Learning impairment in the radial-arm maze following prolonged cannabis treatment in rats.

abstract：RATIONALE:Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT2C antagonists and 5-HT2C knockouts have demonstrated dexfenfluramine hypophagia in the rodent to be mediated by actions at the 5-HT2...

journal_title：Psychopharmacology

authors： Grottick AJ,Whelan K,Sanabria EK,Behan DP,Morgan M,Sage C

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:A history of brief intermittent social defeat stress can escalate cocaine self-administration and induce long-term adaptations in the mesolimbic dopamine system. Extra-hypothalamic corticotrophin releasing factor (CRF) has been shown to be closely associated with stress-induced escalation of drug use. How re...

journal_title：Psychopharmacology

authors： Han X,DeBold JF,Miczek KA

更新日期：2017-09-01 00:00:00

abstract：:Research was conducted to examine the ability of alcohol to impart conditioned reinforcement. Rats were allowed to self-administer solutions of either saline or alcohol (25, 50, and 100 mg/kg/infusion) by the intragastric route. Superimposed on the infusion interval was a buzzer (conditioned reinforcing stimulus). Tes...

journal_title：Psychopharmacology

authors： Smith SG,Werner TE,Davis WM

更新日期：1977-08-16 00:00:00

abstract：:The effects on one-way active avoidance conditioning of pre-training, systemic administration of the selective mu-receptor agonist [D-Ala2,N-Me-Phe4, Gly-ol]enkephalin (DAGO), and the selective mu-receptor antagonist (D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP), were determined in Swiss-Webster mice. A low dose of ...

journal_title：Psychopharmacology

authors： Schulteis G,Martinez JL Jr

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Premature discontinuation of antidepressant drugs is a frequent clinical problem. Adverse effects are common, occur early on in treatment and are reported to be one of the main reasons for discontinuation of antidepressant treatment. OBJECTIVES:To investigate the association between adverse effects occurring...

journal_title：Psychopharmacology

authors： Crawford AA,Lewis S,Nutt D,Peters TJ,Cowen P,O'Donovan MC,Wiles N,Lewis G

更新日期：2014-08-01 00:00:00

abstract：RATIONALE:Kratom is proposed to exhibit therapeutic potential as an opium substitute, but little is known about its dependence-producing profile, particularly of its main psychoactive compound, mitragynine (MG). OBJECTIVES:This study examined the dependence-producing effects of MG using operant-scheduled behaviour in ...

journal_title：Psychopharmacology

authors： Harun N,Johari IS,Mansor SM,Shoaib M

更新日期：2020-03-01 00:00:00

abstract：:CSF GABA levels were not significantly different in a group of drug-free psychotic patients compared to a group of psychotic patients at two points during haloperidol treatment or a neurological comparison group. In the untreated group, CSF GABA was significantly negatively correlated with clinical ratings of anxiety ...

journal_title：Psychopharmacology

authors： Bowers MB Jr,Gold BI,Roth RH

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Cannabidiol is a non-psychoactive phytocannabinoid with great therapeutic potential in diverse psychiatric disorders; however, its antidepressant potential has been mainly ascertained in adult rats. OBJECTIVES:To compare the antidepressant-like response induced by cannabidiol in adolescent and adult rats and...

journal_title：Psychopharmacology

authors： Bis-Humbert C,García-Cabrerizo R,García-Fuster MJ

更新日期：2020-06-01 00:00:00

abstract：:Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administratio...

journal_title：Psychopharmacology

authors： Pomara N,Stanley B,Block R,Guido J,Russ D,Berchou R,Stanley M,Greenblatt DJ,Newton RE,Gershon S

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:The effects of adolescent marijuana use on the developing brain remain unclear, despite its prevalence. Arterial spin labeling (ASL) is a noninvasive imaging technique that characterizes neurovascular status and cerebral blood flow (CBF), potentially revealing contributors to neuropathological alterations. No...

journal_title：Psychopharmacology

authors： Jacobus J,Goldenberg D,Wierenga CE,Tolentino NJ,Liu TT,Tapert SF

更新日期：2012-08-01 00:00:00

abstract：:Previous research has found that the attention of social drinkers is preferentially oriented towards alcohol-related stimuli (attentional capture). This is argued to play a role in escalating craving for alcohol that can result in hazardous drinking. According to incentive theories of drug addiction, the stimuli assoc...

