Abstract：
RATIONALE:Recently, we showed that 2-bromoterguride acted as a dopamine D2 receptor partial agonist, a serotonin 5-HT2A and α2C-adrenergic receptor antagonist, and exhibited antidopaminergic efficacy in amphetamine-induced locomotion (AIL) in rats without inducing catalepsy. OBJECTIVE:To extend our knowledge on the antipsychotic effects of 2-bromoterguride, we used convergent preclinical animal models and tests; i.e., conditioned avoidance response (CAR), predictive of antipsychotic-like effects; Fos protein expression, a molecular marker for (atypical) antipsychotic activity; wet dog shake behavior, a test for the in vivo effects of drugs acting on central 5-HT2A receptors; and investigated metabolic changes as a common side effect of atypical antipsychotic drugs (APDs). RESULTS:Acute treatment with 2-bromoterguride (0.1 and 0.3 mg/kg) decreased the CAR at 30, 90, and 270 min post-injection in rats without inducing escape failures at any time. Fos protein expression, as shown by Western blotting, was enhanced by 2-bromoterguride in the nucleus accumbens (NAc), the dorsolateral striatum (dStr), and the medial prefrontal cortex (mPFC). (±)-2,5-Dimethoxy-4-iodoamphetamine (DOI)-induced wet dog shakes in rats were reduced by 2-bromoterguride. Chronic treatment with 2-bromoterguride did not affect metabolic parameters such as body weight development and body fat composition as well as behavioral parameters such as food intake and locomotor activity. CONCLUSIONS:Our data suggest that 2-bromoterguride is a promising candidate in the treatment of schizophrenia due to its atypical antipsychotic-like activity and its inability to induce weight gain.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Franke RT,Tarland E,Fink H,Pertz HH,Brosda Jdoi
10.1007/s00213-016-4356-0subject
Has Abstractpub_date
2016-08-01 00:00:00pages
3041-50issue
15-16eissn
0033-3158issn
1432-2072pii
10.1007/s00213-016-4356-0journal_volume
233pub_type
杂志文章abstract：:Two studies were conducted to replicate and extend previous demonstrations of smoking-induced, dose-related reports of euphoria, and to confirm this relationship using measures of plasma nicotine. In experiment 1, overnight-deprived subjects, in three different sessions, smoked ultralow-, high-nicotine, and usual-bran...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02247422
更新日期：1992-01-01 00:00:00
abstract：:The suggestions that dopamine (DA) systems are involved in "motor control" and "reward" represent the classic working hypotheses on the behavioral functions of these systems. The research generated by these hypotheses has yielded results that are far more complicated than the simplest form of either hypothesis would i...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF02245133
更新日期：1992-01-01 00:00:00
abstract：:In the present study we have investigated the effects of diazepam (DZP) (10 mg/kg) treatment of rat dams during different periods of gestation or during lactation on the development and behavior of their offspring. The results show that DZP exposure during different phases of early development has differing effects on...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427422
更新日期：1984-01-01 00:00:00
abstract：RATIONALE:The reinforcing effects of stimulant drugs such as D-amphetamine, caffeine, and cocaine are modulated by behavioral demands following drug administration. OBJECTIVE:The objective of this study was to assess the reinforcing effects of methylphenidate under different behavioral demands using a modified progres...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-004-1946-z
更新日期：2005-01-01 00:00:00
abstract：:Offensive and defensive components of aggressive behavior were determined in resident and intruder mice. Withdrawal aggression was measured after the removal of a subcutaneous morphine pellet or after precipitation by naloxone in naive mice and after removal of a morphine pellet in mice with prior fighting experience....
