Abstract:
:A double-blind, placebo-controlled, cross-over study in ten normal volunteers assessed the effects of the subcutaneous administration of adrenaline on platelet MAO activity, in an attempt to replicate previous findings of increased MAO activity following adrenaline. Platelet counts, cortisol plasma concentrations, and uptake of metaraminol by the platelets were also determined to elucidate possible mechanisms of action. Blood pressure and heart rate were used as indices of the concentration of adrenaline effectively in circulation. MAO activity towards benzylamine was significantly increased by adrenaline. Non-significant increases were noted in the deamination of tyramine and tryptamine, in platelet counts, cortisol concentrations and metaraminol uptake. Increases in MAO activity were also noted early in the experimental sessions suggesting that other experimental variables such as venepuncture may affect platelet MAO activity. Possible mechanisms for this adrenaline effect are discussed and it is suggested that variables such as "arousal" and "stress" must be taken into account when interpreting clinical data on platelet MAO.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Gentil V,McCurdy RL,Alevizos B,Lader MHdoi
10.1007/BF00430491subject
Has Abstractpub_date
1976-11-10 00:00:00pages
187-92issue
2eissn
0033-3158issn
1432-2072journal_volume
50pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Several different animal models are currently used to research the neurodegenerative movement disorder Parkinson's disease (PD). RESULTS:Models based on the genetic deficits associated with a small percentage of sufferers demonstrate the pathological accumulation of alpha-synuclein characteristic of the dis...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-007-0931-8
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:People with schizophrenia exhibit a high obesity rate. However, little is known about the prevalence of obesity and its relationship with clinical symptoms and metabolic indicators in first-episode drug-naïve (FEDN) schizophrenia. METHODS:Demographic and lipid parameters were gathered from 297 FEDN schizophr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05727-1
更新日期:2020-11-25 00:00:00
abstract:RATIONALE:Electrophysiological studies have identified a scalp potential, the late positive potential (LPP), which is modulated by the emotional intensity of observed stimuli. Previous work has shown that the LPP reflects the modulation of activity in extrastriate visual cortical structures, but little is known about t...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2426-x
更新日期:2012-02-01 00:00:00
abstract:RATIONALE:The administration of heroin has been shown to inhibit the induction of nitric oxide, a molecule known to play a critical role in immune function. Previous research has shown that this alteration can be conditioned to environmental stimuli that have been associated with drug administration. However, it remain...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0673-z
更新日期:2007-05-01 00:00:00
abstract:RATIONALE:The widespread deficits in cognitive flexibility observed across psychiatric disorders call for improved rodent tests to understand the biology of cognitive flexibility and development of better psychotherapeutics. Current reversal learning paradigms have a forced-choice setup that challenges the interpretati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05687-6
更新日期:2021-02-01 00:00:00
abstract:RATIONALE:Schizophrenia is a disorder with cognitive deficits that could stem from cholinergic dysfunction. OBJECTIVES:Our aim was to examine if donepezil administered to stable, medicated outpatients with schizophrenia improves cognition and psychopathology. METHODS:We conducted a double-blind placebo-controlled tri...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-2235-1
更新日期:2005-09-01 00:00:00
abstract::In two experiments, phenobarbitone sodium (30 mg/kg) reliably enhanced water consumption and extended the duration of drinking in 24h water-deprived male rats. The opiate receptor antagonists naloxone (0.1-10 mg/kg) and naltrexone (0.1-10 mg/kg) both decreased water intake and reduced the duration of drinking. When th...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433011
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:Inattentional blindness (IB) is the inability to detect a salient yet unexpected task irrelevant stimulus in one's visual field when attention is engaged in an ongoing primary task. The present study is the first to examine the impact of both task difficulty and alcohol consumption on IB and primary task perf...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4772-9
更新日期:2018-01-01 00:00:00
abstract::It has been suggested that anxiety may be a critical factor in certain forms of non-opioid environmental analgesia. In the present study, 5-min exposure to the elevated plus-maze test of anxiety (EPM) induced a mild, though enduring, elevation in tail-flick latencies in male mice. Pretreatment with the opiate antagoni...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247133
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:There is evidence that events early in post-weaning life influence brain development and subsequent adult behaviour and therefore play an important role in the causation of certain psychiatric disorders in later life. Exposing rodents to stressors during the juvenile period has been suggested as a model of in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1991-8
更新日期:2011-03-01 00:00:00
abstract::To confirm the conclusions from a previous study supporting the usefullness of electropupillogram (E.P.G.) in predicting clinical response, data from three separate studies with hyperkinetic and learning disabled (L.D.) children treated with stimulants were surveyed. Change in extent of pupillary contraction (E.C.) af...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00426885
更新日期:1978-04-28 00:00:00
abstract::The ability of delta 9-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-OH THC and 8 alpha, 11-diOH THC to antagonise the abdominal constriction response in the mouse induced by formic acid, phenylquinone, 5-hydroxytryptamine, prostaglandin E1 (PGE1) and bradykinin was tested. THC was an effective a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432273
更新日期:1979-03-28 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the relationship between zolpidem use and the risk of acute pancreatitis in Taiwan. METHODS:In this population-based case-control study using the database from the Taiwan National Health Insurance Program from 2000 to 2011, we selected 4535 subjects aged 20-84 years ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3833-6