journal_title：Psychopharmacology

authors： Brown CRH,Duka T,Forster S

更新日期：2018-07-01 00:00:00

abstract：RATIONALE:Each year, over 300,000 individuals in the USA enter treatment for cannabis use disorder (CUD). The development of effective pharmacotherapy for CUD is a priority. OBJECTIVE:This placebo-controlled study examined the effects of zolpidem alone and in combination with nabilone on cannabis withdrawal and a labo...

journal_title：Psychopharmacology

authors： Herrmann ES,Cooper ZD,Bedi G,Ramesh D,Reed SC,Comer SD,Foltin RW,Haney M

更新日期：2016-07-01 00:00:00

abstract：RATIONALE:Low capacity of the central serotonergic system has been associated with impulsive behaviour. Both low platelet monoamine oxidase (MAO) activity and the short (S) allele of the serotonin transporter gene promoter region polymorphism (5-HTTLPR) are proposed to be markers of less efficient serotonergic function...

journal_title：Psychopharmacology

authors： Paaver M,Nordquist N,Parik J,Harro M,Oreland L,Harro J

更新日期：2007-11-01 00:00:00

abstract：INTRODUCTION:Non-medical use of prescription opioids such as the mu opioid receptor (MOP-r) agonist oxycodone is a growing problem in the USA and elsewhere. There is limited information about oxycodone's impact on diverse gene systems in the brain. OBJECTIVES:The current study was designed to examine how chronic oxyco...

journal_title：Psychopharmacology

authors： Zhang Y,Liang Y,Levran O,Randesi M,Yuferov V,Zhao C,Kreek MJ

更新日期：2017-08-01 00:00:00

abstract：RATIONALE:(1S,3aS)-8-(2,3,3,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198), a non-peptidic agonist for the opioid receptor-like1 (ORL1) receptor, exhibits anxiolytic properties in stressful conditions. OBJECTIVE:The present study was aimed at evaluating whether activation of ...

journal_title：Psychopharmacology

authors： Ciccocioppo R,Biondini M,Antonelli L,Wichmann J,Jenck F,Massi M

更新日期：2002-05-01 00:00:00

abstract：:Two studies were conducted to replicate and extend previous demonstrations of smoking-induced, dose-related reports of euphoria, and to confirm this relationship using measures of plasma nicotine. In experiment 1, overnight-deprived subjects, in three different sessions, smoked ultralow-, high-nicotine, and usual-bran...

journal_title：Psychopharmacology

authors： Pomerleau CS,Pomerleau OF

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Accumulating evidence for the presence of GABA(A) ρ receptors within the amygdala which differ from other members of the GABA(A) receptor family in both subunit composition and functional properties has been recently obtained. OBJECTIVES:This work was conducted to study whether GABA(A) ρ receptors may have a...

journal_title：Psychopharmacology

authors： Flores-Gracia C,Nuche-Bricaire A,Crespo-Ramírez M,Miledi R,Fuxe K,Pérez de la Mora M

更新日期：2010-12-01 00:00:00

abstract：RATIONALE:Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (...

journal_title：Psychopharmacology

authors： Houwing DJ,de Waard J,Ramsteijn AS,Woelders T,de Boer SF,Wams EJ,Olivier JDA

更新日期：2020-08-01 00:00:00

abstract：:There is increasing interest in the potential functional role of the octapeptide angiotensin II (AII) in psychiatric and cognitive disorders. The novel angiotensin II (AII) receptor antagonists, losartan and PD123177, selective for the AT1 and AT2 receptor subtypes respectively, constitute important pharmacological to...

journal_title：Psychopharmacology

authors： Shepherd J,Bill DJ,Dourish CT,Grewal SS,McLenachan A,Stanhope KJ

更新日期：1996-08-01 00:00:00

abstract：:The time course of light adaptation after intense light exposure is significantly delayed by alcohol, marijuana, and a combined dose of alcohol and marijuana. These effects were found in a double blind experiment, using 10 subjects. The experimental treatments were placebo, 0.75 ml/kg of 95% ethanol, 8 and 15 mg of de...

journal_title：Psychopharmacology

authors： Adams AJ,Brown B,Haegerstrom-Portnoy G,Flom MC,Jones RT

更新日期：1978-01-31 00:00:00

abstract：:Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-depend...

