Systemic injection of pirenzepine induces a deficit in passive avoidance learning in rats.

abstract：:Three adult baboons were trained using a psychophysical procedure to discriminate between different synthetic vowel sounds [symbol: see text]. Baboons pressed and held a lever down to produce a pulsed train of a single reference vowel that served as the standard stimulus. Animals were trained to release the lever only...

journal_title：Psychopharmacology

authors： Hienz RD,Spear DJ,Pyle DA,Brady JV

更新日期：1995-11-01 00:00:00

abstract：RATIONALE:Schizophrenia is a complex neuropsychiatric disorder characterized, in part, by impaired dopamine signaling. TAK-063 is a selective inhibitor of phosphodiesterase 10A, a key regulator of intracellular signaling pathways that is highly expressed in the striatum. OBJECTIVE:Safety, tolerability, and pharmacokin...

journal_title：Psychopharmacology

authors： Tsai M,Chrones L,Xie J,Gevorkyan H,Macek TA

更新日期：2016-10-01 00:00:00

abstract：RATIONALE:Methylphenidate is a psychostimulant given for extended periods of time as a treatment of attention-deficit/hyperactivity disorder (ADHD). The long-term effects of the drug are not yet known, and it is speculated that repeated exposure may produce drug dependence. OBJECTIVE:To investigate the effects of repe...

journal_title：Psychopharmacology

authors： dela Peña I,Yoon SY,Lee JC,dela Peña JB,Sohn AR,Ryu JH,Shin CY,Cheong JH

更新日期：2012-05-01 00:00:00

abstract：:This study demonstrates that pre-exposure to stress influences subsequent effects of stress on pain sensitivity (stress-induced analgesia) and on plasma corticosterone and brain catecholamine activity. Animals exposed to a 30 min shock session (S1 = 8, 5.0 s shocks) 10 days earlier showed a significant attenuation of ...

journal_title：Psychopharmacology

authors： Caggiula AR,Antelman SM,Aul E,Knopf S,Edwards DJ

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Successive negative contrast (SNC) describes a change in the behaviour of an animal following a downshift in the quantitative or qualitative value of an expected reward. This behavioural response has been hypothesised to be linked to affective state, with negative states associated with larger and/or prolonge...

journal_title：Psychopharmacology

authors： Phelps CE,Mitchell EN,Nutt DJ,Marston HM,Robinson ES

更新日期：2015-08-01 00:00:00

abstract：RATIONALE:Initial sensitivity to drugs of abuse often predicts subsequent use and abuse, but this relationship is not always observed in human studies. Moreover, studies examining the relationship between initial locomotor sensitivity and the rewarding and reinforcing effects of drugs in animal models have also been eq...

journal_title：Psychopharmacology

authors： Roberts AJ,Casal L,Huitron-Resendiz S,Thompson T,Tarantino LM

更新日期：2018-04-01 00:00:00

abstract：:Pigs trained to avoid shocks by crossing a barrier in a shuttle-box according to a continuous avoidance procedure were submitted to a Pavlovian discriminative fear-conditioning procedure in which a tone was always followed by unavoidable shock (CS+) and another tone never followed by shock (CS-). The presentation of t...

journal_title：Psychopharmacology

authors： Dantzer R,Mormede P

更新日期：1976-08-26 00:00:00

abstract：:Normal male volunteers took single acute doses of either diazepam or placebo under double-blind conditions in three simulated public speaking experiments. Measures of palmar sweating and subjective anxiety showed that anticipation of speaking in public increased anxiety relative to baseline and prestress conditions, a...

journal_title：Psychopharmacology

authors： McNair DM,Frankenthaler LM,Czerlinsky T,White TW,Sasson S,Fisher S

更新日期：1982-01-01 00:00:00

abstract：:Following the stereotaxic implantation of chronic cannulae for intracerebroventricular (ICV) infusion, rats were given an alcohol preference test to establish their preferred concentration in comparison with water. After alcohol was removed, 15 mg/kg cyanamide was then injected subcutaneously for 4 days in order to ma...

journal_title：Psychopharmacology

authors： Miñano FJ,Myers RD

更新日期：1989-01-01 00:00:00

abstract：:Although previous studies have shown that pharmacological agents, such as buprenorphine, and alternative nondrug reinforcers, such as money or sweetened solutions, reduce cocaine self-administration, few studies have examined the combined effects of these two approaches. The purpose of the present study was to evaluat...

