Abstract:
:Nine depressed patients were treated with alaproclate, a selective 5-HT uptake inhibitor, for 3 weeks in a dose of 400 mg daily. The pupillary responses to tyramine, phenylephrine, and pilocarpine eye drops were measured on consecutive days before, after 1 week and after 3 weeks of treatment. The tyramine-induced mydriasis was unaffected by alaproclate, suggesting that it does not significantly inhibit the reuptake of noradrenaline. The pilocarpine-induced miosis and the phenylephrine-induced mydriasis were both enhanced after 1 week but not after 3 weeks of treatment. This suggests that alaproclate acutely increases the responsiveness of postsynaptic muscarinic and alpha 1 adrenoceptors.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Thompson C,Checkley SAdoi
10.1007/BF00427324subject
Has Abstractpub_date
1985-01-01 00:00:00pages
65-8issue
1eissn
0033-3158issn
1432-2072journal_volume
85pub_type
杂志文章abstract::The effects of the benzomorphan antagonist Mr 2266 and the selective delta-antagonist ICI 154,129 on the body weight gain of 6-day-old suckling rat pups was observed. Mr 2266 significantly reduced body weight gain in these animals, though ICI 154,129 had no affect on this variable. These findings suggest that mu- and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432046
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Opioid receptor antagonists reliably alter the expression or extinction of ethanol's conditioned motivational effects as indexed by the place conditioning procedure, suggesting endogenous opioids are normally involved. These studies examined how exogenous stimulation of opioid receptors alters ethanol's condi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05658-x
更新日期:2021-01-01 00:00:00
abstract:RATIONALE:Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects often limit use. Drugs acting concomitantly as agonists at μ opioid receptors and antagonists at δ opioid receptors produce antinociceptive effects with a reduced profile of adverse effects; one such drug, benzyl...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05638-1
更新日期:2020-12-01 00:00:00
abstract::Pretreatment of rats with hydantoin (75 mg/kg, PO, an anticonvulsant), trihexyphenidyl (10 mg/kg, SC, a muscarinic cholinergic antagonist), or piperonyl butoxide (500 mg/kg, PO, a metabolic inhibitor) had no effect on the whole blood or brain tissue levels of orally administered DDT (75 mg/kg) or its metabolites DDD a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174359
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:C-reactive protein (CRP), an acute phase protein that is released in response to inflammatory stimuli, is implicated in Alzheimer's disease (AD). However, the role of CRP in memory deficits associated with AD remains unclear. OBJECTIVE:Experiments were carried out to determine whether CRP impaired memory and...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1499-2
更新日期:2009-07-01 00:00:00
abstract::Normal unoperated rats were tested for rotation (i.e., circling behavior) in a spherical "rotometer" and dose-response relationships were generated using d-amphetamine, apomorphine, L-Dopa, haloperidol, and scopolamine. The rotation induced by amphetamine was significantly antagonized by alpha-methyl-p-tyrosine and ha...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427609
更新日期:1976-06-23 00:00:00
abstract:RATIONALE:Caffeine is present in many widely consumed drinks and some foods. In the fairly extensive literature on the psychostimulant effects of caffeine, there are few dose-response studies and even fewer studies of the effects of doses of caffeine lower than 50 mg (the range of the amounts of caffeine contained in, ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000506
更新日期:2000-10-01 00:00:00
abstract:RATIONALE:The role of pharmacotherapy in the treatment of major depressive disorder (MDD) in youth has received much attention in recent years due to concerns of efficacy and safety of the antidepressants for the treatment of MDD in youth. OBJECTIVES:This review describes the existing published and unpublished literat...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-006-0442-z
更新日期:2007-03-01 00:00:00
abstract:RATIONALE:Studies of ethanol's effects on TSH carried out during the daytime, when its secretion is at its nadir, do not reflect the true action of alcohol on TSH secretion since TSH peak occurs at night. OBJECTIVE:The present study investigated the effects of alcohol on the serum concentrations of TSH in healthy volu...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-003-1532-9
更新日期:2003-11-01 00:00:00
abstract:RATIONALE:Inhibition of glutamatergic N-methyl-D-aspartate (NMDA) receptors following the administration of NMDA receptor antagonists results in psychotic-like behaviour. Whereas it is known that pharmacological manipulation of dopaminergic and serotonergic pathways affect this drug-induced psychosis, a role for noradr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000630
更新日期:2001-03-01 00:00:00
abstract:RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be on...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2527-6
更新日期:2012-04-01 00:00:00
abstract:RATIONALE:Dependence on both alcohol and cocaine is a widespread example of polydrug abuse/dependence. It has been hypothesized that ethanol reward is mediated via increased dopaminergic neurotransmission in mesolimbic striatum, as is the case for cocaine. However, little is known about the neurobiology of ethanol in p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1233-9
更新日期:2002-12-01 00:00:00
abstract::To confirm the conclusions from a previous study supporting the usefullness of electropupillogram (E.P.G.) in predicting clinical response, data from three separate studies with hyperkinetic and learning disabled (L.D.) children treated with stimulants were surveyed. Change in extent of pupillary contraction (E.C.) af...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00426885
更新日期:1978-04-28 00:00:00
abstract:OBJECTIVES:Previous studies have investigated the occupancy of the serotonin reuptake transporter (SERT) after clinical doses of citalopram and other selective serotonin reuptake inhibitors. In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioli...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0666-y
更新日期:2007-04-01 00:00:00
