Abstract:
:The effect of pretreatment with ritanserin, a potent and selective serotonin-S2 (5-HT2) receptor antagonist, on the prolactin (PRL) response to electroconvulsive therapy (ECT) was studied in seven female patients suffering from major depressive disorder. They were given either ECT alone, or ECT after 10 or 20 mg ritanserin PO, and PRL was estimated in blood samples taken at times -5, 0, +5, +15, +30 and +60 min. The PRL responses after drug administration were not different from the responses after ECT alone. We conclude that, if serotonergic mechanisms are involved in the ECT-induced PRL increase, this neuroendocrine response seems to be rather a 5-HT1 than 5-HT2 receptor mediated event.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Papakostas Y,Markianos M,Papadimitriou G,Stefanis Cdoi
10.1007/BF02244407subject
Has Abstractpub_date
1990-01-01 00:00:00pages
206-8issue
2eissn
0033-3158issn
1432-2072journal_volume
100pub_type
杂志文章abstract::The pharmacokinetics of flumazenil in the rat were determined after 2.5 mg/kg intravenous and 25 mg/kg oral administration. Following intravenous administration flumazenil was rapidly eliminated with an extremely short terminal half-life (mean +/- SE, n = 8) of 8.3 +/- 0.3 min due to a large total blood clearance of 1...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244294
更新日期:1991-01-01 00:00:00
abstract::The behavioural effects of increasing doses of apomorphine and haloperidol were observed in a group of six marmosets. Behaviour was classified quantitatively into categories: Locomotion, inactivity, checking (small head movements), social interaction and purposeful activities. Statistical analysis revealed that apomor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431987
更新日期:1979-01-01 00:00:00
abstract::This study was designed to compare the therapeutic and adverse effects of tranylcypromine (a monoamine oxidase inhibitor), nortriptyline (a tricyclic antidepressant), and placebo. A total of 122 depressed outpatients randomly assigned to double-blind treatment with one of these agents completed the 4-week protocol. Tr...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427786
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Individuals with schizophrenia have high smoking-related morbidity and mortality rates and need powerful and innovative smoking cessation interventions. OBJECTIVES:This proof-of-concept study investigated the feasibility and initial efficacy of combining a contingency management intervention with bupropion t...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2282-8
更新日期:2011-09-01 00:00:00
abstract::Acute alcohol intoxication disrupts memory acquisition in humans and laboratory animals. This review summarizes recent behavioral and immediate early gene expression studies addressing the mechanisms of this phenomenon. Most behavioral investigations agree that the amnestic effect of alcohol is due to its preferential...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130050687
更新日期:1998-09-01 00:00:00
abstract::The four homoeopathic drugs, Gelsemium, Cannabis Indica, Graphites and Agaricus Muscarius, administered orally in 30th and 200th potencies on white rats, enhanced restraint-induced catalepsy in a similar manner to the two standard drugs pilocarpine and haloperidol (IP injection at 5 mg/kg). All the drugs tested differ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174371
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Paired-associate learning (PAL), as part of the Cambridge Neuropsychological Test Automated Battery, is able to predict who from an at-risk population will develop Alzheimer's disease. Schizophrenic patients are also impaired on this same task. An automated rodent model of PAL would be extremely beneficial in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1526-3
更新日期:2009-07-01 00:00:00
abstract:RATIONALE:The ability of nicotine to induce dependence (result in a withdrawal syndrome) is typically thought to require long-term, daily smoking. Emerging evidence suggests that symptoms of nicotine withdrawal may occur following only a few cigarettes. Whether acute exposure to nicotine can induce dependence in animal...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2814-x
更新日期:2013-01-01 00:00:00
abstract:RATIONALE:Memantine is a potential treatment for alcoholic patients, yet few studies investigate the effect of concurrent treatment with memantine and ethanol on aggression. We evaluated aggressive behavior following ethanol consumption and treatment with glutamatergic drugs to characterize interactions between these c...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2734-9
更新日期:2012-11-01 00:00:00
abstract:RATIONALE:Robust intravenous (i.v.) nicotine self-administration (SA) in rats has been reported by several laboratories, including our own, using fixed ratio (FR) schedules of reinforcement. Studies on other drugs of abuse, however, suggest that progressive ratio (PR) schedules may provide additional information not ga...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051153
更新日期:1999-11-01 00:00:00
abstract:RATIONALE:The hallucinatory effect and potential abuse of salvinorin A, the major ingredient of Salvia divinorum, has not been documented in animals. OBJECTIVE:The effects of salvinorin A on the zebrafish (Danio rerio) model, through its swimming behavior and conditioned place preference (CPP) task, was studied. MATE...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0639-1
更新日期:2007-03-01 00:00:00
abstract:RATIONALE:Clinical observations have shown that pain sensitivity is altered in some schizophrenic patients. OBJECTIVES:To study alterations in pain sensitivity, the ketamine model in schizophrenia research was employed. MATERIALS AND METHODS:Rats were subchronically injected with the dissociative anaesthetic ketamine...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0557-2
更新日期:2006-12-01 00:00:00
abstract:RATIONALE:The occurrence of methamphetamine (METH) use by the smoking route is increasing. A nonhuman primate model for examining the reinforcing effects of smoked METH would be valuable for testing potential interventions for treating METH abuse disorders. OBJECTIVE:The purpose of the present study was to examine the...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0479-z
更新日期:2006-10-01 00:00:00
abstract::In a shuttle-box self-stimulation paradigm, analgesic doses of morphine increase the amount of time a rat leaves rewarding brain stimulation on, without altering average OFF times. This paradigm may serve as a model for the euphoria induced by narcotic drugs and as a useful tool for evaluating the reinforcing effects ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426581