journal_title：Psychopharmacology

authors： Comer SD,Lac ST,Wyvell CL,Carroll ME

更新日期：1996-06-01 00:00:00

abstract：:Chronic oral administration of cannabis extract to rats (daily delta 9-tetrahydrocannabinol dose 20 mg/kg) was examined in three experiments for its residual effect on radial-arm maze learning following a 1-month drug-free period. Learning a simple eight-arm maze was significantly impaired in rats treated for either 6...

journal_title：Psychopharmacology

authors： Stiglick A,Kalant H

更新日期：1982-01-01 00:00:00

abstract：:The importance of brain noradrenaline synthesis and receptor activation for the hyperkinesia induced by carbidopa plus L-Dopa in reserpine-treated or normal mice was analyzed in four different models. After pretreatment with reserpine and the monoamine oxidase inhibitor nialamide, the hyperkinesia induced by L-Dopa (2...

journal_title：Psychopharmacology

authors： Andén NE,Strömbom U,Svensson TH

更新日期：1977-11-15 00:00:00

abstract：BACKGROUND:The serotonin (5-HT) deficiency hypothesis of aggression is being seriously challenged by pharmacological data showing robust anti-aggressive effects of 5-HT1A receptor agonists in dose ranges that concomitantly inhibit 5-HT neurotransmission. Hence, an adequate interpretation of the role of 5-HT activity in...

journal_title：Psychopharmacology

authors： de Boer SF,Newman-Tancredi A

更新日期：2016-03-01 00:00:00

abstract：:Rats were trained to discriminate between two compound stimulus arrays that included exteroceptive (ES) and interoceptive (IS) stimulus components. The ES components were illumination and tactile cues, and the IS components were produced by d-amphetamine (A) or Na pentobarbital (P) treatment (drug versus drug discrimi...

journal_title：Psychopharmacology

authors： Duncan PM

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Corticostriatal circuits are widely implicated in the top-down control of attention including inhibitory control and behavioural flexibility. However, recent neurophysiological evidence also suggests a role for thalamic inputs to striatum in behaviours related to salient, reward-paired cues. OBJECTIVES:Here,...

journal_title：Psychopharmacology

authors： Saund J,Dautan D,Rostron C,Urcelay GP,Gerdjikov TV

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND AND RATIONALE:Despite the popularity of polysubstance abuse among recreational methylendioxymethamphetamine (MDMA) users, relatively few controlled experimental studies have documented the neurobehavioral effects of MDMA in combination with other abused substances. OBJECTIVE:In this study, the combined acut...

journal_title：Psychopharmacology

authors： Panos JJ,Baker LE

更新日期：2010-03-01 00:00:00

abstract：:The protective effects of acute and chronic diazepam administration (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) and picrotoxin were investigated. Considering the incidence of tonic-clonic convulsions, tolerance to the protective effects of diazepam was evident by day 5 if the mice were challenged wi...

journal_title：Psychopharmacology

authors： File SE

更新日期：1983-01-01 00:00:00

abstract：:Serotonin is a neurotransmitter that is widely distributed throughout the central nervous system. The role of serotonin in schizophrenia is still unclear. Postmortem studies of serotonin receptor subtypes in schizophrenia have been inconclusive for the most part. The most promising findings involve a reduction in 5-HT...

journal_title：Psychopharmacology

authors： Ohuoha DC,Hyde TM,Kleinman JE

更新日期：1993-01-01 00:00:00

abstract：:The residual effects of three hypnotics were investigated by the method of 24-h polygraphy (EEG, EMG, and EOG). The drugs were triazolam 0.25 mg and 0.5 mg, flurazepam 15 mg and 30 mg, nitrazepam 5 mg and 10 mg, and placebo. The subjects were healthy volunteers, eight men and eight women with an average age of 34.3 ye...

journal_title：Psychopharmacology

authors： Ogura C,Nakazawa K,Majima K,Nakamura K,Ueda H,Umezawa Y,Wardell WM

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (...

journal_title：Psychopharmacology

authors： Houwing DJ,de Waard J,Ramsteijn AS,Woelders T,de Boer SF,Wams EJ,Olivier JDA

