Cannabidiol modulation of antinociceptive tolerance to Δ9-tetrahydrocannabinol.

abstract：RATIONALE:Compared to men, the smoking behavior of women may be less responsive to nicotine and more responsive to nonpharmacological factors, perhaps including verbal information (e.g., dose instructions). OBJECTIVE:This study compared the influence of the presence vs absence of dose instructions on the subjective an...

journal_title：Psychopharmacology

authors： Perkins KA,Doyle T,Ciccocioppo M,Conklin C,Sayette M,Caggiula A

更新日期：2006-03-01 00:00:00

abstract：RATIONALE:Consistent sex differences are observed in human drug addiction, with females often exceeding males on drug intake. However, there is still a need for animal models for some aspects of addiction such as acquisition of drug self-administration and the subsequent development of drug-seeking. OBJECTIVES:The pre...

journal_title：Psychopharmacology

authors： Swalve N,Smethells JR,Carroll ME

更新日期：2016-03-01 00:00:00

abstract：:Neuroimaging has been identified as a potentially powerful probe for the in vivo study of drug effects on the brain with utility across several phases of drug development spanning preclinical and clinical investigations. Specifically, neuroimaging can provide insight into drug penetration and distribution, target enga...

journal_title：Psychopharmacology

authors： Doyle OM,Mehta MA,Brammer MJ

更新日期：2015-11-01 00:00:00

abstract：RATIONALE:Investigations of the neural consequences of the effects of cocaine on cognition have centered on specific brain circuits including prefrontal cortex, medial temporal lobe and striatum and their roles in controlling drug dependent behavior and addiction. These regions are critical to many aspects of drug abus...

journal_title：Psychopharmacology

authors： Hampson RE,Porrino LJ,Opris I,Stanford T,Deadwyler SA

更新日期：2011-01-01 00:00:00

abstract：:The four homoeopathic drugs, Gelsemium, Cannabis Indica, Graphites and Agaricus Muscarius, administered orally in 30th and 200th potencies on white rats, enhanced restraint-induced catalepsy in a similar manner to the two standard drugs pilocarpine and haloperidol (IP injection at 5 mg/kg). All the drugs tested differ...

journal_title：Psychopharmacology

authors： Sukul NC,Bala SK,Bhattacharyya B

更新日期：1986-01-01 00:00:00

abstract：:It has previously been shown that serotonergic [5-hydroxytryptamine (5-HT)] neurons of the median raphe nucleus (MR) are critically involved in the control of the hippocampal electroencephalogram (EEG). Activation of MR 5-HT neurons desynchronizes the hippocampal EEG, whereas inhibition of MR 5-HT activity produces hi...

journal_title：Psychopharmacology

authors： Kinney GG,Kocsis B,Vertes RP

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:Second-generation antipsychotics are the first-line medications prescribed for schizophrenic patients; however, some of them, such as olanzapine and risperidone, may induce metabolic dysfunctions during short-term treatment. Metformin is an effective adjuvant that attenuates antipsychotic-induced metabolic dy...

journal_title：Psychopharmacology

authors： Luo C,Wang X,Mao X,Huang H,Liu Y,Zhao J,Zhou H,Liu Z,Li X

更新日期：2020-08-01 00:00:00

abstract：:The intracerebroventricular administration of carbachol chloride induced a characteristic wet dog shake response in rats. Neither 5,6-dihydroxytryptamine, a serotonergic depletor, nor DL-p-chlorophenylalanine, an inhibitor of 5-HT synthesis, affected wet dog shakes induced by carbachol. Putative antiserotonergic drugs...

journal_title：Psychopharmacology

authors： Turski L,Turski W,Czuczwar SJ,Kleinrok Z

更新日期：1981-01-01 00:00:00

abstract：:Because of the increasing demand for refined techniques to record drug-induced motoric changes, we designed and evaluated a computer monitoring system with continuous measurement of different parameters of rat motor activity. This system is particularly useful for chronic drug studies because it can characterize patte...

journal_title：Psychopharmacology

authors： Stoff DM,Stauderman K,Wyatt RJ

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Although the effects of D: -cycloserine (DCS) and valproic acid (VPA) on the facilitation of the extinction of fear-conditioned memory have been elucidated in animals, these effects have not been clearly confirmed in humans. OBJECTIVE:This study aimed to determine the effect of DCS (100 mg) and VPA (400 mg) ...

