZ in csf was positively and significantly ...

journal_title：Psychopharmacology

authors： Alfredsson G,Lindberg M,Sedvall G

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Cocaethylene is a pharmacologically active homolog and metabolite of cocaine, formed by transesterification of cocaine in the presence of ethanol. Here we relate findings from a randomized, placebo-controlled, double-blind study in which we examined the physiological and subjective effects and pharmacokinetic...

journal_title：Psychopharmacology

authors： Hart CL,Jatlow P,Sevarino KA,McCance-Katz EF

更新日期：2000-04-01 00:00:00

abstract：RATIONALE:Recent studies suggest that orexin/hypocretin is involved in drug reward and drug-seeking behaviors, including ethanol self-administration. However, orexin's role in ethanol-induced seeking behaviors remains unclear. OBJECTIVE:These studies examined the role of orexin in the acquisition and expression of eth...

journal_title：Psychopharmacology

authors： Voorhees CM,Cunningham CL

更新日期：2011-04-01 00:00:00

abstract：RATIONALE:Although some aspects of memory functions are known to be acutely impaired by delta(9)-tetrahydrocannabinol (delta(9)-THC; the main active constituent of marijuana), effects on other aspects of memory are not known and the time course of functional impairments is unclear. OBJECTIVE:The present study aimed to...

journal_title：Psychopharmacology

authors： Curran HV,Brignell C,Fletcher S,Middleton P,Henry J

更新日期：2002-10-01 00:00:00

abstract：:This pilot study was conducted to evaluate the potential of the new antidepressant moclobemide to inhibit the cytochrome enzyme P4502D6 (CYP2D6) using the cough suppressant dextromethorphan as a substrate in four extensive metabolizers (EM) of debrisoquine. The subjects received seven oral doses of 20 mg dextromethorp...

journal_title：Psychopharmacology

authors： Härtter S,Dingemanse J,Baier D,Ziegler G,Hiemke C

更新日期：1998-01-01 00:00:00

abstract：RATIONALE:Cognitive rehabilitation is now recognized as an important tool in the treatment of schizophrenia, and findings in this area are emerging rapidly. There is a need for a systematic review of the effects of the different training programs. OBJECTIVES:To review quantitatively the controlled studies on cognitive...

journal_title：Psychopharmacology

authors： Krabbendam L,Aleman A

更新日期：2003-09-01 00:00:00

abstract：:Cholinergic neurotransmission has been implicated in various forms of neural plasticity such as kindling and learning. We have previously shown that blockade of muscarinic cholinergic receptors prevents the development of locomotor sensitization to methamphetamine. The present study was conducted to examine whether sc...

journal_title：Psychopharmacology

authors： Ohmori T,Abekawa T,Koyama T

更新日期：1995-09-01 00:00:00

abstract：:The effects of morphine, ketocyclazocine, cyclazocine, and SKF-10,047 were tested alone and in conjunction with naltrexone or naloxone, in rats responding under a multiple fixed-interval 3-min schedule of food presentation. Under this paradigm, electric shock was delivered on a fixed-ratio schedule for responses occur...

journal_title：Psychopharmacology

authors： Snell D,Harris RA

更新日期：1982-01-01 00:00:00

abstract：:Effects of chlordiazepoxide (CDP) and ethanolamine-O-sulphate (EOS) alone and in combination were tested on the acquisition and performance of continuous reinforcement - time out (CR-TO) and variable interval reinforcement - time out (VI-TO) operant discriminations in rats. CDP disrupted acquisition of CR-TO discrimin...

journal_title：Psychopharmacology

authors： Hodges H,Baum S,Taylor P,Green S

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Neuroanatomical evidence suggests that GABAergic deficits and progressive cortical atrophy occur with schizophrenia. OBJECTIVE:To evaluate the hypothesis that neurodevelopmental deficits affect neurodegeneration occurring with schizophrenia, this study examined a novel animal model for schizophrenia-related ...

journal_title：Psychopharmacology

authors： Abekawa T,Ito K,Nakato Y,Koyama T

更新日期：2011-06-01 00:00:00

abstract：:The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50 30 and 40 micrograms/kg IP respectively). Phenoxybenzamine and prazosine did not antagonize the anti-withd...

journal_title：Psychopharmacology

authors： van der Laan JW,Weick G,Hillen FC

更新日期：1983-01-01 00:00:00

abstract：:The daily fluid intake of male Wistar rats with simultaneous access to 6% ethanol and water was determined during a baseline period (1 week), following adrenalectomy (1 week) and for 3 weeks following SC implantation of hormone pellets containing corticosterone (CORT) or dexamethasone (DEX). Ethanol consumption droppe...

journal_title：Psychopharmacology

authors： Fahlke C,Hård E,Eriksson CJ,Engel JA,Hansen S

更新日期：1995-01-01 00:00:00