Abstract:
:There is increasing interest in the potential functional role of the octapeptide angiotensin II (AII) in psychiatric and cognitive disorders. The novel angiotensin II (AII) receptor antagonists, losartan and PD123177, selective for the AT1 and AT2 receptor subtypes respectively, constitute important pharmacological tools for the assessment of the behavioural consequences of modulation of AII function. The present series of studies investigated the effects of each compound in two animal models of anxiety, the rat elevated zero-maze and mouse light/dark box, and two models of working memory in the rat, the operant delayed matching to position (DMTP) task and the spatial reinforced alternation test in the T-maze. Our data indicate that both compounds (0.01-10 mg/kg s.c.) were without significant effect in any of the behavioural assays. Using the present methods and strains of laboratory rodents, these findings provide no support for the involvement of AII receptor function in the mediation of anxiety of working memory.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Shepherd J,Bill DJ,Dourish CT,Grewal SS,McLenachan A,Stanhope KJdoi
10.1007/BF02246450subject
Has Abstractpub_date
1996-08-01 00:00:00pages
206-18issue
3eissn
0033-3158issn
1432-2072journal_volume
126pub_type
杂志文章abstract::Ten rats were trained to lever press for food reward on a schedule of differential reinforcement of low rates of response with a 20-s criterion (DRL 20). Ten more were trained on a new schedule of punishment, designed to be comparable to DRL 20 - differential punishment of high rates of response (DPH 20). Under this s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431812
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:It has recently been reported that chronic nicotine administration at subconvulsive doses causes seizures, a phenomenon referred to as kindling. Evidence points to the involvement of oxidative stress in pharmacological and electrical kindling, sex is known to influence the brain's response to nicotine. OBJEC...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2799-5
更新日期:2013-01-01 00:00:00
abstract:RATIONALE:Gabolysat PC60 is a fish protein hydrolysate with anxiolytic properties commonly used as a nutritional supplement. OBJECTIVE:The diazepam-like effects of PC60 on stress responsiveness of the rat pituitary-adrenal system and on sympathoadrenal activity were studied. METHODS:The activity of the pituitary-adre...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002139900338
更新日期:2000-03-01 00:00:00
abstract:RATIONALE:Increasing concomitant abuse of cocaine and morphine-like opioids has prompted a number of studies aimed at understanding how these drugs interact. OBJECTIVE:The present study was designed to determine if variations in opioid pretreatment time would affect how mu opioid agonists interact with cocaine. METHO...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100732
更新日期:2001-08-01 00:00:00
abstract::The antagonist effects of clocinnamox were evaluated against opioid agonists, acting at mu, kappa and delta-receptors, in rhesus monkeys (n = 3-4) responding under a fixed-ratio 30 (FR 30) schedule for food delivery. Clocinnamox (0.032-0.1 mg/kg) dose-dependently antagonized fentanyl (0.001-0.32 mg/kg) after either a ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246641
更新日期:1996-02-01 00:00:00
abstract::the immediate posttrial injection of oxotremorine (0.250 mu Mol/kg, IP) can facilitate the retention of a passive-avoidance response in mice. After the administration of alfa-methyl-p-tyrosine methylester (alpha-MPT) by intracerebroventricular injection at doses that had no effect on retention (100 microgram, 10 micro...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433098
更新日期:1980-01-01 00:00:00
abstract::Single oral and intramuscular (i.m.) doses of imipramine (IMI) were administered to four normal males. Serum and urine concentrations of IMI, desipramine (DMI) and their unconjugated 2-hydroxy metabolites were measured by high-pressure liquid chromatography (HPLC). Urinary conjugated 2-hydroxy metabolites were also me...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00427676
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Successive negative contrast (SNC) describes a change in the behaviour of an animal following a downshift in the quantitative or qualitative value of an expected reward. This behavioural response has been hypothesised to be linked to affective state, with negative states associated with larger and/or prolonge...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3905-2
更新日期:2015-08-01 00:00:00
abstract::ApolipoproteinE (ApoE) genotype has recently been identified as a major risk factor for Alzheimer's disease (AD) but the mechanism(s) by which ApoE isoforms influence this disease remain unclear. Recent studies suggest that mice deficient in ApoE may exhibit impaired central cholinergic function. Since this neurotrans...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050329
更新日期:1997-07-01 00:00:00
abstract:RATIONALE:Exposure to a single session of uncontrollable inescapable shock (IS), but not to identical controllable escapable shock, produces a potentiation of morphine's rewarding properties that is unusual in that the stressor can be given a number of days before the drug administration in an environment quite differe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1572-1
更新日期:2004-01-01 00:00:00
abstract::When tested in adulthood, male rats that had been treated daily with 50 mg/kg hydroxyzine HCl SC at 10--29 or 23--29 days of age were significantly facilitated in performance of delayed spontaneous alternation relative to saline-injected rats. Treatment at 10--16 days of age did not produce significant facilitation in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427646
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:C-reactive protein (CRP), an acute phase protein that is released in response to inflammatory stimuli, is implicated in Alzheimer's disease (AD). However, the role of CRP in memory deficits associated with AD remains unclear. OBJECTIVE:Experiments were carried out to determine whether CRP impaired memory and...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1499-2
更新日期:2009-07-01 00:00:00
abstract:RATIONALE:Arcaine is a competitive antagonist of the polyamine binding site at the N-methyl-D-aspartic acid receptor which induces state-dependent recall. However, no study has addressed the involvement of other neurotransmitter/neuromodulators in arcaine-induced state dependency. OBJECTIVES:The current study investig...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2215-6
更新日期:2011-06-01 00:00:00
abstract::Rats injected with doses of d-amphetamine 0--5.0 mg/kg were observed continuously in either an enclosed Y-maze or on an elevated Y-shaped platform. Patterns of increased walking and stereotypy were unaffected by the type of apparatus, but rearing remained totally suppressed at all dose levels on the elevated platform....