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174059
更新日期：1986-01-01 00:00:00
abstract：:Efforts to find a correlation between serum levels of chlorpromazine (CPZ) and clinical effect have been rather unsuccessful, which could be due to fluctuations of CPZ and CPZ metabolite levels during treatment, the complicated metabolism of CPZ, or to varying degrees of protein binding. Using a mass fragmentographic ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00431102
更新日期：1981-01-01 00:00:00
abstract：INTRODUCTION:Understanding an individual's vulnerability to drug addiction has important implications for the development of effective personal treatment plans. Although theories acknowledge impulsive behaviour as a key component of drug addiction, little is known about the influence of trait impulsivity on an individu...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3270-y
更新日期：2014-02-01 00:00:00
abstract：RATIONALE:Performance on progressive ratio schedules has been proposed as a means of assessing the effects of drugs on the value or "efficacy" of reinforcers. A mathematical model affords a basis for quantifying the effects of drugs on progressive ratio schedule performance. According to this model, the relation betwee...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-2049-6
更新日期：2005-05-01 00:00:00
abstract：RATIONALE:The precise neural circuitry that encodes fear memory and its extinction within the brain are not yet fully understood. Fearful memories can be persistent, resistant to extinction, and associated with psychiatric disorders, especially post-traumatic stress disorder (PTSD). Here, we investigated the microtopog...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5068-4
更新日期：2019-01-01 00:00:00
abstract：:There were marked strain differences in the duration of the protective effects of diazepam against the convulsant actions of penylenetetrazole and picrotoxin in mice. In no case was significant protection found at 12 h or longer, regardless of whether the incidence of or the latencies to myoclonus or tonic-clonic conv...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431698
更新日期：1985-01-01 00:00:00
abstract：RATIONALE:Environmental stimuli associated with drugs of abuse are believed to play a major role in the motivation to take drugs, drug dependence, and relapse. Previous work from this laboratory demonstrated that the response-contingent presentation of drug-related, visual cues was at least as important as nicotine in ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1156-5
更新日期：2002-09-01 00:00:00
abstract：:Behaviour was observed in mice given L-tryptophan, L-tyrosine or L-phenylalanine and then placed either in an open field or in water in a narrow cylinder. Animals placed in water (swim test) soon assume a characteristic immobile posture. Most antidepressants, including pharmacologically atypical ones, decrease immobil...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00435264
更新日期：1982-01-01 00:00:00
abstract：OBJECTIVE:This study aims to conduct an evidence review of the effectiveness, harms, and cost-effectiveness of pharmacogenomics-guided antidepressant treatment for major depressive disorder. METHODS:We searched MEDLINE®, the Cochrane Central Registry of Controlled Trials, and PsycINFO through February 2017. We used pr...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-017-4622-9
更新日期：2017-06-01 00:00:00
abstract：RATIONALE:It has been suggested that the antipsychotic effect of antipsychotics is mediated by the antagonism of the dopamine D2 receptor in the limbic-cortical regions. Risperidone has an atypical property, but its effect on limbic-cortical regions has not been evaluated. OBJECTIVES:In this study, we examined the rel...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s002130000643
更新日期：2001-02-01 00:00:00
abstract：:Research was conducted to examine the ability of alcohol to impart conditioned reinforcement. Rats were allowed to self-administer solutions of either saline or alcohol (25, 50, and 100 mg/kg/infusion) by the intragastric route. Superimposed on the infusion interval was a buzzer (conditioned reinforcing stimulus). Tes...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00492355
更新日期：1977-08-16 00:00:00
abstract：RATIONALE:Previously, we have shown that d-amphetamine (AMPH) was more potent than d-methamphetamine (METH) at increasing extracellular levels of dopamine (DA) in the prefrontal cortex (PFC) at doses that had similar effects in the nucleus accumbens. Since working memory depends on PFC DA, it was postulated that AMPH w...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1522-y
更新日期：2003-11-01 00:00:00
abstract：RATIONALE:The behavioral effects of racemic zopiclone are similar to those of benzodiazepines that positively modulate GABA at the GABA(A) receptor complex; however, it is not clear how enantiomers or metabolites of zopiclone contribute to the benzodiazepine-like behavioral effects of racemic zopiclone. OBJECTIVES:Rac...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1286-9
