Abstract:
:Normal unoperated rats were tested for rotation (i.e., circling behavior) in a spherical "rotometer" and dose-response relationships were generated using d-amphetamine, apomorphine, L-Dopa, haloperidol, and scopolamine. The rotation induced by amphetamine was significantly antagonized by alpha-methyl-p-tyrosine and haloperidol, but not by diethyldithiocarbamate. The rotation elicited by apomorphine was unaffected by alpha-methyl-p-tyrosine. Rotation was not necessarily in the same direction with high and low doses of amphetamine, or amphetamine and apomorphine administered a week apart from each other. Dopaminergic-cholinergic interactions were evident, since pilocarpine antagonized amphetamine-induced rotation whereas scopolamine did not; scopolamine elicited rotation in the same direction as that induced by amphetamine. Left and right striatal dopamine and tel-diencephalic norepinephrine levels were determined in rats injected with various doses of amphetamine and tested for rotation. There were significant bilateral differences in striatal dopamine which were related to the direction of rotation. Since amphetamine was found to be equally distributed to the two sides of the brain, the difference in striatal dopamine appeared to be the neurochemical substrate for rotation in normal rats. These results suggest that normal rats have asymmetrical levels of striatal dopamine as well as an asymmetrical complement of striatal dopamine receptors.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Jerussi TP,Glick SDdoi
10.1007/BF00427609subject
Has Abstractpub_date
1976-06-23 00:00:00pages
249-60issue
3eissn
0033-3158issn
1432-2072journal_volume
47pub_type
杂志文章abstract::5,7-Dihydroxytryptamine (5,7-DHT) or the vehicle was administered once into both lateral ventricles of the rat. Desmethylimipramine (DMI) was administered IP prior to the intraventricular injection of 5,7-DHT to prevent the destruction of norepinephrine (NE) terminals. Following recovery from surgery, ethanol (5 g/kg,...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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更新日期:2005-08-01 00:00:00
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更新日期:2000-01-01 00:00:00
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更新日期:2002-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1997-07-01 00:00:00
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更新日期:2006-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1984-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2005-07-01 00:00:00
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更新日期:2008-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1978-04-14 00:00:00
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更新日期:1982-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1977-01-31 00:00:00
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更新日期:2013-01-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2010-05-01 00:00:00