Behavioral vigilance in rats: task validation and effects of age, amphetamine, and benzodiazepine receptor ligands.

abstract：RATIONALE:Several studies have demonstrated that males with a family history of alcoholism (FHP) show less of a response to alcohol (e.g. lower ratings of intoxication) than males without a family history of alcoholism (FHN). The purpose of this pilot study was to determine if FHP females also showed a reduced sensitiv...

journal_title：Psychopharmacology

authors： Evans SM,Levin FR

更新日期：2003-08-01 00:00:00

abstract：RATIONALE:Several lines of evidence have indicated that the central histaminergic system might be involved in learning and memory OBJECTIVES:The aim of the present study was to ascertain the impact on memory processes of putative histaminergic-cholinergic interactions in the nucleus basalis magnocellularis (NBM) of th...

journal_title：Psychopharmacology

authors： Orsetti M,Ferretti C,Gamalero R,Ghi P

更新日期：2002-01-01 00:00:00

abstract：:The effects of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801, on cocaine self-administration were investigated. Forty-six male Wistar rats were trained to intravenously self-administer four unit doses of cocaine (0.19, 0.38, 0.75 and 1.5 mg/kg per injection) on a progressive-ratio schedule...

journal_title：Psychopharmacology

authors： Ranaldi R,French E,Roberts DC

更新日期：1996-11-01 00:00:00

abstract：:Food intake of four adult male baboons (Papio c. anubis) was monitored during daily experimental sessions lasting 22 h. Food was available under a two-component operant schedule. Following completion of the first "procurement component" response requirement, access to food, i.e., a meal, became available under the sec...

journal_title：Psychopharmacology

authors： Foltin RW,Fischman MW,Byrne MF

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) refers to the reduction of the startle response magnitude when a startling stimulus is closely preceded by a weak stimulus. PPI is commonly used to measure sensorimotor gating. In rats, the PPI reduction induced by the dopamine agonist apomorphine can be reversed by systemic administ...

journal_title：Psychopharmacology

authors： Larrauri JA,Burke DA,Hall BJ,Levin ED

更新日期：2015-08-01 00:00:00

abstract：RATIONALE:Preclinical studies indicate that gonadal hormones are important determinants of drug self-administration. To date, little is known about the influence of sex and estrous cycle on drug self-administration in ecologically relevant social contexts. OBJECTIVE:The objective of this study was to examine the role ...

journal_title：Psychopharmacology

authors： Lacy RT,Strickland JC,Feinstein MA,Robinson AM,Smith MA

更新日期：2016-09-01 00:00:00

abstract：RATIONALE:The gut microbiota is increasingly recognized as a potential mediator of psychiatric diseases. Depressed patients have been shown to have a different microbiota composition compared with healthy controls, and several lines of research now aim to restore this dysbiosis. To develop novel treatments, preclinical...

journal_title：Psychopharmacology

authors： Tillmann S,Abildgaard A,Winther G,Wegener G

更新日期：2019-05-01 00:00:00

abstract：RATIONALE:Recently, we showed that 2-bromoterguride acted as a dopamine D2 receptor partial agonist, a serotonin 5-HT2A and α2C-adrenergic receptor antagonist, and exhibited antidopaminergic efficacy in amphetamine-induced locomotion (AIL) in rats without inducing catalepsy. OBJECTIVE:To extend our knowledge on the an...

journal_title：Psychopharmacology

authors： Franke RT,Tarland E,Fink H,Pertz HH,Brosda J

更新日期：2016-08-01 00:00:00

abstract：:The effects of 6-OHDA lesions of dopamine terminals within the amygdala were investigated on i) (+) amphetamine-induced locomotor hyperactivity and ii) the acquisition of intravenous self-administration of (+) amphetamine. The lesioned rats exhibited increased locomotor activity in response to (+) amphetamine (0.75 an...

journal_title：Psychopharmacology

authors： Deminière JM,Taghzouti K,Tassin JP,Le Moal M,Simon H

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Several different animal models are currently used to research the neurodegenerative movement disorder Parkinson's disease (PD). RESULTS:Models based on the genetic deficits associated with a small percentage of sufferers demonstrate the pathological accumulation of alpha-synuclein characteristic of the dis...