journal_title：Psychopharmacology

authors： Kuriyama K,Honma M,Soshi T,Fujii T,Kim Y

更新日期：2011-12-01 00:00:00

abstract：:Single oral and intramuscular (i.m.) doses of imipramine (IMI) were administered to four normal males. Serum and urine concentrations of IMI, desipramine (DMI) and their unconjugated 2-hydroxy metabolites were measured by high-pressure liquid chromatography (HPLC). Urinary conjugated 2-hydroxy metabolites were also me...

journal_title：Psychopharmacology

authors： Sutfin TA,DeVane CL,Jusko WJ

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Functional interactions between limbic regions that process emotions and frontal networks that guide response functions provide a substrate for emotional cues to influence behavior. Stimulation of postsynaptic α₂ adrenoceptors enhances the function of prefrontal regions in these networks. However, the impact ...

journal_title：Psychopharmacology

authors： Schulz KP,Clerkin SM,Fan J,Halperin JM,Newcorn JH

更新日期：2013-03-01 00:00:00

abstract：:An operant task for the measurement of sustained attention or vigilance in rats was characterized. The task requires the animals to respond to the presentation of visual signals (presented for 25, 50, or 500 ms) by operating one lever ("hits") and to the absence of a signal by operating the opposite lever ("correct re...

journal_title：Psychopharmacology

authors： McGaughy J,Sarter M

更新日期：1995-02-01 00:00:00

abstract：RATIONALE:In animal studies, the common club drug 3,4-methylendioxymethamphetamine (MDMA, "Ecstasy") consistently caused a prolonged loss of presynaptic serotonergic neurons, and evidence suggests that MDMA consumption may also affect the human serotonergic system. Serotonin (5-HT) has been implicated in the regulation...

journal_title：Psychopharmacology

authors： Quednow BB,Kühn KU,Hoppe C,Westheide J,Maier W,Daum I,Wagner M

更新日期：2007-01-01 00:00:00

abstract：:Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-depend...

journal_title：Psychopharmacology

authors： Mendelson WB,Kuruvilla A,Watlington T,Goehl K,Paul SM,Skolnick P

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:In Koriat's accessibility model (Koriat, Psychol Rev, 100:609-639, 1993; Koriat, J Exp Psychol Gen, 124:311-333, 1995), when a person fails to recall a required target, he or she can nevertheless provide some partial information about the target. Moreover, individuals are able to provide feeling-of-knowing (F...

journal_title：Psychopharmacology

authors： Izaute M,Bacon E

更新日期：2006-11-01 00:00:00

abstract：RATIONALE:The involvement of glutamate in fear extinction is perhaps the most promising in terms of facilitating clinical interventions for posttraumatic stress disorder (PTSD). This study was aimed at elucidating the possible role of zif268 on the D-cycloserine (DCS) facilitation effect on extinction. OBJECTIVE:We in...

journal_title：Psychopharmacology

authors： Wu IT,Tang TH,Ko MC,Chiu CY,Lu KT

更新日期：2015-10-01 00:00:00

abstract：:The effect of pretreatment with ritanserin, a potent and selective serotonin-S2 (5-HT2) receptor antagonist, on the prolactin (PRL) response to electroconvulsive therapy (ECT) was studied in seven female patients suffering from major depressive disorder. They were given either ECT alone, or ECT after 10 or 20 mg ritan...

journal_title：Psychopharmacology

authors： Papakostas Y,Markianos M,Papadimitriou G,Stefanis C

更新日期：1990-01-01 00:00:00

abstract：:Biotransformation of phenacetin via O-deethylation to acetaminophen, an index reaction reflecting activity of Cytochrome P450-1A2, was studied in microsomal preparations from a series of human livers. Acetaminophen formation was consistent with a double Michaelis-Menten system, with low-Km (mean Km1 = 68 microM) and h...

journal_title：Psychopharmacology

authors： von Moltke LL,Greenblatt DJ,Duan SX,Schmider J,Kudchadker L,Fogelman SM,Harmatz JS,Shader RI

更新日期：1996-12-01 00:00:00

abstract：:Forskolin, a diterpene isolated from the plant Coleus forskolii, activates the catalytic subunit of adenylate cyclase, resulting in a hormone receptor-independent increase in the intracellular production of cyclic AMP. This study was undertaken to assess the effect of chronic in vivo infusion of forskolin on noradrene...