更新日期:1977-11-15 00:00:00
abstract::The concurrent influence of dopaminergic, sigma and muscarinic neurotransmitter systems in mediating cocaine-induced lethality is predicted by previous receptor binding results from our laboratories. The present results demonstrate that pharmacological manipulations of these predicted neurotransmitter systems alter th...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050198
更新日期:1997-02-01 00:00:00
abstract:RATIONALE:Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05556-2
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:The thalamus is a major target of dopaminergic projections and is densely connected with the prefrontal cortex. A better understanding of how dopamine changes thalamo-cortical communication may shed light on how dopamine supports cognitive function. Methylphenidate has been shown to facilitate cognitive proc...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-020-05505-z
更新日期:2020-06-01 00:00:00
abstract:RATIONALE:We have recently shown that post-extinction exposure of rats to a sub-threshold reminder shock can reactivate extinguished context-related freezing and found that chronic treatment with fluoxetine before fear extinction prevents this phenomenon. OBJECTIVES:In the present study, we examined whether these find...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2134-y
更新日期:2011-05-01 00:00:00
abstract::The mesolimbic dopamine (DA) system has been implicated in conditioned reward (CR), locomotor sensitization, and the reinforcing properties of psychomotor stimulants. Stimuli with formerly motivationally neutral properties that gain incentive properties by their predictive association with primary reinforcers are term...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050859
更新日期:1999-02-01 00:00:00
abstract:RATIONALE:Brain reward pathways implicated in addiction appear to be less reactive in regular drug users; behavioural manifestations may include decreased sensitivity to natural reinforcers. OBJECTIVES:This study aimed to replicate earlier findings of abstinence-associated incentive motivation deficits in smokers and ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-006-0588-8
更新日期:2006-12-01 00:00:00
abstract:RATIONALE:Despite animal evidence that methylenedioxymethamphetamine (ecstasy) causes lasting damage in brain regions related to long-term memory, results regarding human memory performance have been variable. This variability may reflect the cognitive complexity of the memory tasks. However, previous studies have test...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1766-2
更新日期:2010-03-01 00:00:00
abstract::Ibogaine is currently being investigated for its potential use as an anti-addictive agent. In the present study we sought to determine whether prior morphine exposure influences the ability of ibogaine to inhibit morphine-induced locomotor stimulation. Female Sprague-Dawley rats were pretreated once a day for 1-4 days...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246495
更新日期:1995-10-01 00:00:00
abstract:INTRODUCTION:Understanding an individual's vulnerability to drug addiction has important implications for the development of effective personal treatment plans. Although theories acknowledge impulsive behaviour as a key component of drug addiction, little is known about the influence of trait impulsivity on an individu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3270-y
更新日期:2014-02-01 00:00:00
abstract:RATIONALE:Delaying presentation of a drug can decrease its effectiveness as a reinforcer, but the effect of delaying punishment of drug self-administration is unknown. OBJECTIVE:This study examined whether a histamine injection could punish cocaine self-administration in a drug-drug choice, whether delaying histamine ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2501-3
更新日期:2012-04-01 00:00:00
abstract::Ferret predation on rats was examined in an arena. One hour before the test one of the following drugs was administered. d-Amphetamine (0.8 and 1.4 mg/kg IM), MAPROTILINE (10 AND 40 Mg/kg orally), L-dopa (30 and 60 mg/kg orally), or haloperidol (0.14 and 0.6 mg/kg IM). Provided that capture was successful, the sequenc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427524
更新日期:1979-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Previous studies have demonstrated that sensitization to repeated doses of cocaine results in prolonged changes in glutamate transmission. However, little is known about long-term changes in glutamate transmission following a single dose of cocaine. Our laboratory has previously reported that a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1296-7
更新日期:2003-02-01 00:00:00
abstract::A theory of acute tolerance to alcohol is proposed that includes two assumptions: 1) acute tolerance is a linear process with time, and 2) the slope of the line is a measure of the magnitude of the acute tolerance effect. Evidence that supports the validity of the theory is presented both from studies in which blood a...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF02245438
更新日期:1994-02-01 00:00:00
abstract:RATIONALE:Caffeine and the adenosine A(1) and A(2A) receptor antagonist CGS15943 produce many behavioral effects that are similar to those produced by classic stimulant drugs (e.g. cocaine and amphetamines). OBJECTIVES:The current study evaluated whether CGS15943 would maintain self-administration and reinstate exting...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1410-5
更新日期:2003-07-01 00:00:00
abstract:RATIONALE:Early life exposure to stress and to GABAA receptor modulators have well-defined and persistent behavioral effects. A single neonatal injection of the GABAergic neurosteroid allopregnanolone (3alpha-hydroxy,5alpha-pregnane-20-one, 10 mg/kg, i.p.) alters the localization of prefrontal cortex (PFC) interneurons...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0360-0
更新日期:2006-06-01 00:00:00
abstract::It is commonly believed that repeated exposures diminish the pleasurable effects of drugs and hence that pleasure must have only a minor role in addiction. In six experiments with rats, repeated exposures to amphetamine, morphine, or cocaine were found to enhance the drug-induced rewarding effect as measured by condit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00451687
更新日期:1989-01-01 00:00:00