abstract::Aniamls were administered increasing doses of morphine for 16 days. During withdrawal they were challenged with an apomorphine ester or lergotrile. These dopamine agonists produced quantitatively different effects on behaviour. The results suggest that chronic morphine administration leads to dopamine supersensitivity...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433570
更新日期:1979-05-15 00:00:00
abstract:RATIONALE:Pediatric bipolar disorder (PBD) is a chronic and debilitating psychiatric illness. It is associated with many short-term and long-term complications including poor academic and social performance, legal problems and increased risk of suicide. Moreover, it is often complicated by other serious psychiatric dis...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-006-0569-y
更新日期:2007-03-01 00:00:00
abstract:RATIONALE:Withdrawal seizure-prone and withdrawal seizure-resistant mice were selectively bred to exhibit differences in handling-induced convulsion severity during ethanol withdrawal. The glutamatergic system has been implicated in seizure activity as well as ethanol withdrawal symptoms. OBJECTIVE:This study assessed...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050933
更新日期:1999-04-01 00:00:00
abstract:RATIONALE:Endogenous opioid systems within the mesencephalic periaqueductal gray matter (PAG) appear to be intricately involved in many affective, defensive, submissive, and reflexive responses, and these systems are activated by aversive stimuli. OBJECTIVES:The present experiments evaluated the influence of opioid re...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051101
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVES:To investigate the relationship between benzodiazepine and risk of developing pneumonia in patients with schizophrenia, whose benzodiazepine dosage and usage frequency was higher than that of the general population. METHODS:We conducted a nested case-control study to assess the association between benzodiaz...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5039-9
更新日期:2018-11-01 00:00:00
abstract::Phencyclidine (PCP; 2.5 or 5.0 mg/kg) potentiated the effects of rewarding hypothalamic brain stimulation, causing parallel leftward shifts of the functions that relate rate of responding to stimulation frequency. Thus, like a number of other drugs of abuse, PCP lowered the "dose" of stimulation required to maintain r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02253528
更新日期:1993-01-01 00:00:00
abstract::Sixty-two DSM III chronic schizophrenic inpatients were selected for a double-blind, placebo controlled, multi-centre, relapse prevention study of remoxipride, a selective dopamine (D2)-receptor antagonist. After a 1 month placebo washout, 23 patients had relapsed and were withdrawn. Of the remaining patients 19 were ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF02245134
更新日期:1992-01-01 00:00:00
abstract::The effects of drugs on one aspect of impulsive behaviour were evaluated using a schedule in which rats were trained to complete a fixed consecutive number of responses on one of two levers before pressing the second to obtain a reinforcer (FCN). Terminating the chain before completing the FCN resulted in the omission...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050673
更新日期:1998-08-01 00:00:00
abstract:RATIONALE:Functional interactions between limbic regions that process emotions and frontal networks that guide response functions provide a substrate for emotional cues to influence behavior. Stimulation of postsynaptic α₂ adrenoceptors enhances the function of prefrontal regions in these networks. However, the impact ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-012-2893-8
更新日期:2013-03-01 00:00:00
abstract:RATIONALE:Studies about whether or not the cognitive performance of women is influenced by changes in levels of sex steroid hormones across the menstrual cycle have produced ambiguous results. OBJECTIVES:This study tested whether flight simulator performance differs significantly between the menstrual and the luteal p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100700
更新日期:2001-05-01 00:00:00
abstract::The effects of bilateral nucleus accumbens microinjections of d-ala-met-enkephalinamide (DALA) were assessed in behavioral activation and lateral hypothalamic self-stimulation (LHSS) rate-frequency curve-shift paradigms in normal and accumbens 6-OHDA (4.0 micrograms) treated rats. Microinjections of DALA (2.5 microgra...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244999
更新日期:1994-05-01 00:00:00
abstract::Dosage regimen adjustments because of poor renal function are often assumed to be unnecessary for extensively metabolized antidepressants. This assumption is being increasingly questioned in recognition of the role of active drug metabolites. The purpose of this study was to assess the steady-state accumulation of the...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02412111
更新日期:1986-01-01 00:00:00
abstract::Efforts to find a correlation between serum levels of chlorpromazine (CPZ) and clinical effect have been rather unsuccessful, which could be due to fluctuations of CPZ and CPZ metabolite levels during treatment, the complicated metabolism of CPZ, or to varying degrees of protein binding. Using a mass fragmentographic ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00431102
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:Rivastigmine patches are used for patients with Alzheimer's disease (AD), but little is known about the serum concentration of rivastigmine and its metabolite or clinical adherence in relation to skinfold thickness after rivastigmine patch application. OBJECTIVES:The aim of this study was to examine the asso...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5135-x
更新日期:2019-04-01 00:00:00
abstract::This study demonstrates that the selective delta receptor antagonists ICI 174864 and naltrindole (NTI) attenuate alcohol intake in a dose-dependent manner, without altering water intake, in rats selectively bred for alcohol preference. ICI 174864 had a very limited duration of action, as evidenced by the fact that sup...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246191
更新日期:1995-07-01 00:00:00
abstract::Two putative predictors of placebo response were studied in three samples of psychiatric outpatients. Two groups, 73 university medical center patients and 56 college health service patients, underwent 1 week of placebo treatment. A quasi-control group of 112 patients receiving no medication waited about 1 week before...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00433557
更新日期:1979-06-21 00:00:00