journal_title：Psychopharmacology

authors： Mendelson WB,Kuruvilla A,Watlington T,Goehl K,Paul SM,Skolnick P

更新日期：1983-01-01 00:00:00

abstract：:Risperidone was studied in a 0.16 mg/kg LSD-saline drug discrimination test procedure. At doses varying from 0.0025 to 0.63 mg/kg, no LSD-like agonist effects were observed. Studies on the antagonism of the LSD-cue indicated that risperidone was able to completely block the discriminative stimulus properties of LSD wi...

journal_title：Psychopharmacology

authors： Meert TF,de Haes P,Janssen PA

更新日期：1989-01-01 00:00:00

abstract：:When injected IP, the M1 muscarinic receptor antagonist pirenzepine dose-dependently induced a deficit in passive avoidance learning in rats. This activity was optimal at 75 mg/kg injected 1 h before the acquisition session. The deficit induced by pirenzepine was antagonized by oxotremorine (0.03-0.3 mg/kg SC) and phy...

journal_title：Psychopharmacology

authors： Worms P,Gueudet C,Pério A,Soubrié P

更新日期：1989-01-01 00:00:00

abstract：:5-Hydroxytryptamine1A (5-HT1A) receptors have been shown to be suppressed by corticosteroid hormones in a variety of animal experimental paradigms. It has been suggested that this effect may be central to the pathophysiology of severe clinical depressive illness, a condition in which 5-HT1A receptor function is reduce...

journal_title：Psychopharmacology

authors： Porter RJ,McAllister-Williams RH,Lunn BS,Young AH

更新日期：1998-10-01 00:00:00

abstract：RATIONALE:A subset of male rats that self-administer 3,4-methylenedioxypyrovalerone (MDPV) have unusually high levels of drug intake; however, factor(s) that influence this behavior (e.g., reinforcement history and sex) are unknown. OBJECTIVES:Characterize the reinforcing potency and effectiveness of MDPV in female ra...

journal_title：Psychopharmacology

authors： Doyle MR,Sulima A,Rice KC,Collins GT

更新日期：2020-11-24 00:00:00

abstract：BACKGROUND:Several theories propose alternative explanations for drug addiction. OBJECTIVES:We propose a general theory of transition to addiction that synthesizes knowledge generated in the field of addiction into a unitary explanatory frame. MAJOR PRINCIPLES OF THE THEORY:Transition to addiction results from a sequ...

journal_title：Psychopharmacology

authors： Piazza PV,Deroche-Gamonet V

更新日期：2013-10-01 00:00:00

abstract：RATIONALE:The drug discrimination procedure has proven to be a valuable tool for studying the mechanism of action of psychoactive drugs. Recently, mice with targeted gene mutations have been developed that may also prove useful in evaluating the role of specific receptors in mediating the actions of drugs. We were inte...

journal_title：Psychopharmacology

authors： Smith RL,Barrett RJ,Sanders-Bush E

更新日期：2003-02-01 00:00:00

abstract：:Three recently arrived drug naive Cebus apella monkeys with "spontaneous" stereotyped oral movements were treated with apomorphine and haloperidol using a wide dose range. Low doses of apomorphine (0.05-0.1 mg/kg) suppressed the oral stereotypies without affecting normal behaviour such as grooming and scratching. High...

journal_title：Psychopharmacology

authors： Korsgaard S,Povlsen UJ,Randrup A

更新日期：1985-01-01 00:00:00

abstract：:Several studies have demonstrated a paradoxical form of antinociception induced by the repeated administration of opioid antagonists accompanied by exposure to a painful stimulus. The underlying mechanism of this naloxone-induced antinociception (NIA) is still unknown, but the results of several studies suggest that i...

journal_title：Psychopharmacology

authors： Walker MJ,Poulos CX,Le AD

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:In animal studies, the common club drug 3,4-methylendioxymethamphetamine (MDMA, "Ecstasy") consistently caused a prolonged loss of presynaptic serotonergic neurons, and evidence suggests that MDMA consumption may also affect the human serotonergic system. Serotonin (5-HT) has been implicated in the regulation...

journal_title：Psychopharmacology

authors： Quednow BB,Kühn KU,Hoppe C,Westheide J,Maier W,Daum I,Wagner M

更新日期：2007-01-01 00:00:00