Abstract:
RATIONALE:It has been demonstrated that major differences between mice of the C57BL/6J and DBA/2J inbred strains for amphetamine-induced place conditioning (preference and avoidance, respectively) are evident in standard housing conditions but abolished by temporary restricted feeding. This gene-experience model may be usefully exploited to dissect behavioral phenotypes related to place conditioning induced by addictive drugs. OBJECTIVES:This study evaluated a number of behavioral phenotypes related to amphetamine-induced place preference for strain differences (C57BL/6J vs DBA/2J) susceptible to be abolished by temporary food restriction. METHODS:Mice of the two inbred strains were tested for: (1) conditioned taste aversion and place preference induced by amphetamine within the same dose-range; (2) preference for a novel compartment 24 h after a single exposure to only one of two compartments; (3) amphetamine-induced behavioral sensitization and conditioned hyperactivity; and (4) locomotor activity during exploration of a novel environment. RESULTS:The two strains showed consistent taste aversion at doses of amphetamine that promoted opposite strain-dependent place conditioning. Both strains spent more time exploring the novel rather than the known compartment of the place conditioning apparatus. Instead, only mice of the C57 strain showed amphetamine-induced behavioral sensitization and conditioned hyperactivity. However, temporary food restriction did not affect strain differences for these phenotypes. Finally, C57 mice were more active than DBA in a novel environment and restricted feeding abolished this strain-dependent difference. CONCLUSIONS:These results relate individual differences for amphetamine-induced place conditioning with locomotor response to amphetamine and novelty.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Orsini C,Buchini F,Piazza PV,Puglisi-Allegra S,Cabib Sdoi
10.1007/s00213-003-1647-zsubject
Has Abstractpub_date
2004-03-01 00:00:00pages
264-70issue
3eissn
0033-3158issn
1432-2072journal_volume
172pub_type
杂志文章abstract:RATIONALE:Changes in serotonin(1B) (5-HT(1B)) receptor function appear to modify the reinforcing properties of cocaine, but the direction of this effect is not completely clear. Pharmacological stimulation of 5-HT(1B) enhanced the rewarding properties of self-administered cocaine while attenuating the threshold-reducin...
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journal_title:Psychopharmacology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2017-08-01 00:00:00
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更新日期:2013-06-01 00:00:00
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