更新日期：2003-01-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Previous studies have demonstrated that sensitization to repeated doses of cocaine results in prolonged changes in glutamate transmission. However, little is known about long-term changes in glutamate transmission following a single dose of cocaine. Our laboratory has previously reported that a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1296-7
更新日期：2003-02-01 00:00:00
abstract：:Oral administration of the serotonin (5-HT) precursor L-5-hydroxytryptophan (5-HTP), 200 mg, significantly increased plasma cortisol levels in man. L-5-HTP had no significant effect on the plasma prolactin levels. A borderline effect of 5-HTP on plasma ACTH levels was found. Pretreatment with the 5-HT2/5-HT1c antagoni...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244213
更新日期：1991-01-01 00:00:00
abstract：:The effect of lithium and rubidium on curiosity rearing, and locomotor activity in isolated and group-housed male mice (DBA/2 Han) was investigated. LiCl and RbCl were given with the drinking water (30 mol/l) during 3 weeks. The behaviour of the animals was tested before and after the chronical application of either l...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432270
更新日期：1979-03-28 00:00:00
abstract：:The aim of the present study was to evaluate the effects of nicotinic acetylcholine receptor (nACh-R) agonists such as (-)-nicotine and related compounds on brain monoamine turnover. A single administration of (-)-nicotine (0.04, 0.2, 1.0, and 5.0 mg/kg SC) increased both noradrenaline (NA) and dopamine (DA) turnover ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050184
更新日期：1997-02-01 00:00:00
abstract：RATIONALE:Orexins A and B have recently been discovered and shown to be derived from preproorexin, primarily expressed in the rat hypothalamus. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) administration, including hyperphagia, neuroendocrine modulation and, mo...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000550
更新日期：2001-01-01 00:00:00
abstract：RATIONALE:In patients, ketamine is a fast-acting antidepressant that can induce long-lasting symptom relief. Similar rapid effects have been reported in rodents, but reports of lasting effects are limited. OBJECTIVES:We sought to extend past findings by examining dose-response curves that overlap with the individual d...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2169-8
更新日期：2011-06-01 00:00:00
abstract：:Although previous studies have shown that pharmacological agents, such as buprenorphine, and alternative nondrug reinforcers, such as money or sweetened solutions, reduce cocaine self-administration, few studies have examined the combined effects of these two approaches. The purpose of the present study was to evaluat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246018
更新日期：1996-06-01 00:00:00
abstract：INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-009-1533-4
更新日期：2009-08-01 00:00:00
abstract：:In order to study experimental alcohol intake that leads to heightened aggression, we established ethanol self-administration in aggressive rats. The focus was on low doses of self-administered ethanol and to assess their effects on aggressive behavior in resident rats, using a limited access paradigm followed by a 5-...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050295
更新日期：1997-06-01 00:00:00
abstract：:The anorectic activity of the d and l isomers of d-fenfluramine (d-FF) (l-FF) were compared with d-amphetamine (d-amp) when given separately and together in 12 healthy male volunteers. The study was double blind and placebo controlled. Food intake was measured using an automated food dispenser. Anorectic activity was ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02801976
更新日期：1992-01-01 00:00:00
abstract：:5-Hydroxytryptamine1A (5-HT1A) receptors have been shown to be suppressed by corticosteroid hormones in a variety of animal experimental paradigms. It has been suggested that this effect may be central to the pathophysiology of severe clinical depressive illness, a condition in which 5-HT1A receptor function is reduce...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130050711
更新日期：1998-10-01 00:00:00
abstract：RATIONALE:Whilst the deleterious effects of alcohol on retrospective remembering have been widely documented, no study has yet objectively determined alcohol's effects on prospective memory (PM)--remembering to do something in the future. OBJECTIVES:With this aim, the present study determined the acute effects of alco...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-009-1546-z
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:The rise in heroin addiction has heightened the need for novel and effective treatments. Physical exercise has been shown as an effective treatment for stimulant abuse in clinical and pre-clinical research. However, this treatment has not yet been tested on opioid addiction. This study examined the effects o...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05381-2
更新日期：2020-02-01 00:00:00