journal_title：Psychopharmacology

authors： Suzdak PD,Browne RG

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Coping styles are fundamental characteristics of behavior that affect susceptibility to, and resilience during, mental and physical illness. Shifts from passive to active coping are considered therapeutic goals in many stress-related disorders, but the neural control of coping is poorly understood. Based on e...

journal_title：Psychopharmacology

authors： Haller J,Goldberg SR,Pelczer KG,Aliczki M,Panlilio LV

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Although ethanol is frequently used in combination with other psychoactive drugs, the behavioral and pharmacological reasons for this form of polydrug abuse have not been well described. MATERIALS AND METHODS:Rhesus monkeys with indwelling intravenous catheters produced intravenous injections of ethanol (50...

journal_title：Psychopharmacology

authors： Winger G,Galuska CM,Hursh SR

更新日期：2007-09-01 00:00:00

abstract：:In a test of conditioned punishment, saline-treated controls showed a moderate bias in responding away from a lever producing a response-contingent auditory conditioned stimulus (CS) that had been paired with mild footshock during training and towards a lever producing a neutral auditory CS. Systemic treatment with th...

journal_title：Psychopharmacology

authors： Killcross AS,Everitt BJ,Robins TW

更新日期：1997-01-01 00:00:00

abstract：RATIONALE:Early life exposure to stress and to GABAA receptor modulators have well-defined and persistent behavioral effects. A single neonatal injection of the GABAergic neurosteroid allopregnanolone (3alpha-hydroxy,5alpha-pregnane-20-one, 10 mg/kg, i.p.) alters the localization of prefrontal cortex (PFC) interneurons...

journal_title：Psychopharmacology

authors： Gizerian SS,Moy SS,Lieberman JA,Grobin AC

更新日期：2006-06-01 00:00:00

abstract：:Recent studies indicate that some aspects of memory can be enhanced by the administration of oxygen or glucose. Considering the dependency of glucose metabolism upon oxygen supply, the present study predicted that administering a combination of 100% oxygen with glucose would have greater memory-enhancing effects than ...

journal_title：Psychopharmacology

authors： Winder R,Borrill J

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:The general premise that receptor theory provides a useful framework for understanding the behavioral effects of psychoactive drugs has been a central tenet of behavioral pharmacology. OBJECTIVES:The purpose of this review is to reiterate this basic theme and, in particular, the proposition that current con...

journal_title：Psychopharmacology

authors： Bergman J,France CP,Holtzman SG,Katz JL,Koek W,Stephens DN

更新日期：2000-12-01 00:00:00

abstract：RATIONALE:Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (...

journal_title：Psychopharmacology

authors： Houwing DJ,de Waard J,Ramsteijn AS,Woelders T,de Boer SF,Wams EJ,Olivier JDA

更新日期：2020-08-01 00:00:00

abstract：RATIONALE:Impulsive behavior is associated with both alcohol use disorders and a family history of alcoholism (FHA). One operational definition of impulsive behavior is the stop-signal task (SST) which measures the time needed to stop a ballistic hand movement. OBJECTIVE:Employ functional magnetic resonance imaging (f...

journal_title：Psychopharmacology

authors： Kareken DA,Dzemidzic M,Wetherill L,Eiler W 2nd,Oberlin BG,Harezlak J,Wang Y,O'Connor SJ

更新日期：2013-07-01 00:00:00

abstract：RATIONALE:Kratom is proposed to exhibit therapeutic potential as an opium substitute, but little is known about its dependence-producing profile, particularly of its main psychoactive compound, mitragynine (MG). OBJECTIVES:This study examined the dependence-producing effects of MG using operant-scheduled behaviour in ...

journal_title：Psychopharmacology

authors： Harun N,Johari IS,Mansor SM,Shoaib M

更新日期：2020-03-01 00:00:00

abstract：RATIONALE:Dopamine (DA) plays an important role in working memory. However, the precise functions supported by different DA receptor subtypes in different neural regions remain unclear. OBJECTIVE:The present study used pharmacological, event-related fMRI to test the hypothesis that striatal dopamine is important for t...

journal_title：Psychopharmacology

authors： Dodds CM,Clark L,Dove A,Regenthal R,Baumann F,Bullmore E,Robbins TW,Müller U

更新日期：2009-11-01 00:00:00