GABA(A) ρ receptor mechanisms in the rat amygdala and its role in the modulation of fear and anxiety.

abstract：RATIONALE:Severe, traumatic stress or repeated exposure to stress can result in long-term deleterious effects, including hippocampal cell atrophy and death, which, in turn, result in memory impairments and behavioural abnormalities. The dopaminergic D(2) receptor agonist, bromocriptine, has been shown to modulate learn...

journal_title：Psychopharmacology

authors： Srikumar BN,Raju TR,Shankaranarayana Rao BS

更新日期：2007-08-01 00:00:00

abstract：:Herrnstein's matching equation was used to analyze drug effects on performance in random interval reinforcement schedules. Pimozide caused effects compatible with both motor and motivational impairments, in a 5-component multiple schedule, a 3-schedule 3-day cycle (ALT-3), and a 2-schedule 2-day cycle (ALT-2). However...

journal_title：Psychopharmacology

authors： Willner P,Sampson D,Phillips G,Muscat R

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:It has been proposed that cannabinoid-1 receptor inverse agonists might be effective for smoking cessation. We evaluated this hypothesis with the cannabinoid-1 receptor inverse agonist taranabant. METHODS:Adults who smoked > or =10 cigarettes a day for >1 year and had an expired CO level of > or =10 ppm part...

journal_title：Psychopharmacology

authors： Morrison MF,Ceesay P,Gantz I,Kaufman KD,Lines CR

更新日期：2010-04-01 00:00:00

abstract：:DL-2-amino-5-phosphonovaleric acid (AP-5), which blocks glutamatergic transmission at the NMDA-preferring receptor, was injected into the antero-dorsal striatum of rats. AP-5-induced behavioural changes were assessed i) using a stereotypy rating scale and ii) using an experimental chamber designed to quantify sniffing...

journal_title：Psychopharmacology

authors： Schmidt WJ

更新日期：1986-01-01 00:00:00

abstract：:The subjective, psychomotor, and physiological effects of analgesic doses of oral codeine and morphine were examined in 12 healthy volunteers. Subjects ingested placebo, morphine 20 or 40 mg, or codeine 60 or 120 mg in a randomized, double-blind, crossover design. The smaller and larger doses of each drug were putativ...

journal_title：Psychopharmacology

authors： Walker DJ,Zacny JP

更新日期：1998-11-01 00:00:00

abstract：RATIONALE:Contemporary animal models of cocaine addiction focus on increasing the amount of drug consumption to produce addiction-like behavior. However, another critical factor is the temporal pattern of consumption, which in humans is characterized by intermittency, both within and between bouts of use. OBJECTIVE:To...

journal_title：Psychopharmacology

authors： Kawa AB,Bentzley BS,Robinson TE

更新日期：2016-10-01 00:00:00

abstract：RATIONALE:Second-generation antipsychotics are the first-line medications prescribed for schizophrenic patients; however, some of them, such as olanzapine and risperidone, may induce metabolic dysfunctions during short-term treatment. Metformin is an effective adjuvant that attenuates antipsychotic-induced metabolic dy...

journal_title：Psychopharmacology

authors： Luo C,Wang X,Mao X,Huang H,Liu Y,Zhao J,Zhou H,Liu Z,Li X

更新日期：2020-08-01 00:00:00

abstract：RATIONALE:A glutamate-dopamine interaction has been implicated in the psychosis-like effects of glutamate N-methyl- D-aspartate (NMDA) receptor antagonists, such as phencyclidine and ketamine. However, recent imaging studies addressing striatal glutamate-dopamine interaction directly in vivo in man have been controvers...

journal_title：Psychopharmacology

authors： Aalto S,Hirvonen J,Kajander J,Scheinin H,Någren K,Vilkman H,Gustafsson L,Syvälahti E,Hietala J

更新日期：2002-12-01 00:00:00

abstract：RATIONALE:The antidepressant action of acute nicotine administration in clinical and animal studies is well recognized. But the underlying mechanism for this effect has not been carefully discovered. OBJECTIVES:We attempted to evaluate the possible role of N-Methyl-D-aspartate (NMDA) receptors in the antidepressant-li...

journal_title：Psychopharmacology

authors： Haj-Mirzaian A,Kordjazy N,Haj-Mirzaian A,Ostadhadi S,Ghasemi M,Amiri S,Faizi M,Dehpour A