journal_title：Psychopharmacology

authors： Lane E,Dunnett S

更新日期：2008-08-01 00:00:00

abstract：:A venous blood sample and an umbilical cord blood sample were obtained from five young women treated with the neuroleptic drug, cis(Z)-flupentixol decanoate in Viscoleo (intramuscularly) or flupentixol (orally) at the time of giving birth. In two cases amniotic fluid was also obtained, and from three of the mothers mi...

journal_title：Psychopharmacology

authors： Kirk L,Jørgensen A

更新日期：1980-01-01 00:00:00

abstract：:2,4-Dithiobiuret (DTB) is a sulfonated derivative of urea that is used as a reducing agent in chemical manufacture. Its low acute toxicity to rodents belies a peripherally mediated, delayed-onset muscle weakness which develops during repeated daily exposure. In experiment 1, a standard dose regimen of DTB (0.5 mg/kg p...

journal_title：Psychopharmacology

authors： Bushnell PJ,Oshiro WM

更新日期：1996-02-01 00:00:00

abstract：:In a shuttle-box self-stimulation paradigm, analgesic doses of morphine increase the amount of time a rat leaves rewarding brain stimulation on, without altering average OFF times. This paradigm may serve as a model for the euphoria induced by narcotic drugs and as a useful tool for evaluating the reinforcing effects ...

journal_title：Psychopharmacology

authors： Levitt RA,Baltzer JH,Evers TM,Stilwell DJ,Furby JE

更新日期：1977-11-15 00:00:00

abstract：RATIONALE:Therapeutic efficacy of antidepressant drugs appears to be related to their ability in producing neuroadaptive changes that restore normal brain function. Activity-regulated cytoskeletal associated protein (Arc) is an effector immediate early gene that plays a fundamental role in activity-dependent neural pla...

journal_title：Psychopharmacology

authors： Molteni R,Calabrese F,Mancini M,Racagni G,Riva MA

更新日期：2008-12-01 00:00:00

abstract：RATIONALE:Numerous preclinical and clinical studies have reported the rapid and sustained antidepressant effects of the NMDA receptor antagonist ketamine. Because ketamine induces several undesirable and dangerous effects, a variety of strategies have been suggested to avoid such effects. OBJECTIVES:Here, we propose t...

journal_title：Psychopharmacology

authors： Podkowa K,Pochwat B,Brański P,Pilc A,Pałucha-Poniewiera A

更新日期：2016-08-01 00:00:00

abstract：:To investigate the role of D1 dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 mg/kg, IM) from saline. Administration of various doses of cocaine resulted in a dose-related in...

journal_title：Psychopharmacology

authors： Kleven MS,Anthony EW,Goldberg LI,Woolverton WL

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Nicotine replacement is commonly used to treat tobacco use in heavy-drinking smokers. However, few studies have examined the effect of nicotine replacement on subjective and physiological responses to alcohol and alcohol drinking behavior. OBJECTIVE:The primary aim of this within-subject, double-blind study ...

journal_title：Psychopharmacology

authors： McKee SA,O'Malley SS,Shi J,Mase T,Krishnan-Sarin S

更新日期：2008-02-01 00:00:00

abstract：RATIONALE:Considerable research indicates that "ecstasy" users perceive their memory for future intentions (prospective memory) to be impaired. However, only one empirical study to date has directly tested how this capacity is affected by ecstasy use, and this study provided relatively limited information regarding the...

journal_title：Psychopharmacology

authors： Rendell PG,Gray TJ,Henry JD,Tolan A

更新日期：2007-11-01 00:00:00

abstract：:A double-blind, placebo-controlled, cross-over study in ten normal volunteers assessed the effects of the subcutaneous administration of adrenaline on platelet MAO activity, in an attempt to replicate previous findings of increased MAO activity following adrenaline. Platelet counts, cortisol plasma concentrations, and...

journal_title：Psychopharmacology

authors： Gentil V,McCurdy RL,Alevizos B,Lader MH

更新日期：1976-11-10 00:00:00

abstract：:The serotonin 5-HT(3) receptor is thought to play a role in the reward pathway and drug abuse by modulating dopamine release within the mesolimbic pathway. Dopamine release stimulated by cocaine and methamphetamine is blocked by administration of 5-HT(3) receptor antagonists. Animal studies demonstrate that 5-HT(3) re...

