Abstract:
RATIONALE:Gabolysat PC60 is a fish protein hydrolysate with anxiolytic properties commonly used as a nutritional supplement. OBJECTIVE:The diazepam-like effects of PC60 on stress responsiveness of the rat pituitary-adrenal system and on sympathoadrenal activity were studied. METHODS:The activity of the pituitary-adrenal axis, measured by plasma levels of adrenocorticotropic hormone (ACTH) and corticosterone (B) of the sympathoadrenal complex, measured by circulating levels of noradrenaline (NA) and adrenaline (A), and the gamma aminobutyric acid (GABA) content in the hippocampus and the hypothalamus were investigated in male rats which received daily, by an intragastric feeding tube, for 5 days running either diazepam (1 mg/kg) or PC60 (300 or 1,200 mg/kg). Controls received only solvent (carboxymethylcellulose 1%). Six hours after the last force-feeding, the rats were subjected to 3 min ether inhalation or 30 min restraint and killed by decapitation 30 min after ether stress or at the end of restraint. RESULTS:Baseline plasma levels of ACTH, B, NA and A were not affected by either diazepam or PC60. Both ether- and restraint-induced release of ACTH, but not B, were similarly and drastically reduced by diazepam and PC60 (1,200 mg/kg). Both diazepam and PC60 (1,200 mg/kg) deleted restraint-induced NA and A increases. Both treatments also reduced the ether-induced rise of A. Basal levels of GABA were significantly increased in both the hippocampus and the hypothalamus in PC60-treated rats and only in the hippocampus in diazepam-treated ones. In controls, ether inhalation as well as restraint increased GABA content of these two brain structures. In contrast, such stress procedures performed in PC60-treated rats reduced GABA content slightly in the hippocampus but significantly in the hypothalamus. In diazepam-treated rats, GABA content of the hypothalamus was unaffected by stresses but that of the hippocampus was slightly decreased. CONCLUSIONS:Present data suggest diazepam-like effects of PC60 on stress responsiveness of the rat pituitary adrenal axis and the sympathoadrenal activity as well as GABA content of the hippocampus and the hypothalamus under resting and stress conditions. These effects of PC60 agree with anxiolytic properties of this nutritional supplement, previously reported in both rats and humans.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Bernet F,Montel V,Noël B,Dupouy JPdoi
10.1007/s002139900338subject
Has Abstractpub_date
2000-03-01 00:00:00pages
34-40issue
1eissn
0033-3158issn
1432-2072journal_volume
149pub_type
杂志文章abstract:RATIONALE:Humans typically self-administer cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) together repeatedly (as in cannabis, cannabis extract, or Sativex®) to relieve pain. It has been suggested that one benefit of the drug combination may be decreased tolerance development. OBJECTIVE:The present study com...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5036-z
更新日期:2018-11-01 00:00:00
abstract::Systemic administration of RB 101, a complete inhibitor of the enkephalin degrading enzymes, has been reported to induce naltrindole-reversed antidepressant-like effects in the conditioned suppression of motility (CSM) test in mice. The selective CCKB antagonist L-365,260 also elicits the same naltrindole-blocked resp...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245811
更新日期:1995-08-01 00:00:00
abstract::The thymoleptics potentiate and modify the behavioral effects of apomorphine (probably the most specific dopaminergic agonist) as well as those of Dopa. The effect of the thymoleptics is not abolished by emptying of amine stores, and this together with other evidence suggests that these drugs facilitate the access of ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427282
更新日期:1976-09-17 00:00:00
abstract::The effects of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801, on cocaine self-administration were investigated. Forty-six male Wistar rats were trained to intravenously self-administer four unit doses of cocaine (0.19, 0.38, 0.75 and 1.5 mg/kg per injection) on a progressive-ratio schedule...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050113
更新日期:1996-11-01 00:00:00
abstract:RATIONALE:Prepulse inhibition (PPI) of the startle response in mice is increasingly used as a paradigm of sensory gating with potential predictive and construct validity towards schizophrenia. OBJECTIVES:Establishment of a mouse PPI paradigm in which typical and atypical antipsychotic drugs directly improve a low perf...