更新日期：2015-10-01 00:00:00

abstract：:Neuroleptic-free schizophrenic patients received caerulein, a potent analogue of cholecystokinin octapeptide, in a fixed- and rising-dose schedule. In addition, neuroleptic-treated patients received a single dose of the peptide with a 4-week follow-up. No significant change in mental status was observed after any of t...

journal_title：Psychopharmacology

authors： Tamminga CA,Littman RL,Alphs LD,Chase TN,Thaker GK,Wagman AM

更新日期：1986-01-01 00:00:00

abstract：:The effect of the dopamine receptor antagonist haloperidol on the development of sensitization to ethanol-induced increases in locomotor activity was examined in DBA/2J mice. In Experiment 1, different groups of mice were given saline or ethanol (2 g/kg) immediately before each of four locomotor activity sessions (48-...

journal_title：Psychopharmacology

authors： Broadbent J,Grahame NJ,Cunningham CL

更新日期：1995-08-01 00:00:00

abstract：:Serotonin(5-HT)-stimulated intracellular calcium(Ca) mobilization was measured in the platelets of depressed patients to assess 5-HT2 receptor function. The 5-HT-induced Ca response was significantly higher in unmedicated patients with bipolar depression and melancholic major depression than in those with non-melancho...

journal_title：Psychopharmacology

authors： Kusumi I,Koyama T,Yamashita I

更新日期：1994-01-01 00:00:00

abstract：INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...

journal_title：Psychopharmacology

authors： Robinson OJ,Sahakian BJ

更新日期：2009-08-01 00:00:00

abstract：RATIONALE:Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, tolerance, and withdrawal. The neurosteroid allopregnanolone is also able to substitute for drugs with abuse potential and possesses reinforcing properties. OBJECTIVES:The effects of acute treatment with, and ...

journal_title：Psychopharmacology

authors： Concas A,Sogliano C,Porcu P,Marra C,Brundu A,Biggio G

更新日期：2006-06-01 00:00:00

abstract：:The role of the nucleus accumbens septi (ACB) and corpus striatum (CPU) in self-stimulation were investigated by injecting directly or indirectly acting stimulant drugs or a dopamine-(DA)-receptor blocking agent into each site bilaterally. d-Amphetamine (68 nmol) facilitated hypothalamic self-stimulation when injected...

journal_title：Psychopharmacology

authors： Stephens DN,Herberg LJ

更新日期：1977-08-31 00:00:00

abstract：:Patients who develop persistent parkinsonism while on chronic neuroleptic therapy may be predisposed towards the development of tardive dyskinesia (TD). We investigated this issue in an animal model of TD by examining the association between catalepsy and the syndrome of neuroleptic-induced vacuous chewing movements (...

journal_title：Psychopharmacology

authors： Hyde TM,Egan MF,Wing LL,Wyatt RJ,Weinberger DR,Kleinman JE

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated intracellular calcium (Ca(2+))-dependent activation of the PKA cascade after ethanol administration. Thu...

journal_title：Psychopharmacology

authors： Baliño P,Ledesma JC,Aragon CM

更新日期：2014-12-01 00:00:00

abstract：RATIONALE:The hallucinatory effect and potential abuse of salvinorin A, the major ingredient of Salvia divinorum, has not been documented in animals. OBJECTIVE:The effects of salvinorin A on the zebrafish (Danio rerio) model, through its swimming behavior and conditioned place preference (CPP) task, was studied. MATE...

journal_title：Psychopharmacology

authors： Braida D,Limonta V,Pegorini S,Zani A,Guerini-Rocco C,Gori E,Sala M

更新日期：2007-03-01 00:00:00

abstract：:Different benzodiazepines, when administered to fasting cats, increased both the total amount of food eaten and also the rate at which food was ingested. Moreover, when injected to foodsatiated cats, these compounds made them resume eating voraciously. Pentobarbital also stimulated food intake, but was much less poten...

journal_title：Psychopharmacology

authors： Mereu GP,Fratta W,Chessa P,Gessa GL

更新日期：1976-05-05 00:00:00

abstract：RATIONALE:The efficacy of methadone for treating heroin dependence derives, in part, from suppression of opiate withdrawal and attenuation of the effects of heroin. OBJECTIVES:The purpose of this double-blind, within-subject, inpatient study was to determine whether larger doses of methadone, which are more effective ...

journal_title：Psychopharmacology

authors： Donny EC,Walsh SL,Bigelow GE,Eissenberg T,Stitzer ML

更新日期：2002-05-01 00:00:00

abstract：:Red blood cell (RBC) glycine levels were examined in 27 bipolar patients, treated with lithium carbonate for a minimum of 8 months, who were either hypomanic, depressed, or euthymic in their mood. We found no difference in the RBC glycine or in the RBC: plasma glycine ratio between the hypomanic, depressed, or euthymi...