journal_title：Psychopharmacology

authors： Allan AM,Galindo R,Chynoweth J,Engel SR,Savage DD

更新日期：2001-10-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) represents a normal sensorimotor gating response that is typically impaired in schizophrenic patients. It is known that cannabinoid CB1 agonists reduce sensorimotor gating in rats, suggesting that the CB1 receptor and the cannabinoid system are involved in sensorimotor gating. OBJEC...

journal_title：Psychopharmacology

authors： Fernandez-Espejo E,Galan-Rodriguez B

更新日期：2004-09-01 00:00:00

abstract：RATIONALE:Higher rates of delay discounting, or impulsive choice, may be related to relapse during abstinence reinforcement interventions for cigarette smoking, and a transdermal nicotine patch may attenuate delay discounting. OBJECTIVE:The objectives of this study are to assess the relation between delay discounting ...

journal_title：Psychopharmacology

authors： Dallery J,Raiff BR

更新日期：2007-03-01 00:00:00

abstract：:The ability of mu and kappa opioids to alter the discriminative-stimulus and rate-decreasing effects of the 5-HT1A receptor agonist 8-OH-DPAT was examined in rats trained to discriminate either a low (0.1 mg/kg) or a high (0.3 mg/kg) dose of 8-OH-DPAT from water using a two-lever food-reinforced drug discrimination pr...

journal_title：Psychopharmacology

authors： Morgan D,Picker MJ

更新日期：1995-12-01 00:00:00

abstract：:Ibogaine is currently being investigated for its potential use as an anti-addictive agent. In the present study we sought to determine whether prior morphine exposure influences the ability of ibogaine to inhibit morphine-induced locomotor stimulation. Female Sprague-Dawley rats were pretreated once a day for 1-4 days...

journal_title：Psychopharmacology

authors： Pearl SM,Johnson DW,Glick SD

更新日期：1995-10-01 00:00:00

abstract：RATIONALE:We previously demonstrated that the addition of the selective norepinephrine reuptake inhibitor reboxetine attenuates olanzapine-induced weight gain. Using the same study sample, we also sought to determine whether reboxetine's weight-attenuating effect was accompanied by a beneficial effect on metabolic and ...

journal_title：Psychopharmacology

authors： Amrami-Weizman A,Maayan R,Gil-Ad I,Pashinian A,Fuchs C,Kotler M,Poyurovsky M

更新日期：2013-11-01 00:00:00

abstract：:In a double-blind, balanced crossover study, eight healthy male volunteers ingested either DL-308 (10 mg), DL-308 (20 mg), oxazepam (30 mg) or placebo. Subjective estimates of coordination and anxiety, objective performance measurements and cardiovascular measurements were taken at 1, 3, 5 and 8 h after ingestion. DL-...

journal_title：Psychopharmacology

authors： Herbert M,Standen PJ,Short AH,Birmingham AT

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Opioid neurotransmission mediates hedonic value of sweet tastants; their intake may be exaggerated by the consumption of exogenous opioids (e.g., opioid dependence). Sweet Taste Test (STT) is a validated quantitative instrument assessing taste perception and hedonic features of sugar (sucrose) using a random...

journal_title：Psychopharmacology

authors： Langleben DD,Busch EL,O'Brien CP,Elman I

更新日期：2012-04-01 00:00:00

abstract：:Rats were trained to discriminate between two compound stimulus arrays that included exteroceptive (ES) and interoceptive (IS) stimulus components. The ES components were illumination and tactile cues, and the IS components were produced by d-amphetamine (A) or Na pentobarbital (P) treatment (drug versus drug discrimi...

journal_title：Psychopharmacology

authors： Duncan PM

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Conditioned behavioral responses to discrete drug-associated cues can be modulated by the environmental context in which those cues are experienced, a process that may facilitate relapse in humans. Rodent models of drug self-administration have been adapted to reveal the capacity of contexts to trigger drug s...

journal_title：Psychopharmacology

authors： Chaudhri N,Sahuque LL,Janak PH

更新日期：2009-12-01 00:00:00

abstract：:The development of a differential tolerance to morphine was investigated with respect to the mean effective dose, the threshold dose of tolerance, the degree of tolerance after a fixed dose, and the speed of tolerance loss. The mean effective doses, the threshold doses of tolerance, and the degree of tolerance differe...

journal_title：Psychopharmacology

authors： Fernandes M,Kluwe S,Coper H

更新日期：1982-01-01 00:00:00