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更新日期:2001-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF02246244
更新日期:1992-01-01 00:00:00
abstract::The present report investigated several parametric and pharmacological aspects of the enhanced self-grooming behavior of rats following systemic administration of the selective D1 dopamine (DA) receptor agonist SKF 38393. The amount of time that rats spent grooming themselves was measured continuously for 30 min follo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245478
更新日期:1992-01-01 00:00:00
abstract::Mice ran in a circular runway. Some received milk at every third circuit in a designated direction, clockwise or counterclockwise, in daily 1000-s sessions. Under control conditions, about 10 times as many circuits were made in the reinforced direction as in the non-reinforced direction. Cocaine (10, 30, 100 microM/kg...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244125
更新日期:1990-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:1990-01-01 00:00:00
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更新日期:2018-07-01 00:00:00
abstract:RATIONALE:Available neurochemical probes that lower brain dopamine (DA) levels in man are limited by their tolerability and efficacy. For instance, the acute lowering of brain tyrosine is well tolerated, but only modestly lowers brain DA levels. Modification of tyrosine depletion to robustly lower DA levels would provi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-2977-0
更新日期:2013-05-01 00:00:00
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journal_title:Psychopharmacology
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doi:10.1007/s00213-018-5107-1
更新日期:2019-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427573
更新日期:1983-01-01 00:00:00
abstract::The action of copper (CuSO4, 5 mg/kg, oral) on selected neuropharmacological actions of cannabis resin (CI, oral) was studied on albino rats and mice. Copper potentiated the barbiturate hypnosis-potentiating activity of CI in albino rats and mice and had no effect on hypothermic activity in albino rats. Single doses o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432855
更新日期:1978-04-11 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000616
更新日期:2001-04-01 00:00:00
abstract::In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was assessed over nine widely spaced sessions of 20 trials each. AOAA-treated animals showed learning with...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431848
更新日期:1978-03-01 00:00:00
abstract::Two 2-(di-n-propylamino)tetralin (DPAT) compounds, 8-OH-DPAT and 5-OH-DPAT, with reported effects on central 5-HT and DA receptors respectively, were tested for their effects on the acoustic startle response in rats. 8-OH-DPAT was given in doses of 0.25-2.0 mg/kg IP and 5-OH-DPAT in doses of 1.0-8.0 mg/kg IP. Both com...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427793
更新日期:1983-01-01 00:00:00
abstract::Monoamine oxidase inhibitors (MAOIs) are widely accepted as effective antidepressants. Unfortunately their use has been limited by their capacity to potentiate dietary tyramine (the so called "cheese effect") and their interaction with other drugs. The latter poses a particular problem for patients undergoing anaesthe...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426882
更新日期:1978-04-28 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2002-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 信件
doi:10.1007/s00213-005-0246-6
更新日期:2006-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000508
更新日期:2000-09-01 00:00:00
abstract::Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administratio...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00555210
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Both central serotonergic and nicotinic systems play important roles in a variety of neurobehavioral functions; however, the interactions of these two systems have not been fully characterized. The current study served to determine the impact of a relatively selective 5-HT2A receptor antagonist, ketanserin, o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-2060-y
更新日期:2005-05-01 00:00:00
abstract::Under the fixed-consecutive-number schedule (FCN), pigeons were reinforced for responding eight or more times on one response key (work key), and then responding once on a second response key. In one component of this schedule, an external stimulus signalled the completion of the response requirement on the work key (...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174698
更新日期:1988-01-01 00:00:00
abstract::Haloperidol disposition has been associated with reversible metabolism: it is reversibly reduced to its metabolite, reduced haloperidol, which has less pharmacologic activity than the parent compound. To characterize the interconversion process, six healthy male schizophrenics were administered a single dose of 10 mg ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02253726
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:Intermittent footshock stress effectively reinstates extinguished heroin-, cocaine- and alcohol-taking behaviors, but not behaviors previously maintained by food reinforcers. Here we tested further the generality of the phenomenon of stress-induced reinstatement by determining the effect of footshock on reins...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050992
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:Traumatic events are associated with alcohol use problems with increased alcohol craving as a potential mediator. There is still a lack of knowledge regarding the causal nature of this association and its underlying mechanisms. This study investigated the effects of acute trauma exposure on alcohol craving i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-4979-4
更新日期:2018-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1861-3
更新日期:2004-10-01 00:00:00