journal_title：Psychopharmacology

authors： Peselow ED,Deutsch SI,Stanley M,Banay-Schwartz M,Virgilio J,Fieve RR

更新日期：1982-01-01 00:00:00

abstract：:Few studies have examined the association between ethanol use and cigarette smoking topography. In particular, no study has objectively investigated the relationship between chronic ethanol exposure and cigarette smoking. The aim of this study was to quantify the relationship between cigarette smoking and past and cur...

journal_title：Psychopharmacology

authors： Keenan RM,Hatsukami DK,Pickens RW,Gust SW,Strelow LJ

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Nicotine and other agonists of nicotinic cholinergic receptors (nAChR) have been shown to improve performance in specific memory domains in rodents and monkeys. Such beneficial effects are observed in preclinical models of age-related cognitive decline, stimulating interest in nAChR ligands as possible therap...

journal_title：Psychopharmacology

authors： Katner SN,Davis SA,Kirsten AJ,Taffe MA

更新日期：2004-09-01 00:00:00

abstract：RATIONALE:Opioid antagonism reduces the consumption of palatable foods in humans but the neural substrates implicated in these effects are less well understood. OBJECTIVES:The aim of the present study was to examine the effects of the opioid antagonist, naltrexone, on neural response to rewarding and aversive sight an...

journal_title：Psychopharmacology

authors： Murray E,Brouwer S,McCutcheon R,Harmer CJ,Cowen PJ,McCabe C

更新日期：2014-11-01 00:00:00

abstract：RATIONALE:Results from clinical studies have shown that topiramate effectively reduces alcohol consumption in a population of heavy-drinking alcohol-dependent humans. OBJECTIVES:We undertook this preclinical study in order to establish topiramate's efficacy in a rodent model and to determine whether topiramate's effic...

journal_title：Psychopharmacology

authors： Breslin FJ,Johnson BA,Lynch WJ

更新日期：2010-01-01 00:00:00

abstract：:Rats were trained to discriminate fenfluramine (1.0 mg/kg) from saline in a two-lever drug discrimination task. The dose-response curve for this discrimination was orderly with an ED50 of about one-half of the training dose (0.52 mg/kg). In substitution tests, indirect (p-chloroamphetamine) and direct (quipazine, MK-2...

journal_title：Psychopharmacology

authors： White FJ,Appel JB

更新日期：1981-01-01 00:00:00

abstract：:Rats were trained to self-stimulate by interrupting a photobeam and brain stimulation was maintained for as long as the beam of light was broken. d-Amphetamine sulphate was then administered and response rate and total duration of stimulation were recorded. Both response rate and total duration were elevated by 1.0, 2...

journal_title：Psychopharmacology

authors： Zacharko RM,Wishart TB

更新日期：1979-08-08 00:00:00

abstract：RATIONALE:Hypericum perforatum L., known as St. John's wort (SJW), is used as a phytotherapeutic agent for the treatment of mild to moderate forms of depression. OBJECTIVES:The aim of the present study was to evaluate the effect of SJW extract (STW 3-VI; 250 and 500 mg/kg; p.o.) and fluoxetine (10 mg/kg, p.o.) on gene...

journal_title：Psychopharmacology

authors： Jungke P,Ostrow G,Li JL,Norton S,Nieber K,Kelber O,Butterweck V

更新日期：2011-02-01 00:00:00

abstract：RATIONALE:Drug addiction is a chronically relapsing disorder characterised by compulsive drug use and loss of control over drug intake. Although several theories propose impulsivity as a key component of addiction, the precise nature of this relationship remains unclear. OBJECTIVES:This study aims to investigate the s...

journal_title：Psychopharmacology

authors： Kolokotroni KZ,Rodgers RJ,Harrison AA

更新日期：2012-01-01 00:00:00

abstract：:The daily fluid intake of male Wistar rats with simultaneous access to 6% ethanol and water was determined during a baseline period (1 week), following adrenalectomy (1 week) and for 3 weeks following SC implantation of hormone pellets containing corticosterone (CORT) or dexamethasone (DEX). Ethanol consumption droppe...

journal_title：Psychopharmacology

authors： Fahlke C,Hård E,Eriksson CJ,Engel JA,Hansen S

更新日期：1995-01-01 00:00:00