Abstract:
RATIONALE:It has been suggested that the antipsychotic effect of antipsychotics is mediated by the antagonism of the dopamine D2 receptor in the limbic-cortical regions. Risperidone has an atypical property, but its effect on limbic-cortical regions has not been evaluated. OBJECTIVES:In this study, we examined the relationship among doses of risperidone and limbic-cortical dopamine D2 receptor occupancy using positron emission tomography. METHODS:Seven patients with schizophrenia were scanned during the steady state with risperidone. Their occupancies in limbic-cortical regions were determined using positron emission tomography with [11C]FLB 457. RESULTS:The average occupancy ranged from 38% to 80% on doses of 1-6 mg/day. The saturation curve plotted against the drug level fit the data well. CONCLUSIONS:Our results demonstrate that the D2 receptor occupancy with risperidone in the limbic-cortical regions seems to be similar to that of previous reports regarding the striatum, and it would be comparable to that of typical antipsychotics.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Yasuno F,Suhara T,Okubo Y,Sudo Y,Inoue M,Ichimiya T,Tanada Sdoi
10.1007/s002130000643subject
Has Abstractpub_date
2001-02-01 00:00:00pages
112-4issue
1eissn
0033-3158issn
1432-2072journal_volume
154pub_type
临床试验,杂志文章abstract::The effects of monoamine oxidase inhibitors (MAOIs) that selectively inhibit the MAO-A or MAO-B forms of MAO were studied in rats performing under a differential-reinforcement-of-low-rate 72-s (DRL 72-s) schedule of reinforcement. Clorgyline and CGP11'305A, irreversible and reversible MAO-A inhibitors, respectively, i...
journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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pub_type: 杂志文章
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