Abstract:
:Cholinergic neurotransmission has been implicated in various forms of neural plasticity such as kindling and learning. We have previously shown that blockade of muscarinic cholinergic receptors prevents the development of locomotor sensitization to methamphetamine. The present study was conducted to examine whether scopolamine, a muscarinic cholinergic antagonist, would also block augmentation of stereotypy induced by chronic methamphetamine (MA) treatment. Rats treated with MA (2.5 mg/kg, SC) for 10 days indicated significantly enhanced stereotyped behavior when tested with MA (2.5 mg/kg) after a 7- to 8- day withdrawal. Pretreatment with scopolamine (3 mg/kg) prior to MA administration prevented the augmentation of stereotypy. Rats treated with scopolamine alone showed no difference in MA-induced stereotypy compared to those treated with saline. Scopolamine methylbromide, a derivative of scopolamine that does not easily cross the blood-brain barrier, had no effect on the augmentation of stereotypy. These results suggest that stimulation of central muscarinic cholinergic receptors plays a role in the development of sensitization to the stereotypy stimulating effect of methamphetamine.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Ohmori T,Abekawa T,Koyama Tdoi
10.1007/BF02245625subject
Has Abstractpub_date
1995-09-01 00:00:00pages
158-63issue
2eissn
0033-3158issn
1432-2072journal_volume
121pub_type
杂志文章abstract:RATIONALE:Subthreshold smokers (who smoke < or =5 cigarettes/day) experience withdrawal symptoms, yet they smoke less than is required to maintain serum nicotine levels. OBJECTIVES:For study 1, our aim was to determine (1) if adult subthreshold smokers report withdrawal symptoms; (2) how they rate symptom severity; (3...
journal_title:Psychopharmacology
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doi:10.1007/s00213-006-0497-x
更新日期:2006-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1977-08-31 00:00:00
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pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-03-01 00:00:00
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更新日期:2002-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1979-03-14 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2005-08-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:1983-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00432855
更新日期:1978-04-11 00:00:00
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pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00431655
更新日期:1981-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00179930
更新日期:1987-01-01 00:00:00
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doi:10.1007/s00213-008-1315-4
更新日期:2009-01-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2004-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1783-1
更新日期:2010-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s002130050523
更新日期:1998-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-2163-0
更新日期:2005-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433021
更新日期:1983-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-008-1082-2
更新日期:2008-09-01 00:00:00