更新日期:2015-06-01 00:00:00
abstract::Nine VA Medical Centers are participating in a 2-year double-blind placebo controlled study of antioxidant treatment for tardive dyskinesia (TD) conducted by the Department of Veteran Affairs Cooperative Studies Program. One of the principal outcome measures of this study is the score derived from the instrumental ass...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s002130050320
更新日期:1997-07-01 00:00:00
abstract::This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) reflex of the rabbit. The NM reflex was elicited by varying intensities of a tactile stimulus and the magnitudes of the...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050820
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine. METHODS:Using an isolation-r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4579-8
更新日期:2017-05-01 00:00:00
abstract::Intact male and ovariectomized female rats were trained to lever press under a random ratio (RR) schedule of food reinforcement. Effects of different doses of pentobarbital (1-16 mg/kg) and progesterone (10-80 mg/kg) on response output were studied. Low doses of pentobarbital increased responding, high doses decreased...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179930
更新日期:1987-01-01 00:00:00
abstract::Single-dose pharmacokinetics of alprazolam was studied in 42 normal male volunteers (14 Caucasians, 14 American-born Asians, and 14 foreign-born Asians), after both oral and parenteral (IV) administration of a small dose (0.5 mg) of the test drug. Asians manifested significantly higher Cmax, larger AUC, slower CL and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00216063
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:The drug discrimination procedure has proven to be a valuable tool for studying the mechanism of action of psychoactive drugs. Recently, mice with targeted gene mutations have been developed that may also prove useful in evaluating the role of specific receptors in mediating the actions of drugs. We were inte...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1252-6
更新日期:2003-02-01 00:00:00
abstract::The phase of highly focused, repetitive behavior (stereotypy) induced by amphetamine in rats emerges after an initial period of locomotor activation. To assess the neuronal correlates of this behavioral transition, single-unit activity was recorded from the dorsal striatum of awake, unrestrained rats. Units were first...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050249
更新日期:1997-04-01 00:00:00
abstract:RATIONALE:Medication and illicit drugs can have detrimental side effects which impair driving performance. A drug's impairing potential should be determined by well-validated, reliable, and sensitive tests and ideally be calibrated by benchmark drugs and doses. To date, no consensus has been reached on the issue of whi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3408-y
更新日期:2014-06-01 00:00:00
abstract::The behavioural effects of selective mu-, kappa- and delta-opioid agonists in 5-, 10- and 20-day-old rats were investigated by observational analysis. The predominant response to mu-agonists was behavioural depression. High doses (10 mg/kg IP) of morphine and DAGO (D-Ala2, NMe-Phe4, Glyol5-enkephalin) produced overt s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439459
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Animal models of alcohol-seeking are useful for understanding alcohol addiction and for treatment development, but throughput in these models is limited by the extensive pretraining required to overcome the aversive taste of ethanol. Work by Augier et al. (Psychopharmacology 231: 4561-4568, 2014) indicates th...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4824-1
更新日期:2018-04-01 00:00:00
abstract::Naloxone HCl (10 micrograms/0.5 ml) was injected in the locus coeruleus (LC) of morphine-dependent rats and the behavioural manifestations of morphine withdrawal and the cortical levels of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) were measured 30 min later. Naloxone precipitated a withdrawal syndrome...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00187263
更新日期:1987-01-01 00:00:00
abstract:AIM:Excess consumption of alcohol leads to impaired cognition and decision making; hence, alcohol-containing products and advertising contain warning messages about the adverse effects of excess drinking. However, there is a need to understand how alcohol influences the processing of advisory messages. METHOD:The curr...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-009-1762-6
更新日期:2010-03-01 00:00:00
abstract::Rats chronically treated with increasing daily doses of delta 9-tetrahydrocannabinol (delta 9-THC) for up to 5 or 10 days exhibit a withdrawal-like behavioural response when challenged with clomipramine, a potent inhibitor of serotonin (5-hydroxytryptamine) reuptake, at the time when the next injection of delta 9-THC ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431112
更新日期:1981-01-01 00:00:00
abstract::Two sets of experiments were carried out to compare the effects of fenfluramine and fluoxetine on consummatory and operant behaviour. In food-deprived rats allowed access to a 35% sucrose solution, an initial period of sucrose consumption was followed by a short period of grooming and exploratory behaviour, later supe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245933
更新日期:1990-01-01 00:00:00
abstract::Two groups of socially housed rhesus monkeys were raised under conditions differing in the degree of control or mastery over appetitive stimuli (food, water, and treats) in the 1st year of life. At age 18-24 months, a benzodiazepine receptor inverse agonist, beta-carboline-3-carboxylic acid ethyl ester (beta-CCE), was...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02431537
更新日期:1988-01-01 00:00:00
abstract::Tardive dyskinesia has been hypothesized to be caused by a neuroleptic-induced dopamine hypersensitivity in the nigrostriatal system. This study evaluated with dopamine antagonists the possibility that such dopamine hypersensitivity extends to the tuberoinfundibular dopamine (TIDA) system, which regulates, by inhibiti...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428314
更新日期:1979-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Previous studies have demonstrated that sensitization to repeated doses of cocaine results in prolonged changes in glutamate transmission. However, little is known about long-term changes in glutamate transmission following a single dose of cocaine. Our laboratory has previously reported that a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1296-7
更新日期:2003-02-01 00:00:00