更新日期：2020-08-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) and locomotor activity have been used to investigate the effects of antipsychotic and stimulant drugs and their underlying dopaminergic mechanisms. Whereas D2-like agonists consistently decreased PPI and increased locomotion in rats in previous studies, we recently reported that thes...

journal_title：Psychopharmacology

authors： Ralph RJ,Caine SB

更新日期：2007-04-01 00:00:00

abstract：RATIONALE:Reductions in cue-induced craving and subjective response to drugs of abuse are commonly used as initial outcome measures when testing novel medications for the treatment of addiction. Yet neither the relationship between these two measures at the individual level nor the moderating effects of pharmacotherapi...

journal_title：Psychopharmacology

authors： Roche DJO,Worley MJ,Courtney KE,Bujarski S,London ED,Shoptaw S,Ray LA

更新日期：2017-07-01 00:00:00

abstract：RATIONALE:Preclinical studies suggest that medications enhancing the brain gamma amino butyric acid (GABA) system attenuate the rewarding effects of stimulants including nicotine. These preclinical studies have not been followed up in systematic human studies. OBJECTIVES:This study was conducted to examine the effects...

journal_title：Psychopharmacology

authors： Sofuoglu M,Mouratidis M,Yoo S,Culligan K,Kosten T

更新日期：2005-09-01 00:00:00

abstract：RATIONALE:The effect of LSD in humans has been described as occurring in two temporal phases. The behavioral effects in rats also occur in two temporal phases: an initial suppression of exploration followed by increased locomotor activity. OBJECTIVES:We decided to investigate this phenomenon from the perspective that ...

journal_title：Psychopharmacology

authors： Marona-Lewicka D,Thisted RA,Nichols DE

更新日期：2005-07-01 00:00:00

abstract：:Nine VA Medical Centers are participating in a 2-year double-blind placebo controlled study of antioxidant treatment for tardive dyskinesia (TD) conducted by the Department of Veteran Affairs Cooperative Studies Program. One of the principal outcome measures of this study is the score derived from the instrumental ass...

journal_title：Psychopharmacology

authors： Caligiuri MP,Lohr JB,Rotrosen J,Adler L,Lavori P,Edson R,Tracy K

更新日期：1997-07-01 00:00:00

abstract：:Monoamine oxidases A and B (MAO-A and B) catalyze the oxidative catabolism of biogenic amines and xenobiotics. Investigation of these mitochondrial membrane proteins shows that they differ in substrate preference, inhibitor specificity, tissue and neuronal cell distribution, immunological properties, and nucleotide an...

journal_title：Psychopharmacology

authors： Kwan SW,Bergeron JM,Abell CW

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Rolipram, an inhibitor of cyclic AMP phosphodiesterase (PDE4) produces discriminative stimulus effects in rats. These effects may be related to a wide range of central nervous system effects described previously. OBJECTIVE:The purposes of the present study were to: (i) assess the specificity of the discrimin...

journal_title：Psychopharmacology

authors： Makhay MM,Houslay MD,O'Donnell JM

更新日期：2001-11-01 00:00:00

abstract：:Benztropine mesylate (Cogentin) and physostigmine salicylate (Antilirium), were tested for changes in tongue protrusions, retrusions, and swallowing acts in rats anesthetized with a 100 mg/kg IM injection of ketamine hydrochloride. These ketamine-induced linguopharyngeal events were monitored by means of a force displ...

journal_title：Psychopharmacology

authors： Marco LA,Joshi RS,Brown C,Aldes LD,Chronister RB

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Numerous preclinical and clinical studies have reported the rapid and sustained antidepressant effects of the NMDA receptor antagonist ketamine. Because ketamine induces several undesirable and dangerous effects, a variety of strategies have been suggested to avoid such effects. OBJECTIVES:Here, we propose t...

journal_title：Psychopharmacology

authors： Podkowa K,Pochwat B,Brański P,Pilc A,Pałucha-Poniewiera A

更新日期：2016-08-01 00:00:00

abstract：:The behavioral consequences of prolonged continuous exposure to cocaine were examined in rhesus monkeys. Operant behavior was sampled for 0.5 h every 6 h, and cocaine was continuously infused through an intravenous catheter. Cocaine (4.0-32 mg/kg/day) initially caused reductions in the rate of responding for food and ...

journal_title：Psychopharmacology

authors： Woolverton WL,Kleven MS

更新日期：1988-01-01 00:00:00