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431954
更新日期:1979-04-25 00:00:00
abstract:RATIONALE:Both methylphenidate (MPH), a catecholamine reuptake blocker, and guanfacine, an alpha2A agonist, are used to treat attention-deficit hyperactivity disorder (ADHD). Childhood impulsivity, including delay discounting, is associated with increased substance use during adolescence. These effects can be mitigated...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5096-0
更新日期:2019-02-01 00:00:00
abstract:RATIONALE:2-Bromoterguride, a dopamine D2 receptor partial agonist with antagonist properties at serotonin 5-HT2A receptors and α2C-adrenoceptors, meets the prerequisites of a putative atypical antipsychotic drug (APD). We recently showed that 2-bromoterguride is effective in tests of positive symptoms of schizophrenia...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4747-x
更新日期:2018-01-01 00:00:00
abstract:RATIONALE:Stress experience during adolescence has been linked to the development of psychiatric disorders in adulthood, many of which are associated with impairments in prefrontal cortex function. OBJECTIVE:The current study was designed to determine the immediate and enduring effects of repeated social stress on a p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3654-7
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the relationship between zolpidem use and the risk of acute pancreatitis in Taiwan. METHODS:In this population-based case-control study using the database from the Taiwan National Health Insurance Program from 2000 to 2011, we selected 4535 subjects aged 20-84 years ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3833-6
更新日期:2015-06-01 00:00:00
abstract:RATIONALE:It has been suggested that the antipsychotic effect of antipsychotics is mediated by the antagonism of the dopamine D2 receptor in the limbic-cortical regions. Risperidone has an atypical property, but its effect on limbic-cortical regions has not been evaluated. OBJECTIVES:In this study, we examined the rel...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130000643
更新日期:2001-02-01 00:00:00
abstract::The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50 30 and 40 micrograms/kg IP respectively). Phenoxybenzamine and prazosine did not antagonize the anti-withd...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427276
更新日期:1983-01-01 00:00:00
abstract::The anxiolytic activity of diazepam (DZP) (0.25-1 mg/kg) was investigated in streptozotocin (STZ)-induced diabetic adult Charles Foster albino rats of either sex. Diabetes was induced by injecting STZ IP (50 mg/kg; in citrate buffer, pH 4.5). Experiments were performed 72 h later. The rats were subjected to various an...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050523
更新日期:1998-02-01 00:00:00
abstract:RATIONALE:Deficits in response inhibition associated with heroin use could last several months after abstinence in heroin users, and their response inhibition can also be interfered with task-irrelevant drug-related cues. However, it is unclear whether exposure to drug-related cues affects subsequent response inhibitio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05434-6
更新日期:2020-04-01 00:00:00
abstract:RATIONALE:Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0138-9
更新日期:2005-11-01 00:00:00
abstract::Suriclone is a new anxiolytic drug belonging to the family of cyclopyrrolones. Although chemically entirely different from the benzodiazepines, it acts as a benzodiazepine agonist with very high affinity for the benzodiazepine receptors. In the present cross-over study, 33 out-patients with a diagnosis of neurotic anx...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00187246
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:A dopamine receptor 4 variable number tandem repeat (DRD4 VNTR) polymorphism has been related to reactivity to smoking cues among smokers, but the effect of this genetic variation on brain responses to smoking cues has not been evaluated. OBJECTIVES:The present study evaluated the relationship between carryi...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-007-0860-6
更新日期:2007-11-01 00:00:00
abstract:RATIONALE:The endogenous oxytocin system has emerged as an inhibitor of drug-seeking and stress in preclinical models. OBJECTIVES:The goal of this study was to examine whether systemic oxytocin administration attenuated methamphetamine (METH)-seeking in rats pre-exposed to a predator odor threat. METHODS:In Experimen...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4184-7
更新日期:2016-03-01 00:00:00
abstract:RATIONALE:F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial in patients with schizophrenia (Bitter et al. Neuropsych...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05387-w
更新日期:2020-02-01 00:00:00
abstract:INTRODUCTION:Recently we demonstrated that genetic or pharmacological suppression of the central ghrelin signaling system, involving the growth hormone secretagogue receptor 1A (GHS-R1A), lead to a reduced reward profile from alcohol. As the target circuits for ghrelin in the brain include a mesolimbic reward pathway t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1907-7
更新日期:2010-09-01 00:00:00
abstract:RATIONALE:A number of studies have indicated a relationship between the intake of palatable foods or fluids and drug self-administration. OBJECTIVES:Two experiments were conducted to determine whether the intake of sucrose or fat was related to subsequent cocaine self-administration. METHODS:In separate groups of rat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000375
更新日期:2000-04-01 00:00:00
abstract::m-Chlorophenylpiperazine (mCPP), a major metabolite of the atypical antidepressant trazadone, has been observed to produce marked physiological and behavioral effects in both humans and animals. These effects have been attributed to the interaction of mCPP with serotonergic receptors. The present study was designed to...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246164
更新日期:1995-05-01 00:00:00